TRP channel modulator - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	TRP channel modulator	go back to main search page
Accession:	CHEBI:142783	browse the term
Definition:	An agent that modulates the passage of cations through the transient receptor potential (TRP) channels.
Synonyms:	related_synonym:	TRP channel modulators

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Rat (137) Mouse (136) Human (135) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (1) Green Monkey (0) Naked Mole-rat (0) All
Genes (137)

gadolinium trichloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4

multiple interactions

gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

acetyl-CoA carboxylase alpha

multiple interactions

gadolinium chloride promotes the reaction [Ethanol results in decreased expression of ACACA protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of ACACA mRNA

PMID:28882574 PMID:34878122

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA thioesterase 1

multiple interactions

gadolinium chloride promotes the reaction [perfluoro-n-nonanoic acid results in increased expression of ACOT1 mRNA]

NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163

G

actin alpha 2, smooth muscle

multiple interactions

gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adhesion G protein-coupled receptor E1

multiple interactions

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of ADGRE1 mRNA
gadolinium chloride inhibits the reaction [Ethanol results in increased expression of ADGRE1 protein]

PMID:25813056 PMID:28882574

NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000

G

adiponectin, C1Q and collagen domain containing

decreases expression

gadolinium chloride results in decreased expression of ADIPOQ mRNA

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

apolipoprotein B

multiple interactions

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of APOB mRNA]

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

activating transcription factor 4

affects expression

gadolinium chloride affects the expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

multiple interactions
increases expression
affects expression

Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ATF6 protein]
gadolinium chloride affects the expression of ATF6 mRNA

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

BCL2, apoptosis regulator

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

basic helix-loop-helix ARNT like 1

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of BMAL1 protein

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

bone morphogenetic protein 2

multiple interactions

gadolinium chloride promotes the reaction [Carbon Tetrachloride results in increased expression of BMP2 mRNA]

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

caspase 3

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

gadolinium chloride inhibits the reaction [[Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CCL2 mRNA]; gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]

PMID:25813056 PMID:26177832

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin E1

increases expression

gadolinium chloride results in increased expression of CCNE1

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

CD163 molecule

multiple interactions

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA]

PMID:25813056 PMID:26177832

NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878

G

Cd68 molecule

multiple interactions

gadolinium chloride inhibits the reaction [[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CD68 mRNA]
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 mRNA; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 protein; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD68 mRNA]

PMID:23438451 PMID:25813056 PMID:26177832

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

carnitine palmitoyltransferase 1A

multiple interactions

gadolinium chloride promotes the reaction [perfluoro-n-nonanoic acid results in increased expression of CPT1A mRNA]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of CPT1A mRNA

PMID:22648072 PMID:34878122

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

C-X-C motif chemokine ligand 1

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL1 mRNA]

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 2

multiple interactions

gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA]
gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL2 mRNA]

PMID:22157104 PMID:26177832

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions

gadolinium chloride inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]; gadolinium chloride inhibits the reaction [Progesterone results in increased expression of CXCL1 mRNA]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP1A2 protein]

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

gadolinium chloride inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B1 protein]

PMID:10918498 PMID:18202523

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

multiple interactions

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B2 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B2 protein]

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

gadolinium chloride inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP2C11 protein]

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 protein]; gadolinium chloride inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein]

PMID:18079364 PMID:18202523

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 4, subfamily a, polypeptide 1

multiple interactions

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of CYP4A1 mRNA]

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

DNA-damage inducible transcript 3

multiple interactions
increases expression
affects expression

Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of DDIT3 protein]
gadolinium chloride affects the expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases expression

gadolinium chloride results in increased expression of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ERN1 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

fatty acid binding protein 4

decreases expression

gadolinium chloride results in decreased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid synthase

multiple interactions

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of FASN mRNA
gadolinium chloride promotes the reaction [Ethanol results in decreased expression of FASN protein]

PMID:25813056 PMID:28882574

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

glutamic--pyruvic transaminase

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of GPT protein]; gadolinium chloride inhibits the reaction [Vitamin A results in increased activity of GPT protein]
gadolinium chloride inhibits the reaction [Amiodarone promotes the reaction [Dexamethasone results in increased expression of GPT protein]]

PMID:8627517 PMID:25900201 PMID:26177832

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

hepcidin antimicrobial peptide

increases expression

gadolinium chloride results in increased expression of HAMP

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of HIF1A mRNA

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hemojuvelin BMP co-receptor

decreases expression

gadolinium chloride results in decreased expression of HJV

NCBI chr 2:184,065,944...184,069,851
Ensembl chr 2:184,065,970...184,069,850

G

high mobility group box 1

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein]

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

multiple interactions

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA]

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of HSPA1A mRNA]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of HSPA1A protein]

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 5

increases expression
affects expression
multiple interactions

gadolinium chloride results in increased expression of HSPA5 protein
gadolinium chloride affects the expression of HSPA5 mRNA
Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

intercellular adhesion molecule 1

multiple interactions

gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

affects expression
increases expression

gadolinium chloride affects the expression of IFNG protein
gadolinium chloride results in increased expression of IFNG mRNA

PMID:15590129 PMID:19404939

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

multiple interactions

gadolinium chloride inhibits the reaction [Lipopolysaccharides results in decreased expression of IGF1 protein]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein 3

multiple interactions

gadolinium chloride inhibits the reaction [Lipopolysaccharides results in decreased expression of IGFBP3 protein]

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

interleukin 10

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL10 mRNA]; gadolinium chloride inhibits the reaction [perfluoro-n-nonanoic acid results in decreased expression of IL10 protein]

PMID:22648072 PMID:26177832

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

increases expression

gadolinium chloride results in increased expression of IL13 mRNA

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 1 alpha

multiple interactions

gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression
multiple interactions

gadolinium chloride results in increased expression of IL1B
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of IL1B mRNA
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL1B mRNA; gadolinium chloride inhibits the reaction [perfluoro-n-nonanoic acid results in increased expression of IL1B protein]

PMID:19721414 PMID:22648072 PMID:25813056 PMID:34878122

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

affects expression

gadolinium chloride affects the expression of IL4 mRNA; gadolinium chloride affects the expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
increases expression

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL6 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL6 mRNA]; gadolinium chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of IL6 mRNA
gadolinium chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
gadolinium chloride results in increased expression of IL6
gadolinium chloride results in increased expression of IL6 mRNA

PMID:12127824 PMID:12963478 PMID:19404939 PMID:19721414 PMID:24849676 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

lipase E, hormone sensitive type

multiple interactions

gadolinium chloride inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein]

NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310

G

lymphotoxin beta

increases expression

gadolinium chloride results in increased expression of LTB mRNA

NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381

G

mitogen activated protein kinase 1

decreases phosphorylation
multiple interactions
increases activity

gadolinium chloride results in decreased phosphorylation of MAPK1 protein
gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK1 protein]
gadolinium chloride results in increased activity of MAPK1 protein
Pertussis Toxin inhibits the reaction [gadolinium chloride results in decreased phosphorylation of MAPK1 protein]

PMID:12493575 PMID:21605080 PMID:26177832

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions
increases activity

gadolinium chloride results in decreased phosphorylation of MAPK3 protein
gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK3 protein]
Pertussis Toxin inhibits the reaction [gadolinium chloride results in decreased phosphorylation of MAPK3 protein]
gadolinium chloride results in increased activity of MAPK3 protein

PMID:12493575 PMID:21605080 PMID:26177832

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 13

multiple interactions
increases expression

[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP13 mRNA; SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP13 mRNA]

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 14

multiple interactions
increases expression

[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP14 mRNA
gadolinium chloride results in increased expression of MMP14 mRNA; gadolinium chloride results in increased expression of MMP14 protein

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 9

increases expression
multiple interactions

gadolinium chloride results in increased expression of MMP9 mRNA
SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP9 mRNA]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

gadolinium chloride inhibits the reaction [Thioacetamide results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

NFE2 like bZIP transcription factor 2

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of NFE2L2 mRNA

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of NFKB1 mRNA

PMID:15025948 PMID:34878122

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nitric oxide synthase 2

increases expression

gadolinium chloride results in increased expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

platelet derived growth factor subunit A

decreases expression

gadolinium chloride results in decreased expression of PDGFA mRNA

NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497

G

platelet derived growth factor subunit B

decreases expression

gadolinium chloride results in decreased expression of PDGFB mRNA

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

peroxisome proliferator activated receptor alpha

multiple interactions

gadolinium chloride promotes the reaction [perfluoro-n-nonanoic acid results in increased expression of PPARA mRNA]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

decreases expression

gadolinium chloride results in decreased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein tyrosine kinase 2

increases activity

gadolinium chloride results in increased activity of PTK2

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

RB transcriptional corepressor 1

increases phosphorylation

gadolinium chloride results in increased phosphorylation of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of RELA protein

PMID:15025948 PMID:34878122

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

S100 calcium binding protein A8

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A8 mRNA]

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA]

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

stearoyl-CoA desaturase

multiple interactions

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of SCD1 mRNA]
gadolinium chloride promotes the reaction [Ethanol results in decreased expression of SCD1 protein]

PMID:25813056 PMID:28882574

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

solute carrier family 40 member 1

decreases expression

gadolinium chloride results in decreased expression of SLC40A1

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

G

secreted phosphoprotein 1

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

sequestosome 1

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of SQSTM1 mRNA

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 1

multiple interactions

gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

transforming growth factor, beta 1

multiple interactions
increases expression
affects expression

gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of TGFB1 mRNA
gadolinium chloride results in increased expression of TGFB1 protein
gadolinium chloride results in increased expression of TGFB1 mRNA
gadolinium chloride affects the expression of TGFB1 mRNA

PMID:11408273 PMID:15590129 PMID:15964588 PMID:19404939 PMID:34878122

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

toll-like receptor 4

multiple interactions

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TLR4 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TLR4 protein]

PMID:25813056 PMID:26177832

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions
decreases expression
increases expression

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TNF mRNA; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; gadolinium chloride inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; gadolinium chloride inhibits the reaction [perfluoro-n-nonanoic acid results in increased expression of TNF protein]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of TNF protein]
gadolinium trichloride inhibits the reaction [estriol enhances the reaction [lipopolysaccharide increases expression of Tnf mRNA in liver]]
gadolinium chloride inhibits the reaction [lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of TNF protein]
gadolinium chloride results in increased expression of TNF
gadolinium chloride results in increased expression of TNF mRNA

CTD
RGD

PMID:12127824 PMID:12963478 PMID:14687926 PMID:15025948 PMID:15590129 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11B

increases expression

gadolinium chloride results in increased expression of TNFRSF11B mRNA

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF receptor superfamily member 1A

increases expression

gadolinium chloride results in increased expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF superfamily member 10

increases expression

gadolinium chloride results in increased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

TNF superfamily member 11

decreases expression

gadolinium chloride results in decreased expression of TNFSF11 mRNA

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

uncoupling protein 2

multiple interactions

gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of UCP2 mRNA]

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

vascular endothelial growth factor A

increases expression

gadolinium chloride results in increased expression of VEGFA mRNA; gadolinium chloride results in increased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

X-box binding protein 1

increases splicing

gadolinium chloride results in increased splicing of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

N-(p-amylcinnamoyl)anthranilic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

4-amylcinnamoylanthranilic acid inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP3 protein]
4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin results in increased activity of CASP3 protein]]

PMID:33309544 PMID:35395232

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin results in increased activity of CASP8 protein]]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

4-amylcinnamoylanthranilic acid inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP9 protein]
4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin results in increased activity of CASP9 protein]]

PMID:33309544 PMID:35395232

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

solute carrier family 13 member 2

multiple interactions

[4-amylcinnamoylanthranilic acid results in decreased activity of SLC13A2 protein] which results in decreased susceptibility to diethylene glycol metabolite

NCBI chr10:63,291,813...63,319,127
Ensembl chr10:63,291,815...63,319,127

G

transient receptor potential cation channel, subfamily M, member 2

multiple interactions
decreases activity

4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]]
4-amylcinnamoylanthranilic acid results in decreased activity of TRPM2 protein
4-amylcinnamoylanthranilic acid inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]

PMID:18204483 PMID:30229906 PMID:33309544 PMID:34958835 PMID:35395232

NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181

pymetrozine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

thyroid hormone receptor beta

affects binding

pymetrozine binds to THRB protein

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

ruthenium red

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA carboxylase alpha

multiple interactions

Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

adiponectin, C1Q and collagen domain containing

multiple interactions

Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

agouti related neuropeptide

multiple interactions

Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA]

NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584

G

AKT serine/threonine kinase 1

multiple interactions

Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

amyloid beta precursor protein

multiple interactions

Ruthenium Red inhibits the reaction [APP protein modified form results in increased uptake of Calcium]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

autophagy related 5

multiple interactions

Ruthenium Red inhibits the reaction [Cadmium Compounds results in increased expression of ATG5 protein]

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

autophagy related 7

multiple interactions

Ruthenium Red inhibits the reaction [Cadmium Compounds results in increased expression of ATG7 protein]

NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Aconitine co-treated with Ruthenium Red] results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

calcitonin-related polypeptide alpha

multiple interactions

Ruthenium Red inhibits the reaction [Dronabinol affects the secretion of CALCA protein]

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

caspase 12

multiple interactions

[Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein]

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions

[Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein]
[Aconitine co-treated with Ruthenium Red] results in increased cleavage of CASP3 protein

PMID:19631781 PMID:23219522 PMID:37506855

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cholecystokinin

multiple interactions

[N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine co-treated with Ruthenium Red] inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]; Ruthenium Red inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

glial fibrillary acidic protein

multiple interactions

Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA]

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

ghrelin and obestatin prepropeptide

multiple interactions

Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHRL protein]

NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621

G

growth hormone secretagogue receptor

multiple interactions

Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]

NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865

G

glutamate metabotropic receptor 1

multiple interactions

Ruthenium Red inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Ruthenium Red inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]

NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170

G

insulin-like growth factor 1

multiple interactions

Ruthenium Red inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 6

multiple interactions

Ruthenium Red inhibits the reaction [Capsaicin results in increased expression of IL6 mRNA]
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of IL6 protein]

PMID:16173059 PMID:32652086

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 2

multiple interactions

Ruthenium Red inhibits the reaction [INS protein results in increased uptake of cobaltous chloride]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

leptin

multiple interactions

Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of LEP protein]

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

Ruthenium Red inhibits the reaction [Cadmium Compounds results in increased lipidation of MAP1LC3B protein]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

mitogen activated protein kinase 1

multiple interactions

Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK1 protein]

PMID:16513848 PMID:23219522 PMID:23994502 PMID:27818125

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK3 protein]
Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]

PMID:16513848 PMID:23219522 PMID:23994502 PMID:27818125

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitochondrial calcium uniporter

multiple interactions

[Aconitine co-treated with Ruthenium Red] results in increased expression of MCU protein

NCBI chr20:27,417,529...27,580,110
Ensembl chr20:27,417,526...27,580,110

G

mitofusin 2

multiple interactions

Ruthenium Red inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

mitochondrial calcium uptake 1

multiple interactions

Ruthenium Red inhibits the reaction [tianhuang inhibits the reaction [Dexamethasone results in decreased expression of MICU1 protein]]; Ruthenium Red promotes the reaction [Dexamethasone results in decreased expression of MICU1 protein]

NCBI chr20:27,668,681...27,816,322
Ensembl chr20:27,668,747...27,814,964

G

matrix metallopeptidase 1

affects expression
multiple interactions

Ruthenium Red affects the expression of MMP1 mRNA; Ruthenium Red affects the expression of MMP1 protein
Ruthenium Red inhibits the reaction [Vehicle Emissions results in increased secretion of MMP1 protein]

PMID:17508023 PMID:21245013

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

myeloperoxidase

multiple interactions

Ruthenium Red inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein]; Ruthenium Red inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

PMID:21466812 PMID:22882778

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

nuclear factor kappa B subunit 1

multiple interactions

Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NFKB1 mRNA]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

natriuretic peptide A

multiple interactions

Ruthenium Red inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

neuropeptide Y

multiple interactions

Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NPY mRNA]

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA]

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

proopiomelanocortin

multiple interactions

Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

Ruthenium Red inhibits the reaction [tianhuang inhibits the reaction [Dexamethasone results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein]]; Ruthenium Red promotes the reaction [Dexamethasone results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein]

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase AMP-activated non-catalytic subunit gamma 2

multiple interactions

Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA]

NCBI chr 4:10,010,890...10,252,155
Ensembl chr 4:10,010,890...10,252,142

G

peptide YY

multiple interactions

[Ruthenium Red co-treated with N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine] inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form]; Ruthenium Red inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form]

NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815

G

tumor necrosis factor

multiple interactions

Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

transient receptor potential cation channel, subfamily A, member 1

multiple interactions
decreases activity

Ruthenium Red inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]
Ruthenium Red inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [Arachidonic Acid results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]
Ruthenium Red results in decreased activity of TRPA1 protein

PMID:15046718 PMID:15843607 PMID:17684094 PMID:23994502

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions
affects binding

Ruthenium Red inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased abundance of Calcium]]; Ruthenium Red inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]]
Ruthenium Red binds to TRPV1 protein
Ruthenium Red inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium]; Ruthenium Red inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Cobalt]; Ruthenium Red inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Ruthenium Red inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of TRPV1 protein]
Ruthenium Red binds to and results in decreased activity of TRPV1 protein; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV1 mRNA]

PMID:11140687 PMID:18172555 PMID:18230619 PMID:23264033 PMID:23747933 More...

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

transient receptor potential cation channel, subfamily V, member 3

multiple interactions

Ruthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium]
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV3 mRNA]

PMID:20086034 PMID:32652086

NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296

G

transient receptor potential cation channel, subfamily V, member 4

multiple interactions
decreases activity

[Ruthenium Red results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine

NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517

G

vascular endothelial growth factor A

multiple interactions

Ruthenium Red inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

scalaradial

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 1 beta

multiple interactions

scalaradial inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; scalaradial inhibits the reaction [IL1B protein results in increased expression of TNF protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

myeloperoxidase

multiple interactions

scalaradial inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

prostaglandin-endoperoxide synthase 2

multiple interactions

scalaradial inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; scalaradial inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

tumor necrosis factor

multiple interactions

scalaradial inhibits the reaction [IL1B protein results in increased expression of TNF protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

SKF-96365 hydrochloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

autophagy related 9A

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of ATG9A protein]

NCBI chr 9:76,677,403...76,688,050
Ensembl chr 9:76,677,404...76,687,986

G

brain-derived neurotrophic factor

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Oxygen deficiency results in increased secretion of BDNF protein]

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of BECN1 protein]

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

caspase 3

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole promotes the reaction [Propofol results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

calcium-sensing receptor

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [CASR protein results in increased uptake of Calcium]

NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811

G

death-associated protein kinase 2

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of DAPK2 protein]

NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567

G

DNA-damage inducible transcript 3

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Doxorubicin results in increased expression of DDIT3 protein]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

glutamate metabotropic receptor 1

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]

NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170

G

heat shock protein family A (Hsp70) member 5

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

insulin 2

decreases response to substance

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole results in decreased susceptibility to INS protein

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

leptin

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium]

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

mitogen activated protein kinase 1

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

myosin light chain 9

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MYL9 protein]

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

nuclear factor of activated T-cells 1

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Lipopolysaccharides affects the localization of NFATC1 protein]

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

nitric oxide synthase 3

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [fluoranthene results in increased expression of NOS3 protein]; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [fluorene results in increased expression of NOS3 protein]; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [naphthalene results in increased expression of NOS3 protein]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

ORAI calcium release-activated calcium modulator 1

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of ORAI1 protein]

NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405

G

prostaglandin-endoperoxide synthase 2

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Particulate Matter co-treated with Methylene Chloride] results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

sequestosome 1

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in decreased expression of SQSTM1 protein]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

stromal interaction molecule 1

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of STIM1 protein]

NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363

G

transient receptor potential cation channel, subfamily C, member 3

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium]

NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855

G

transient receptor potential cation channel, subfamily C, member 6

multiple interactions
decreases activity

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole promotes the reaction [Propofol results in decreased expression of TRPC6 protein]
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole results in decreased activity of TRPC6 protein

PMID:11179201 PMID:11535132 PMID:36640868

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092

G

tubulin, beta 3 class III

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole promotes the reaction [2,3',4,4',5-pentachlorobiphenyl results in decreased expression of TUBB3 protein]

NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19811
role	19818
biological role	19785
biophysical role	14056
membrane transport modulator	13899
TRP channel modulator	137
TRP channel blocker +	136
TRPV channel modulator +	1

paths to the root