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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diethyldithiocarbamic acid
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Accession:CHEBI:144353 term browser browse the term
Definition:A member of the class of dithiocarbamic acids that is diethylcarbamic acid in which both of the oxygens are replaced by sulfur.
Synonyms:exact_synonym: diethylcarbamodithioic acid
 related_synonym: Ditiocarb;   Formula=C5H11NS2;   InChI=1S/C5H11NS2/c1-3-6(4-2)5(7)8/h3-4H2,1-2H3,(H,7,8);   InChIKey=LMBWSYZSUOEYSN-UHFFFAOYSA-N;   N,N-diethylcarbamodithioic acid;   N,N-diethyldithiocarbamic acid;   SMILES=C(=S)(S)N(CC)CC
 xref: CAS:147-84-2;   DrugBank:DB02520;   KEGG:C19150
 xref_mesh: MESH:D004050
 xref: PMID:1848982;   PMID:1851986;   PMID:2902461;   PMID:31465063;   Reaxys:1747741
 cyclic_relationship: is_conjugate_acid_of CHEBI:144359


show annotations for term's descendants           Sort by:
diethyldithiocarbamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase multiple interactions
decreases activity		 EXP Ditiocarb inhibits the reaction [Ditiocarb analog results in decreased activity of ALAD protein]; Ditiocarb inhibits the reaction [lead acetate results in decreased activity of ALAD protein] CTD PMID:2177232 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases chemical synthesis ISO ALDH3A1 protein results in increased chemical synthesis of Ditiocarb CTD PMID:18591790 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Anxa1 annexin A1 increases expression EXP Ditiocarb results in increased expression of ANXA1 mRNA CTD PMID:16603213 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein] CTD PMID:22951949 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein] CTD PMID:28242320 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA] CTD PMID:28242320 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Casp1 caspase 1 multiple interactions
affects expression		 ISO [Ditiocarb co-treated with Zinc] results in decreased expression of CASP1 protein
Ditiocarb affects the expression of CASP1 protein		 CTD PMID:25929180 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 [[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]
[Ditiocarb co-treated with Arsenic Trioxide] results in increased activity of CASP3 protein		 CTD PMID:22951949 PMID:27592447 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Ditiocarb binds to Copper] which results in increased activity of CASP8 protein CTD PMID:22951949 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein] CTD PMID:22951949 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression ISO Ditiocarb results in decreased expression of CAT mRNA CTD PMID:8279580 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccs copper chaperone for superoxide dismutase decreases expression EXP Ditiocarb results in decreased expression of CCS protein CTD PMID:20452388 NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915 		JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase increases expression EXP Ditiocarb results in increased expression of CNP protein CTD PMID:22874009 NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720 		JBrowse link
G Cp ceruloplasmin multiple interactions ISO Ditiocarb inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]] CTD PMID:16756764 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]; [Ditiocarb binds to Copper] which affects the localization of CYCS protein CTD PMID:22951949 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP
ISO		 Ditiocarb inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Ditiocarb results in increased expression of CYP2B1 mRNA CTD PMID:8390837 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Ditiocarb results in increased expression of CYP2B2 mRNA CTD PMID:8390837 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO Ditiocarb results in decreased activity of CYP2C19 protein CTD PMID:8819299 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions		 EXP
ISO		 Ditiocarb results in decreased activity of CYP2E1 protein
Ditiocarb inhibits the reaction [[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Benzene]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of methylformamide]; Ditiocarb inhibits the reaction [pyridine results in increased activity of CYP2E1 protein]
[Ditiocarb co-treated with CYP2E1 gene mutant form] results in decreased metabolism of Styrene; [Ditiocarb results in decreased activity of CYP2E1 protein] which results in decreased oxidation of Benzene
Ditiocarb inhibits the reaction [CYP2E1 protein results in increased glutathionylation of Lamotrigine]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 2-xylene]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 3-xylene]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-xylene]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of Theobromine]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of Toluene]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]		 CTD PMID:1356728 PMID:1538706 PMID:1664256 PMID:8558417 PMID:8560479 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression EXP Ditiocarb results in increased expression of DDIT4 protein CTD PMID:24764117 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression EXP Ditiocarb results in increased expression of DPYSL2 protein CTD PMID:22874009 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 multiple interactions EXP Ditiocarb binds to and results in decreased activity of GSTA3 protein CTD PMID:6095330 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP Ditiocarb binds to and results in decreased activity of GSTM1 protein CTD PMID:6095330 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Ditiocarb results in increased expression of GSTP1 protein CTD PMID:22874009 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha decreases expression EXP Ditiocarb results in decreased expression of HADHA protein CTD PMID:22874009 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Ditiocarb results in increased expression of HMOX1 protein CTD PMID:19467251 PMID:20452388 PMID:22874009 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Ditiocarb results in decreased activity of HSD11B2 protein CTD PMID:22796344 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [[Paraquat co-treated with Ditiocarb] results in decreased activity of SOD1 protein] which results in increased expression of ICAM1 protein CTD PMID:10644010 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma increases expression
multiple interactions		 ISO Ditiocarb results in increased expression of IFNG protein
Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; Polysaccharides inhibits the reaction [Ditiocarb results in increased expression of IFNG protein]
Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]		 CTD PMID:11498278 PMID:26826268 PMID:28242320 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO Polysaccharides inhibits the reaction [Ditiocarb results in increased expression of IL1B protein] CTD PMID:26826268 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP Ditiocarb results in increased phosphorylation of MAPK1 protein
Acetylcysteine inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]; Nitric Oxide affects the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]		 CTD PMID:16603213 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP Ditiocarb results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK3 protein]; Nitric Oxide affects the reaction [Ditiocarb results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK3 protein]		 CTD PMID:16603213 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mbp myelin basic protein increases expression EXP Ditiocarb results in increased expression of MBP protein CTD PMID:22874009 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Ditiocarb inhibits the reaction [Isoflurane affects the localization of NFKB1 protein] CTD PMID:18708911 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 affects expression
multiple interactions		 ISO Ditiocarb affects the expression of NLRP3 protein
[Ditiocarb co-treated with Zinc] results in decreased expression of NLRP3 protein		 CTD PMID:25929180 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO		 Ditiocarb inhibits the reaction [Isoflurane results in increased expression of NOS2 protein]
Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]		 CTD PMID:18708911 PMID:28242320 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]; Nitric Oxide affects the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]; Nitric Oxide affects the reaction [Ditiocarb results in increased expression of PLA2G4A protein]; U 0126 inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]; U 0126 inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A protein]
Ditiocarb results in increased expression of PLA2G4A mRNA; Ditiocarb results in increased expression of PLA2G4A protein		 CTD PMID:16603213 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pln phospholamban multiple interactions
increases phosphorylation		 EXP 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ditiocarb results in increased phosphorylation of PLN protein] CTD PMID:16288776 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Prdx2 peroxiredoxin 2 increases expression EXP Ditiocarb results in increased expression of PRDX2 protein CTD PMID:22874009 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Prdx6 peroxiredoxin 6 increases expression EXP Ditiocarb results in increased expression of PRDX6 protein CTD PMID:22874009 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355 		JBrowse link
G Prnp prion protein increases expression EXP Ditiocarb results in increased expression of PRNP protein CTD PMID:20452388 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA] CTD PMID:28242320 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 multiple interactions ISO Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA] CTD PMID:28242320 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Pygb glycogen phosphorylase B increases expression EXP Ditiocarb results in increased expression of PYGB protein CTD PMID:22874009 NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Ditiocarb inhibits the reaction [Isoflurane affects the localization of RELA protein] CTD PMID:18708911 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 increases expression EXP Ditiocarb results in increased expression of SLC6A3 protein CTD PMID:22874009 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Snca synuclein alpha increases expression EXP Ditiocarb results in increased expression of SNCA protein CTD PMID:22874009 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases activity
increases expression		 ISO
EXP		 [[Paraquat co-treated with Ditiocarb] results in decreased activity of SOD1 protein] which results in increased expression of ICAM1 protein
Ditiocarb results in decreased activity of SOD1 protein; Ditiocarb results in decreased activity of SOD1 protein mutant form
Ditiocarb inhibits the reaction [lactacystin affects the localization of SOD1 protein mutant form]
Ditiocarb results in increased expression of SOD1 mRNA
Ditiocarb results in increased expression of SOD1 protein		 CTD PMID:8279580 PMID:10644010 PMID:15034941 PMID:16681429 PMID:19467251 More... NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Ditiocarb results in decreased expression of and results in increased phosphorylation of TH protein CTD PMID:22874009 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ditiocarb inhibits the reaction [Asbestos, Crocidolite results in increased secretion of TNF protein] CTD PMID:10486238 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO Ditiocarb results in increased expression of TP53 protein
Ditiocarb inhibits the reaction [cobaltous chloride results in increased expression of and results in increased activity of TP53 protein]; Ditiocarb inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein]		 CTD PMID:10951577 PMID:11964141 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO
EXP		 Ditiocarb results in decreased activity of and results in decreased ubiquitination of UBA1 protein
Ditiocarb binds to and results in decreased activity of UBA1 protein		 CTD PMID:22874009 PMID:25714994 NCBI chr  X:1,508,700...1,530,677
Ensembl chr  X:1,508,666...1,530,636 		JBrowse link
G Ucp2 uncoupling protein 2 increases expression ISO Ditiocarb results in increased expression of UCP2 protein CTD PMID:18082129 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      chemical role 19422
        ligand 6727
          chelator 6714
            diethyldithiocarbamic acid 54
              zinc diethyldithiocarbamate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organosulfur compound 17334
                                  thiocarbonyl compound 7911
                                    dithiocarbamic acids 409
                                      diethyldithiocarbamic acid 54
                                        zinc diethyldithiocarbamate + 0
paths to the root