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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:andrastin A
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Accession:CHEBI:142842 term browser browse the term
Definition:A 19-oxo steroid that is that is andrastin B in which the hydroxy group at position 19 has been oxidised to give the corresponding aldehyde. A farnesyltransferase inhibitor produced by Penicillium roqueforti, a filamentous fungus involved in the ripening of several kinds of blue cheeses.
Synonyms:exact_synonym: methyl 3beta-acetoxy-15-hydroxy-4,4,8alpha,12,16-pentamethyl-17,19-dioxo-5beta,9beta,10alpha,13alpha-androsta-11,15-diene-14-carboxylate
 related_synonym: Formula=C28H38O7;   InChI=1S/C28H38O7/c1-15-13-19-25(6,28(23(33)34-8)22(32)16(2)21(31)26(15,28)7)11-9-18-24(4,5)20(35-17(3)30)10-12-27(18,19)14-29/h13-14,18-20,32H,9-12H2,1-8H3/t18-,19-,20+,25+,26+,27+,28-/m1/s1;   InChIKey=SNSSSENJBPCLPM-OXILWVMOSA-N;   SMILES=C1C[C@@H](C([C@@]2([C@@]1([C@]3([C@](CC2)([C@]4([C@@](C(=C3)C)(C(C(=C4O)C)=O)C)C(OC)=O)C)[H])C=O)[H])(C)C)OC(C)=O;   methyl (3beta,5beta,8alpha,9beta,10alpha,13alpha)-3-acetoxy-15-hydroxy-4,4,8,12,16-pentamethyl-17,19-dioxoandrosta-11,15-diene-14-carboxylate
 xref: CAS:174232-42-9
 xref_mesh: MESH:C100395
 xref: PMID:16279417;   PMID:19837474;   PMID:26731665;   PMID:28529508;   PMID:28799296;   PMID:29270163;   PMID:29853169;   PMID:8682716;   PMID:8682717;   PMID:9531989;   Wikipedia:Andrastin_A
 cyclic_relationship: is_conjugate_acid_of CHEBI:142823


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andrastin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions EXP andrastin A results in increased expression of and results in increased secretion of CSF2 protein CTD PMID:28535995 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP andrastin A results in increased expression of and results in increased secretion of TGFB1 protein CTD PMID:28535995 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP andrastin A results in increased expression of and results in increased secretion of TNF protein CTD PMID:28535995 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      application 21760
        fuel 11478
          methanol 3990
            methyl ester 3925
              andrastin A 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            heteroorganic entity 21500
                              organochalcogen compound 20983
                                organooxygen compound 20824
                                  carbon oxoacid 19606
                                    carboxylic acid 19602
                                      carboacyl group 18299
                                        univalent carboacyl group 18299
                                          formyl group 9126
                                            aldehyde 9126
                                              steroid aldehyde 91
                                                andrastin A 3
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