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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3,5,6-trichloro-2-pyridinol
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Accession:CHEBI:143794 term browser browse the term
Definition:A hydroxypyridine that is pyridin-2-ol substituted by chloro groups at positions 3,5 and 6. It is a metabolite of the agrochemical chlorpyrifos.
Synonyms:related_synonym: 2,3,5-trichloropyridine-6-ol;   2-hydroxy-3,5,6-trichloropyridine;   3,5,6-trichloro-2-hydroxypyridine;   3,5,6-trichloropyridin-2-ol;   3,5,6-tris(chloranyl)pyridin-2-ol;   Formula=C5H2Cl3NO;   InChI=1S/C5H2Cl3NO/c6-2-1-3(7)5(10)9-4(2)8/h1H,(H,9,10);   InChIKey=WCYYAQFQZQEUEN-UHFFFAOYSA-N;   SMILES=C=1(N=C(C(=CC1Cl)Cl)Cl)O;   TCPy;   TCpyol
 xref: CAS:6515-38-4;   HMDB:HMDB0039853
 xref_mesh: MESH:C012587
 xref: PDB:6GNP;   PDBeChem:F4Z;   PMID:28939184;   PMID:29846064;   PMID:30226982;   PMID:30343485;   PMID:30903958;   PMID:30929106;   PMID:31108286
 cyclic_relationship: is_tautomer_of CHEBI:83490

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3,5,6-trichloro-2-pyridinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
increases expression		 ISO 3,5,6-trichloro-2-pyridinol results in decreased activity of ACHE protein
3,5,6-trichloro-2-pyridinol results in increased expression of ACHE mRNA		 CTD PMID:21224175 PMID:23220036 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Afp alpha-fetoprotein increases expression
affects expression		 ISO 3,5,6-trichloro-2-pyridinol results in increased expression of AFP mRNA
3,5,6-trichloro-2-pyridinol affects the expression of AFP mRNA		 CTD PMID:23220036 PMID:25137620 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO 3,5,6-trichloro-2-pyridinol results in decreased activity of BCHE protein CTD PMID:21224175 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA]; 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA protein] CTD PMID:32017950 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases chemical synthesis ISO CYP2C19 protein results in increased chemical synthesis of 3,5,6-trichloro-2-pyridinol CTD PMID:22281205 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases chemical synthesis ISO CYP3A4 results in increased chemical synthesis of 3,5,6-trichloro-2-pyridinol CTD PMID:20709133 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 protein] CTD PMID:32017950 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305 		JBrowse link
G Kdr kinase insert domain receptor increases expression ISO 3,5,6-trichloro-2-pyridinol results in increased expression of KDR mRNA CTD PMID:23220036 PMID:25137620 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Myh6 myosin heavy chain 6 increases expression ISO 3,5,6-trichloro-2-pyridinol results in increased expression of MYH6 mRNA CTD PMID:23220036 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO 3,5,6-trichloro-2-pyridinol results in decreased expression of NANOG mRNA CTD PMID:23220036 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268 		JBrowse link
G Nefm neurofilament medium decreases expression
increases expression		 ISO 3,5,6-trichloro-2-pyridinol results in decreased expression of NEFM mRNA
3,5,6-trichloro-2-pyridinol results in increased expression of NEFM mRNA		 CTD PMID:23220036 PMID:25137620 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604 		JBrowse link
G Nes nestin decreases expression
increases expression
affects expression		 ISO 3,5,6-trichloro-2-pyridinol results in decreased expression of NES mRNA
3,5,6-trichloro-2-pyridinol results in increased expression of NES mRNA
3,5,6-trichloro-2-pyridinol affects the expression of NES mRNA		 CTD PMID:23220036 PMID:25137620 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases expression
increases expression
decreases activity		 ISO 3,5,6-trichloro-2-pyridinol results in decreased expression of PNPLA6 mRNA
3,5,6-trichloro-2-pyridinol results in increased expression of PNPLA6 mRNA
3,5,6-trichloro-2-pyridinol results in decreased activity of PNPLA6 protein		 CTD PMID:23220036 PMID:25137620 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression ISO 3,5,6-trichloro-2-pyridinol results in increased expression of POU5F1 mRNA CTD PMID:23220036 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; [3,5,6-trichloro-2-pyridinol co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG protein CTD PMID:32017950 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      biological role 19833
        biochemical role 19370
          metabolite 19350
            xenobiotic metabolite 14261
              human xenobiotic metabolite 13590
                3,5,6-trichloro-2-pyridinol 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic molecule 19596
                              organic cyclic compound 19407
                                organic heterocyclic compound 18517
                                  organic heteromonocyclic compound 16622
                                    pyridines 8427
                                      hydroxypyridine 66
                                        3,5,6-trichloro-2-pyridinol 15
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