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G
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Cxcl10
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C-X-C motif chemokine ligand 10
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increases expression
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ISO
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KRN 7000 results in increased expression of CXCL10 protein
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CTD |
PMID:15867097 |
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NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261
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G
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Il12b
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interleukin 12B
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increases expression
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ISO
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KRN 7000 results in increased expression of IL12B protein
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CTD |
PMID:15867097 |
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NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194
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G
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Aifm1
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apoptosis inducing factor, mitochondria associated 1
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affects localization multiple interactions
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ISO
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phytosphingosine affects the localization of AIFM1 protein 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [phytosphingosine affects the localization of AIFM1 protein]
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CTD |
PMID:15486061 |
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NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237
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G
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Bax
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BCL2 associated X, apoptosis regulator
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multiple interactions affects localization increases expression
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ISO
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3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein] phytosphingosine affects the localization of BAX protein phytosphingosine results in increased expression of BAX protein
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CTD |
PMID:15486061 PMID:17237268 PMID:36334778 PMID:37956922 |
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NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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G
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Bcl2
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BCL2, apoptosis regulator
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increases expression
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ISO
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phytosphingosine results in increased expression of BCL2 protein
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CTD |
PMID:36334778 |
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NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
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G
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Casp3
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caspase 3
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multiple interactions increases expression
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ISO
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3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein; phytosphingosine results in increased expression of and results in increased cleavage of CASP3 protein; SB 203580 inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein] phytosphingosine results in increased expression of CASP3 protein
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CTD |
PMID:17237268 PMID:36334778 PMID:37956922 |
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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G
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Casp9
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caspase 9
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multiple interactions increases expression
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ISO
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3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein] phytosphingosine results in increased expression of CASP9 protein
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CTD |
PMID:17237268 PMID:37956922 |
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Ensembl chr 5:159,391,188...159,409,648
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G
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Ccnb1
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cyclin B1
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decreases expression
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ISO
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phytosphingosine results in decreased expression of CCNB1 protein
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CTD |
PMID:37956922 |
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NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
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G
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Cdk1
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cyclin-dependent kinase 1
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decreases expression
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ISO
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phytosphingosine results in decreased expression of CDK1 protein
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CTD |
PMID:37956922 |
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NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455
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G
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Cycs
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cytochrome c, somatic
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increases expression
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ISO
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phytosphingosine results in increased expression of CYCS protein
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CTD |
PMID:36334778 |
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NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816 Ensembl chr18:80,982,668...80,984,816
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G
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Mapk1
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mitogen activated protein kinase 1
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multiple interactions
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ISO
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[arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK1 protein
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CTD |
PMID:17237268 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
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G
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Mapk14
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mitogen activated protein kinase 14
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multiple interactions
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ISO
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3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein]
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CTD |
PMID:17237268 |
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NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294
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G
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Mapk3
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mitogen activated protein kinase 3
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multiple interactions
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ISO
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[arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK3 protein
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CTD |
PMID:17237268 |
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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G
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Parp1
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poly (ADP-ribose) polymerase 1
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multiple interactions increases activity increases cleavage
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ISO
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3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein; [Arsenic Trioxide co-treated with phytosphingosine] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein] phytosphingosine results in increased activity of PARP1 protein phytosphingosine results in increased cleavage of PARP1 protein
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CTD |
PMID:15486061 PMID:17237268 PMID:37956922 |
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NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
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G
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Pink1
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PTEN induced kinase 1
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decreases expression
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ISO
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phytosphingosine results in decreased expression of PINK1 protein
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CTD |
PMID:36334778 |
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NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950
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