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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:spiroiminodihydantoin
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Accession:CHEBI:142623 term browser browse the term
Definition:An azaspiro compound that is 1,3,6,8-tetraazaspiro[4.4]non-6-ene which is substituted by oxo groups at positions 2, 4, and 9. Both enantiomers are highly mutagenic products resulting from the oxidation of guanine and 8-oxo-7,8-dihydroguanine in DNA by reactive oxygen species.
Synonyms:exact_synonym: 7-amino-1,3,6,8-tetraazaspiro[4.4]non-6-ene-2,4,9-trione
 related_synonym: Formula=C5H5N5O3;   InChI=1S/C5H5N5O3/c6-3-7-1(11)5(9-3)2(12)8-4(13)10-5/h(H3,6,7,9,11)(H2,8,10,12,13);   InChIKey=HJWQNCPSKFANJK-UHFFFAOYSA-N;   SMILES=N1C(NC(C12N=C(NC2=O)N)=O)=O
 xref: PMID:15540949;   PMID:17915881;   PMID:19146379;   PMID:19485408;   PMID:20014751;   PMID:23360616;   PMID:24649945;   PMID:26572218;   PMID:26807878;   PMID:27074396;   PMID:28230976;   PMID:28514164;   PMID:28845978;   PMID:30592213


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  CHEBI ontology 24775
    role 24693
      biological role 24662
        aetiopathogenetic role 23529
          genotoxin 19660
            mutagen 19395
              spiroiminodihydantoin 0
Path 2
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  CHEBI ontology 24775
    subatomic particle 24735
      composite particle 24735
        hadron 24735
          baryon 24735
            nucleon 24735
              atomic nucleus 24735
                atom 24735
                  main group element atom 24601
                    p-block element atom 24601
                      carbon group element atom 24393
                        carbon atom 24357
                          organic molecular entity 24357
                            organic molecule 24240
                              organic cyclic compound 23484
                                organic heterocyclic compound 21767
                                  organic heteromonocyclic compound 17994
                                    diazolidine 715
                                      imidazolidines 705
                                        imidazolidinone 609
                                          imidazolidine-2,4-dione 470
                                            hydantoin 412
                                              spiroiminodihydantoin 0
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