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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
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Accession:CHEBI:144093 term browser browse the term
Definition:A member of the class of (trifluoromethyl)benzenes that is 4-amino-2-(trifluoromethyl)benzonitrile in which one of the amino hydrogens is substituted by a 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanoyl group.
Synonyms:related_synonym: Formula=C18H14F4N2O4S;   InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25);   InChIKey=LKJPYSCBVHEWIU-UHFFFAOYSA-N;   SMILES=C=1(C(=CC=C(C1)NC(C(CS(C=2C=CC(=CC2)F)(=O)=O)(O)C)=O)C#N)C(F)(F)F


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bicalutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aamp angio-associated, migratory cell protein increases expression ISO bicalutamide results in increased expression of AAMP mRNA CTD PMID:16631469 NCBI chr 9:81,560,836...81,566,642
Ensembl chr 9:81,560,842...81,566,642
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO bicalutamide results in decreased activity of ABCB11 protein CTD PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO bicalutamide results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acp3 acid phosphatase 3 decreases expression ISO bicalutamide results in decreased expression of ACP3 mRNA CTD PMID:15638997 NCBI chr 8:112,838,574...112,884,062
Ensembl chr 8:112,834,707...112,884,077
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO bicalutamide results in increased expression of ACSL1 mRNA CTD PMID:15790403 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of ADAM9 protein] CTD PMID:17342749 NCBI chr16:71,810,377...71,887,926
Ensembl chr16:71,810,377...71,887,926
JBrowse link
G Adrb2 adrenoceptor beta 2 decreases expression
multiple interactions
ISO bicalutamide results in decreased expression of ADRB2 mRNA; bicalutamide results in decreased expression of ADRB2 protein
bicalutamide inhibits the reaction [Triiodothyronine results in increased expression of ADRB2 protein]
CTD PMID:18454446 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member increases expression ISO bicalutamide results in increased expression of AGR2 mRNA CTD PMID:15638997 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO bicalutamide inhibits the reaction [Metribolone results in increased phosphorylation of AKT1 protein] CTD PMID:17325745 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of ALDH1A3 mRNA] CTD PMID:17526768 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression ISO bicalutamide results in increased expression of ALDH3A2 mRNA CTD PMID:15638997 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Amacr alpha-methylacyl-CoA racemase decreases expression ISO bicalutamide results in decreased expression of AMACR mRNA CTD PMID:15638997 NCBI chr 2:60,949,276...60,961,342
Ensembl chr 2:60,949,256...60,961,326
JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 increases expression ISO bicalutamide results in increased expression of AMD1 mRNA CTD PMID:15790403 NCBI chr20:45,384,000...45,399,694
Ensembl chr20:45,384,000...45,399,694
JBrowse link
G Ankib1 ankyrin repeat and IBR domain containing 1 increases expression ISO bicalutamide results in increased expression of ANKIB1 mRNA CTD PMID:16631469 NCBI chr 4:27,473,477...27,597,206
Ensembl chr 4:27,473,477...27,597,206
JBrowse link
G Ar androgen receptor decreases response to substance
decreases expression
multiple interactions
increases expression
decreases activity
affects binding
affects response to substance
affects localization
ISO
EXP
AR gene mutant form results in decreased susceptibility to bicalutamide; AR protein alternative form results in decreased susceptibility to bicalutamide
bicalutamide results in decreased expression of AR protein
bicalutamide binds to and results in decreased activity of AR protein; bicalutamide inhibits the reaction [[Testosterone binds to AR protein] inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]]
bicalutamide results in increased localization of and results in increased activity of AR protein
bicalutamide results in increased expression of AR; bicalutamide results in increased expression of AR protein
bicalutamide results in decreased expression of AR; bicalutamide results in decreased expression of AR mRNA
bicalutamide results in decreased activity of AR protein
[bicalutamide binds to AR protein] which binds to KLK3 promoter; bicalutamide binds to AR protein
AR protein affects the susceptibility to bicalutamide
[Azacitidine analog results in increased expression of AR protein] which results in increased susceptibility to bicalutamide; [bicalutamide binds to and results in decreased activity of AR protein] inhibits the reaction [Dehydroepiandrosterone results in decreased expression of CYP1A2 mRNA]; [bicalutamide co-treated with Testosterone] affects the expression of and results in decreased activity of AR protein; [bicalutamide results in decreased susceptibility to bicalutamide] which results in increased expression of and affects the localization of AR protein alternative form; [bicalutamide results in decreased susceptibility to bicalutamide] which results in increased expression of AR mRNA; [bicalutamide results in decreased susceptibility to bicalutamide] which results in increased expression of AR mRNA alternative form; [bicalutamide results in decreased susceptibility to bicalutamide] which results in increased expression of AR protein; [Dihydrotestosterone co-treated with bicalutamide] promotes the reaction [AR protein binds to PHB protein]; [Dihydrotestosterone co-treated with bicalutamide] promotes the reaction [AR protein binds to SMARCA4 protein]; [Goserelin co-treated with bicalutamide] results in decreased expression of AR protein; [Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of AR protein; [Goserelin co-treated with Dutasteride co-treated with bicalutamide] results in decreased expression of AR protein; AR protein promotes the reaction [bicalutamide promotes the reaction [PHB protein binds to KLK3 promoter]]; bicalutamide binds to and affects the localization of and affects the activity of AR protein; bicalutamide binds to and results in decreased activity of AR protein; bicalutamide binds to and results in increased activity of AR protein mutant form; bicalutamide inhibits the reaction [[Dihydrotestosterone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; bicalutamide inhibits the reaction [[Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; bicalutamide inhibits the reaction [alpha-naphthoflavone inhibits the reaction [Particulate Matter analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]]; bicalutamide inhibits the reaction [alpha-naphthoflavone inhibits the reaction [Vehicle Emissions analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]]; bicalutamide inhibits the reaction [AR protein alternative form binds to KLK3 promoter]; bicalutamide inhibits the reaction [AR protein alternative form promotes the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]]; bicalutamide inhibits the reaction [AR protein binds to KLK3 promoter]; bicalutamide inhibits the reaction [AR protein binds to NCOA1 protein]; bicalutamide inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to AR protein]]; bicalutamide inhibits the reaction [Cadmium Chloride results in decreased expression of AR mRNA]; bicalutamide inhibits the reaction [Cadmium Chloride results in decreased expression of AR protein]; bicalutamide inhibits the reaction [Dihydrotestosterone affects the localization of AR protein]; bicalutamide inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; bicalutamide inhibits the reaction [Dihydrotestosterone binds to AR protein]; bicalutamide inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to MYC enhancer]]; bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of AR mRNA]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein mutant form]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of and results in increased phosphorylation of AR protein]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; bicalutamide inhibits the reaction [Estradiol results in increased activity of AR protein mutant form]; bicalutamide inhibits the reaction [Estradiol results in increased activity of AR protein]; bicalutamide inhibits the reaction [Fludrocortisone results in increased activity of AR protein mutant form]; bicalutamide inhibits the reaction [Flutamide results in increased activity of AR protein mutant form]; bicalutamide inhibits the reaction [Metribolone results in increased activity of AR protein mutant form]; bicalutamide inhibits the reaction [Metribolone results in increased activity of AR protein]; bicalutamide inhibits the reaction [Metribolone results in increased folding of and results in increased stability of AR protein]; bicalutamide inhibits the reaction [OSM protein results in increased activity of AR protein]; bicalutamide inhibits the reaction [Sirolimus results in increased activity of AR protein]; bicalutamide inhibits the reaction [Testosterone results in increased activity of AR protein]; bicalutamide promotes the reaction [AR protein binds to KLK3 promoter]; bicalutamide promotes the reaction [AR protein binds to NCOR2 protein]; bicalutamide promotes the reaction [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein]; methoxyacetic acid inhibits the reaction [bicalutamide inhibits the reaction [Testosterone results in increased activity of AR protein]]; mibolerone inhibits the reaction [bicalutamide results in increased expression of AR protein]; Resveratrol promotes the reaction [bicalutamide results in decreased activity of AR protein]
bicalutamide affects the localization of AR protein
CTD PMID:10053169, PMID:11751618, PMID:11845989, PMID:11956172, PMID:11981028, PMID:12015321, PMID:12114440, PMID:12376534, PMID:12730620, PMID:12970580, PMID:15171712, PMID:15308689, PMID:15336702, PMID:15638997, PMID:15994348, PMID:16015592, PMID:16266977, PMID:16877366, PMID:17606915, PMID:17723170, PMID:17804755, PMID:18324645, PMID:18324785, PMID:18486176, PMID:18487222, PMID:18776922, PMID:18922931, PMID:19131511, PMID:19359544, PMID:19587329, PMID:20032058, PMID:20729295, PMID:21036700, PMID:21308717, PMID:21506597, PMID:23562765, PMID:23603339, PMID:24323034, PMID:24759320, PMID:25752796, PMID:26867867, PMID:27473015, PMID:27720946, PMID:28500234, PMID:28757136, PMID:29383186, PMID:29427707, PMID:29462692 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arg1 arginase 1 decreases expression ISO bicalutamide results in decreased expression of ARG1 protein CTD PMID:20711410 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arg2 arginase 2 increases expression ISO bicalutamide results in increased expression of ARG2 protein CTD PMID:20711410 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Asap2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 increases expression ISO bicalutamide results in increased expression of ASAP2 mRNA CTD PMID:16631469 NCBI chr 6:43,231,178...43,348,606
Ensembl chr 6:43,234,526...43,343,551
JBrowse link
G Atf3 activating transcription factor 3 decreases expression
increases expression
ISO bicalutamide results in decreased expression of ATF3 protein
bicalutamide results in increased expression of ATF3 mRNA
CTD PMID:15638997, PMID:16516039 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atp5me ATP synthase membrane subunit e increases expression ISO bicalutamide results in increased expression of ATP5ME mRNA CTD PMID:16631469 NCBI chr14:2,325,308...2,326,436
Ensembl chr14:2,325,308...2,326,436
JBrowse link
G B4galt6 beta-1,4-galactosyltransferase 6 increases expression ISO bicalutamide results in increased expression of B4GALT6 mRNA CTD PMID:16631469 NCBI chr18:15,462,913...15,525,584
Ensembl chr18:15,462,913...15,525,579
JBrowse link
G Bard1 BRCA1 associated RING domain 1 decreases expression ISO bicalutamide results in decreased expression of BARD1 mRNA CTD PMID:15638997 NCBI chr 9:78,297,723...78,368,777
Ensembl chr 9:78,294,834...78,369,031
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
multiple interactions
ISO bicalutamide results in decreased expression of BAX
bicalutamide results in increased expression of BAX protein
[bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Niclosamide co-treated with bicalutamide] results in increased expression of BAX protein; bicalutamide inhibits the reaction [Niclosamide results in decreased expression of BAX protein]
CTD PMID:11845989, PMID:27132804, PMID:28500234 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase decreases expression ISO bicalutamide results in decreased expression of BCHE mRNA CTD PMID:15638997 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
ISO bicalutamide results in increased expression of BCL2
bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2 protein]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2 protein]
CTD PMID:11845989, PMID:28500234 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO bicalutamide results in decreased expression of BCL2L1 protein
bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2L1 protein]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2L1 protein]
CTD PMID:28500234 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO bicalutamide results in decreased expression of BIRC5 mRNA CTD PMID:15638997 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO bicalutamide results in increased expression of BNIP3 mRNA CTD PMID:15790403 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Btbd3 BTB domain containing 3 increases expression ISO bicalutamide results in increased expression of BTBD3 mRNA CTD PMID:16631469 NCBI chr 3:131,330,338...131,360,554
Ensembl chr 3:131,351,587...131,357,929
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO bicalutamide results in decreased expression of BUB1B mRNA CTD PMID:15638997 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; bicalutamide results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:15638997, PMID:27132804 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO bicalutamide promotes the reaction [Niclosamide results in increased expression of CASP7 protein modified form] CTD PMID:28500234 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]] CTD PMID:16317058 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO bicalutamide results in decreased expression of CCNA2 mRNA CTD PMID:15887248 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO bicalutamide results in decreased expression of CCNB1 mRNA CTD PMID:15887248 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb1ip1 cyclin B1 interacting protein 1 increases expression ISO bicalutamide results in increased expression of CCNB1IP1 mRNA CTD PMID:15638997 NCBI chr15:27,720,220...27,736,528
Ensembl chr15:27,720,223...27,733,785
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Niclosamide promotes the reaction [bicalutamide results in decreased expression of CCND1 protein] CTD PMID:28500234 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng2 cyclin G2 increases expression ISO bicalutamide results in increased expression of CCNG2 mRNA CTD PMID:15790403 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Ccpg1 cell cycle progression 1 increases expression ISO bicalutamide results in increased expression of CCPG1 mRNA CTD PMID:15638997 NCBI chr 8:79,660,634...79,692,044
Ensembl chr 8:79,660,657...79,692,039
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]] CTD PMID:16317058 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd9 CD9 molecule increases expression ISO bicalutamide results in increased expression of CD9 mRNA CTD PMID:15790403 NCBI chr 4:157,977,163...158,010,091
Ensembl chr 4:157,977,162...158,010,166
JBrowse link
G Cdc20 cell division cycle 20 decreases expression ISO bicalutamide results in decreased expression of CDC20 mRNA CTD PMID:15638997 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO bicalutamide results in decreased expression of CDC6 mRNA; bicalutamide results in decreased expression of CDC6 protein CTD PMID:15887248 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdh1 cadherin 1 affects localization ISO bicalutamide affects the localization of CDH1 protein CTD PMID:17440980 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO bicalutamide results in decreased expression of CDK1 mRNA CTD PMID:15638997 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO bicalutamide results in increased expression of CDKN1A; bicalutamide results in increased expression of CDKN1A mRNA; bicalutamide results in increased expression of CDKN1A protein
[bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein
CTD PMID:11845989, PMID:15638997, PMID:27132804 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO bicalutamide results in increased expression of CDKN1B CTD PMID:11845989 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C decreases expression ISO bicalutamide results in decreased expression of CDKN2C mRNA CTD PMID:15638997 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO bicalutamide results in decreased expression of CKS2 mRNA CTD PMID:15638997 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423
JBrowse link
G Clgn calmegin increases expression ISO bicalutamide results in increased expression of CLGN mRNA CTD PMID:15638997 NCBI chr19:24,545,257...24,578,527
Ensembl chr19:24,545,318...24,576,798
JBrowse link
G Clu clusterin multiple interactions ISO bicalutamide inhibits the reaction [Metribolone results in increased expression of CLU mRNA]; bicalutamide inhibits the reaction [Metribolone results in increased expression of CLU protein] CTD PMID:17148459, PMID:17325745 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Copb2 COPI coat complex subunit beta 2 increases expression ISO bicalutamide results in increased expression of COPB2 mRNA CTD PMID:16631469 NCBI chr 8:106,582,339...106,603,763 JBrowse link
G Crebbp CREB binding protein multiple interactions ISO bicalutamide inhibits the reaction [Metribolone results in decreased expression of CREBBP protein] CTD PMID:15378487 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP bicalutamide inhibits the reaction [Androstenedione results in increased expression of CYP11A1 protein]; bicalutamide inhibits the reaction [Testosterone results in increased expression of CYP11A1 protein] CTD PMID:21273442 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions EXP bicalutamide inhibits the reaction [Androstenedione results in increased expression of CYP19A1 protein]; bicalutamide inhibits the reaction [Testosterone results in increased expression of CYP19A1 protein] CTD PMID:21273442 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [bicalutamide binds to and results in decreased activity of AR protein] inhibits the reaction [Dehydroepiandrosterone results in decreased expression of CYP1A2 mRNA]; bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased degradation of CYP1A2 mRNA] CTD PMID:23603339 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions EXP bicalutamide inhibits the reaction [[Testosterone binds to AR protein] inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]] CTD PMID:20032058 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Deptor DEP domain containing MTOR-interacting protein multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of DEPTOR mRNA] CTD PMID:26558456 NCBI chr 7:94,795,161...95,000,750
Ensembl chr 7:94,795,214...94,995,809
JBrowse link
G Dio3 iodothyronine deiodinase 3 increases expression ISO bicalutamide results in increased expression of DIO3 mRNA CTD PMID:15638997 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Dkc1 dyskerin pseudouridine synthase 1 decreases expression ISO bicalutamide results in decreased expression of DKC1 mRNA CTD PMID:15638997 NCBI chr  X:155,844,914...155,862,363
Ensembl chr  X:155,844,857...155,862,475
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO bicalutamide results in increased expression of DNAJB9 mRNA CTD PMID:15638997 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Drd4 dopamine receptor D4 decreases expression
multiple interactions
ISO bicalutamide results in decreased expression of DRD4 mRNA
FSHB protein inhibits the reaction [bicalutamide results in decreased expression of DRD4 protein]
CTD PMID:19587329 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Ebp EBP, cholestenol delta-isomerase decreases expression ISO bicalutamide results in decreased expression of EBP mRNA CTD PMID:15638997 NCBI chr  X:15,049,394...15,055,782
Ensembl chr  X:15,049,462...15,055,781
JBrowse link
G Egf epidermal growth factor multiple interactions ISO bicalutamide inhibits the reaction [FOS protein results in increased expression of EGF mRNA] CTD PMID:15466214 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO bicalutamide inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to AR protein]]; bicalutamide inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to ESR2 protein]]; bicalutamide inhibits the reaction [bisphenol A results in increased phosphorylation of EGFR protein] CTD PMID:29383186 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [bicalutamide co-treated with Testosterone] results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:21036700 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Eppin epididymal peptidase inhibitor decreases expression
multiple interactions
ISO bicalutamide results in decreased expression of EPPIN mRNA
FSHB protein inhibits the reaction [bicalutamide results in decreased expression of EPPIN protein]
CTD PMID:19587329 NCBI chr 3:161,043,761...161,050,550
Ensembl chr 3:161,041,727...161,050,557
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO bicalutamide inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to ESR2 protein]] CTD PMID:29383186 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Etl4 enhancer trap locus 4 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of KIAA1217 mRNA] CTD PMID:17624924 NCBI chr17:87,173,265...87,681,268
Ensembl chr17:87,274,944...87,681,317
JBrowse link
G Etv1 ETS variant transcription factor 1 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of ETV1 mRNA] CTD PMID:28757136 NCBI chr 6:58,467,215...58,558,640
Ensembl chr 6:58,467,254...58,558,631
JBrowse link
G Ezr ezrin multiple interactions ISO bicalutamide inhibits the reaction [Metribolone results in increased expression of EZR mRNA]; bicalutamide inhibits the reaction [Metribolone results in increased phosphorylation of EZR protein] CTD PMID:16873375 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of FABP4 protein] CTD PMID:18801408 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fgf13 fibroblast growth factor 13 increases expression ISO bicalutamide results in increased expression of FGF13 mRNA CTD PMID:15638997 NCBI chr  X:142,053,648...142,589,274
Ensembl chr  X:142,053,654...142,248,369
JBrowse link
G Fkbp11 FKBP prolyl isomerase 11 increases expression ISO bicalutamide results in increased expression of FKBP11 mRNA CTD PMID:15638997 NCBI chr 7:140,398,253...140,402,664
Ensembl chr 7:140,398,199...140,437,467
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 decreases expression
multiple interactions
ISO bicalutamide results in decreased expression of FKBP5 mRNA
[Niclosamide co-treated with bicalutamide] results in decreased expression of FKBP5 mRNA
CTD PMID:28500234 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of FOS mRNA]; bicalutamide inhibits the reaction [FOS protein results in increased expression of EGF mRNA] CTD PMID:15466214 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO FSHB protein inhibits the reaction [bicalutamide results in decreased expression of DRD4 protein]; FSHB protein inhibits the reaction [bicalutamide results in decreased expression of EPPIN protein]; FSHB protein inhibits the reaction [bicalutamide results in decreased expression of GPD1 protein]; FSHB protein inhibits the reaction [bicalutamide results in decreased expression of RHOX5 protein] CTD PMID:19587329 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO bicalutamide results in increased expression of GADD45A mRNA CTD PMID:15638997 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gcg glucagon decreases expression ISO bicalutamide results in decreased expression of GCG mRNA CTD PMID:15638997 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gpc1 glypican 1 decreases expression ISO bicalutamide results in decreased expression of GPC1 mRNA CTD PMID:15638997 NCBI chr 9:99,998,275...100,026,818
Ensembl chr 9:99,998,275...100,026,818
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 decreases expression
multiple interactions
ISO bicalutamide results in decreased expression of GPD1 mRNA
FSHB protein inhibits the reaction [bicalutamide results in decreased expression of GPD1 protein]
CTD PMID:19587329 NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928
JBrowse link
G Gpnmb glycoprotein nmb increases expression ISO bicalutamide results in increased expression of GPNMB mRNA CTD PMID:15638997 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A decreases expression ISO bicalutamide results in decreased expression of GPRC5A mRNA CTD PMID:15638997 NCBI chr 4:168,832,937...168,851,650
Ensembl chr 4:168,832,910...168,851,652
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions ISO bicalutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA] CTD PMID:16496412 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
JBrowse link
G Gtpbp2 GTP binding protein 2 increases expression ISO bicalutamide results in increased expression of GTPBP2 mRNA CTD PMID:15638997 NCBI chr 9:17,198,957...17,208,456
Ensembl chr 9:17,198,957...17,209,220
JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression ISO bicalutamide results in increased expression of HYOU1 mRNA CTD PMID:15638997 NCBI chr 8:48,699,796...48,711,912
Ensembl chr 8:48,699,769...48,711,910
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]] CTD PMID:16317058 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases expression
ISO [bicalutamide co-treated with Tamoxifen] results in decreased expression of IGF1 protein; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1 mRNA]
bicalutamide results in increased expression of IGF1 mRNA; bicalutamide results in increased expression of IGF1 protein
CTD PMID:16368782, PMID:16847815 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions ISO [bicalutamide co-treated with Tamoxifen] results in increased expression of IGFBP1 protein CTD PMID:16847815 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 multiple interactions
increases expression
ISO
EXP
bicalutamide promotes the reaction [Dihydrotestosterone results in increased expression of IGFBP2 mRNA]
bicalutamide results in increased expression of IGFBP2 mRNA
CTD PMID:10604720, PMID:16368782 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions
increases expression
decreases secretion
decreases expression
ISO
EXP
[bicalutamide co-treated with Tamoxifen] results in increased expression of IGFBP3 protein
bicalutamide results in increased expression of IGFBP3 protein
bicalutamide results in increased expression of IGFBP3 mRNA
bicalutamide results in decreased secretion of IGFBP3 protein
bicalutamide results in decreased expression of IGFBP3 mRNA
CTD PMID:10604720, PMID:16368782, PMID:16847815 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 increases expression EXP bicalutamide results in increased expression of IGFBP4 mRNA CTD PMID:10604720 NCBI chr10:86,950,555...86,962,563
Ensembl chr10:86,950,557...86,962,578
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 increases expression EXP bicalutamide results in increased expression of IGFBP5 mRNA CTD PMID:10604720 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein results in increased expression of NCOA2 protein] which results in decreased susceptibility to bicalutamide; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [BCG Vaccine results in increased expression of IL6 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; bicalutamide inhibits the reaction [IL6 protein results in increased expression of KLK3 mRNA] CTD PMID:11410519, PMID:14532843, PMID:16317058, PMID:19240160 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO bicalutamide results in decreased expression of KIF20A mRNA CTD PMID:15638997 NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 increases expression ISO bicalutamide results in increased expression of LAMP2 mRNA CTD PMID:16631469 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044
JBrowse link
G Lamp3 lysosomal-associated membrane protein 3 increases expression ISO bicalutamide results in increased expression of LAMP3 mRNA CTD PMID:15638997 NCBI chr11:84,930,965...85,000,694
Ensembl chr11:84,972,132...85,000,681
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO bicalutamide results in increased expression of LCN2 mRNA CTD PMID:15638997 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Ldlr low density lipoprotein receptor affects localization ISO bicalutamide affects the localization of LDLR protein CTD PMID:17440980 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lmnb1 lamin B1 decreases expression ISO bicalutamide results in decreased expression of LMNB1 mRNA CTD PMID:15638997 NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264
JBrowse link
G LOC102549061 histone H2B type 1-N-like increases expression ISO bicalutamide results in increased expression of H2BC3 mRNA CTD PMID:15790403 NCBI chr17:43,627,872...43,628,518
Ensembl chr17:43,627,930...43,628,310
JBrowse link
G Lrba LPS responsive beige-like anchor protein increases expression ISO bicalutamide results in increased expression of LRBA mRNA CTD PMID:15790403 NCBI chr 2:185,590,983...186,110,491
Ensembl chr 2:185,524,774...186,110,495
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO bicalutamide results in decreased expression of MAD2L1 mRNA CTD PMID:15638997 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Man1a1 mannosidase, alpha, class 1A, member 1 increases expression ISO bicalutamide results in increased expression of MAN1A1 mRNA CTD PMID:15638997 NCBI chr20:35,257,688...35,450,132
Ensembl chr20:35,257,985...35,450,513
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K1 protein]; bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:15466214 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein CTD PMID:15466214 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bicalutamide inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bicalutamide results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:15466214, PMID:29383186 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bicalutamide inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bicalutamide results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:15466214, PMID:29383186 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 increases expression ISO bicalutamide results in increased expression of MBD2 mRNA CTD PMID:16631469 NCBI chr18:65,814,026...65,885,115
Ensembl chr18:65,814,026...65,885,114
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO bicalutamide results in decreased expression of MCM2 mRNA CTD PMID:15638997 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mdk midkine increases expression ISO bicalutamide results in increased expression of MDK mRNA CTD PMID:15638997 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO bicalutamide inhibits the reaction [Testosterone results in increased expression of MET mRNA] CTD PMID:11139396, PMID:17371283 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mir21 microRNA 21 multiple interactions ISO bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA] CTD PMID:23052036, PMID:25969534 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO bicalutamide results in decreased expression of MKI67 mRNA CTD PMID:15638997 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mme membrane metallo-endopeptidase increases expression ISO bicalutamide results in increased expression of MME mRNA CTD PMID:15790403 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO bicalutamide inhibits the reaction [Androgens results in increased expression of MMP13 mRNA] CTD PMID:15138554 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO bicalutamide inhibits the reaction [Metribolone results in increased expression of MMP2 mRNA] CTD PMID:16888681 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
decreases expression
ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC protein; bicalutamide inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to MYC enhancer]]; bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of MYC mRNA]; Niclosamide inhibits the reaction [bicalutamide results in increased expression of MYC protein]
bicalutamide results in decreased expression of MYC mRNA
CTD PMID:15638997, PMID:24759320, PMID:28500234 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myo6 myosin VI increases expression ISO bicalutamide results in increased expression of MYO6 mRNA CTD PMID:15790403, PMID:16631469 NCBI chr 8:87,583,649...87,731,271
Ensembl chr 8:87,630,916...87,731,269
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO bicalutamide inhibits the reaction [AR protein binds to NCOA1 protein] CTD PMID:11981028 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO [IL6 protein results in increased expression of NCOA2 protein] which results in decreased susceptibility to bicalutamide CTD PMID:19240160 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO bicalutamide promotes the reaction [AR protein binds to NCOR2 protein] CTD PMID:11981028 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701
JBrowse link
G Nebl nebulette increases expression ISO bicalutamide results in increased expression of NEBL mRNA CTD PMID:15638997 NCBI chr17:84,141,014...84,247,038
Ensembl chr17:84,140,489...84,488,601
JBrowse link
G Nek2 NIMA-related kinase 2 decreases expression ISO bicalutamide results in decreased expression of NEK2 mRNA CTD PMID:15638997 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link
G Niban1 niban apoptosis regulator 1 increases expression ISO bicalutamide results in increased expression of NIBAN1 mRNA CTD PMID:15638997 NCBI chr13:68,949,665...69,101,600
Ensembl chr13:68,949,665...69,101,588
JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions
decreases expression
ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of NKX3-1 mRNA; bicalutamide inhibits the reaction [Antimony Potassium Tartrate results in increased expression of NKX3-1 mRNA]; bicalutamide inhibits the reaction [Cadmium Chloride results in increased expression of NKX3-1 mRNA]; bicalutamide inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]
bicalutamide results in decreased expression of NKX3-1 mRNA
CTD PMID:11751618, PMID:15638997, PMID:28500234, PMID:29462692 NCBI chr15:51,065,316...51,067,908
Ensembl chr15:51,065,316...51,068,421
JBrowse link
G Nrp1 neuropilin 1 decreases expression ISO bicalutamide results in decreased expression of NRP1 mRNA CTD PMID:15638997 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nts neurotensin decreases response to substance ISO NTS protein results in decreased susceptibility to bicalutamide CTD PMID:17044078 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 decreases expression ISO bicalutamide results in decreased expression of NUSAP1 mRNA CTD PMID:15638997 NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971
JBrowse link
G Osm oncostatin M multiple interactions ISO bicalutamide inhibits the reaction [OSM protein results in increased activity of AR protein] CTD PMID:12114440 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Pa2g4 proliferation-associated 2G4 multiple interactions
increases response to substance
ISO bicalutamide promotes the reaction [PA2G4 protein binds to KLK3 promoter]
PA2G4 protein results in increased susceptibility to bicalutamide
CTD PMID:15994225 NCBI chr 7:2,979,587...2,987,055
Ensembl chr 7:2,979,588...2,987,055
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO bicalutamide promotes the reaction [Niclosamide results in increased expression of PARP1 protein modified form] CTD PMID:28500234 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pbk PDZ binding kinase decreases expression ISO bicalutamide results in decreased expression of PBK mRNA CTD PMID:15638997 NCBI chr15:42,489,253...42,500,377
Ensembl chr15:42,489,377...42,500,395
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO bicalutamide results in decreased expression of PCNA mRNA CTD PMID:15638997 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pds5b PDS5 cohesin associated factor B multiple interactions ISO bicalutamide inhibits the reaction [Calcitriol results in increased expression of APRIN] CTD PMID:15754350 NCBI chr12:659,995...794,042
Ensembl chr12:660,011...794,042
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase increases expression ISO bicalutamide results in increased expression of PECR mRNA CTD PMID:15638997 NCBI chr 9:79,601,937...79,630,547
Ensembl chr 9:79,601,901...79,630,536
JBrowse link
G Pgr progesterone receptor multiple interactions ISO bicalutamide binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Phb prohibitin multiple interactions ISO [Dihydrotestosterone co-treated with bicalutamide] promotes the reaction [AR protein binds to PHB protein]; AR protein promotes the reaction [bicalutamide promotes the reaction [PHB protein binds to KLK3 promoter]]; bicalutamide promotes the reaction [PHB protein binds to KLK3 promoter]; PHB protein promotes the reaction [bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]]; PHB protein promotes the reaction [bicalutamide promotes the reaction [SMARCA4 protein binds to KLK3 promoter]] CTD PMID:18487222 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Pip prolactin induced protein decreases expression
multiple interactions
ISO bicalutamide results in decreased expression of PIP mRNA
bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of PIP mRNA]
CTD PMID:10402478 NCBI chr 4:71,320,859...71,325,153
Ensembl chr 4:71,320,859...71,325,153
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO bicalutamide results in decreased expression of PRC1 mRNA CTD PMID:15638997 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases activity
ISO bicalutamide promotes the reaction [PTEN protein results in decreased expression of KLK3 mRNA]
bicalutamide results in increased activity of PTEN protein
CTD PMID:16637073 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]] CTD PMID:16317058 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO bicalutamide results in decreased expression of RACGAP1 mRNA CTD PMID:15638997 NCBI chr 7:141,277,303...141,308,849
Ensembl chr 7:141,277,312...141,307,233
JBrowse link
G Ranbp1 RAN binding protein 1 decreases expression ISO bicalutamide results in decreased expression of RANBP1 mRNA CTD PMID:15638997 NCBI chr11:86,890,585...86,898,818
Ensembl chr11:86,890,585...86,898,818
JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO bicalutamide results in increased expression of RARB mRNA CTD PMID:15790403 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation ISO bicalutamide results in increased phosphorylation of RB1 protein CTD PMID:17599054 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rom1 retinal outer segment membrane protein 1 increases expression ISO bicalutamide results in increased expression of ROM1 mRNA CTD PMID:15790403 NCBI chr 1:225,126,732...225,128,740
Ensembl chr 1:225,126,734...225,128,740
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO [bicalutamide co-treated with Testosterone] results in decreased phosphorylation of RPS6 protein CTD PMID:21036700 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [bicalutamide co-treated with Testosterone] results in decreased phosphorylation of RPS6KB1 protein CTD PMID:21036700 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO bicalutamide results in decreased expression of RRM2 mRNA CTD PMID:15638997 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Rxrb retinoid X receptor beta decreases expression ISO bicalutamide results in decreased expression of RXRB CTD PMID:11845989 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
JBrowse link
G Scgb2a1 secretoglobin, family 2A, member 1 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of SCGB2A1 mRNA] CTD PMID:16020486 NCBI chr 1:225,899,313...225,902,676
Ensembl chr 1:225,899,313...225,902,676
JBrowse link
G Sem1 SEM1, 26S proteasome complex subunit increases expression ISO bicalutamide results in increased expression of SEM1 mRNA CTD PMID:16631469 NCBI chr 4:32,067,444...32,087,600
Ensembl chr 4:32,067,444...32,087,600
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]] CTD PMID:16317058 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO bicalutamide results in increased expression of SLC3A2 mRNA CTD PMID:15638997 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc4a4 solute carrier family 4 member 4 decreases expression ISO bicalutamide results in decreased expression of SLC4A4 mRNA CTD PMID:15638997 NCBI chr14:20,476,258...20,817,042
Ensembl chr14:20,479,323...20,920,286
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO bicalutamide results in increased expression of SLC7A11 mRNA CTD PMID:15638997 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 multiple interactions ISO [Dihydrotestosterone co-treated with bicalutamide] promotes the reaction [AR protein binds to SMARCA4 protein]; bicalutamide promotes the reaction [SMARCA4 protein binds to KLK3 promoter]; PHB protein promotes the reaction [bicalutamide promotes the reaction [SMARCA4 protein binds to KLK3 promoter]] CTD PMID:18487222 NCBI chr 8:22,648,323...22,739,468
Ensembl chr 8:22,648,323...22,739,468
JBrowse link
G Snap25 synaptosome associated protein 25 increases expression ISO bicalutamide results in increased expression of SNAP25 mRNA CTD PMID:15790403 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400
JBrowse link
G Sord sorbitol dehydrogenase increases expression ISO bicalutamide results in increased expression of SORD mRNA CTD PMID:15790403 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366
JBrowse link
G Spint2 serine peptidase inhibitor, Kunitz type, 2 increases expression ISO bicalutamide results in increased expression of SPINT2 mRNA CTD PMID:15790403 NCBI chr 1:87,199,373...87,221,826
Ensembl chr 1:87,199,313...87,221,892
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO bicalutamide results in increased expression of SQSTM1 mRNA CTD PMID:15638997 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO bicalutamide results in decreased expression of STIP1 mRNA CTD PMID:15638997 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148
JBrowse link
G Tamm41 TAM41 mitochondrial translocator assembly and maintenance homolog increases expression ISO bicalutamide results in increased expression of TAMM41 mRNA CTD PMID:16631469 NCBI chr 4:146,922,085...146,954,159
Ensembl chr 4:146,922,085...146,954,159
JBrowse link
G Tert telomerase reverse transcriptase decreases activity
decreases expression
ISO bicalutamide results in decreased activity of TERT protein
bicalutamide results in decreased expression of TERT mRNA
CTD PMID:15638997 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO bicalutamide results in decreased expression of TK1 mRNA CTD PMID:15638997 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]] CTD PMID:16317058 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tmeff2 transmembrane protein with EGF-like and two follistatin-like domains 2 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of TMEFF2 protein] CTD PMID:23405127 NCBI chr 9:55,379,130...55,673,704
Ensembl chr 9:55,384,100...55,673,829
JBrowse link
G Tmprss2 transmembrane serine protease 2 multiple interactions ISO [Goserelin co-treated with bicalutamide] results in decreased expression of TMPRSS2 protein; [Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of TMPRSS2 protein; [Goserelin co-treated with Dutasteride co-treated with bicalutamide] results in decreased expression of TMPRSS2 protein; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA] CTD PMID:23708653, PMID:24323034, PMID:28757136 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290
JBrowse link
G Tmsb4x thymosin beta 4, X-linked multiple interactions
increases expression
ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of TMSB4X mRNA]
bicalutamide results in increased expression of TMSB4X mRNA
CTD PMID:17916567 NCBI chr  X:28,593,405...28,617,267
Ensembl chr  X:28,593,405...28,595,395
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:16317058 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO bicalutamide results in increased expression of TP53 protein
bicalutamide inhibits the reaction [bisphenol A results in increased phosphorylation of TP53 protein]
CTD PMID:15638997, PMID:29383186 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO bicalutamide results in increased expression of TP53I3 mRNA CTD PMID:15638997 NCBI chr13:75,101,759...75,145,967
Ensembl chr13:75,105,615...75,143,441
JBrowse link
G Tpd52 tumor protein D52 decreases response to substance ISO TPD52 protein results in decreased susceptibility to bicalutamide CTD PMID:17875733 NCBI chr 2:94,959,732...95,041,277
Ensembl chr 2:95,008,311...95,040,514
JBrowse link
G Tpx2 TPX2, microtubule nucleation factor decreases expression ISO bicalutamide results in decreased expression of TPX2 mRNA CTD PMID:15638997 NCBI chr 3:148,327,965...148,370,187
Ensembl chr 3:148,327,965...148,370,187
JBrowse link
G Tram1 translocation associated membrane protein 1 increases expression ISO bicalutamide results in increased expression of TRAM1 mRNA CTD PMID:16631469 NCBI chr 5:5,215,196...5,297,337
Ensembl chr 5:5,215,196...5,316,685
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO bicalutamide results in increased expression of TRIB3 mRNA CTD PMID:15638997 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Tyms thymidylate synthetase decreases expression ISO bicalutamide results in decreased expression of TYMS protein CTD PMID:17599054 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 increases expression ISO bicalutamide results in increased expression of UAP1 mRNA CTD PMID:15790403 NCBI chr13:88,463,532...88,497,901
Ensembl chr13:88,463,532...88,497,901
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of UBE2C mRNA CTD PMID:28500234 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 decreases expression ISO bicalutamide results in decreased expression of UGT2B17 mRNA CTD PMID:15638997 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO bicalutamide results in increased expression of UPP1 mRNA CTD PMID:15638997 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link
G Uxt ubiquitously-expressed, prefoldin-like chaperone affects response to substance ISO UXT protein affects the susceptibility to bicalutamide CTD PMID:19318562 NCBI chr  X:1,275,402...1,287,781
Ensembl chr  X:1,275,612...1,287,512
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:16317058 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO bicalutamide results in increased expression of WARS1 mRNA CTD PMID:15638997 NCBI chr 6:132,771,026...132,802,262
Ensembl chr 6:132,771,021...132,802,210
JBrowse link
G Ythdf3 YTH N(6)-methyladenosine RNA binding protein 3 increases expression ISO bicalutamide results in increased expression of YTHDF3 mRNA CTD PMID:16631469 NCBI chr 2:100,677,388...100,711,365
Ensembl chr 2:100,677,411...100,710,417
JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO bicalutamide results in increased expression of ZMAT3 mRNA CTD PMID:15638997 NCBI chr 2:118,715,229...118,746,109
Ensembl chr 2:118,721,334...118,745,766
JBrowse link
G Zwint ZW10 interacting kinetochore protein decreases expression ISO bicalutamide results in decreased expression of ZWINT mRNA CTD PMID:15638997 NCBI chr20:17,075,781...17,091,715
Ensembl chr20:17,075,771...17,091,766
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      group 19698
        pseudohalo group 2882
          cyano group 2882
            nitrile 2882
              N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide 188
                (R)-bicalutamide + 188
                (S)-bicalutamide + 188
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                monocarboxylic acid amide 14553
                                                  N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide 188
                                                    (R)-bicalutamide + 188
                                                    (S)-bicalutamide + 188
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.