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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:spiroiminodihydantoin
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Accession:CHEBI:142623 term browser browse the term
Definition:An azaspiro compound that is 1,3,6,8-tetraazaspiro[4.4]non-6-ene which is substituted by oxo groups at positions 2, 4, and 9. Both enantiomers are highly mutagenic products resulting from the oxidation of guanine and 8-oxo-7,8-dihydroguanine in DNA by reactive oxygen species.
Synonyms:exact_synonym: 7-amino-1,3,6,8-tetraazaspiro[4.4]non-6-ene-2,4,9-trione
 related_synonym: Formula=C5H5N5O3;   InChI=1S/C5H5N5O3/c6-3-7-1(11)5(9-3)2(12)8-4(13)10-5/h(H3,6,7,9,11)(H2,8,10,12,13);   InChIKey=HJWQNCPSKFANJK-UHFFFAOYSA-N;   SMILES=N1C(NC(C12N=C(NC2=O)N)=O)=O
 xref: PMID:15540949;   PMID:17915881;   PMID:19146379;   PMID:19485408;   PMID:20014751;   PMID:23360616;   PMID:24649945;   PMID:26572218;   PMID:26807878;   PMID:27074396;   PMID:28230976;   PMID:28514164;   PMID:28845978;   PMID:30592213


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  CHEBI ontology 19786
    role 19732
      biological role 19732
        aetiopathogenetic role 18987
          genotoxin 17476
            mutagen 17376
              spiroiminodihydantoin 0
Path 2
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  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic molecule 19519
                              organic cyclic compound 19349
                                organic heterocyclic compound 18574
                                  organic heteromonocyclic compound 17072
                                    diazolidine 982
                                      imidazolidines 972
                                        imidazolidinone 605
                                          imidazolidine-2,4-dione 470
                                            hydantoin 412
                                              spiroiminodihydantoin 0
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