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ONTOLOGY REPORT - ANNOTATIONS


Term:ravuconazole
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Accession:CHEBI:143825 term browser browse the term
Definition:A member of the class of triazoles that is 1-butyl-1H-1,2,4-triazole in which the butyl group is substituted at positions 2, 2, and 3 by hydroxy, 2,4-difluorophenyl, and 4-(p-cyanophenyl)-1,3-thiazol-2-yl groups, respectively (the R,R stereoisomer). It exhibits antifungal activity by inhibition of 14alpha demethylase, an enzyme involved in sterol synthesis, resulting in lysis of the fungal cell wall and fungal cell death. (NCIO4)
Synonyms:exact_synonym: 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile
 related_synonym: BMS-20714;   ER-30346;   Formula=C22H17F2N5OS;   InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-7-6-17(23)8-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1;   InChIKey=OPAHEYNNJWPQPX-RCDICMHDSA-N;   SMILES=C=1C(=C(C=C(C1)F)F)[C@@]([C@@H](C)C2=NC(=CS2)C=3C=CC(=CC3)C#N)(O)CN4C=NC=N4;   ravuconazol;   ravuconazolum
 xref: CAS:182760-06-1 "KEGG DRUG";   DrugBank:DB06440;   KEGG:D02556;   PMCID:PMC105592 "Europe PMC";   PMID:11709320 "Europe PMC";   PMID:18548464 "Europe PMC";   PMID:20112166 "Europe PMC";   PMID:20404124 "Europe PMC";   PMID:22935068 "Europe PMC";   PMID:24071640 "Europe PMC";   PMID:24945848 "Europe PMC";   PMID:25742996 "Europe PMC";   PMID:27904057 "Europe PMC";   PMID:29768713 "Europe PMC";   PMID:29982734 "Europe PMC";   PMID:30733479 "SUBMITTER";   PMID:8891121 "Europe PMC";   PMID:9527778 "Europe PMC";   Patent:US2011087030;   Patent:WO2011042827;   Wikipedia:Ravuconazole


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Path 1
Term Annotations click to browse term
  CHEBI ontology 19748
    chemical entity 19746
      group 19653
        pseudohalo group 2775
          cyano group 2775
            nitrile 2775
              ravuconazole 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19748
    subatomic particle 19744
      composite particle 19744
        hadron 19744
          baryon 19744
            nucleon 19744
              atomic nucleus 19744
                atom 19744
                  main group element atom 19628
                    p-block element atom 19628
                      carbon group element atom 19522
                        carbon atom 19516
                          organic molecular entity 19516
                            organic molecule 19434
                              organic cyclic compound 19201
                                organic heterocyclic compound 18270
                                  heteroarene 15815
                                    monocyclic heteroarene 13132
                                      azole 12259
                                        thiazoles 401
                                          1,3-thiazoles 348
                                            ravuconazole 0
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