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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,2-dichloropropane
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Accession:CHEBI:142468 term browser browse the term
Definition:A chloroalkane that is propane in which a hydrogen from each of two adjacent carbons has been replaced by chlorines.
Synonyms:related_synonym: Formula=C3H6Cl2;   InChI=1S/C3H6Cl2/c1-3(5)2-4/h3H,2H2,1H3;   InChIKey=KNKRKFALVUDBJE-UHFFFAOYSA-N;   SMILES=CC(CCl)Cl
 xref: Reaxys:1718880


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rac-1,2-dichloropropane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAT1 acetyl-CoA acetyltransferase 1 multiple interactions
decreases expression		 ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of ACAT1 protein] CTD PMID:32435916 NCBI chr11:108,116,705...108,147,603
Ensembl chr11:108,116,695...108,147,603 		JBrowse link
G ACOT2 acyl-CoA thioesterase 2 increases expression
multiple interactions		 ISO propylene dichloride results in increased expression of ACOT2 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of ACOT2 protein]		 CTD PMID:32435916 NCBI chr14:73,567,620...73,575,658
Ensembl chr14:73,567,620...73,575,658 		JBrowse link
G AICDA activation induced cytidine deaminase affects expression EXP propylene dichloride affects the expression of AICDA mRNA CTD PMID:30452740 NCBI chr12:8,602,170...8,612,859
Ensembl chr12:8,602,155...8,613,242 		JBrowse link
G ALDH1B1 aldehyde dehydrogenase 1 family member B1 increases expression
multiple interactions		 ISO propylene dichloride results in increased expression of ALDH1B1 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of ALDH1B1 protein]		 CTD PMID:32435916 NCBI chr 9:38,392,702...38,398,661
Ensembl chr 9:38,392,702...38,398,661 		JBrowse link
G CA3 carbonic anhydrase 3 decreases expression
multiple interactions		 ISO propylene dichloride results in decreased expression of CAR3 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of CAR3 protein]		 CTD PMID:32435916 NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040 		JBrowse link
G CES3 carboxylesterase 3 decreases expression
multiple interactions		 ISO propylene dichloride results in decreased expression of CES3B protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of CES3B protein]		 CTD PMID:32435916 NCBI chr16:66,961,266...66,975,149
Ensembl chr16:66,961,245...66,975,149 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases oxidation EXP CYP2E1 protein results in increased oxidation of propylene dichloride CTD PMID:1664256 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G ECH1 enoyl-CoA hydratase 1 multiple interactions
increases expression		 ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of ECH1 protein] CTD PMID:32435916 NCBI chr19:38,815,422...38,831,794
Ensembl chr19:38,815,422...38,831,841 		JBrowse link
G FTCD formimidoyltransferase cyclodeaminase decreases expression
multiple interactions		 ISO propylene dichloride results in decreased expression of FTCD protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of FTCD protein]		 CTD PMID:32435916 NCBI chr21:46,136,262...46,155,579
Ensembl chr21:46,136,160...46,155,579 		JBrowse link
G FTH1 ferritin heavy chain 1 multiple interactions
increases expression		 ISO 1-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased expression of FTH1 protein] CTD PMID:32435916 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634 		JBrowse link
G FTL ferritin light chain multiple interactions
increases expression		 ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of FTL1 protein] CTD PMID:32435916 NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,966,879 		JBrowse link
G GPT glutamic--pyruvic transaminase increases expression ISO propylene dichloride results in increased expression of GPT protein CTD PMID:1980407 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 multiple interactions
increases expression		 ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of GSTM1 protein]; NFE2L2 gene mutant form inhibits the reaction [propylene dichloride results in increased expression of GSTM1 mRNA]
propylene dichloride results in increased expression of GSTM1 mRNA; propylene dichloride results in increased expression of GSTM1 protein		 CTD PMID:32435916 PMID:37326970 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039 		JBrowse link
G H2AX H2A.X variant histone increases phosphorylation
multiple interactions		 EXP
ISO		 propylene dichloride results in increased phosphorylation of H2AX protein
NFE2L2 gene mutant form inhibits the reaction [propylene dichloride results in increased expression of H2AX protein]; propylene dichloride results in increased expression of and results in increased phosphorylation of H2AX protein
1-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; Disulfiram inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; Fomepizole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]		 CTD PMID:28300663 PMID:37326970 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465 		JBrowse link
G INMT indolethylamine N-methyltransferase decreases expression
multiple interactions		 ISO propylene dichloride results in decreased expression of INMT protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of INMT protein]		 CTD PMID:32435916 NCBI chr 7:30,752,135...30,757,602
Ensembl chr 7:30,697,985...30,757,602 		JBrowse link
G KRT8 keratin 8 decreases expression
multiple interactions		 ISO propylene dichloride results in decreased expression of KRT8 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of KRT8 protein]		 CTD PMID:32435916 NCBI chr12:52,897,191...52,949,860
Ensembl chr12:52,897,187...52,949,954 		JBrowse link
G MGST1 microsomal glutathione S-transferase 1 multiple interactions ISO [propylene dichloride co-treated with Methylene Chloride] affects the activity of and affects the expression of MGST1 protein; propylene dichloride affects the activity of and affects the expression of MGST1 protein CTD PMID:30240022 NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259 		JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I multiple interactions
decreases expression		 ISO [propylene dichloride co-treated with Methylene Chloride] affects the expression of COX1 protein
propylene dichloride results in decreased expression of COX1 protein		 CTD PMID:30240022 NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445 		JBrowse link
G NDUFB8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression ISO propylene dichloride results in decreased expression of NDUFB8 protein CTD PMID:30240022 NCBI chr10:100,523,729...100,529,923
Ensembl chr10:100,523,740...100,530,000 		JBrowse link
G NDUFS3 NADH:ubiquinone oxidoreductase core subunit S3 multiple interactions
decreases expression		 ISO [propylene dichloride co-treated with Methylene Chloride] results in decreased expression of NDUFS3 protein
propylene dichloride results in decreased expression of NDUFS3 protein		 CTD PMID:30240022 NCBI chr11:47,579,074...47,584,562
Ensembl chr11:47,565,336...47,584,562 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
increases response to substance		 ISO NFE2L2 gene mutant form inhibits the reaction [propylene dichloride results in increased expression of G6PD2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [propylene dichloride results in increased expression of GSTM1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [propylene dichloride results in increased expression of H2AX protein]; NFE2L2 gene mutant form inhibits the reaction [propylene dichloride results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [propylene dichloride results in increased expression of SLC7A11 mRNA]
NFE2L2 results in increased susceptibility to propylene dichloride		 CTD PMID:37326970 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression		 ISO NFE2L2 gene mutant form inhibits the reaction [propylene dichloride results in increased expression of NQO1 mRNA] CTD PMID:37326970 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G OTC ornithine transcarbamylase increases activity ISO propylene dichloride results in increased activity of OTC protein CTD PMID:2744274 NCBI chr  X:38,327,684...38,422,928
Ensembl chr  X:38,352,586...38,421,446 		JBrowse link
G RGN regucalcin decreases expression
multiple interactions		 ISO propylene dichloride results in decreased expression of RGN protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of RGN protein]		 CTD PMID:32435916 NCBI chr  X:47,078,443...47,093,313
Ensembl chr  X:47,078,355...47,093,314 		JBrowse link
G SDHA succinate dehydrogenase complex flavoprotein subunit A decreases expression ISO propylene dichloride results in decreased expression of SDHA protein CTD PMID:30240022 NCBI chr 5:218,320...268,746
Ensembl chr 5:218,303...257,082 		JBrowse link
G SDHB succinate dehydrogenase complex iron sulfur subunit B decreases expression
multiple interactions		 ISO propylene dichloride results in decreased expression of SDHB protein
[propylene dichloride co-treated with Methylene Chloride] affects the expression of SDHB protein		 CTD PMID:30240022 NCBI chr 1:17,018,722...17,054,032
Ensembl chr 1:17,018,664...17,054,032 		JBrowse link
G SDHC succinate dehydrogenase complex subunit C decreases expression
multiple interactions		 ISO propylene dichloride results in decreased expression of SDHC protein
[propylene dichloride co-treated with Methylene Chloride] affects the expression of SDHC protein		 CTD PMID:30240022 NCBI chr 1:161,314,381...161,363,206
Ensembl chr 1:161,314,381...161,363,206 		JBrowse link
G SDHD succinate dehydrogenase complex subunit D affects expression
multiple interactions		 ISO propylene dichloride affects the expression of SDHD protein
[propylene dichloride co-treated with Methylene Chloride] affects the expression of SDHD protein		 CTD PMID:30240022 NCBI chr11:112,086,873...112,095,794
Ensembl chr11:112,086,824...112,120,016 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases expression
multiple interactions		 ISO propylene dichloride results in increased expression of SLC7A11 mRNA
NFE2L2 gene mutant form inhibits the reaction [propylene dichloride results in increased expression of SLC7A11 mRNA]		 CTD PMID:37326970 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
G TNF tumor necrosis factor increases expression EXP propylene dichloride results in increased expression of TNF mRNA CTD PMID:30452740 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 affects localization EXP propylene dichloride affects the localization of TP53BP1 protein CTD PMID:28300663 NCBI chr15:43,403,061...43,510,640
Ensembl chr15:43,403,061...43,510,728 		JBrowse link
G UBP1 upstream binding protein 1 multiple interactions
decreases expression		 ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of UBP1 protein] CTD PMID:32435916 NCBI chr 3:33,388,336...33,441,399
Ensembl chr 3:33,388,336...33,441,371 		JBrowse link
G UQCRC2 ubiquinol-cytochrome c reductase core protein 2 multiple interactions
decreases expression		 ISO [propylene dichloride co-treated with Methylene Chloride] affects the expression of UQCRC2 protein
propylene dichloride results in decreased expression of UQCRC2 protein		 CTD PMID:30240022 NCBI chr16:21,953,361...21,983,660
Ensembl chr16:21,953,288...21,983,660 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    chemical entity 26024
      molecular entity 25991
        polyatomic entity 25876
          molecule 25277
            organic molecule 25222
              volatile organic compound 16137
                1,2-dichloropropane 33
                  (R)-1,2-dichloropropane + 33
                  (S)-1,2-dichloropropane + 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    main group molecular entity 25834
                      s-block molecular entity 25166
                        hydrogen molecular entity 24765
                          hydrides 22965
                            organic hydride 21924
                              organic fundamental parent 21924
                                hydrocarbon 21350
                                  halohydrocarbon 15904
                                    haloalkane 12781
                                      chloroalkane 9269
                                        1,2-dichloropropane 33
                                          (R)-1,2-dichloropropane + 33
                                          (S)-1,2-dichloropropane + 33
paths to the root