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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:CHIC-35
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Accession:CHEBI:142489 term browser browse the term
Definition:An organic heterotricyclic compound resulting from the formal fusion of the 2-3 bond of 5-chloroindole with the 2-3 bond of cycloheptanecarboxamide (the S enantiomer). It is a potent, cell-permeable, metabolically stable and selective inhibitor of the deacetylase SIRT1.
Synonyms:exact_synonym: (6S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide
 related_synonym: Compound (S)-35;   Formula=C14H15ClN2O;   InChI=1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1;   InChIKey=ABIVOOWWGYJNLV-JTQLQIEISA-N;   SIRT1 Inhibitor IV, (S)-35;   SMILES=C1C2=C(NC=3C2=CC(=CC3)Cl)[C@@H](C(=O)N)CCC1
 xref: CAS:848193-72-6;   PMID:16335928;   PMID:21699209;   PMID:23499872;   PMID:26792944;   Reaxys:10274604



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Term Annotations click to browse term
  CHEBI ontology 19659
    chemical entity 19658
      molecular entity 19658
        polyatomic entity 19617
          molecule 19525
            cyclic compound 19383
              aromatic compound 19233
                CHIC-35 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic group 18752
                              organic divalent group 18771
                                organodiyl group 18737
                                  carbonyl group 18704
                                    carbonyl compound 18738
                                      carboxylic acid 18409
                                        carboacyl group 17570
                                          univalent carboacyl group 17599
                                            carbamoyl group 17407
                                              carboxamide 17407
                                                primary carboxamide 5906
                                                  CHIC-35 0
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