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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:spiroiminodihydantoin
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Accession:CHEBI:142623 term browser browse the term
Definition:An azaspiro compound that is 1,3,6,8-tetraazaspiro[4.4]non-6-ene which is substituted by oxo groups at positions 2, 4, and 9. Both enantiomers are highly mutagenic products resulting from the oxidation of guanine and 8-oxo-7,8-dihydroguanine in DNA by reactive oxygen species.
Synonyms:exact_synonym: 7-amino-1,3,6,8-tetraazaspiro[4.4]non-6-ene-2,4,9-trione
 related_synonym: Formula=C5H5N5O3;   InChI=1S/C5H5N5O3/c6-3-7-1(11)5(9-3)2(12)8-4(13)10-5/h(H3,6,7,9,11)(H2,8,10,12,13);   InChIKey=HJWQNCPSKFANJK-UHFFFAOYSA-N;   SMILES=N1C(NC(C12N=C(NC2=O)N)=O)=O
 xref: PMID:15540949;   PMID:17915881;   PMID:19146379;   PMID:19485408;   PMID:20014751;   PMID:23360616;   PMID:24649945;   PMID:26572218;   PMID:26807878;   PMID:27074396;   PMID:28230976;   PMID:28514164;   PMID:28845978;   PMID:30592213


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  CHEBI ontology 21746
    role 21724
      biological role 21722
        aetiopathogenetic role 20869
          genotoxin 19014
            mutagen 18888
              spiroiminodihydantoin 0
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  CHEBI ontology 21746
    subatomic particle 21732
      composite particle 21732
        hadron 21732
          baryon 21732
            nucleon 21732
              atomic nucleus 21732
                atom 21732
                  main group element atom 21647
                    p-block element atom 21647
                      carbon group element atom 21454
                        carbon atom 21353
                          organic molecular entity 21353
                            organic molecule 21249
                              organic cyclic compound 20838
                                organic heterocyclic compound 19837
                                  organic heteromonocyclic compound 17522
                                    diazolidine 716
                                      imidazolidines 707
                                        imidazolidinone 610
                                          imidazolidine-2,4-dione 473
                                            hydantoin 414
                                              spiroiminodihydantoin 0
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