Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aldrithiol
go back to main search page
Accession:CHEBI:143170 term browser browse the term
Definition:A member of the class of pyridines that is pyridine which is substituted by a pyridin-2-yldisulfanediyl group at position 2. It is a reagent used in molecular biology as an oxidizing agent. Also used in peptide synthesis and for detecting thiols.
Synonyms:exact_synonym: 2,2'-disulfanediyldipyridine
 related_synonym: 2,2'-dipyridyl disulfide;   2,2'-dipyridyldisulphide;   2,2'-dithiobis-pyridine;   2,2'-dithiobispyridine;   2,2'-dithiodipyridine;   2,2'-pyridine disulfide;   2-dipyridyl disulfide;   2-pyridinyl disulfide;   Formula=C10H8N2S2;   InChI=1S/C10H8N2S2/c1-3-7-11-9(5-1)13-14-10-6-2-4-8-12-10/h1-8H;   InChIKey=HAXFWIACAGNFHA-UHFFFAOYSA-N;   SMILES=S(SC=1N=CC=CC1)C=2N=CC=CC2;   aldrithiol-2;   bis(2-pyridyl)disulfide;   di(2-pyridyl)disulfide
 xref: Beilstein:154629;   CAS:2127-03-9
 xref_mesh: MESH:C001105
 xref: PMID:11331359;   PMID:16998480;   PMID:17506610;   PMID:20965543;   PMID:22561701;   PMID:22807723;   PMID:23751221;   PMID:30597776;   Wikipedia:2\,2'-Dipyridyldisulfide



show annotations for term's descendants           Sort by:
 
aldrithiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity EXP 2,2'-dipyridyl disulfide results in increased activity of CASP3 protein CTD PMID:11331359 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity EXP 2,2'-dipyridyl disulfide results in increased activity of CASP9 protein CTD PMID:11331359 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK1 protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; phenyl-N-tert-butylnitrone inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:11331359 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP 2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:11331359 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nppa natriuretic peptide A multiple interactions
increases expression
EXP polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased expression of NPPA protein] CTD PMID:25449040 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A increases phosphorylation
multiple interactions
EXP 2,2'-dipyridyl disulfide results in increased phosphorylation of PPP1R12A protein
polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of PPP1R12A protein]
CTD PMID:25449040 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      chemical role 19279
        oxidising agent 11159
          aldrithiol 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic molecule 19506
                              organic cyclic compound 19324
                                organic heterocyclic compound 18682
                                  organic heteromonocyclic compound 17501
                                    pyridines 9180
                                      aldrithiol 6
paths to the root