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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aldrithiol
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Accession:CHEBI:143170 term browser browse the term
Definition:A member of the class of pyridines that is pyridine which is substituted by a pyridin-2-yldisulfanediyl group at position 2. It is a reagent used in molecular biology as an oxidizing agent. Also used in peptide synthesis and for detecting thiols.
Synonyms:exact_synonym: 2,2'-disulfanediyldipyridine
 related_synonym: 2,2'-dipyridyl disulfide;   2,2'-dipyridyldisulphide;   2,2'-dithiobis-pyridine;   2,2'-dithiobispyridine;   2,2'-dithiodipyridine;   2,2'-pyridine disulfide;   2-dipyridyl disulfide;   2-pyridinyl disulfide;   Formula=C10H8N2S2;   InChI=1S/C10H8N2S2/c1-3-7-11-9(5-1)13-14-10-6-2-4-8-12-10/h1-8H;   InChIKey=HAXFWIACAGNFHA-UHFFFAOYSA-N;   SMILES=S(SC=1N=CC=CC1)C=2N=CC=CC2;   aldrithiol-2;   bis(2-pyridyl)disulfide;   di(2-pyridyl)disulfide
 xref: Beilstein:154629;   CAS:2127-03-9
 xref_mesh: MESH:C001105
 xref: PMID:11331359;   PMID:16998480;   PMID:17506610;   PMID:20965543;   PMID:22561701;   PMID:22807723;   PMID:23751221;   PMID:30597776;   Wikipedia:2\,2'-Dipyridyldisulfide


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aldrithiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity ISO 2,2'-dipyridyl disulfide results in increased activity of CASP3 protein CTD PMID:11331359 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 increases activity ISO 2,2'-dipyridyl disulfide results in increased activity of CASP9 protein CTD PMID:11331359 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO 2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK1 protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; phenyl-N-tert-butylnitrone inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:11331359 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO 2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:11331359 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G NPPA natriuretic peptide A multiple interactions
increases expression		 ISO polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased expression of NPPA protein] CTD PMID:25449040 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345 		JBrowse link
G PPP1R12A protein phosphatase 1 regulatory subunit 12A increases phosphorylation
multiple interactions		 ISO 2,2'-dipyridyl disulfide results in increased phosphorylation of PPP1R12A protein
polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of PPP1R12A protein]		 CTD PMID:25449040 NCBI chr12:79,773,563...79,935,460
Ensembl chr12:79,773,563...79,935,460 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      chemical role 24242
        oxidising agent 12640
          aldrithiol 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic heterocyclic compound 22328
                                  organic heteromonocyclic compound 19212
                                    pyridines 12190
                                      aldrithiol 6
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