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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid
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Accession:CHEBI:143205 term browser browse the term
Definition:A perfluorinated compound that is 2-propoxypentanoic acid in which all 11 of the hydrogens attached to carbon atoms have been replaced by fluorine atoms. Used as an alternative to perfluorooctanoic acid in the fluoropolymer industry for years, its widespread environmental distribution, high bioaccumulation capability, and human exposure have caused great concern, particularly as its potential toxicity and health risk is still largely unknown.
Synonyms:related_synonym: 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid;   FRD-908;   Formula=C6HF11O3;   GenX;   HFPO-DA;   InChI=1S/C6HF11O3/c7-2(1(18)19,4(10,11)12)20-6(16,17)3(8,9)5(13,14)15/h(H,18,19);   InChIKey=CSEBNABAWMZWIF-UHFFFAOYSA-N;   SMILES=C(C(C(OC(C(O)=O)(F)C(F)(F)F)(F)F)(F)F)(F)(F)F;   hexafluoropropylene oxide dimer acid
 xref: CAS:13252-13-6
 xref_mesh: MESH:C000608800
 xref: PMID:20823541;   PMID:26106903;   PMID:28853567;   PMID:30207460;   PMID:30256633;   PMID:30594801;   PMID:30785727;   PMID:30920876;   PMID:31146223;   PMID:31181522;   PMID:31215065;   PMID:31251593;   Wikipedia:FRD-903


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2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid inhibits the reaction [ABCB1 protein results in increased transport of (N-5-(4-nitrobenzofurazan-7-yl)lysyl(8))cyclosporine]; 2-chloro-5-nitrobenzanilide inhibits the reaction [2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid inhibits the reaction [ABCB1 protein results in increased transport of (N-5-(4-nitrobenzofurazan-7-yl)lysyl(8))cyclosporine]] CTD PMID:32212926 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid inhibits the reaction [ABCG2 protein results in increased transport of BODIPY-FL prazosin] CTD PMID:32212926 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of ACAA2 mRNA CTD PMID:30920876 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of ACADL mRNA CTD PMID:30920876 NCBI chr 9:73,833,368...73,871,857
Ensembl chr 9:73,833,388...73,871,888
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of ACADM mRNA CTD PMID:30920876 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of ACOX1 mRNA CTD PMID:30920876 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acox2 acyl-CoA oxidase 2 increases expression ISO 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of ACOX2 mRNA CTD PMID:32068100 NCBI chr15:18,449,304...18,481,472
Ensembl chr15:18,451,144...18,481,470
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of ACSL1 mRNA CTD PMID:30920876 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of ACSL3 mRNA CTD PMID:30920876 NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of ACSL4 mRNA CTD PMID:30920876 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of ANGPTL4 mRNA CTD PMID:30920876 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Aqp7 aquaporin 7 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of AQP7 mRNA CTD PMID:30920876 NCBI chr 5:57,358,297...57,372,332
Ensembl chr 5:57,358,327...57,372,239
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression ISO 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid affects the expression of BAX mRNA CTD PMID:32068100 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in decreased expression of CCNB1 mRNA CTD PMID:32068100 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in decreased expression of CCNE1 mRNA CTD PMID:32068100 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in decreased expression of CDK4 mRNA CTD PMID:32068100 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP
ISO
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of CPT1A mRNA CTD PMID:30920876, PMID:31676336 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of CPT1B mRNA CTD PMID:30920876 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of CPT2 mRNA CTD PMID:30920876 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of DGAT1 mRNA CTD PMID:30920876 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression ISO 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in decreased expression of DNMT3A mRNA CTD PMID:32068100 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in decreased expression of DNMT3B mRNA CTD PMID:32068100 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of ECH1 mRNA CTD PMID:30920876 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of EHHADH mRNA CTD PMID:30920876 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Etfdh electron transfer flavoprotein dehydrogenase increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of ETFDH mRNA CTD PMID:30920876 NCBI chr 2:178,367,547...178,389,641
Ensembl chr 2:178,367,549...178,389,608
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of FABP1 mRNA CTD PMID:30920876 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of FABP5 mRNA CTD PMID:30920876 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378
JBrowse link
G Fads2 fatty acid desaturase 2 increases expression EXP
ISO
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of FADS2 mRNA CTD PMID:30920876, PMID:32068100 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524
JBrowse link
G Gk glycerol kinase increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of GK mRNA CTD PMID:30920876 NCBI chr  X:54,227,291...54,303,897
Ensembl chr  X:54,227,397...54,303,864
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of HMGCR mRNA CTD PMID:32068100 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression EXP
ISO
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of HMGCS2 mRNA CTD PMID:30920876, PMID:31676336 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of HSPD1 mRNA CTD PMID:30920876 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Lpl lipoprotein lipase increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of LPL mRNA CTD PMID:30920876 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mlycd malonyl-CoA decarboxylase increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of MLYCD mRNA CTD PMID:30920876 NCBI chr19:52,032,950...52,048,773
Ensembl chr19:52,032,886...52,048,753
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of PCK1 mRNA CTD PMID:30920876 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Plin2 perilipin 2 increases expression ISO 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of PLIN2 mRNA CTD PMID:31676336 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Rxrg retinoid X receptor gamma increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of RXRG mRNA CTD PMID:30920876 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of SCD1 mRNA CTD PMID:30920876 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of SLC22A5 mRNA CTD PMID:30920876 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc27a2 solute carrier family 27 member 2 increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of SLC27A2 mRNA CTD PMID:30920876 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531
JBrowse link
G Txnip thioredoxin interacting protein increases expression EXP 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of TXNIP mRNA CTD PMID:30920876 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link

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  CHEBI ontology 19787
    chemical entity 19787
      atom 19784
        nonmetal atom 19659
          oxygen atom 19323
            oxygen molecular entity 19323
              organooxygen compound 18778
                ether 15940
                  2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid 41
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  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid 41
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