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Accession:CHEBI:142418 term browser browse the term
Definition:A pyrrolopyrimidine obtained by formal condensation of the carboxy group of (6S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylic acid with the amino group of (R)-[(2R,5S)-5-(4-aminobenzyl)pyrrolidin-2-yl](phenyl)methanol. It is a beta3-adrenergic receptor agonist currently in clinical development for the treatment of patients with overactive bladder.
Synonyms:exact_synonym: (6S)-N-[4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxamide
 related_synonym: Beova;   Formula=C26H28N4O3;   InChI=1S/C26H28N4O3/c31-24-14-15-27-23-13-12-22(30(23)24)26(33)29-19-8-6-17(7-9-19)16-20-10-11-21(28-20)25(32)18-4-2-1-3-5-18/h1-9,14-15,20-22,25,28,32H,10-13,16H2,(H,29,33)/t20-,21+,22-,25+/m0/s1;   InChIKey=DJXRIQMCROIRCZ-XOEOCAAJSA-N;   MK-4618;   SMILES=C(NC1=CC=C(C=C1)C[C@@H]2CC[C@@H](N2)[C@@H](C3=CC=CC=C3)O)([C@H]4N5C(C=CN=C5CC4)=O)=O;   vibegronum
 xref: CAS:1190389-15-1 "ChemIDplus";   KEGG:D10433;   PMID:26709102 "Europe PMC";   PMID:27965369 "Europe PMC";   PMID:29366513 "Europe PMC";   PMID:29752752 "Europe PMC";   Pubchem:44472635 "SUBMITTER";   Reaxys:19541234 "Reaxys"

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  CHEBI ontology 19745
    role 19692
      application 19347
        refrigerant 17097
          ammonia 16695
            organic amino compound 16694
              amine 7581
                secondary amine 1659
                  vibegron 0
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  CHEBI ontology 19745
    subatomic particle 19741
      composite particle 19741
        hadron 19741
          baryon 19741
            nucleon 19741
              atomic nucleus 19741
                atom 19741
                  main group element atom 19625
                    p-block element atom 19625
                      carbon group element atom 19519
                        carbon atom 19513
                          organic molecular entity 19513
                            organic group 18424
                              organic divalent group 18416
                                organodiyl group 18416
                                  carbonyl group 18304
                                    carbonyl compound 18304
                                      carboxylic acid 17970
                                        carboacyl group 17080
                                          univalent carboacyl group 17080
                                            carbamoyl group 16809
                                              carboxamide 16809
                                                secondary carboxamide 205
                                                  vibegron 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.