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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aldrithiol
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Accession:CHEBI:143170 term browser browse the term
Definition:A member of the class of pyridines that is pyridine which is substituted by a pyridin-2-yldisulfanediyl group at position 2. It is a reagent used in molecular biology as an oxidizing agent. Also used in peptide synthesis and for detecting thiols.
Synonyms:exact_synonym: 2,2'-disulfanediyldipyridine
 related_synonym: 2,2'-dipyridyl disulfide;   2,2'-dipyridyldisulphide;   2,2'-dithiobis-pyridine;   2,2'-dithiobispyridine;   2,2'-dithiodipyridine;   2,2'-pyridine disulfide;   2-dipyridyl disulfide;   2-pyridinyl disulfide;   Formula=C10H8N2S2;   InChI=1S/C10H8N2S2/c1-3-7-11-9(5-1)13-14-10-6-2-4-8-12-10/h1-8H;   InChIKey=HAXFWIACAGNFHA-UHFFFAOYSA-N;   SMILES=S(SC=1N=CC=CC1)C=2N=CC=CC2;   aldrithiol-2;   bis(2-pyridyl)disulfide;   di(2-pyridyl)disulfide
 xref: Beilstein:154629;   CAS:2127-03-9
 xref_mesh: MESH:C001105
 xref: PMID:11331359;   PMID:16998480;   PMID:17506610;   PMID:20965543;   PMID:22561701;   PMID:22807723;   PMID:23751221;   PMID:30597776;   Wikipedia:2\,2'-Dipyridyldisulfide


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aldrithiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity EXP 2,2'-dipyridyl disulfide results in increased activity of CASP3 protein CTD PMID:11331359 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity EXP 2,2'-dipyridyl disulfide results in increased activity of CASP9 protein CTD PMID:11331359 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK1 protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; phenyl-N-tert-butylnitrone inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:11331359 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP 2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:11331359 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
increases expression		 EXP polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased expression of NPPA protein] CTD PMID:25449040 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A increases phosphorylation
multiple interactions		 EXP 2,2'-dipyridyl disulfide results in increased phosphorylation of PPP1R12A protein
polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of PPP1R12A protein]		 CTD PMID:25449040 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      chemical role 19529
        oxidising agent 12010
          aldrithiol 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            organic molecule 19764
                              organic cyclic compound 19553
                                organic heterocyclic compound 18905
                                  organic heteromonocyclic compound 17827
                                    pyridines 11530
                                      aldrithiol 6
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