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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,2-dichloropropane
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Accession:CHEBI:142468 term browser browse the term
Definition:A chloroalkane that is propane in which a hydrogen from each of two adjacent carbons has been replaced by chlorines.
Synonyms:related_synonym: Formula=C3H6Cl2;   InChI=1S/C3H6Cl2/c1-3(5)2-4/h3H,2H2,1H3;   InChIKey=KNKRKFALVUDBJE-UHFFFAOYSA-N;   SMILES=CC(CCl)Cl
 xref: Reaxys:1718880



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rac-1,2-dichloropropane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression
multiple interactions
ISO propylene dichloride results in decreased expression of ACAT1 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of ACAT1 protein]
CTD PMID:32435916 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Acot2 acyl-CoA thioesterase 2 multiple interactions
increases expression
ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of ACOT2 protein] CTD PMID:32435916 NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Aicda activation-induced cytidine deaminase affects expression ISO propylene dichloride affects the expression of AICDA mRNA CTD PMID:30452740 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 increases expression
multiple interactions
ISO propylene dichloride results in increased expression of ALDH1B1 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of ALDH1B1 protein]
CTD PMID:32435916 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression
multiple interactions
ISO propylene dichloride results in decreased expression of CAR3 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of CAR3 protein]
CTD PMID:32435916 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Ces3a carboxylesterase 3a decreases expression
multiple interactions
ISO propylene dichloride results in decreased expression of CES3B protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of CES3B protein]
CTD PMID:32435916 NCBI chr19:32,992,386...33,000,562 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases oxidation ISO CYP2E1 protein results in increased oxidation of propylene dichloride CTD PMID:1664256 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression
multiple interactions
ISO propylene dichloride results in increased expression of ECH1 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of ECH1 protein]
CTD PMID:32435916 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase decreases expression
multiple interactions
ISO propylene dichloride results in decreased expression of FTCD protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of FTCD protein]
CTD PMID:32435916 NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression
multiple interactions
ISO propylene dichloride results in increased expression of FTH1 protein
1-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased expression of FTH1 protein]
CTD PMID:32435916 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Ftl1 ferritin light chain 1 increases expression
multiple interactions
ISO propylene dichloride results in increased expression of FTL1 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of FTL1 protein]
CTD PMID:32435916 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP propylene dichloride results in increased expression of GPT protein CTD PMID:1980407 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression
multiple interactions
ISO propylene dichloride results in increased expression of GSTM1 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of GSTM1 protein]
CTD PMID:32435916 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions
ISO propylene dichloride results in increased phosphorylation of H2AX protein
1-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; Disulfiram inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; Fomepizole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]
CTD PMID:28300663 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Inmt indolethylamine N-methyltransferase multiple interactions
decreases expression
ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of INMT protein] CTD PMID:32435916 NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
JBrowse link
G Krt8 keratin 8 decreases expression
multiple interactions
ISO propylene dichloride results in decreased expression of KRT8 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of KRT8 protein]
CTD PMID:32435916 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Otc ornithine transcarbamylase increases activity EXP propylene dichloride results in increased activity of OTC protein CTD PMID:2744274 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Rgn regucalcin multiple interactions
decreases expression
ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of RGN protein] CTD PMID:32435916 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450
JBrowse link
G Tnf tumor necrosis factor increases expression ISO propylene dichloride results in increased expression of TNF mRNA CTD PMID:30452740 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 affects localization ISO propylene dichloride affects the localization of TP53BP1 protein CTD PMID:28300663 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link
G Ubp1 upstream binding protein 1 decreases expression
multiple interactions
ISO propylene dichloride results in decreased expression of UBP1 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of UBP1 protein]
CTD PMID:32435916 NCBI chr 8:113,869,771...113,915,625
Ensembl chr 8:113,869,979...113,915,625
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    chemical entity 19823
      molecular entity 19821
        polyatomic entity 19743
          molecule 19595
            organic molecule 19572
              volatile organic compound 14511
                1,2-dichloropropane 21
                  (R)-1,2-dichloropropane + 21
                  (S)-1,2-dichloropropane + 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    main group molecular entity 19720
                      s-block molecular entity 19502
                        hydrogen molecular entity 19495
                          hydrides 18855
                            organic hydride 18361
                              organic fundamental parent 18361
                                hydrocarbon 18074
                                  halohydrocarbon 14069
                                    haloalkane 11708
                                      chloroalkane 9140
                                        1,2-dichloropropane 21
                                          (R)-1,2-dichloropropane + 21
                                          (S)-1,2-dichloropropane + 21
paths to the root