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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hexahydronaphthalenes
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Accession:CHEBI:142348 term browser browse the term
Definition:Any carbobycyclic compound that is an hexahydronaphthalene or a compound obtained from an hexahydronaphthalene by formal substitution of one or more hydrogens.



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lovastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 increases expression
decreases expression
multiple interactions
ISO
EXP
Lovastatin results in increased expression of ABCA1 mRNA
lovastatin decreases expression of ABCA1 mRNA in HepG2 cells
[Dietary Fats co-treated with Lovastatin] affects the expression of ABCA1 mRNA
Lovastatin results in decreased expression of ABCA1 mRNA
CTD
RGD
PMID:19260826 PMID:29852127 PMID:27765770 RGD:18936994 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions
decreases activity
ISO Lovastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Lovastatin results in decreased activity of ABCB11 protein
CTD PMID:23956101 PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A increases transport
decreases activity
multiple interactions
ISO ABCB1 protein results in increased transport of Lovastatin; ABCB1 protein results in increased transport of Lovastatin analog
Lovastatin analog results in decreased activity of ABCB1 protein
Lovastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]
CTD PMID:15616150 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 decreases activity
multiple interactions
EXP Lovastatin results in decreased activity of ABCC1 protein
[Lovastatin results in decreased activity of ABCC1 protein] which results in increased susceptibility to Antimony Sodium Gluconate; Doxorubicin inhibits the reaction [Lovastatin results in increased expression of ABCC1 mRNA]
CTD PMID:18056276 PMID:22712078 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 multiple interactions
increases expression
decreases activity
ISO ABCC2 protein binds to and results in increased uptake of Lovastatin analog; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
Lovastatin results in increased expression of ABCC2 mRNA
Lovastatin analog results in decreased activity of ABCC2 protein
ABCC2 protein binds to and results in increased uptake of Lovastatin analog; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin promotes the reaction [Cisplatin results in decreased expression of ABCC2 mRNA]
CTD PMID:15616150 PMID:23562342 PMID:26739623 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 affects expression
multiple interactions
EXP Lovastatin affects the expression of ABCG5 mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of ABCG5 mRNA
CTD PMID:27208389 PMID:29852127 NCBI chr17:84,965,602...84,990,439
Ensembl chr17:84,965,662...84,990,439
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 affects expression EXP Lovastatin affects the expression of ABCG8 mRNA CTD PMID:27208389 NCBI chr17:84,983,730...85,007,761
Ensembl chr17:84,983,730...85,007,761
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of ACACA mRNA CTD PMID:29852127 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of ACOX1 mRNA CTD PMID:29852127 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of ACSS2 mRNA CTD PMID:29852127 NCBI chr 2:155,359,963...155,404,663
Ensembl chr 2:155,359,868...155,427,644
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions
decreases expression
ISO Lovastatin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
Lovastatin results in decreased expression of ACTA2 protein
CTD PMID:22129737 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Actb actin, beta decreases expression
increases expression
EXP Lovastatin results in decreased expression of ACTB mRNA
Lovastatin results in increased expression of ACTB mRNA
CTD PMID:20493250 NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509
JBrowse link
G Actr3 ARP3 actin-related protein 3 increases expression EXP Lovastatin results in increased expression of ACTR3 mRNA CTD PMID:20493250 NCBI chr 1:125,320,642...125,363,464
Ensembl chr 1:125,320,642...125,363,464
JBrowse link
G Adam10 a disintegrin and metallopeptidase domain 10 increases expression
multiple interactions
ISO Lovastatin results in increased expression of ADAM10 protein
[Lovastatin co-treated with APP protein] results in increased expression of ADAM10 protein
CTD PMID:29341888 NCBI chr 9:70,586,133...70,687,511
Ensembl chr 9:70,586,279...70,687,511
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing affects expression
multiple interactions
EXP Lovastatin affects the expression of ADIPOQ mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of ADIPOQ mRNA
CTD PMID:27208389 PMID:29852127 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
JBrowse link
G Ahcy S-adenosylhomocysteine hydrolase decreases expression EXP Lovastatin results in decreased expression of AHCY mRNA CTD PMID:20493250 NCBI chr 2:154,901,230...154,916,417
Ensembl chr 2:154,901,230...154,916,417
JBrowse link
G Akap7 A kinase anchor protein 7 decreases response to substance ISO AKAP7 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr10:25,044,988...25,175,115
Ensembl chr10:25,044,988...25,183,768
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
ISO Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in decreased expression of AKT1 protein]
Lovastatin results in decreased phosphorylation of AKT1 protein
CTD PMID:16425225 PMID:17472962 PMID:19760159 PMID:20578043 PMID:35734936 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions ISO Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased activity of ALOX15 protein] CTD PMID:35734936 NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857
JBrowse link
G Ank2 ankyrin 2, brain decreases response to substance ISO ANK2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 3:126,715,256...127,293,996
Ensembl chr 3:126,715,261...127,292,999
JBrowse link
G Anxa4 annexin A4 decreases expression EXP Lovastatin results in decreased expression of ANXA4 mRNA CTD PMID:20493250 NCBI chr 6:86,713,822...86,770,616
Ensembl chr 6:86,713,822...86,770,566
JBrowse link
G Anxa5 annexin A5 decreases expression EXP Lovastatin results in decreased expression of ANXA5 mRNA CTD PMID:20493250 NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043
JBrowse link
G Apoa1 apolipoprotein A-I multiple interactions ISO [Lovastatin co-treated with Niacin] results in increased expression of APOA1 protein; [Niacin co-treated with Lovastatin] results in increased expression of APOA1 protein CTD PMID:12633795 PMID:17319473 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764
JBrowse link
G Apob apolipoprotein B multiple interactions
decreases secretion
ISO [Niacin co-treated with Lovastatin] results in decreased expression of APOB protein
Lovastatin results in decreased secretion of APOB protein
CTD PMID:11728391 PMID:12633795 NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835
JBrowse link
G Apoe apolipoprotein E affects expression
multiple interactions
EXP Lovastatin affects the expression of APOE mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of APOE mRNA
CTD PMID:27208389 PMID:29852127 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases cleavage
increases secretion
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in increased secretion of APP protein modified form]; TAPI-2 inhibits the reaction [Lovastatin results in increased secretion of APP protein modified form]; U 0126 inhibits the reaction [Lovastatin results in increased secretion of APP protein]
[APP protein co-treated with Lovastatin] results in increased secretion of APP protein; [Lovastatin co-treated with APP protein] results in decreased expression of BACE1 protein; [Lovastatin co-treated with APP protein] results in increased expression of ADAM10 protein; [Lovastatin co-treated with APP protein] results in increased expression of BACE2 protein; [Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein; [Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein; [Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; U 0126 inhibits the reaction [[APP protein co-treated with Lovastatin] results in increased secretion of APP protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein]
Lovastatin results in increased cleavage of APP protein
Lovastatin results in increased secretion of APP protein; Lovastatin results in increased secretion of APP protein modified form
CTD PMID:19741129 PMID:29341888 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression EXP Lovastatin results in increased expression of ARHGDIA mRNA CTD PMID:20493250 NCBI chr11:120,468,925...120,472,450
Ensembl chr11:120,468,930...120,472,450
JBrowse link
G Atm ataxia telangiectasia mutated multiple interactions ISO Lovastatin inhibits the reaction [Cisplatin results in increased expression of ATM protein modified form] CTD PMID:26739623 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
JBrowse link
G Atr ataxia telangiectasia and Rad3 related multiple interactions ISO Lovastatin inhibits the reaction [Cisplatin results in increased expression of ATR protein modified form] CTD PMID:26739623 NCBI chr 9:95,739,655...95,834,813
Ensembl chr 9:95,739,650...95,833,834
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 multiple interactions
decreases expression
ISO [Lovastatin co-treated with APP protein] results in decreased expression of BACE1 protein
Lovastatin results in decreased expression of BACE1 protein
CTD PMID:29341888 NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697
JBrowse link
G Bace2 beta-site APP-cleaving enzyme 2 multiple interactions
increases expression
ISO [Lovastatin co-treated with APP protein] results in increased expression of BACE2 protein
Lovastatin results in increased expression of BACE2 protein
CTD PMID:29341888 NCBI chr16:97,157,928...97,244,136
Ensembl chr16:97,157,942...97,244,136
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
affects localization
ISO
EXP
Lovastatin results in increased expression of BAX protein
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of BAX protein]; Lovastatin promotes the reaction [Cisplatin results in increased expression of BAX mRNA]
Lovastatin affects the localization of BAX protein
CTD PMID:10473109 PMID:15180944 PMID:26739623 PMID:35734936 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcar1 breast cancer anti-estrogen resistance 1 increases cleavage
multiple interactions
ISO Lovastatin results in increased cleavage of BCAR1 protein
Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of BCAR1 protein]
CTD PMID:16367743 NCBI chr 8:112,437,106...112,470,481
Ensembl chr 8:112,437,106...112,470,441
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions
ISO Lovastatin results in decreased expression of BCL2 protein
Lovastatin inhibits the reaction [Cholesterol, Dietary results in decreased expression of BCL2 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2 protein]
CTD PMID:10473109 PMID:11178870 PMID:12094262 PMID:35734936 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression
multiple interactions
ISO Lovastatin results in decreased expression of BCL2L1 protein
Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2L1 protein]
CTD PMID:11178870 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression
ISO pyrazolanthrone inhibits the reaction [Lovastatin results in increased expression of BCL2L11 protein]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of BCL2L11 protein]
CTD PMID:18766339 PMID:35734936 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions ISO Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein] CTD PMID:24718106 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO farnesyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein] CTD PMID:17472962 PMID:18815881 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
JBrowse link
G Brca2 breast cancer 2, early onset multiple interactions EXP Lovastatin inhibits the reaction [Doxorubicin results in increased expression of BRCA2 mRNA] CTD PMID:22712078 NCBI chr 5:150,445,759...150,493,612
Ensembl chr 5:150,446,095...150,493,794
JBrowse link
G C1qbp complement component 1, q subcomponent binding protein increases expression EXP Lovastatin results in increased expression of C1QBP mRNA CTD PMID:20493250 NCBI chr11:70,868,672...70,873,852
Ensembl chr11:70,868,662...70,873,852
JBrowse link
G Calr calreticulin increases expression EXP Lovastatin results in increased expression of CALR mRNA CTD PMID:20493250 NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II, beta multiple interactions ISO Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein] CTD PMID:24718106 NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362
JBrowse link
G Casp2 caspase 2 increases activity
multiple interactions
ISO
EXP
Lovastatin results in increased activity of CASP2 protein
Lovastatin promotes the reaction [RHOB protein binds to CASP2 protein]
CTD PMID:12933658 PMID:16234849 NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
decreases expression
ISO
EXP
farnesyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]
Lovastatin analog results in increased cleavage of CASP3 protein
Lovastatin results in increased activity of CASP3 protein
Lovastatin results in decreased expression of CASP3 mRNA
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of CASP3 protein]; Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein; Mevalonic Acid inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]
CTD PMID:11720884 PMID:12933658 PMID:15180944 PMID:16367743 PMID:18034278 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp6 caspase 6 increases activity ISO Lovastatin results in increased activity of CASP6 protein CTD PMID:11720884 NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752
JBrowse link
G Casp8 caspase 8 increases activity ISO
EXP
Lovastatin results in increased activity of CASP8 protein CTD PMID:15180944 PMID:15705602 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
EXP
ISO
Lovastatin results in increased activity of CASP9 protein
Lovastatin inhibits the reaction [Cholesterol, Dietary results in decreased expression of CASP9 protein]
CTD PMID:12933658 PMID:15180944 PMID:15705602 PMID:35734936 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions ISO Lovastatin inhibits the reaction [Cholesterol, Dietary results in decreased activity of CAT protein] CTD PMID:35734936 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CCN2 mRNA]; Lovastatin inhibits the reaction [Epirubicin results in increased expression of CCN2 mRNA] CTD PMID:22712078 PMID:28710503 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581
JBrowse link
G Ccnd1 cyclin D1 decreases expression
increases expression
ISO Lovastatin results in decreased expression of CCND1 protein
Lovastatin results in increased expression of CCND1 mRNA; Lovastatin results in increased expression of CCND1 protein
CTD PMID:18034278 PMID:20578043 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Lovastatin results in decreased expression of CCND3 protein CTD PMID:10502407 NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616
JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 increases expression EXP Lovastatin results in increased expression of CCT5 mRNA CTD PMID:20493250 NCBI chr15:31,590,946...31,601,992
Ensembl chr15:31,590,946...31,601,950
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A increases expression EXP Lovastatin results in increased expression of CCT6A mRNA CTD PMID:20493250 NCBI chr 5:129,864,420...129,875,284
Ensembl chr 5:129,864,062...129,875,212
JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 decreases expression EXP Lovastatin results in decreased expression of CCT8 mRNA CTD PMID:20493250 NCBI chr16:87,280,213...87,292,757
Ensembl chr16:87,280,214...87,292,761
JBrowse link
G Cd40 CD40 antigen multiple interactions EXP Lovastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
JBrowse link
G Cd44 CD44 antigen decreases expression ISO Lovastatin results in decreased expression of CD44 mRNA; Lovastatin results in decreased expression of CD44 protein CTD PMID:21199873 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010
JBrowse link
G Cdc42 cell division cycle 42 increases expression
decreases expression
ISO
EXP
Lovastatin results in increased expression of CDC42 protein
Lovastatin results in decreased expression of CDC42 mRNA
CTD PMID:18766339 PMID:20493250 NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO Lovastatin results in decreased activity of CDK2 protein CTD PMID:10502407 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cdk4 cyclin dependent kinase 4 decreases expression ISO Lovastatin results in decreased expression of CDK4 mRNA; Lovastatin results in decreased expression of CDK4 protein CTD PMID:20578043 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
JBrowse link
G Cdk5 cyclin dependent kinase 5 decreases cleavage ISO Lovastatin results in decreased cleavage of CDK5 protein CTD PMID:19741129 NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression
multiple interactions
ISO
EXP
Lovastatin results in increased expression of CDKN1A protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]
CTD PMID:18034278 PMID:22712078 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B increases expression ISO Lovastatin results in increased expression of CDKN1B mRNA; Lovastatin results in increased expression of CDKN1B protein CTD PMID:9848777 PMID:10502407 PMID:15118409 PMID:18034278 PMID:20578043 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Cdkn3 cyclin dependent kinase inhibitor 3 multiple interactions ISO Lovastatin inhibits the reaction [Cisplatin results in increased expression of CDKN3 protein modified form] CTD PMID:26739623 NCBI chr14:46,997,912...47,008,987
Ensembl chr14:46,997,998...47,009,126
JBrowse link
G Cenpf centromere protein F increases expression
multiple interactions
ISO Lovastatin results in increased expression of CENPF protein
Lovastatin promotes the reaction [Paclitaxel results in increased expression of CENPF protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of CENPF protein]
CTD PMID:12467231 NCBI chr 1:189,372,803...189,420,302
Ensembl chr 1:189,372,803...189,420,283
JBrowse link
G Cfl1 cofilin 1, non-muscle decreases phosphorylation ISO Lovastatin results in decreased phosphorylation of CFL1 protein CTD PMID:20578043 NCBI chr19:5,540,483...5,544,059
Ensembl chr19:5,540,483...5,545,229
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein]; Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of CHEK1 protein]
Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK1 protein modified form]
CTD PMID:17088865 PMID:21356574 PMID:26739623 NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK2 protein modified form] CTD PMID:26739623 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011
JBrowse link
G Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 multiple interactions
increases expression
ISO [Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein]
Lovastatin results in increased expression of CHRNA7 mRNA; Lovastatin results in increased expression of CHRNA7 protein
U 0126 inhibits the reaction [Lovastatin results in increased expression of CHRNA7 protein]
CTD PMID:29341888 NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317
JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression EXP Lovastatin results in decreased expression of CLIC1 mRNA CTD PMID:20493250 NCBI chr17:35,269,219...35,277,695
Ensembl chr17:35,268,942...35,277,725
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression EXP Lovastatin results in increased expression of COX5A mRNA CTD PMID:20493250 NCBI chr 9:57,423,012...57,439,710
Ensembl chr 9:57,428,557...57,439,709
JBrowse link
G Cp ceruloplasmin multiple interactions ISO Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of CP protein] CTD PMID:35734936 NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein] CTD PMID:24718106 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Crk v-crk avian sarcoma virus CT10 oncogene homolog increases expression EXP Lovastatin results in increased expression of CRK mRNA CTD PMID:20493250 NCBI chr11:75,570,020...75,599,254
Ensembl chr11:75,570,085...75,597,734
JBrowse link
G Crp C-reactive protein, pentraxin-related multiple interactions ISO Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of CRP protein] CTD PMID:35734936 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
JBrowse link
G Ctnnb1 catenin beta 1 decreases degradation
increases expression
multiple interactions
ISO
EXP
Lovastatin results in decreased degradation of CTNNB1 protein
Lovastatin results in increased expression of CTNNB1 mRNA
Lovastatin affects the localization of and results in increased expression of CTNNB1 protein
CTD PMID:17234346 PMID:19741129 PMID:24742230 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
EXP Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CYP1A1 mRNA]; Lovastatin results in increased expression of and results in increased activity of CYP1A1 protein
Lovastatin results in increased expression of CYP1A1 mRNA
CTD PMID:1311272 PMID:22712078 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Lovastatin results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases activity ISO Lovastatin results in decreased activity of CYP2C8 protein CTD PMID:15601807 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
JBrowse link
G Dctn2 dynactin 2 decreases expression EXP Lovastatin results in decreased expression of DCTN2 mRNA CTD PMID:20493250 NCBI chr10:127,102,131...127,117,828
Ensembl chr10:127,102,237...127,117,819
JBrowse link
G Ddt D-dopachrome tautomerase decreases expression EXP Lovastatin results in decreased expression of DDT mRNA CTD PMID:20493250 NCBI chr10:75,607,067...75,609,208
Ensembl chr10:75,607,064...75,609,248
JBrowse link
G Dlg3 discs large MAGUK scaffold protein 3 multiple interactions ISO Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein] CTD PMID:24718106 NCBI chr  X:99,811,200...99,862,016
Ensembl chr  X:99,811,328...99,862,016
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase decreases expression EXP Lovastatin results in decreased expression of DLST mRNA CTD PMID:20493250 NCBI chr12:85,157,597...85,180,865
Ensembl chr12:85,157,607...85,181,619
JBrowse link
G Dock7 dedicator of cytokinesis 7 increases expression EXP Lovastatin results in increased expression of DOCK7 mRNA CTD PMID:20493250 NCBI chr 4:98,824,669...99,019,190
Ensembl chr 4:98,824,908...99,009,152
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression EXP Lovastatin results in increased expression of DPYSL2 mRNA CTD PMID:20493250 NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,106,137
JBrowse link
G Dstn destrin decreases expression EXP Lovastatin results in decreased expression of DSTN mRNA CTD PMID:20493250 NCBI chr 2:143,757,251...143,785,244
Ensembl chr 2:143,757,240...143,785,244
JBrowse link
G Eaf2 ELL associated factor 2 decreases response to substance ISO EAF2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr16:36,613,246...36,695,275
Ensembl chr16:36,613,246...36,695,365
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression EXP Lovastatin results in decreased expression of EEF2 mRNA CTD PMID:20493250 NCBI chr10:81,012,465...81,018,343
Ensembl chr10:81,012,465...81,018,332
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Lovastatin inhibits the reaction [EGF protein promotes the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of RAF1 protein] CTD PMID:12942316 PMID:19760159 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Lovastatin inhibits the reaction [EGF protein promotes the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:12942316 PMID:19760159 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I decreases expression EXP Lovastatin results in decreased expression of EIF3I mRNA CTD PMID:20493250 NCBI chr 4:129,485,767...129,494,441
Ensembl chr 4:129,485,753...129,494,441
JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 increases expression
multiple interactions
ISO Lovastatin results in increased expression of ERCC1 mRNA
Lovastatin promotes the reaction [Cisplatin results in increased expression of ERCC1 mRNA]
CTD PMID:26739623 NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449
JBrowse link
G Ercc5 excision repair cross-complementing rodent repair deficiency, complementation group 5 multiple interactions
increases expression
ISO Lovastatin promotes the reaction [Cisplatin results in increased expression of ERCC5 mRNA]
Lovastatin results in increased expression of ERCC5 mRNA
CTD PMID:26739623 NCBI chr 1:44,184,084...44,220,399
Ensembl chr 1:44,186,904...44,220,420
JBrowse link
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 increases expression ISO Lovastatin results in increased expression of ERCC6 mRNA CTD PMID:26739623 NCBI chr14:32,235,248...32,302,947
Ensembl chr14:32,235,478...32,302,947
JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression EXP Lovastatin results in decreased expression of ERP29 mRNA CTD PMID:20493250 NCBI chr 5:121,582,816...121,590,537
Ensembl chr 5:121,566,653...121,590,569
JBrowse link
G Fads2 fatty acid desaturase 2 multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of FADS2 mRNA CTD PMID:29852127 NCBI chr19:10,040,129...10,078,867
Ensembl chr19:10,040,129...10,079,110
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of FAS protein]
CTD PMID:17088865 PMID:35734936 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fasl Fas ligand multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FASLG mRNA] CTD PMID:17088865 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Fasn fatty acid synthase increases expression ISO Lovastatin results in increased expression of FASN mRNA CTD PMID:11728391 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions
increases expression
EXP geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]; Lovastatin promotes the reaction [Fenofibrate results in increased expression of FBXO32 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]
Lovastatin results in increased expression of FBXO32 mRNA; Lovastatin results in increased expression of FBXO32 protein
CTD PMID:19406843 PMID:33408297 NCBI chr15:58,039,275...58,078,288
Ensembl chr15:58,039,275...58,078,328
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases activity ISO Lovastatin results in increased activity of FDFT1 protein CTD PMID:8517861 NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027
JBrowse link
G Fdps farnesyl diphosphate synthetase multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of FDPS mRNA CTD PMID:29852127 NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266
JBrowse link
G Flot1 flotillin 1 decreases expression EXP Lovastatin results in decreased expression of FLOT1 protein CTD PMID:12628479 NCBI chr17:36,134,243...36,143,674
Ensembl chr17:36,134,122...36,143,683
JBrowse link
G Fos FBJ osteosarcoma oncogene affects expression
multiple interactions
decreases expression
ISO
EXP
Lovastatin affects the expression of FOS protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FOS mRNA]
Lovastatin results in decreased expression of FOS
CTD PMID:10412747 PMID:12392621 PMID:22712078 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Fosb FBJ osteosarcoma oncogene B multiple interactions ISO Lovastatin inhibits the reaction [benserazide, levodopa drug combination results in increased expression of FOSB protein] CTD PMID:18434508 NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976
JBrowse link
G Foxo1 forkhead box O1 multiple interactions
decreases phosphorylation
EXP Lovastatin promotes the reaction [Fenofibrate results in increased expression of FOXO1 protein]
Lovastatin results in decreased phosphorylation of FOXO1 protein
CTD PMID:33034787 PMID:33408297 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression EXP Lovastatin results in decreased expression of FSCN1 mRNA CTD PMID:20493250 NCBI chr 5:142,946,110...142,958,944
Ensembl chr 5:142,946,098...142,958,940
JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 increases expression EXP Lovastatin results in increased expression of G3BP1 mRNA CTD PMID:20493250 NCBI chr11:55,360,521...55,391,722
Ensembl chr11:55,360,511...55,395,664
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of G6PD mRNA CTD PMID:29852127 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800
JBrowse link
G Gale galactose-4-epimerase, UDP decreases expression EXP Lovastatin results in decreased expression of GALE mRNA CTD PMID:20493250 NCBI chr 4:135,690,550...135,695,489
Ensembl chr 4:135,691,038...135,695,489
JBrowse link
G Gap43 growth associated protein 43 increases expression EXP
ISO
Lovastatin results in increased expression of GAP43 protein CTD PMID:20694854 NCBI chr16:42,068,915...42,161,014
Ensembl chr16:42,068,805...42,161,014
JBrowse link
G Gdi2 GDP dissociation inhibitor 2 increases expression EXP Lovastatin results in increased expression of GDI2 mRNA CTD PMID:20493250 NCBI chr13:3,588,075...3,616,261
Ensembl chr13:3,588,063...3,617,871
JBrowse link
G Gk glycerol kinase multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of GK mRNA CTD PMID:29852127 NCBI chr  X:84,745,543...84,820,425
Ensembl chr  X:84,745,543...84,820,425
JBrowse link
G Gmps guanine monophosphate synthetase increases expression EXP Lovastatin results in increased expression of GMPS mRNA CTD PMID:20493250 NCBI chr 3:63,871,054...63,928,975
Ensembl chr 3:63,883,527...63,930,000
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of GPT protein; Lovastatin inhibits the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:29852127 PMID:30853469 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Lovastatin inhibits the reaction [Doxorubicin results in increased expression of GPX1 mRNA] CTD PMID:28710503 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) multiple interactions ISO Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein] CTD PMID:24718106 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
increases phosphorylation
ISO Lovastatin results in decreased phosphorylation of GSK3B protein
Lovastatin results in increased phosphorylation of GSK3B protein
CTD PMID:17234346 PMID:19741129 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO
EXP
Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of H2AX protein]
Lovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form]
Lovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form]; Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein]
CTD PMID:21356574 PMID:22712078 PMID:26739623 PMID:28710503 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
JBrowse link
G Hdac1 histone deacetylase 1 increases expression EXP Lovastatin results in increased expression of HDAC1 mRNA CTD PMID:20493250 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression EXP Lovastatin results in increased expression of HINT1 mRNA CTD PMID:20493250 NCBI chr11:54,757,209...54,761,332
Ensembl chr11:54,757,209...54,761,327
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions
affects expression
decreases activity
increases expression
ISO
EXP
[Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate; [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of geranylgeranyl pyrophosphate; Lovastatin inhibits the reaction [HMGCR protein results in increased abundance of geranyl diphosphate]
[Dietary Fats co-treated with Lovastatin] affects the expression of HMGCR mRNA
Lovastatin affects the expression of HMGCR mRNA
Lovastatin results in increased expression of HMGCR mRNA
CTD PMID:8517861 PMID:8593127 PMID:17208200 PMID:19260826 PMID:19699819 More... NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of HMGCS1 mRNA CTD PMID:29852127 NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Lovastatin results in increased expression of HMOX1 protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]
CTD PMID:20594940 PMID:21910007 PMID:28710503 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B increases expression EXP Lovastatin results in increased expression of HNRNPAB mRNA CTD PMID:20493250 NCBI chr11:51,490,927...51,497,708
Ensembl chr11:51,490,927...51,497,674
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression EXP Lovastatin results in decreased expression of HNRNPDL mRNA CTD PMID:20493250 NCBI chr 5:100,181,436...100,187,769
Ensembl chr 5:100,181,436...100,187,523
JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F increases expression EXP Lovastatin results in increased expression of HNRNPF mRNA CTD PMID:20493250 NCBI chr 6:117,877,301...117,902,583
Ensembl chr 6:117,877,285...117,902,583
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K decreases expression
increases expression
EXP Lovastatin results in decreased expression of HNRNPK mRNA
Lovastatin results in increased expression of HNRNPK mRNA
CTD PMID:20493250 NCBI chr13:58,538,946...58,551,157
Ensembl chr13:58,538,956...58,551,157
JBrowse link
G Hras Harvey rat sarcoma virus oncogene decreases prenylation
multiple interactions
ISO Lovastatin results in decreased prenylation of HRAS protein
Lovastatin results in decreased prenylation of and results in decreased localization of HRAS protein
CTD PMID:16156861 PMID:19360310 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 decreases expression EXP Lovastatin results in decreased expression of HSP90AB1 mRNA CTD PMID:20493250 NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197
JBrowse link
G Hspa8 heat shock protein 8 increases expression EXP Lovastatin results in increased expression of HSPA8 mRNA CTD PMID:20493250 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) increases expression EXP Lovastatin results in increased expression of HSPD1 mRNA CTD PMID:20493250 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402
JBrowse link
G Ifng interferon gamma multiple interactions EXP Lovastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance EXP IGF1 protein results in decreased susceptibility to Lovastatin CTD PMID:9525472 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Igf1r insulin-like growth factor I receptor multiple interactions ISO Lovastatin promotes the reaction [INS protein results in increased phosphorylation of IGF1R protein] CTD PMID:19741129 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416
JBrowse link
G Il18 interleukin 18 multiple interactions EXP [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein] CTD PMID:18809656 PMID:21430599 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of IL6 protein]
CTD PMID:28710503 PMID:35734936 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Ins2 insulin II multiple interactions ISO Lovastatin promotes the reaction [INS protein results in increased phosphorylation of IGF1R protein]; Lovastatin promotes the reaction [INS protein results in increased phosphorylation of INSR protein] CTD PMID:19741129 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Insig1 insulin induced gene 1 increases expression
multiple interactions
ISO
EXP
Lovastatin results in increased expression of INSIG1 mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of INSIG1 mRNA
CTD PMID:19260826 PMID:29852127 NCBI chr 5:28,276,410...28,283,660
Ensembl chr 5:28,276,361...28,283,660
JBrowse link
G Insig2 insulin induced gene 2 multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of INSIG2 mRNA CTD PMID:29852127 NCBI chr 1:121,232,082...121,260,391
Ensembl chr 1:121,232,082...121,260,318
JBrowse link
G Insr insulin receptor multiple interactions ISO Lovastatin promotes the reaction [INS protein results in increased phosphorylation of INSR protein] CTD PMID:19741129 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617
JBrowse link
G Ipo5 importin 5 decreases expression EXP Lovastatin results in decreased expression of IPO5 mRNA CTD PMID:20493250 NCBI chr14:121,134,271...121,185,451
Ensembl chr14:121,148,636...121,185,411
JBrowse link
G Irf4 interferon regulatory factor 4 decreases expression EXP Lovastatin results in decreased expression of IRF4 protein CTD PMID:33034787 NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of IRS1 mRNA CTD PMID:29852127 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of IRS2 mRNA CTD PMID:29852127 NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458
JBrowse link
G Isyna1 myo-inositol 1-phosphate synthase A1 increases expression EXP Lovastatin results in increased expression of ISYNA1 mRNA CTD PMID:20493250 NCBI chr 8:71,047,131...71,049,940
Ensembl chr 8:71,047,023...71,049,940
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) decreases expression EXP Lovastatin results in decreased expression of ITGB1 protein CTD PMID:12405293 NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681
JBrowse link
G Jun jun proto-oncogene affects expression
multiple interactions
decreases expression
ISO
EXP
Lovastatin affects the expression of JUN protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of JUN mRNA]
Lovastatin results in decreased expression of JUN
CTD PMID:10412747 PMID:12392621 PMID:22712078 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 affects activity ISO Lovastatin affects the activity of KCNH2 protein CTD PMID:16278312 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog decreases prenylation
increases expression
affects localization
increases activity
ISO
EXP
Lovastatin results in decreased prenylation of KRAS protein
Lovastatin results in increased expression of KRAS protein
Lovastatin affects the localization of KRAS protein
Lovastatin results in increased activity of KRAS protein
CTD PMID:12106604 PMID:12907238 PMID:16156861 PMID:17005160 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965
JBrowse link
G Krt18 keratin 18 decreases expression EXP Lovastatin results in decreased expression of KRT18 mRNA CTD PMID:20493250 NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462
JBrowse link
G Lasp1 LIM and SH3 protein 1 decreases expression EXP Lovastatin results in decreased expression of LASP1 mRNA CTD PMID:20493250 NCBI chr11:97,689,748...97,729,591
Ensembl chr11:97,689,826...97,729,590
JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of LCN2 mRNA CTD PMID:30853469 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases activity
increases expression
ISO
EXP
OSM protein promotes the reaction [Lovastatin results in increased expression of LDLR mRNA]
[Dietary Fats co-treated with Lovastatin] affects the expression of LDLR mRNA
[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA; Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA]
Lovastatin results in increased activity of LDLR protein
CTD PMID:8593127 PMID:11728391 PMID:12524230 PMID:20578043 PMID:29852127 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 affects localization ISO Lovastatin affects the localization of LEF1 protein CTD PMID:17234346 NCBI chr 3:130,903,972...131,018,006
Ensembl chr 3:130,904,120...131,018,005
JBrowse link
G Lipc lipase, hepatic affects expression EXP Lovastatin affects the expression of LIPC mRNA CTD PMID:27208389 NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508
JBrowse link
G Lmnb1 lamin B1 decreases farnesylation
increases degradation
affects localization
ISO Lovastatin results in decreased farnesylation of LMNB1 protein
Lovastatin results in increased degradation of LMNB1 protein
Lovastatin affects the localization of LMNB1 protein
CTD PMID:10203554 PMID:11720884 NCBI chr18:56,840,885...56,886,496
Ensembl chr18:56,840,885...56,886,496
JBrowse link
G Lpin2 lipin 2 decreases response to substance ISO LPIN2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr17:71,490,527...71,556,813
Ensembl chr17:71,489,555...71,556,812
JBrowse link
G Lpl lipoprotein lipase affects expression
multiple interactions
EXP Lovastatin affects the expression of LPL mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of LPL mRNA
CTD PMID:27208389 PMID:29852127 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100
JBrowse link
G Lrp5 low density lipoprotein receptor-related protein 5 increases expression EXP Lovastatin results in increased expression of LRP5 mRNA CTD PMID:24742230 NCBI chr19:3,634,825...3,736,574
Ensembl chr19:3,634,828...3,736,564
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
decreases activity
decreases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Lovastatin results in increased phosphorylation of MAPK1 protein]
Lovastatin results in decreased activity of MAPK1 protein
[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein]
CTD PMID:12213976 PMID:16952276 PMID:19360310 PMID:19760159 PMID:20578043 More... NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
decreases activity
decreases phosphorylation
ISO [Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein]
Lovastatin results in increased phosphorylation of MAPK3 protein
Lovastatin results in decreased activity of MAPK3 protein
Lovastatin results in decreased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [benserazide, levodopa drug combination results in increased phosphorylation of MAPK3 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Lovastatin results in increased phosphorylation of MAPK3 protein]
CTD PMID:16952276 PMID:18434508 PMID:19360310 PMID:19760159 PMID:20578043 More... NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Lovastatin inhibits the reaction [Cisplatin results in increased expression of MAPK8 protein modified form] CTD PMID:26739623 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Lovastatin inhibits the reaction [Cisplatin results in increased expression of MAPK9 protein modified form] CTD PMID:26739623 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Mbp myelin basic protein multiple interactions
increases expression
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin results in increased expression of MBP mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of MBP mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of MBP mRNA] CTD PMID:20578043 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762
JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP Lovastatin inhibits the reaction [Doxorubicin results in increased expression of MFN2 mRNA] CTD PMID:28710503 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161
JBrowse link
G Mir133b microRNA 133b multiple interactions EXP [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR133B mRNA CTD PMID:30853469 NCBI chr 1:20,752,993...20,753,111
Ensembl chr 1:20,752,993...20,753,111
JBrowse link
G Mir206 microRNA 206 multiple interactions EXP [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR206 mRNA CTD PMID:30853469 NCBI chr 1:20,749,234...20,749,306
Ensembl chr 1:20,749,234...20,749,306
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Lovastatin results in decreased expression of MMP2 protein CTD PMID:19360310 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions EXP Lovastatin inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA] CTD PMID:28710503 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Lovastatin results in decreased expression of MMP9 protein CTD PMID:19360310 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of MPO protein] CTD PMID:35734936 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Mstn myostatin increases expression EXP Lovastatin results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 1:53,100,799...53,107,238
Ensembl chr 1:53,100,799...53,107,238
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions EXP Doxorubicin inhibits the reaction [Lovastatin results in increased expression of NFE2L2 mRNA]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of NFE2L2 mRNA] CTD PMID:22712078 PMID:28710503 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nmral1 NmrA-like family domain containing 1 increases expression EXP Lovastatin results in increased expression of NMRAL1 mRNA CTD PMID:20493250 NCBI chr16:4,529,181...4,537,220
Ensembl chr16:4,527,923...4,537,220
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO
Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of NOS2 protein]
CTD PMID:18809656 PMID:35734936 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nppa natriuretic peptide type A multiple interactions EXP Lovastatin inhibits the reaction [Doxorubicin results in increased expression of NPPA mRNA] CTD PMID:28710503 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression EXP Lovastatin results in increased expression of NQO1 mRNA CTD PMID:1311272 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Lovastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:17041008 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Nras neuroblastoma ras oncogene decreases prenylation ISO Lovastatin results in decreased prenylation of NRAS protein CTD PMID:16156861 NCBI chr 3:102,965,643...102,975,230
Ensembl chr 3:102,965,601...102,975,230
JBrowse link
G Nucb1 nucleobindin 1 increases expression EXP Lovastatin results in increased expression of NUCB1 mRNA CTD PMID:20493250 NCBI chr 7:45,142,300...45,159,813
Ensembl chr 7:45,139,882...45,159,830
JBrowse link
G Oat ornithine aminotransferase decreases expression EXP Lovastatin results in decreased expression of OAT mRNA CTD PMID:20493250 NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127
JBrowse link
G Osm oncostatin M multiple interactions ISO OSM protein promotes the reaction [Lovastatin results in increased expression of LDLR mRNA] CTD PMID:12524230 NCBI chr11:4,186,831...4,191,027
Ensembl chr11:4,186,420...4,191,026
JBrowse link
G Pa2g4 proliferation-associated 2G4 increases expression EXP Lovastatin results in increased expression of PA2G4 mRNA CTD PMID:20493250 NCBI chr10:128,393,635...128,401,803
Ensembl chr10:128,393,635...128,401,856
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO Lovastatin analog results in increased cleavage of PARP1 protein CTD PMID:26863638 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Parvb parvin, beta decreases response to substance ISO PARVB SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr15:84,116,244...84,199,890
Ensembl chr15:84,116,244...84,199,889
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of PCK1 mRNA CTD PMID:29852127 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066
JBrowse link
G Pdgfra platelet derived growth factor receptor, alpha polypeptide decreases expression ISO Lovastatin results in decreased expression of PDGFRA mRNA CTD PMID:20578043 NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876
JBrowse link
G Pdia3 protein disulfide isomerase associated 3 decreases expression
increases expression
EXP Lovastatin results in decreased expression of PDIA3 mRNA
Lovastatin results in increased expression of PDIA3 mRNA
CTD PMID:20493250 NCBI chr 2:121,244,383...121,269,168
Ensembl chr 2:121,244,256...121,269,168
JBrowse link
G Pdia4 protein disulfide isomerase associated 4 decreases expression EXP Lovastatin results in decreased expression of PDIA4 mRNA CTD PMID:20493250 NCBI chr 6:47,773,075...47,790,446
Ensembl chr 6:47,773,075...47,790,364
JBrowse link
G Pgam1 phosphoglycerate mutase 1 increases expression
decreases expression
EXP Lovastatin results in increased expression of PGAM1 mRNA
Lovastatin results in decreased expression of PGAM1 mRNA
CTD PMID:20493250 NCBI chr19:41,900,310...41,907,104
Ensembl chr19:41,900,362...41,907,099
JBrowse link
G Pkm pyruvate kinase, muscle decreases expression EXP Lovastatin results in decreased expression of PKM mRNA CTD PMID:20493250 NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658
JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) increases expression ISO Lovastatin results in increased expression of PLA2G4A mRNA CTD PMID:20578043 NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041
JBrowse link
G Plat plasminogen activator, tissue multiple interactions
increases secretion
increases expression
ISO
EXP
geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PLAT protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PLAT protein]
Lovastatin results in increased secretion of PLAT protein
CTD PMID:10412747 PMID:12405293 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860
JBrowse link
G Plau plasminogen activator, urokinase decreases secretion EXP Lovastatin results in decreased secretion of PLAU protein CTD PMID:12405293 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453
JBrowse link
G Pon3 paraoxonase 3 increases hydrolysis
increases metabolic processing
multiple interactions
ISO
EXP
PON3 protein results in increased hydrolysis of Lovastatin
PON3 protein results in increased metabolism of Lovastatin
7-ketocholesterol inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]; Phosphatidylcholines inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]
CTD PMID:12615656 PMID:15772423 NCBI chr 6:5,216,253...5,256,236
Ensembl chr 6:5,220,852...5,256,286
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
affects localization
increases expression
ISO
EXP
2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin analog affects the localization of PPARG protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Lovastatin analog affects the localization of PPARG protein]; PPARG protein affects the reaction [Lovastatin results in increased expression of PTEN protein]
geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA]; Lovastatin results in increased expression of and affects the localization of PPARG protein; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]
[Dietary Fats co-treated with Lovastatin] affects the expression of PPARG mRNA; PPARG affects the reaction [Lovastatin results in increased expression of PTEN protein]
CTD PMID:16425225 PMID:20578043 PMID:26863638 PMID:29852127 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions EXP Lovastatin inhibits the reaction [Doxorubicin results in increased expression of PPARGC1A mRNA] CTD PMID:28710503 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases expression EXP Lovastatin results in decreased expression of PPP1CA mRNA CTD PMID:20493250 NCBI chr19:4,242,173...4,245,418
Ensembl chr19:4,242,064...4,245,419
JBrowse link
G Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha increases expression EXP Lovastatin results in increased expression of PPP2R1A mRNA CTD PMID:20493250 NCBI chr17:21,165,716...21,186,167
Ensembl chr17:21,165,573...21,186,178
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
increases cleavage
ISO benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Lovastatin results in increased cleavage of PRKCD protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of PRKCD protein] CTD PMID:16367743 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
JBrowse link
G Psma3 proteasome subunit alpha 3 decreases expression EXP Lovastatin results in decreased expression of PSMA3 mRNA CTD PMID:20493250 NCBI chr12:71,016,082...71,042,651
Ensembl chr12:71,021,395...71,043,121
JBrowse link
G Psma6 proteasome subunit alpha 6 decreases expression EXP Lovastatin results in decreased expression of PSMA6 mRNA CTD PMID:20493250 NCBI chr12:55,431,007...55,465,244
Ensembl chr12:55,431,007...55,465,239
JBrowse link
G Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 decreases expression EXP Lovastatin results in decreased expression of PSMC2 mRNA CTD PMID:20493250 NCBI chr 5:21,990,273...22,008,785
Ensembl chr 5:21,990,281...22,008,785
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression
ISO
EXP
Cycloheximide inhibits the reaction [Lovastatin results in increased expression of PTEN protein]; PPARG protein affects the reaction [Lovastatin results in increased expression of PTEN protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA]; Lovastatin results in increased expression of and results in increased phosphorylation of PTEN protein; PTEN protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]
PPARG affects the reaction [Lovastatin results in increased expression of PTEN protein]
CTD PMID:16425225 PMID:20578043 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
increases expression
multiple interactions
ISO Lovastatin results in decreased expression of PTGS2 protein
Lovastatin analog results in increased expression of PTGS2 mRNA; Lovastatin analog results in increased expression of PTGS2 protein
Mevalonic Acid affects the reaction [Lovastatin analog results in increased expression of PTGS2 protein]
Lovastatin results in increased expression of PTGS2 mRNA; Lovastatin results in increased expression of PTGS2 protein
CTD PMID:20578043 PMID:21910007 PMID:26863638 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rab1a RAB1A, member RAS oncogene family decreases expression EXP Lovastatin results in decreased expression of RAB1A mRNA CTD PMID:20493250 NCBI chr11:20,151,412...20,176,856
Ensembl chr11:20,151,432...20,176,856
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions
affects localization
decreases activity
increases expression
ISO geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RAC1 protein]; Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RAC1 protein]
Lovastatin results in decreased activity of RAC1 protein
Lovastatin results in increased expression of RAC1 protein
CTD PMID:12933658 PMID:18766339 PMID:19360310 PMID:21356574 NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791
JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 multiple interactions
decreases activity
ISO Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of RAF1 protein]
Lovastatin results in decreased activity of RAF1 protein
CTD PMID:19360310 PMID:19760159 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596
JBrowse link
G Rap1a RAS-related protein 1a increases expression ISO Lovastatin results in increased expression of RAP1A protein CTD PMID:12467231 NCBI chr 3:105,634,576...105,708,740
Ensembl chr 3:105,634,583...105,708,652
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Lovastatin results in decreased phosphorylation of RB1 protein CTD PMID:9848777 PMID:10502407 PMID:15118409 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
JBrowse link
G Rhoa ras homolog family member A multiple interactions
decreases expression
decreases prenylation
affects localization
ISO
EXP
geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RHOA protein]
Lovastatin results in decreased geranoylation of and affects the localization of RHOA protein
Lovastatin results in decreased expression of RHOA mRNA
Lovastatin results in decreased prenylation of RHOA protein
Farnesol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]
CTD PMID:9398081 PMID:11178870 PMID:12405293 PMID:12933658 PMID:16156861 More... NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
JBrowse link
G Rhob ras homolog family member B decreases prenylation
multiple interactions
increases expression
ISO
EXP
Lovastatin results in decreased prenylation of RHOB protein
Lovastatin promotes the reaction [RHOB protein binds to CASP2 protein]
Lovastatin results in increased expression of RHOB protein
CTD PMID:12467231 PMID:16156861 PMID:16234849 NCBI chr12:8,547,661...8,550,009
Ensembl chr12:8,547,661...8,550,009
JBrowse link
G Rpl27 ribosomal protein L27 increases expression EXP Lovastatin results in increased expression of RPL27 mRNA CTD PMID:20493250 NCBI chr11:101,333,071...101,336,422
Ensembl chr11:101,333,124...101,336,355
JBrowse link
G Rpl9 ribosomal protein L9 increases expression EXP Lovastatin results in increased expression of RPL9 mRNA CTD PMID:20493250 NCBI chr 5:65,545,707...65,548,774
Ensembl chr 5:65,545,707...65,548,787
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression EXP Lovastatin results in increased expression of RPLP0 mRNA CTD PMID:20493250 NCBI chr 5:115,697,526...115,701,788
Ensembl chr 5:115,697,526...115,701,786
JBrowse link
G Rpsa ribosomal protein SA increases expression EXP Lovastatin results in increased expression of RPSA mRNA CTD PMID:20493250 NCBI chr 9:119,956,832...119,961,435
Ensembl chr 9:119,956,755...119,961,435
JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 decreases expression EXP Lovastatin results in decreased expression of RUVBL2 mRNA CTD PMID:20493250 NCBI chr 7:45,071,320...45,084,817
Ensembl chr 7:45,071,184...45,087,520
JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) multiple interactions EXP [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A8 mRNA CTD PMID:30853469 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342
JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) multiple interactions EXP [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A9 mRNA CTD PMID:30853469 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression EXP Lovastatin results in decreased expression of SAE1 mRNA CTD PMID:20493250 NCBI chr 7:16,054,161...16,121,821
Ensembl chr 7:16,054,159...16,121,731
JBrowse link
G Scap SREBF chaperone multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of SCAP mRNA CTD PMID:29852127 NCBI chr 9:110,162,356...110,214,017
Ensembl chr 9:110,162,356...110,214,018
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
affects expression
EXP [Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]
Lovastatin affects the expression of SCARB1 mRNA
CTD PMID:20404351 PMID:27208389 NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of SCD1 mRNA CTD PMID:29852127 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
JBrowse link
G Sephs1 selenophosphate synthetase 1 increases expression EXP Lovastatin results in increased expression of SEPHS1 mRNA CTD PMID:20493250 NCBI chr 2:4,886,375...4,915,368
Ensembl chr 2:4,886,375...4,915,368
JBrowse link
G Slc31a1 solute carrier family 31, member 1 increases expression ISO Lovastatin results in increased expression of SLC31A1 mRNA CTD PMID:26739623 NCBI chr 4:62,278,821...62,310,006
Ensembl chr 4:62,278,964...62,310,006
JBrowse link
G Sox10 SRY (sex determining region Y)-box 10 multiple interactions
increases expression
ISO geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of SOX10 mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA] CTD PMID:20578043 NCBI chr15:79,039,113...79,048,690
Ensembl chr15:79,039,108...79,049,440
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression
EXP
ISO
[Dietary Fats co-treated with Lovastatin] affects the expression of SREBF1 mRNA
Lovastatin results in increased expression of SREBF1 mRNA
CTD PMID:29852127 PMID:32739440 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
JBrowse link
G Srebf2 sterol regulatory element binding factor 2 increases localization
multiple interactions
ISO
EXP
Lovastatin results in increased localization of SREBF2 protein
[Dietary Fats co-treated with Lovastatin] affects the expression of SREBF2 mRNA
[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein; Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein]
CTD PMID:11728391 PMID:20578043 PMID:29852127 NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580
JBrowse link
G Steap2 six transmembrane epithelial antigen of prostate 2 decreases response to substance ISO STEAP2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 5:5,714,829...5,744,649
Ensembl chr 5:5,714,829...5,744,578
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression EXP Lovastatin results in decreased expression of STIP1 mRNA CTD PMID:20493250 NCBI chr19:6,998,064...7,017,394
Ensembl chr19:6,998,070...7,017,335
JBrowse link
G Syngap1 synaptic Ras GTPase activating protein 1 homolog (rat) multiple interactions ISO Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein] CTD PMID:24718106 NCBI chr17:27,160,186...27,191,408
Ensembl chr17:27,160,227...27,191,408
JBrowse link
G Tcp1 t-complex protein 1 increases expression EXP Lovastatin results in increased expression of TCP1 mRNA CTD PMID:20493250 NCBI chr17:13,135,216...13,143,954
Ensembl chr17:13,134,588...13,143,954
JBrowse link
G Tg thyroglobulin increases secretion ISO Lovastatin results in increased secretion of TG protein CTD PMID:12843138 NCBI chr15:66,542,606...66,722,570
Ensembl chr15:66,542,602...66,722,570
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Lovastatin inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]; Lovastatin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:22129737 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions
ISO
EXP
Lovastatin results in increased expression of TH protein
Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein]
CTD PMID:20694854 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
JBrowse link
G Thop1 thimet oligopeptidase 1 increases expression EXP Lovastatin results in increased expression of THOP1 mRNA CTD PMID:20493250 NCBI chr10:80,905,917...80,918,194
Ensembl chr10:80,905,869...80,918,393
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of TNF protein]
CTD PMID:18809656 PMID:21430599 PMID:22712078 PMID:35734936 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) increases expression EXP Lovastatin results in increased expression of TNFRSF11B mRNA CTD PMID:24742230 NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 increases response to substance ISO Lovastatin results in increased susceptibility to TNFSF10 protein CTD PMID:17928957 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576
JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 decreases expression EXP Lovastatin results in decreased expression of TNFSF11 mRNA CTD PMID:24742230 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483
JBrowse link
G Top2a topoisomerase (DNA) II alpha multiple interactions EXP Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TOP2A mRNA] CTD PMID:22712078 NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015
JBrowse link
G Trim63 tripartite motif-containing 63 multiple interactions EXP Lovastatin promotes the reaction [Fenofibrate results in increased expression of TRIM63 protein] CTD PMID:33408297 NCBI chr 4:134,042,431...134,056,940
Ensembl chr 4:134,042,431...134,056,940
JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases expression
ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Lovastatin results in increased expression of and results in increased phosphorylation of TP53 protein
Lovastatin inhibits the reaction [Cisplatin results in increased expression of TP53 protein modified form]
Lovastatin results in increased expression of TP53 mRNA
CTD PMID:17088865 PMID:21199873 PMID:26739623 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Ttc7 tetratricopeptide repeat domain 7 multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of FSN mRNA CTD PMID:29852127 NCBI chr17:87,590,328...87,689,197
Ensembl chr17:87,590,314...87,689,197
JBrowse link
G Tuba1a tubulin, alpha 1A increases expression EXP Lovastatin results in increased expression of TUBA1A mRNA CTD PMID:20493250 NCBI chr15:98,847,728...98,851,382
Ensembl chr15:98,847,718...98,851,584
JBrowse link
G Tuba1b tubulin, alpha 1B decreases expression
increases expression
EXP Lovastatin results in decreased expression of TUBA1B mRNA
Lovastatin results in increased expression of TUBA1B mRNA
CTD PMID:20493250 NCBI chr15:98,829,310...98,832,271
Ensembl chr15:98,829,306...98,832,446
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression EXP Lovastatin results in decreased expression of TUBB5 mRNA CTD PMID:20493250 NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases expression EXP Lovastatin results in decreased expression of TUFM mRNA CTD PMID:20493250 NCBI chr 7:126,086,445...126,089,903
Ensembl chr 7:126,086,533...126,089,903
JBrowse link
G U2af2 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 increases expression EXP Lovastatin results in increased expression of U2AF2 mRNA CTD PMID:20493250 NCBI chr 7:5,063,884...5,082,937
Ensembl chr 7:5,065,142...5,082,937
JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) multiple interactions EXP [Dietary Fats co-treated with Lovastatin] affects the expression of UCP2 mRNA CTD PMID:29852127 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227
JBrowse link
G Usp5 ubiquitin specific peptidase 5 (isopeptidase T) decreases expression EXP Lovastatin results in decreased expression of USP5 mRNA CTD PMID:20493250 NCBI chr 6:124,791,982...124,806,404
Ensembl chr 6:124,791,982...124,806,447
JBrowse link
G Vcp valosin containing protein decreases expression
increases expression
EXP Lovastatin results in decreased expression of VCP mRNA
Lovastatin results in increased expression of VCP mRNA
CTD PMID:20493250 NCBI chr 4:42,979,964...43,000,507
Ensembl chr 4:42,979,963...43,000,507
JBrowse link
G Wee1 WEE 1 homolog 1 (S. pombe) multiple interactions
increases expression
EXP Lovastatin inhibits the reaction [Doxorubicin results in increased expression of WEE1 mRNA]
Lovastatin results in increased expression of WEE1 mRNA
CTD PMID:22712078 NCBI chr 7:109,721,266...109,742,506
Ensembl chr 7:109,721,253...109,742,493
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression ISO Lovastatin results in increased expression of XIAP mRNA CTD PMID:26739623 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533
JBrowse link
G Xpa xeroderma pigmentosum, complementation group A increases expression ISO Lovastatin results in increased expression of XPA mRNA CTD PMID:26739623 NCBI chr 4:46,175,222...46,196,317
Ensembl chr 4:46,155,347...46,196,311
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide increases expression EXP Lovastatin results in increased expression of YWHAE mRNA CTD PMID:20493250 NCBI chr11:75,620,121...75,656,667
Ensembl chr11:75,623,695...75,656,671
JBrowse link
mevastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 affects expression
decreases expression
multiple interactions
ISO
EXP
mevastatin affects the expression of ABCA1 mRNA
Mevastatin (compactin) decreases expression of abca1 mRNA in rat peripheral fibroblasts
Mevalonic Acid inhibits the reaction [mevastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased expression of ABCA1 protein]]
CTD
RGD
PMID:16415093 PMID:17526932 PMID:17526932 RGD:2308820 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions EXP mevastatin inhibits the reaction [BDNF protein results in decreased activity of HU 211] CTD PMID:20554863 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO mevastatin results in increased expression of BMP2 mRNA; mevastatin results in increased expression of BMP2 protein CTD PMID:10814523 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805
JBrowse link
G Cd40 CD40 antigen multiple interactions EXP mevastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
decreases expression
EXP EIF2S1 protein modified form inhibits the reaction [mevastatin results in decreased expression of DDIT3 mRNA] CTD PMID:16330322 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation EXP mevastatin results in increased phosphorylation of EIF2AK3 protein CTD PMID:16330322 NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha multiple interactions EXP EIF2S1 protein modified form inhibits the reaction [mevastatin results in decreased expression of DDIT3 mRNA]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased cleavage of SREBF1 protein]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of IDI1 mRNA]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of MSMO1 mRNA] CTD PMID:16330322 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784
JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation EXP mevastatin results in decreased phosphorylation of FOXO1 protein CTD PMID:33034787 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase multiple interactions
increases expression
EXP EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of IDI1 mRNA] CTD PMID:16330322 NCBI chr13:8,935,642...8,942,432
Ensembl chr13:8,935,537...8,942,487
JBrowse link
G Ifng interferon gamma multiple interactions EXP mevastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO mevastatin promotes the reaction [IL1B protein results in increased expression of SELE protein] CTD PMID:10946302 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Irf4 interferon regulatory factor 4 decreases expression EXP mevastatin results in decreased expression of IRF4 protein CTD PMID:33034787 NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959
JBrowse link
G Msmo1 methylsterol monoxygenase 1 increases expression
multiple interactions
EXP mevastatin results in increased expression of MSMO1 mRNA
EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of MSMO1 mRNA]
CTD PMID:16330322 NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826
JBrowse link
G Mstn myostatin increases expression EXP mevastatin results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 1:53,100,799...53,107,238
Ensembl chr 1:53,100,799...53,107,238
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Mevastatin increases expression of NR1H3 mRNA in mononuclear cells RGD PMID:16252156 RGD:401827902 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [mevastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein promotes the reaction [mevastatin results in increased expression of CYP3A4 mRNA] CTD PMID:12235278 PMID:17041008 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP mevastatin results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein] CTD PMID:16734383 NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791
JBrowse link
G Rhoa ras homolog family member A decreases lipidation
multiple interactions
ISO mevastatin results in decreased lipidation of RHOA protein
Mevalonic Acid inhibits the reaction [mevastatin results in decreased lipidation of RHOA protein]
CTD PMID:17322126 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO mevastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]; mevastatin promotes the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:10946302 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
increases cleavage
multiple interactions
ISO
EXP
mevastatin results in decreased expression of SREBF1 protein
mevastatin results in increased cleavage of SREBF1 protein
EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased cleavage of SREBF1 protein]
CTD PMID:16330322 PMID:17526932 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
JBrowse link
G Srebf2 sterol regulatory element binding factor 2 increases expression
increases cleavage
ISO
EXP
mevastatin results in increased expression of SREBF2 protein
mevastatin results in increased cleavage of SREBF2 protein
CTD PMID:16330322 PMID:17526932 NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO mevastatin promotes the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:10946302 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP Tunicamycin inhibits the reaction [mevastatin results in increased cleavage of XBP1 protein] CTD PMID:16330322 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
JBrowse link
pravastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 multiple interactions
increases expression
decreases expression
ISO [[colestimide co-treated with Pravastatin] results in increased expression of ABCA1 protein] which results in decreased abundance of Cholesterol; [colestimide co-treated with Pravastatin] affects the expression of ABCA1 mRNA; [colestimide co-treated with Pravastatin] affects the expression of ABCA1 protein
cotreatment with pravastatin and colestimide increases expression of abca1 mRNA and protein in rat liver; and decreases expression of abca1 mRNA and protein in rat small intestine
Pravastatin results in decreased expression of ABCA1
CTD
RGD
PMID:17526932 PMID:19461118 PMID:17526932 RGD:2308820 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions
affects import
ISO Pravastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]
ABCB11 protein affects the import of Pravastatin
CTD PMID:15901796 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A increases transport ISO ABCB1 protein results in increased transport of Pravastatin; ABCB1 protein results in increased transport of Pravastatin analog CTD PMID:15616150 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 increases expression ISO Pravastatin results in increased expression of ABCB4 mRNA CTD PMID:15242490 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 affects export
increases expression
multiple interactions
affects transport
ISO
EXP
ABCC2 protein affects the export of Pravastatin
Pravastatin results in increased expression of ABCC2 protein
ABCC2 protein binds to and results in increased uptake of Pravastatin analog; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the transport of Pravastatin
CTD PMID:15901800 PMID:15955871 PMID:23562342 PMID:24909372 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 increases expression ISO Pravastatin results in increased expression of ABCC3 protein CTD PMID:24909372 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 increases transport ISO ABCC4 protein results in increased transport of Pravastatin CTD PMID:17939016 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631
JBrowse link
G Abcd3 ATP-binding cassette, sub-family D member 3 decreases expression EXP Pravastatin results in decreased expression of ABCD3 mRNA CTD PMID:27225895 NCBI chr 3:121,552,553...121,609,851
Ensembl chr 3:121,552,423...121,608,951
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) affects export
increases activity
ISO ABCG2 protein affects the export of Pravastatin
Pravastatin results in increased activity of ABCG2 protein
CTD PMID:15901800 PMID:27475308 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression ISO Pravastatin results in increased expression of ABCG5 mRNA CTD PMID:15242490 NCBI chr17:84,965,602...84,990,439
Ensembl chr17:84,965,662...84,990,439
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression ISO Pravastatin results in increased expression of ABCG8 mRNA CTD PMID:15242490 NCBI chr17:84,983,730...85,007,761
Ensembl chr17:84,983,730...85,007,761
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B decreases expression EXP Pravastatin results in decreased expression of ACAA1B mRNA CTD PMID:27225895 NCBI chr 9:118,977,111...118,986,149
Ensembl chr 9:118,977,091...118,986,161
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 decreases expression EXP
ISO
Pravastatin results in decreased expression of ACAA2 mRNA CTD PMID:27225895 NCBI chr18:74,912,283...74,939,278
Ensembl chr18:74,912,268...74,939,279
JBrowse link
G Acat1 acetyl-Coenzyme A acetyltransferase 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of ACAT1 mRNA CTD PMID:27225895 NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions ISO [INS1 protein co-treated with Pravastatin] inhibits the reaction [Streptozocin results in increased expression of ACE protein] CTD PMID:29682576 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790
JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions ISO [INS1 protein co-treated with Pravastatin] inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein] CTD PMID:29682576 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416
JBrowse link
G Acnat1 acyl-coenzyme A amino acid N-acyltransferase 1 decreases expression EXP Pravastatin results in decreased expression of ACNAT1 mRNA CTD PMID:27225895 NCBI chr 4:49,443,532...49,481,315
Ensembl chr 4:49,447,105...49,473,912
JBrowse link
G Acnat2 acyl-coenzyme A amino acid N-acyltransferase 2 decreases expression EXP Pravastatin results in decreased expression of ACNAT2 mRNA CTD PMID:27225895 NCBI chr 4:49,374,458...49,408,151
Ensembl chr 4:49,379,840...49,408,151
JBrowse link
G Acot1 acyl-CoA thioesterase 1 decreases expression
increases expression
EXP
ISO
Pravastatin results in decreased expression of ACOT1 mRNA
Pravastatin results in increased expression of ACOT1 mRNA
CTD PMID:27225895 NCBI chr12:84,056,276...84,064,444
Ensembl chr12:84,056,264...84,065,145
JBrowse link
G Acot12 acyl-CoA thioesterase 12 decreases expression ISO
EXP
Pravastatin results in decreased expression of ACOT12 mRNA CTD PMID:27225895 NCBI chr13:91,889,635...91,934,271
Ensembl chr13:91,889,631...91,934,267
JBrowse link
G Acot2 acyl-CoA thioesterase 2 affects expression EXP Pravastatin affects the expression of ACOT2 mRNA CTD PMID:27225895 NCBI chr12:84,034,635...84,040,651
Ensembl chr12:84,034,635...84,040,647
JBrowse link
G Acot3 acyl-CoA thioesterase 3 decreases expression EXP Pravastatin results in decreased expression of ACOT3 mRNA CTD PMID:27225895 NCBI chr12:84,098,918...84,107,174
Ensembl chr12:84,098,918...84,107,176
JBrowse link
G Acot4 acyl-CoA thioesterase 4 decreases expression EXP Pravastatin results in decreased expression of ACOT4 mRNA CTD PMID:27225895 NCBI chr12:84,084,028...84,091,497
Ensembl chr12:84,085,153...84,095,375
JBrowse link
G Acot5 acyl-CoA thioesterase 5 decreases expression EXP Pravastatin results in decreased expression of ACOT5 mRNA CTD PMID:27225895 NCBI chr12:84,115,908...84,122,798
Ensembl chr12:84,116,099...84,122,794
JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl decreases expression ISO
EXP
Pravastatin results in decreased expression of ACOX1 mRNA CTD PMID:27225895 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871
JBrowse link
G Acsf2 acyl-CoA synthetase family member 2 decreases expression
increases expression
EXP
ISO
Pravastatin results in decreased expression of ACSF2 mRNA
Pravastatin results in increased expression of ACSF2 mRNA
CTD PMID:27225895 NCBI chr11:94,447,928...94,492,822
Ensembl chr11:94,447,928...94,492,697
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression EXP Pravastatin results in decreased expression of ACSL1 mRNA CTD PMID:27225895 NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088
JBrowse link
G Acta1 actin alpha 1, skeletal muscle decreases expression EXP
ISO
Pravastatin results in decreased expression of ACTA1 mRNA CTD PMID:27225895 NCBI chr 8:124,618,497...124,621,514
Ensembl chr 8:124,618,508...124,621,490
JBrowse link
G Adamdec1 ADAM-like, decysin 1 increases expression EXP
ISO
Pravastatin results in increased expression of ADAMDEC1 mRNA CTD PMID:27225895 NCBI chr14:68,800,829...68,819,535
Ensembl chr14:68,800,829...68,819,544
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) decreases expression ISO
EXP
Pravastatin results in decreased expression of ADH1 mRNA CTD PMID:27225895 NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide decreases expression EXP
ISO
Pravastatin results in decreased expression of ADH7 mRNA CTD PMID:27225895 NCBI chr 3:137,903,828...137,937,803
Ensembl chr 3:137,923,521...137,939,143
JBrowse link
G Agt angiotensinogen decreases expression EXP
ISO
Pravastatin results in decreased expression of AGT mRNA CTD PMID:27225895 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of AIF1 mRNA CTD PMID:27225895 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 decreases expression ISO
EXP
Pravastatin results in decreased expression of AKR1C3 mRNA
Pravastatin results in decreased expression of AKR1C18 mRNA
CTD PMID:27225895 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
increases phosphorylation
EXP
ISO
Pravastatin inhibits the reaction [Carboplatin results in increased activity of and results in increased phosphorylation of AKT1 protein]
[Pravastatin co-treated with olmesartan] results in increased phosphorylation of AKT1 protein; [resveratrol co-treated with Pravastatin] results in increased phosphorylation of AKT1 protein
Pravastatin results in increased phosphorylation of AKT1 protein
CTD PMID:17170375 PMID:17188708 PMID:18483861 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 decreases expression EXP
ISO
Pravastatin results in decreased expression of ALDH1A1 mRNA CTD PMID:16763553 PMID:27225895 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829
JBrowse link
G Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 multiple interactions
decreases expression
EXP Cholesterol, Dietary inhibits the reaction [Pravastatin results in decreased expression of ALDH1A2 mRNA] CTD PMID:16763553 NCBI chr 9:71,123,071...71,203,525
Ensembl chr 9:71,123,071...71,203,525
JBrowse link
G Aldh1a3 aldehyde dehydrogenase family 1, subfamily A3 affects expression ISO
EXP
Pravastatin affects the expression of ALDH1A3 mRNA CTD PMID:27225895 NCBI chr 7:66,040,640...66,077,225
Ensembl chr 7:66,040,638...66,077,265
JBrowse link
G Aldoart2 aldolase 1 A, retrogene 2 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of ALDOART2 mRNA
Pravastatin results in decreased expression of ALDOART2 mRNA
CTD PMID:27225895 NCBI chr12:55,611,990...55,613,681
Ensembl chr12:55,612,024...55,613,681
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression EXP
ISO
Pravastatin results in increased expression of AMPD3 mRNA CTD PMID:27225895 NCBI chr 7:110,367,291...110,411,612
Ensembl chr 7:110,367,413...110,411,612
JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO
EXP
Pravastatin results in decreased expression of ANGPTL3 mRNA CTD PMID:27225895 NCBI chr 4:98,919,191...98,926,429
Ensembl chr 4:98,919,191...98,934,348
JBrowse link
G Ank2 ankyrin 2, brain increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of ANK2 mRNA
Pravastatin results in decreased expression of ANK2 mRNA
CTD PMID:27225895 NCBI chr 3:126,715,256...127,293,996
Ensembl chr 3:126,715,261...127,292,999
JBrowse link
G Anks6 ankyrin repeat and sterile alpha motif domain containing 6 increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of ANKS6 mRNA
Pravastatin results in decreased expression of ANKS6 mRNA
CTD PMID:27225895 NCBI chr 4:47,015,365...47,057,339
Ensembl chr 4:47,015,669...47,057,427
JBrowse link
G Apoa1 apolipoprotein A-I increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of APOA1 mRNA
Pravastatin results in decreased expression of APOA1 mRNA
CTD PMID:27225895 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764
JBrowse link
G Apon apolipoprotein N decreases expression EXP Pravastatin results in decreased expression of APON mRNA CTD PMID:27225895 NCBI chr10:128,090,000...128,091,770
Ensembl chr10:128,089,965...128,091,765
JBrowse link
G App amyloid beta precursor protein increases expression ISO Pravastatin results in increased expression of APP CTD PMID:19461118 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Arg2 arginase type II increases expression EXP Pravastatin results in increased expression of ARG2 mRNA CTD PMID:27225895 NCBI chr12:79,177,562...79,203,075
Ensembl chr12:79,177,551...79,203,075
JBrowse link
G Arhgap11a Rho GTPase activating protein 11A decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of ARHGAP11A mRNA
Pravastatin affects the expression of ARHGAP11A mRNA
CTD PMID:27225895 NCBI chr 2:113,661,837...113,679,006
Ensembl chr 2:113,661,837...113,679,006
JBrowse link
G Arrdc3 arrestin domain containing 3 decreases expression ISO
EXP
Pravastatin results in decreased expression of ARRDC3 mRNA CTD PMID:27225895 NCBI chr13:81,031,508...81,044,161
Ensembl chr13:81,031,503...81,044,161
JBrowse link
G Atp4a ATPase, H+/K+ exchanging, gastric, alpha polypeptide decreases expression ISO
EXP
Pravastatin results in decreased expression of ATP4A mRNA CTD PMID:27225895 NCBI chr 7:30,411,634...30,424,959
Ensembl chr 7:30,411,634...30,424,959
JBrowse link
G Atp6v0d2 ATPase, H+ transporting, lysosomal V0 subunit D2 increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of ATP6V0D2 mRNA
Pravastatin results in decreased expression of ATP6V0D2 mRNA
CTD PMID:27225895 NCBI chr 4:19,876,838...19,922,566
Ensembl chr 4:19,876,841...19,922,605
JBrowse link
G Axin2 axin 2 decreases expression EXP
ISO
Pravastatin results in decreased expression of AXIN2 mRNA CTD PMID:27225895 NCBI chr11:108,808,687...108,841,609
Ensembl chr11:108,811,175...108,841,609
JBrowse link
G Bard1 BRCA1 associated RING domain 1 affects expression
decreases expression
EXP
ISO
Pravastatin affects the expression of BARD1 mRNA
Pravastatin results in decreased expression of BARD1 mRNA
CTD PMID:27225895 NCBI chr 1:71,066,694...71,142,300
Ensembl chr 1:71,066,657...71,142,305
JBrowse link
G Bax BCL2-associated X protein multiple interactions EXP [LDLR gene mutant form results in increased susceptibility to Pravastatin] which affects the expression of BAX protein CTD PMID:26875785 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions EXP [LDLR gene mutant form results in increased susceptibility to Pravastatin] which affects the expression of BCL2 protein CTD PMID:26875785 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 decreases expression EXP
ISO
Pravastatin results in decreased expression of BHLHA15 mRNA CTD PMID:27225895 NCBI chr 5:144,127,104...144,131,259
Ensembl chr 5:144,127,104...144,131,259
JBrowse link
G Bmal2 basic helix-loop-helix ARNT like 2 affects expression
increases expression
ISO
EXP
Pravastatin affects the expression of BMAL2 mRNA
Pravastatin results in increased expression of BMAL2 mRNA
CTD PMID:27225895 NCBI chr 6:146,696,230...146,735,027
Ensembl chr 6:146,697,553...146,735,027
JBrowse link
G Bmper BMP-binding endothelial regulator affects expression
increases expression
ISO
EXP
Pravastatin affects the expression of BMPER mRNA
Pravastatin results in increased expression of BMPER mRNA
CTD PMID:27225895 NCBI chr 9:23,134,372...23,396,511
Ensembl chr 9:23,134,372...23,396,496
JBrowse link
G Bub1b BUB1B, mitotic checkpoint serine/threonine kinase affects expression
decreases expression
EXP
ISO
Pravastatin affects the expression of BUB1B mRNA
Pravastatin results in decreased expression of BUB1B mRNA
CTD PMID:27225895 NCBI chr 2:118,428,684...118,472,073
Ensembl chr 2:118,428,692...118,472,072
JBrowse link
G C1qb complement component 1, q subcomponent, beta polypeptide decreases expression ISO
EXP
Pravastatin results in decreased expression of C1QB mRNA CTD PMID:27225895 NCBI chr 4:136,607,437...136,613,511
Ensembl chr 4:136,607,440...136,613,498
JBrowse link
G C1qc complement component 1, q subcomponent, C chain decreases expression ISO
EXP
Pravastatin results in decreased expression of C1QC mRNA CTD PMID:27225895 NCBI chr 4:136,617,115...136,620,225
Ensembl chr 4:136,617,115...136,620,376
JBrowse link
G C5ar1 complement component 5a receptor 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of C5AR1 mRNA CTD PMID:27225895 NCBI chr 7:15,980,668...15,993,465
Ensembl chr 7:15,980,668...15,993,465
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP
ISO
[LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in increased cleavage of CASP3 protein; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]
Pravastatin results in increased cleavage of CASP3 protein
Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]; Pravastatin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]
CTD PMID:18483861 PMID:20368269 PMID:26875785 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP9 protein] CTD PMID:18483861 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase increases activity ISO Pravastatin results in increased activity of CAT protein CTD PMID:17479860 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccl12 C-C motif chemokine ligand 12 decreases expression EXP
ISO
Pravastatin results in decreased expression of CCL12 mRNA CTD PMID:27225895 NCBI chr11:81,992,671...81,994,225
Ensembl chr11:81,992,671...81,994,226
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP
ISO
Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]; Pravastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
Pravastatin inhibits the reaction [lopinavir-ritonavir drug combination results in increased secretion of CCL2 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of CCL2 protein]
CTD PMID:18323514 PMID:20884875 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccl6 C-C motif chemokine ligand 6 decreases expression EXP
ISO
Pravastatin results in decreased expression of CCL6 mRNA CTD PMID:27225895 NCBI chr11:83,478,712...83,483,913
Ensembl chr11:83,478,708...83,483,913
JBrowse link
G Cd209d CD209d antigen decreases expression ISO
EXP
Pravastatin results in decreased expression of CD209 mRNA CTD PMID:27225895 NCBI chr 8:3,921,824...3,928,548
Ensembl chr 8:3,921,824...3,928,555
JBrowse link
G Cd28 CD28 antigen affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of CD28 mRNA
Pravastatin results in decreased expression of CD28 mRNA
CTD PMID:27225895 NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518
JBrowse link
G Cd40 CD40 antigen affects expression EXP
ISO
Pravastatin affects the expression of CD40 mRNA CTD PMID:27225895 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
JBrowse link
G Cd7 CD7 antigen decreases expression EXP
ISO
Pravastatin results in decreased expression of CD7 mRNA CTD PMID:27225895 NCBI chr11:120,927,573...120,930,304
Ensembl chr11:120,927,573...120,930,244
JBrowse link
G Cdc27 cell division cycle 27 increases expression
affects expression
EXP
ISO
Pravastatin results in increased expression of CDC27 mRNA
Pravastatin affects the expression of CDC27 mRNA
CTD PMID:27225895 NCBI chr11:104,393,350...104,441,371
Ensembl chr11:104,393,571...104,441,446
JBrowse link
G Cdc6 cell division cycle 6 decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of CDC6 mRNA
Pravastatin affects the expression of CDC6 mRNA
CTD PMID:27225895 NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766
JBrowse link
G Cdca7l cell division cycle associated 7 like affects expression
decreases expression
EXP
ISO
Pravastatin affects the expression of CDCA7L mRNA
Pravastatin results in decreased expression of CDCA7L mRNA
CTD PMID:27225895 NCBI chr12:117,807,209...117,842,441
Ensembl chr12:117,768,024...117,842,441
JBrowse link
G Cdhr5 cadherin-related family member 5 increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of CDHR5 mRNA
Pravastatin results in decreased expression of CDHR5 mRNA
CTD PMID:27225895 NCBI chr 7:140,848,993...140,856,708
Ensembl chr 7:140,848,996...140,856,699
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions ISO Pravastatin inhibits the reaction [Benzo(a)pyrene results in decreased degradation of CDKN1A protein]; Pravastatin inhibits the reaction [Fluorouracil results in decreased degradation of CDKN1A protein] CTD PMID:15625077 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cds1 CDP-diacylglycerol synthase 1 increases expression EXP
ISO
Pravastatin results in increased expression of CDS1 mRNA CTD PMID:27225895 NCBI chr 5:101,913,001...101,971,724
Ensembl chr 5:101,912,996...101,971,724
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP Pravastatin results in increased expression of CEBPD mRNA CTD PMID:27225895 NCBI chr16:15,705,150...15,707,409
Ensembl chr16:15,705,150...15,708,895
JBrowse link
G Cers6 ceramide synthase 6 decreases expression EXP Pravastatin results in decreased expression of CERS6 mRNA CTD PMID:27225895 NCBI chr 2:68,691,489...68,944,628
Ensembl chr 2:68,691,785...68,944,626
JBrowse link
G Ces1e carboxylesterase 1E decreases expression EXP Pravastatin results in decreased expression of CES1E mRNA CTD PMID:27225895 NCBI chr 8:93,927,846...93,956,233
Ensembl chr 8:93,927,846...93,956,247
JBrowse link
G Ces1f carboxylesterase 1F decreases expression EXP Pravastatin results in decreased expression of CES1F mRNA CTD PMID:27225895 NCBI chr 8:93,982,864...94,006,394
Ensembl chr 8:93,982,864...94,006,375
JBrowse link
G Ces2b carboxyesterase 2B increases expression EXP Pravastatin results in increased expression of CES2B mRNA CTD PMID:27225895 NCBI chr 8:105,555,130...105,566,725
Ensembl chr 8:105,558,204...105,566,725
JBrowse link
G Cfap96 cilia and flagella associated protein 96 increases expression ISO Pravastatin results in increased expression of CFAP96 mRNA CTD PMID:27225895 NCBI chr 8:46,387,980...46,428,290
Ensembl chr 8:46,406,643...46,428,477
JBrowse link
G Cip2a cell proliferation regulating inhibitor of protein phosphatase 2A decreases expression ISO Pravastatin results in decreased expression of CIP2A mRNA CTD PMID:27225895 NCBI chr16:48,814,524...48,840,079
Ensembl chr16:48,814,548...48,840,072
JBrowse link
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 decreases expression
increases expression
EXP
ISO
Pravastatin results in decreased expression of CITED1 mRNA
Pravastatin results in increased expression of CITED1 mRNA
CTD PMID:27225895 NCBI chr  X:101,290,984...101,295,787
Ensembl chr  X:101,290,987...101,295,787
JBrowse link
G Clcn6 chloride channel, voltage-sensitive 6 increases expression ISO
EXP
Pravastatin results in increased expression of CLCN6 mRNA CTD PMID:27225895 NCBI chr 4:148,088,716...148,123,270
Ensembl chr 4:148,088,716...148,123,278
JBrowse link
G Clec4f C-type lectin domain family 4, member f decreases expression EXP
ISO
Pravastatin results in decreased expression of CLEC4F mRNA CTD PMID:27225895 NCBI chr 6:83,621,524...83,633,098
Ensembl chr 6:83,621,524...83,633,169
JBrowse link
G Clstn3 calsyntenin 3 decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of CLSTN3 mRNA
Pravastatin affects the expression of CLSTN3 mRNA
CTD PMID:27225895 NCBI chr 6:124,407,715...124,441,743
Ensembl chr 6:124,407,540...124,441,753
JBrowse link
G Cnn1 calponin 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of CNN1 mRNA CTD PMID:27225895 NCBI chr 9:22,010,501...22,020,517
Ensembl chr 9:22,010,512...22,020,926
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1b, muscle decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of CPT1B mRNA
Pravastatin affects the expression of CPT1B mRNA
CTD PMID:27225895 NCBI chr15:89,300,608...89,310,065
Ensembl chr15:89,300,608...89,310,066
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression EXP Pravastatin results in decreased expression of CPT2 mRNA CTD PMID:27225895 NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807
JBrowse link
G Crat carnitine acetyltransferase increases expression
affects expression
ISO
EXP
Pravastatin results in increased expression of CRAT mRNA
Pravastatin affects the expression of CRAT mRNA
CTD PMID:27225895 NCBI chr 2:30,290,483...30,305,602
Ensembl chr 2:30,290,483...30,305,825
JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of CREB3L3 mRNA
Pravastatin results in decreased expression of CREB3L3 mRNA
CTD PMID:27225895 NCBI chr10:80,920,163...80,934,706
Ensembl chr10:80,920,158...80,934,708
JBrowse link
G Crp C-reactive protein, pentraxin-related increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of CRP mRNA
Pravastatin results in decreased expression of CRP mRNA
CTD PMID:27225895 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
JBrowse link
G Csad cysteine sulfinic acid decarboxylase decreases expression EXP
ISO
Pravastatin results in decreased expression of CSAD mRNA CTD PMID:27225895 NCBI chr15:102,085,432...102,112,685
Ensembl chr15:102,085,434...102,113,159
JBrowse link
G Csf1r colony stimulating factor 1 receptor decreases expression EXP
ISO
Pravastatin results in decreased expression of CSF1R mRNA CTD PMID:27225895 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221
JBrowse link
G Csmd1 CUB and Sushi multiple domains 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of CSMD1 mRNA CTD PMID:27225895 NCBI chr 8:15,942,538...17,586,908
Ensembl chr 8:15,942,537...17,585,602
JBrowse link
G Ctnnb1 catenin beta 1 affects localization
multiple interactions
ISO Pravastatin affects the localization of CTNNB1 protein
[resveratrol co-treated with Pravastatin] affects the localization of CTNNB1 protein
CTD PMID:17188708 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO Pravastatin inhibits the reaction [lopinavir-ritonavir drug combination results in increased secretion of CXCL8 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of CXCL8 protein] CTD PMID:20884875 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 affects expression
increases expression
ISO
EXP
Pravastatin affects the expression of CXCL2 mRNA
Pravastatin results in increased expression of CXCL2 mRNA
CTD PMID:27225895 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
JBrowse link
G Cyba cytochrome b-245, alpha polypeptide decreases expression ISO Pravastatin results in decreased expression of CYBA protein CTD PMID:17170375 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Pravastatin inhibits the reaction [Carboplatin results in increased expression of CYCS protein] CTD PMID:18483861 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression EXP
ISO
Pravastatin results in decreased expression of CYP1A2 mRNA CTD PMID:27225895 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 affects expression
increases expression
ISO
EXP
Pravastatin affects the expression of CYP1B1 mRNA
Pravastatin results in increased expression of CYP1B1 mRNA
CTD PMID:27225895 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 affects expression EXP Pravastatin affects the expression of CYP2B10 mRNA CTD PMID:27225895 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2b23 cytochrome P450, family 2, subfamily b, polypeptide 23 affects expression EXP Pravastatin affects the expression of CYP2B23 mRNA CTD PMID:27225895 NCBI chr 7:26,364,652...26,389,788
Ensembl chr 7:26,364,652...26,385,862
JBrowse link
G Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 decreases expression EXP Pravastatin results in decreased expression of CYP2C23 mRNA CTD PMID:27225895 NCBI chr19:43,993,461...44,017,695
Ensembl chr19:43,993,461...44,017,647
JBrowse link
G Cyp2d10 cytochrome P450, family 2, subfamily d, polypeptide 10 decreases expression EXP Pravastatin results in decreased expression of CYP2D10 mRNA CTD PMID:27225895 NCBI chr15:82,287,046...82,291,449
Ensembl chr15:82,287,047...82,291,396
JBrowse link
G Cyp2j6 cytochrome P450, family 2, subfamily j, polypeptide 6 decreases expression EXP Pravastatin results in decreased expression of CYP2J6 mRNA CTD PMID:27225895 NCBI chr 4:96,404,375...96,449,835
Ensembl chr 4:96,404,375...96,441,898
JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 decreases expression ISO Pravastatin results in decreased expression of CYP2J4 mRNA CTD PMID:27225895 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 decreases expression EXP Pravastatin results in decreased expression of CYP3A11 mRNA CTD PMID:27225895 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774
JBrowse link
G Cyp3a16 cytochrome P450, family 3, subfamily a, polypeptide 16 decreases expression EXP Pravastatin results in decreased expression of CYP3A16 mRNA CTD PMID:27225895 NCBI chr 5:145,373,119...145,406,550
Ensembl chr 5:145,373,119...145,406,533
JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 decreases expression EXP Pravastatin results in decreased expression of CYP4A10 mRNA CTD PMID:27225895 NCBI chr 4:115,375,484...115,390,846
Ensembl chr 4:115,375,461...115,390,846
JBrowse link
G Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B decreases expression ISO Pravastatin results in decreased expression of CYP4A1 mRNA CTD PMID:27225895 NCBI chr 4:115,268,821...115,296,231
Ensembl chr 4:115,268,821...115,296,231
JBrowse link
G Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 decreases expression EXP Pravastatin results in decreased expression of CYP4A14 mRNA CTD PMID:27225895 NCBI chr 4:115,343,397...115,353,355
Ensembl chr 4:115,343,397...115,353,339
JBrowse link
G Cyp4a31 cytochrome P450, family 4, subfamily a, polypeptide 31 decreases expression EXP Pravastatin results in decreased expression of CYP4A31 mRNA CTD PMID:27225895 NCBI chr 4:115,420,824...115,436,212
Ensembl chr 4:115,420,846...115,436,212
JBrowse link
G Cyp4a32 cytochrome P450, family 4, subfamily a, polypeptide 32 decreases expression EXP Pravastatin results in decreased expression of CYP4A32 mRNA CTD PMID:27225895 NCBI chr 4:115,458,124...115,479,704
Ensembl chr 4:115,458,166...115,478,799
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP
ISO
Pravastatin results in increased expression of CYP51 mRNA CTD PMID:27225895 NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746
JBrowse link
G Decr1 2,4-dienoyl CoA reductase 1, mitochondrial decreases expression ISO
EXP
Pravastatin results in decreased expression of DECR1 mRNA CTD PMID:27225895 NCBI chr 4:15,917,240...15,945,377
Ensembl chr 4:15,917,240...15,945,507
JBrowse link
G Depdc1b DEP domain containing 1B decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of DEPDC1B mRNA
Pravastatin affects the expression of DEPDC1B mRNA
CTD PMID:27225895 NCBI chr13:108,452,592...108,526,100
Ensembl chr13:108,452,866...108,544,316
JBrowse link
G Derl3 Der1-like domain family, member 3 decreases expression EXP
ISO
Pravastatin results in decreased expression of DERL3 mRNA CTD PMID:27225895 NCBI chr10:75,729,232...75,731,775
Ensembl chr10:75,729,247...75,731,775
JBrowse link
G Dio3 deiodinase, iodothyronine type III decreases expression ISO
EXP
Pravastatin results in decreased expression of DIO3 mRNA CTD PMID:27225895 NCBI chr12:110,245,664...110,247,531
Ensembl chr12:110,245,502...110,247,531
JBrowse link
G Dlgap1 DLG associated protein 1 increases expression ISO
EXP
Pravastatin results in increased expression of DLGAP1 mRNA CTD PMID:27225895 NCBI chr17:70,276,068...71,128,408
Ensembl chr17:70,276,068...71,128,408
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 affects farnesylation ISO Pravastatin affects the farnesylation of DNAJA1 protein CTD PMID:20884875 NCBI chr 4:40,722,468...40,734,965
Ensembl chr 4:40,722,150...40,737,149
JBrowse link
G Dnase2b deoxyribonuclease II beta increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of DNASE2B mRNA
Pravastatin results in decreased expression of DNASE2B mRNA
CTD PMID:27225895 NCBI chr 3:146,275,488...146,322,815
Ensembl chr 3:146,286,740...146,321,351
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression ISO
EXP
Pravastatin results in increased expression of DPYSL2 mRNA CTD PMID:27225895 NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,106,137
JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase affects expression
decreases expression
EXP
ISO
Pravastatin affects the expression of DTL mRNA
Pravastatin results in decreased expression of DTL mRNA
CTD PMID:27225895 NCBI chr 1:191,269,468...191,307,656
Ensembl chr 1:191,269,468...191,307,656
JBrowse link
G Ech1 enoyl coenzyme A hydratase 1, peroxisomal decreases expression ISO
EXP
Pravastatin results in decreased expression of ECH1 mRNA CTD PMID:27225895 NCBI chr 7:28,524,763...28,531,664
Ensembl chr 7:28,524,642...28,531,672
JBrowse link
G Edn1 endothelin 1 decreases expression ISO Pravastatin results in decreased expression of EDN1 protein
Pravastatin results in decreased expression of EDN1 mRNA; Pravastatin results in decreased expression of EDN1 protein
CTD PMID:12105140 PMID:19812503 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Efhb EF hand domain family, member B increases expression ISO
EXP
Pravastatin results in increased expression of EFHB mRNA CTD PMID:27225895 NCBI chr17:53,705,077...53,770,362
Ensembl chr17:53,705,917...53,770,349
JBrowse link
G Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase decreases expression ISO
EXP
Pravastatin results in decreased expression of EHHADH mRNA CTD PMID:27225895 NCBI chr16:21,580,035...21,606,589
Ensembl chr16:21,580,037...21,606,557
JBrowse link
G Enpp5 ectonucleotide pyrophosphatase/phosphodiesterase 5 decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of ENPP5 mRNA
Pravastatin affects the expression of ENPP5 mRNA
CTD PMID:27225895 NCBI chr17:44,389,693...44,397,458
Ensembl chr17:44,389,704...44,397,458
JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of ENTPD2 mRNA
Pravastatin results in decreased expression of ENTPD2 mRNA
CTD PMID:27225895 NCBI chr 2:25,285,886...25,291,335
Ensembl chr 2:25,285,886...25,291,333
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic decreases expression ISO
EXP
Pravastatin results in decreased expression of EPHX2 mRNA CTD PMID:27225895 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949
JBrowse link
G Ephx4 epoxide hydrolase 4 increases expression
affects expression
ISO
EXP
Pravastatin results in increased expression of EPHX4 mRNA
Pravastatin affects the expression of EPHX4 mRNA
CTD PMID:27225895 NCBI chr 5:107,551,379...107,577,901
Ensembl chr 5:107,550,602...107,577,901
JBrowse link
G Evi2a ecotropic viral integration site 2a decreases expression ISO
EXP
Pravastatin results in decreased expression of EVI2A mRNA CTD PMID:27225895 NCBI chr11:79,417,386...79,421,435
Ensembl chr11:79,417,386...79,421,435
JBrowse link
G F13a1 coagulation factor XIII, A1 subunit decreases expression EXP
ISO
Pravastatin results in decreased expression of F13A1 mRNA CTD PMID:27225895 NCBI chr13:37,051,150...37,234,220
Ensembl chr13:37,051,152...37,234,220
JBrowse link
G Fabp1 fatty acid binding protein 1, liver decreases expression EXP Pravastatin results in decreased expression of FABP1 mRNA CTD PMID:27225895 NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007
JBrowse link
G Fabp2 fatty acid binding protein 2, intestinal increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of FABP2 mRNA
Pravastatin results in decreased expression of FABP2 mRNA
CTD PMID:27225895 NCBI chr 3:122,688,721...122,693,155
Ensembl chr 3:122,688,721...122,693,155
JBrowse link
G Fabp5 fatty acid binding protein 5, epidermal increases expression ISO
EXP
Pravastatin results in increased expression of FABP5 mRNA CTD PMID:27225895 NCBI chr 3:10,077,645...10,081,670
Ensembl chr 3:10,077,608...10,081,667
JBrowse link
G Far1 fatty acyl CoA reductase 1 increases expression EXP
ISO
Pravastatin results in increased expression of FAR1 mRNA CTD PMID:27225895 NCBI chr 7:113,113,008...113,170,713
Ensembl chr 7:113,113,041...113,170,718
JBrowse link
G Fbn1 fibrillin 1 increases expression EXP Pravastatin results in increased expression of FBN1 mRNA CTD PMID:27225895 NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913
JBrowse link
G Fbp2 fructose bisphosphatase 2 affects expression ISO Pravastatin affects the expression of FBP2 mRNA CTD PMID:27225895 NCBI chr13:62,984,698...63,006,214
Ensembl chr13:62,984,691...63,006,236
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 affects activity ISO Pravastatin affects the activity of FDFT1 protein CTD PMID:8517861 NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027
JBrowse link
G Fgd2 FYVE, RhoGEF and PH domain containing 2 decreases expression EXP
ISO
Pravastatin results in decreased expression of FGD2 mRNA CTD PMID:27225895 NCBI chr17:29,579,878...29,598,509
Ensembl chr17:29,579,888...29,598,635
JBrowse link
G Fgf13 fibroblast growth factor 13 affects expression
increases expression
ISO
EXP
Pravastatin affects the expression of FGF13 mRNA
Pravastatin results in increased expression of FGF13 mRNA
CTD PMID:27225895 NCBI chr  X:58,107,499...58,630,932
Ensembl chr  X:58,107,505...58,613,431
JBrowse link
G Flacc1 flagellum associated containing coiled-coil domains 1 increases expression EXP
ISO
Pravastatin results in increased expression of FLACC1 mRNA CTD PMID:27225895 NCBI chr 1:58,696,085...58,735,167
Ensembl chr 1:58,686,062...58,735,148
JBrowse link
G Flot1 flotillin 1 decreases expression EXP Pravastatin results in decreased expression of FLOT1 protein CTD PMID:12628479 NCBI chr17:36,134,243...36,143,674
Ensembl chr17:36,134,122...36,143,683
JBrowse link
G Folr2 folate receptor beta decreases expression ISO
EXP
Pravastatin results in decreased expression of FOLR2 mRNA CTD PMID:27225895 NCBI chr 7:101,489,195...101,506,397
Ensembl chr 7:101,489,195...101,506,401
JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation EXP Pravastatin results in decreased phosphorylation of FOXO1 protein CTD PMID:33034787 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
JBrowse link
G Gck glucokinase decreases expression ISO Pravastatin results in decreased expression of GCK mRNA CTD PMID:27225895 NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of GCLC mRNA
Pravastatin results in decreased expression of GCLC mRNA
CTD PMID:27225895 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of GCNT2 mRNA
Pravastatin results in increased expression of GCNT2 mRNA
CTD PMID:27225895 NCBI chr13:41,013,417...41,114,368
Ensembl chr13:41,013,230...41,114,368
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO Pravastatin inhibits the reaction [lopinavir-ritonavir drug combination results in increased activity of GLB1 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein] CTD PMID:20884875 NCBI chr 9:114,230,146...114,303,447
Ensembl chr 9:114,230,144...114,303,966
JBrowse link
G Gldc glycine decarboxylase decreases expression EXP
ISO
Pravastatin results in decreased expression of GLDC mRNA CTD PMID:27225895 NCBI chr19:30,075,847...30,152,829
Ensembl chr19:30,075,847...30,152,829
JBrowse link
G Gls2 glutaminase 2 (liver, mitochondrial) decreases expression EXP
ISO
Pravastatin results in decreased expression of GLS2 mRNA CTD PMID:27225895 NCBI chr10:128,030,504...128,045,873
Ensembl chr10:128,030,326...128,045,873
JBrowse link
G Gpr85 G protein-coupled receptor 85 increases expression ISO
EXP
Pravastatin results in increased expression of GPR85 mRNA CTD PMID:27225895 NCBI chr 6:13,834,405...13,839,951
Ensembl chr 6:13,834,457...13,839,941
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of GSTK1 mRNA CTD PMID:27225895 NCBI chr 6:42,222,869...42,227,375
Ensembl chr 6:42,222,869...42,227,381
JBrowse link
G Hadh hydroxyacyl-Coenzyme A dehydrogenase decreases expression ISO
EXP
Pravastatin results in decreased expression of HADH mRNA CTD PMID:27225895 NCBI chr 3:131,027,068...131,065,750
Ensembl chr 3:131,027,068...131,065,750
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha decreases expression ISO
EXP
Pravastatin results in decreased expression of HADHA mRNA CTD PMID:27225895 NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression EXP
ISO
Pravastatin results in decreased expression of HADHB mRNA CTD PMID:27225895 NCBI chr 5:30,360,251...30,389,591
Ensembl chr 5:30,360,246...30,389,591
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression ISO
EXP
Pravastatin results in increased expression of HAMP mRNA CTD PMID:27225895 NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457
JBrowse link
G Hax1 HCLS1 associated X-1 multiple interactions ISO Pravastatin inhibits the reaction [Carboplatin results in decreased expression of HAX1 protein] CTD PMID:18483861 NCBI chr 3:89,902,753...89,906,023
Ensembl chr 3:89,902,753...89,906,087
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase decreases response to substance
increases expression
decreases activity
affects expression
ISO
EXP
HMGCR gene SNP results in decreased susceptibility to Pravastatin
Pravastatin results in increased expression of HMGCR mRNA
Pravastatin results in decreased activity of HMGCR protein
Pravastatin affects the expression of HMGCR mRNA
CTD PMID:8517861 PMID:8593127 PMID:15199031 PMID:27225895 PMID:29969672 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 increases expression EXP Pravastatin results in increased expression of HMGCS1 mRNA CTD PMID:27225895 NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
[[Pravastatin co-treated with pirinixic acid] co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA; [Pravastatin co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA; [Pravastatin co-treated with pirinixic acid] results in increased expression of HMOX1 mRNA; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Pravastatin results in increased expression of HMOX1 protein]; Pravastatin promotes the reaction [PPARA protein binds to HMOX1 promoter] CTD PMID:20368269 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hopx HOP homeobox decreases expression EXP
ISO
Pravastatin results in decreased expression of HOPX mRNA CTD PMID:27225895 NCBI chr 5:77,234,831...77,262,970
Ensembl chr 5:77,234,835...77,262,968
JBrowse link
G Hrg histidine-rich glycoprotein decreases expression ISO
EXP
Pravastatin results in decreased expression of HRG mRNA CTD PMID:27225895 NCBI chr16:22,769,822...22,780,409
Ensembl chr16:22,769,822...22,780,406
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression ISO
EXP
Pravastatin results in increased expression of HSD17B7 mRNA CTD PMID:27225895 NCBI chr 1:169,777,109...169,796,757
Ensembl chr 1:169,777,104...169,796,810
JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of HSDL2 mRNA
Pravastatin results in decreased expression of HSDL2 mRNA
CTD PMID:27225895 NCBI chr 4:59,581,515...59,618,694
Ensembl chr 4:59,581,563...59,618,689
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase increases expression ISO
EXP
Pravastatin results in increased expression of IDI1 mRNA CTD PMID:27225895 NCBI chr13:8,935,642...8,942,432
Ensembl chr13:8,935,537...8,942,487
JBrowse link
G Ifnb1 interferon beta 1, fibroblast multiple interactions EXP Pravastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Pravastatin inhibits the reaction [Palmitic Acid results in increased expression of IFNB1 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA] CTD PMID:18323514 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011
JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of IL1B mRNA
Pravastatin results in decreased expression of IL1B mRNA
CTD PMID:27225895 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
EXP
ISO
Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]; Pravastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Pravastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Pravastatin inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]; Pravastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]
Pravastatin inhibits the reaction [lopinavir-ritonavir drug combination results in increased secretion of IL6 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of IL6 protein]
Pravastatin results in decreased expression of IL6 protein
CTD PMID:17729120 PMID:18323514 PMID:19330073 PMID:20884875 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Ins1 insulin I multiple interactions
increases response to substance
EXP
ISO
[LDLR gene mutant form results in increased susceptibility to Pravastatin] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of INS1 protein
[INS1 protein co-treated with Pravastatin] inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein]; [INS1 protein co-treated with Pravastatin] inhibits the reaction [Streptozocin results in increased expression of ACE protein]
[LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in increased susceptibility to INS1 protein
CTD PMID:26875785 PMID:29682576 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions EXP Pravastatin inhibits the reaction [Palmitic Acid results in increased phosphorylation of IRF3 protein] CTD PMID:18323514 NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272
JBrowse link
G Itga2 integrin alpha 2 multiple interactions ISO geranylgeraniol inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein] CTD PMID:12500026 NCBI chr13:114,969,617...115,068,588
Ensembl chr13:114,969,617...115,068,636
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) multiple interactions ISO geranylgeraniol inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein] CTD PMID:12500026 NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681
JBrowse link
G Itgb6 integrin beta 6 affects expression EXP Pravastatin affects the expression of ITGB6 mRNA CTD PMID:27225895 NCBI chr 2:60,428,636...60,553,005
Ensembl chr 2:60,428,636...60,552,987
JBrowse link
G Kcns3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 increases expression ISO
EXP
Pravastatin results in increased expression of KCNS3 mRNA CTD PMID:27225895 NCBI chr12:11,140,738...11,201,186
Ensembl chr12:11,140,203...11,201,057
JBrowse link
G Kctd12 potassium channel tetramerisation domain containing 12 decreases expression ISO
EXP
Pravastatin results in decreased expression of KCTD12 mRNA CTD PMID:27225895 NCBI chr14:103,214,017...103,220,073
Ensembl chr14:103,214,017...103,220,073
JBrowse link
G Kif20a kinesin family member 20A affects expression
decreases expression
EXP
ISO
Pravastatin affects the expression of KIF20A mRNA
Pravastatin results in decreased expression of KIF20A mRNA
CTD PMID:27225895 NCBI chr18:34,757,677...34,766,330
Ensembl chr18:34,757,666...34,766,330
JBrowse link
G Kif20b kinesin family member 20B affects expression
decreases expression
EXP
ISO
Pravastatin affects the expression of KIF20B mRNA
Pravastatin results in decreased expression of KIF20B mRNA
CTD PMID:27225895 NCBI chr19:34,899,735...34,953,150
Ensembl chr19:34,899,761...34,953,145
JBrowse link
G Kif23 kinesin family member 23 decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of KIF23 mRNA
Pravastatin affects the expression of KIF23 mRNA
CTD PMID:27225895 NCBI chr 9:61,824,559...61,854,078
Ensembl chr 9:61,823,187...61,854,056
JBrowse link
G Kitl kit ligand affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of KITL mRNA
Pravastatin results in increased expression of KITLG mRNA
CTD PMID:27225895 NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278
JBrowse link
G Klb klotho beta decreases expression EXP
ISO
Pravastatin results in decreased expression of KLB mRNA CTD PMID:27225895 NCBI chr 5:65,505,754...65,544,300
Ensembl chr 5:65,505,657...65,541,350
JBrowse link
G Krt23 keratin 23 decreases expression EXP
ISO
Pravastatin results in decreased expression of KRT23 mRNA CTD PMID:27225895 NCBI chr11:99,368,799...99,383,946
Ensembl chr11:99,368,800...99,383,963
JBrowse link
G Ldlr low density lipoprotein receptor increases activity
increases response to substance
multiple interactions
ISO
EXP
Pravastatin results in increased activity of LDLR protein
[LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in increased susceptibility to INS1 protein; LDLR gene mutant form results in increased susceptibility to Pravastatin
[LDLR gene mutant form results in increased susceptibility to Pravastatin] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which affects the expression of BAX protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which affects the expression of BCL2 protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of INS1 protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of SNAP25 protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of STX1A protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of VAMP2 protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in increased cleavage of CASP3 protein
CTD PMID:8593127 PMID:26875785 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
JBrowse link
G Lep leptin multiple interactions EXP Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]; Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]; Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA] CTD PMID:18323514 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
JBrowse link
G Lgals4 lectin, galactose binding, soluble 4 decreases expression
increases expression
EXP
ISO
Pravastatin results in decreased expression of LGALS4 mRNA
Pravastatin results in increased expression of LGALS4 mRNA
CTD PMID:27225895 NCBI chr 7:28,533,559...28,541,128
Ensembl chr 7:28,533,279...28,541,133
JBrowse link
G Lgi2 leucine-rich repeat LGI family, member 2 increases expression ISO
EXP
Pravastatin results in increased expression of LGI2 mRNA CTD PMID:27225895 NCBI chr 5:52,690,859...52,723,689
Ensembl chr 5:52,690,859...52,723,804
JBrowse link
G Lmna lamin A increases expression ISO Pravastatin results in increased expression of LMNA protein CTD PMID:20884875 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263
JBrowse link
G Lpl lipoprotein lipase decreases expression ISO
EXP
Pravastatin results in decreased expression of LPL mRNA CTD PMID:27225895 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100
JBrowse link
G Lrmda leucine rich melanocyte differentiation associated decreases expression EXP Pravastatin results in decreased expression of LRMDA mRNA CTD PMID:27225895 NCBI chr14:22,069,567...23,106,161
Ensembl chr14:22,069,780...23,106,153
JBrowse link
G Lss lanosterol synthase increases expression ISO
EXP
Pravastatin results in increased expression of LSS mRNA CTD PMID:27225895 NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972
JBrowse link
G Ltbp2 latent transforming growth factor beta binding protein 2 increases expression EXP
ISO
Pravastatin results in increased expression of LTBP2 mRNA CTD PMID:27225895 NCBI chr12:84,829,986...84,923,581
Ensembl chr12:84,829,986...84,923,306
JBrowse link
G Ly86 lymphocyte antigen 86 decreases expression EXP
ISO
Pravastatin results in decreased expression of LY86 mRNA CTD PMID:27225895 NCBI chr13:37,529,276...37,603,012
Ensembl chr13:37,529,184...37,603,012
JBrowse link
G Mapt microtubule-associated protein tau affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of MAPT
Pravastatin results in decreased expression of MAPT mRNA
CTD PMID:19461118 PMID:27225895 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Mastl microtubule associated serine/threonine kinase-like decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of MASTL mRNA
Pravastatin affects the expression of MASTL mRNA
CTD PMID:27225895 NCBI chr 2:23,006,549...23,046,036
Ensembl chr 2:23,005,618...23,046,036
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 increases phosphorylation
increases expression
multiple interactions
ISO Pravastatin results in increased phosphorylation of MDM2 protein
Pravastatin results in increased expression of MDM2 protein
[Pravastatin results in increased phosphorylation of MDM2 protein] which results in increased degradation of TP53 protein; Sirolimus inhibits the reaction [Pravastatin results in increased phosphorylation of MDM2 protein]; U 0126 inhibits the reaction [Pravastatin results in increased phosphorylation of MDM2 protein]
CTD PMID:15625077 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
JBrowse link
G Meiob meiosis specific with OB domains increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of MEIOB mRNA
Pravastatin results in decreased expression of MEIOB mRNA
CTD PMID:27225895 NCBI chr17:25,023,275...25,058,762
Ensembl chr17:25,023,263...25,058,762
JBrowse link
G Mgll monoglyceride lipase affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of MGLL mRNA
Pravastatin results in decreased expression of MGLL mRNA
CTD PMID:27225895 NCBI chr 6:88,701,397...88,805,342
Ensembl chr 6:88,701,394...88,805,342
JBrowse link
G Miox myo-inositol oxygenase decreases expression EXP Pravastatin results in decreased expression of MIOX mRNA CTD PMID:27225895 NCBI chr15:89,218,676...89,221,210
Ensembl chr15:89,218,601...89,221,218
JBrowse link
G Mis18a MIS18 kinetochore protein A decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of MIS18A mRNA
Pravastatin results in increased expression of MIS18A mRNA
CTD PMID:27225895 NCBI chr16:90,516,200...90,524,259
Ensembl chr16:90,516,200...90,524,292
JBrowse link
G Mlycd malonyl-CoA decarboxylase decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of MLYCD mRNA
Pravastatin affects the expression of MLYCD mRNA
CTD PMID:27225895 NCBI chr 8:120,121,591...120,148,577
Ensembl chr 8:120,121,617...120,137,841
JBrowse link
G Mme membrane metallo endopeptidase affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of MME mRNA
Pravastatin results in decreased expression of MME mRNA
CTD PMID:27225895 NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451
JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) decreases expression ISO Pravastatin results in decreased expression of MMP14 mRNA CTD PMID:16935385 NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity
decreases expression
ISO Pravastatin results in decreased activity of MMP2 protein
Pravastatin results in decreased expression of MMP2 mRNA
CTD PMID:16935385 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp3 matrix metallopeptidase 3 affects response to substance ISO MMP3 promoter polymorphism affects the susceptibility to Pravastatin CTD PMID:8662692 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
decreases expression
ISO Pravastatin results in decreased activity of MMP9 protein
Pravastatin results in decreased expression of MMP9 mRNA
CTD PMID:16935385 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mss51 MSS51 mitochondrial translational activator decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of MSS51 mRNA
Pravastatin results in increased expression of MSS51 mRNA
CTD PMID:27225895 NCBI chr14:20,532,925...20,546,969
Ensembl chr14:20,532,935...20,546,969
JBrowse link
G Mstn myostatin increases expression EXP Pravastatin results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 1:53,100,799...53,107,238
Ensembl chr 1:53,100,799...53,107,238
JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation ISO Pravastatin results in increased phosphorylation of MTOR protein CTD PMID:15625077 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Mvd mevalonate (diphospho) decarboxylase increases expression ISO
EXP
Pravastatin results in increased expression of MVD mRNA CTD PMID:27225895 NCBI chr 8:123,160,335...123,170,161
Ensembl chr 8:123,160,340...123,170,161
JBrowse link
G Nfe2 nuclear factor, erythroid derived 2 increases expression ISO
EXP
Pravastatin results in increased expression of NFE2 mRNA CTD PMID:27225895 NCBI chr15:103,156,640...103,166,809
Ensembl chr15:103,156,639...103,166,830
JBrowse link
G Nnmt nicotinamide N-methyltransferase decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of NNMT mRNA
Pravastatin results in increased expression of NNMT protein
Pravastatin results in increased expression of NNMT mRNA
CTD PMID:27225895 PMID:33073877 NCBI chr 9:48,448,905...48,518,958
Ensembl chr 9:48,503,177...48,516,453
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP Pravastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Pravastatin inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA] CTD PMID:18323514 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions
increases phosphorylation
ISO [resveratrol co-treated with Pravastatin] results in increased phosphorylation of NOS3 protein; Pravastatin promotes the reaction [NOS3 protein binds to NOS3 protein]; Pravastatin promotes the reaction [olmesartan results in increased activity of and results in increased phosphorylation of NOS3 protein]; Pravastatin results in increased activity of and results in increased phosphorylation of NOS3 protein
Pravastatin results in increased phosphorylation of NOS3 protein
CTD PMID:17170375 PMID:17188708 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO
EXP
Pravastatin results in decreased expression of NR0B2 mRNA CTD PMID:27225895 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like increases expression ISO
EXP
Pravastatin results in increased expression of NSDHL mRNA CTD PMID:27225895 NCBI chr  X:71,962,127...72,002,134
Ensembl chr  X:71,962,163...72,002,120
JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 increases expression EXP Pravastatin results in increased expression of OLR1 mRNA CTD PMID:27225895 NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128
JBrowse link
G Orc1 origin recognition complex, subunit 1 decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of ORC1 mRNA
Pravastatin affects the expression of ORC1 mRNA
CTD PMID:27225895 NCBI chr 4:108,436,651...108,472,030
Ensembl chr 4:108,436,620...108,472,030
JBrowse link
G P2ry10b purinergic receptor P2Y, G-protein coupled 10B affects expression EXP
ISO
Pravastatin affects the expression of P2RY10B mRNA CTD PMID:27225895 NCBI chr  X:106,192,533...106,217,268
Ensembl chr  X:106,192,533...106,217,267
JBrowse link
G Pcdhb5 protocadherin beta 5 increases expression EXP
ISO
Pravastatin results in increased expression of PCDHB4 mRNA CTD PMID:27225895 NCBI chr18:37,453,434...37,456,966
Ensembl chr18:37,453,434...37,456,968
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression EXP
ISO
Pravastatin results in increased expression of PCSK9 mRNA CTD PMID:27225895 NCBI chr 4:106,299,531...106,321,522
Ensembl chr 4:106,299,526...106,321,526
JBrowse link
G Pctp phosphatidylcholine transfer protein decreases expression EXP Pravastatin results in decreased expression of PCTP mRNA CTD PMID:27225895 NCBI chr11:89,873,370...89,893,720
Ensembl chr11:89,873,491...89,893,720
JBrowse link
G Pde4a phosphodiesterase 4A, cAMP specific decreases expression
increases expression
EXP
ISO
Pravastatin results in decreased expression of PDE4A mRNA
Pravastatin results in increased expression of PDE4A mRNA
CTD PMID:27225895 NCBI chr 9:21,076,998...21,124,544
Ensembl chr 9:21,077,010...21,124,544
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 affects expression
increases expression
ISO
EXP
Pravastatin affects the expression of PDK4 mRNA
Pravastatin results in increased expression of PDK4 mRNA
CTD PMID:27225895 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase decreases expression EXP
ISO
Pravastatin results in decreased expression of PEMT mRNA CTD PMID:27225895 NCBI chr11:59,861,440...59,937,394
Ensembl chr11:59,861,440...59,937,315
JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha decreases expression EXP
ISO
Pravastatin results in decreased expression of PEX11A mRNA CTD PMID:27225895 NCBI chr 7:79,385,705...79,392,879
Ensembl chr 7:79,385,705...79,392,879
JBrowse link
G Pf4 platelet factor 4 decreases expression ISO
EXP
Pravastatin results in decreased expression of PF4 mRNA CTD PMID:27225895 NCBI chr 5:90,920,362...90,921,242
Ensembl chr 5:90,920,294...90,921,242
JBrowse link
G Pla2r1 phospholipase A2 receptor 1 increases expression ISO
EXP
Pravastatin results in increased expression of PLA2R1 mRNA CTD PMID:27225895 NCBI chr 2:60,247,887...60,383,669
Ensembl chr 2:60,247,887...60,383,652
JBrowse link
G Plppr1 phospholipid phosphatase related 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of PLPPR1 mRNA CTD PMID:27225895 NCBI chr 4:49,054,986...49,340,261
Ensembl chr 4:49,059,273...49,340,259
JBrowse link
G Pmvk phosphomevalonate kinase increases expression ISO
EXP
Pravastatin results in increased expression of PMVK mRNA CTD PMID:27225895 NCBI chr 3:89,361,848...89,376,321
Ensembl chr 3:89,361,848...89,376,320
JBrowse link
G Pnpla7 patatin-like phospholipase domain containing 7 decreases expression EXP
ISO
Pravastatin results in decreased expression of PNPLA7 mRNA CTD PMID:27225895 NCBI chr 2:24,865,235...24,944,084
Ensembl chr 2:24,866,045...24,944,069
JBrowse link
G Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of POLE2 mRNA
Pravastatin affects the expression of POLE2 mRNA
CTD PMID:27225895 NCBI chr12:69,248,547...69,274,979
Ensembl chr12:69,248,547...69,274,969
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression
multiple interactions
affects localization
EXP
ISO
Pravastatin results in increased expression of PPARA protein
Pravastatin promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]
Pravastatin affects the localization of PPARA protein
[[Pravastatin co-treated with pirinixic acid] co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA; [Pravastatin co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Pravastatin affects the localization of PPARA protein]; Pravastatin promotes the reaction [PPARA protein binds to HMOX1 promoter]
CTD PMID:18812576 PMID:20368269 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO Pravastatin inhibits the reaction [[troglitazone binds to and results in increased activity of PPARG protein] which results in increased abundance of Cholesterol] CTD PMID:12044893 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppm1j protein phosphatase 1J decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of PPM1J mRNA
Pravastatin results in increased expression of PPM1J mRNA
CTD PMID:27225895 NCBI chr 3:104,688,322...104,693,334
Ensembl chr 3:104,688,372...104,693,334
JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit increases activity ISO Pravastatin results in increased activity of PRKAA1 protein CTD PMID:33073877 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380
JBrowse link
G Prnd prion like protein doppel decreases expression EXP
ISO
Pravastatin results in decreased expression of PRND mRNA CTD PMID:27225895 NCBI chr 2:131,792,781...131,798,051
Ensembl chr 2:131,792,781...131,798,050
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Pravastatin results in increased expression of PTGS2 protein CTD PMID:20368269 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Ptprn protein tyrosine phosphatase receptor type N affects expression
increases expression
ISO
EXP
Pravastatin affects the expression of PTPRN mRNA
Pravastatin results in increased expression of PTPRN mRNA
CTD PMID:27225895 NCBI chr 1:75,223,679...75,241,437
Ensembl chr 1:75,223,671...75,241,146
JBrowse link
G Rdh11 retinol dehydrogenase 11 increases expression ISO
EXP
Pravastatin results in increased expression of RDH11 mRNA CTD PMID:27225895 NCBI chr12:79,221,007...79,238,629
Ensembl chr12:79,221,111...79,239,067
JBrowse link
G Reep1 receptor accessory protein 1 affects expression
increases expression
ISO
EXP
Pravastatin affects the expression of REEP1 mRNA
Pravastatin results in increased expression of REEP1 mRNA
CTD PMID:27225895 NCBI chr 6:71,684,413...71,787,694
Ensembl chr 6:71,684,545...71,787,694
JBrowse link
G Retsat retinol saturase (all trans retinol 13,14 reductase) decreases expression ISO
EXP
Pravastatin results in decreased expression of RETSAT mRNA CTD PMID:27225895 NCBI chr 6:72,575,585...72,584,471
Ensembl chr 6:72,575,458...72,585,408
JBrowse link
G Rgs16 regulator of G-protein signaling 16 decreases expression ISO
EXP
Pravastatin results in decreased expression of RGS16 mRNA CTD PMID:27225895 NCBI chr 1:153,616,099...153,621,212
Ensembl chr 1:153,616,095...153,621,214
JBrowse link
G Rnf186 ring finger protein 186 decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of RNF186 mRNA
Pravastatin affects the expression of RNF186 mRNA
CTD PMID:27225895 NCBI chr 4:138,694,430...138,695,676
Ensembl chr 4:138,694,423...138,695,676
JBrowse link
G Rragd Ras-related GTP binding D decreases expression EXP Pravastatin results in decreased expression of RRAGD mRNA CTD PMID:27225895 NCBI chr 4:32,982,998...33,022,180
Ensembl chr 4:32,983,037...33,022,180
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO [[Pravastatin co-treated with pirinixic acid] co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA; [Pravastatin co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA CTD PMID:20368269 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969
JBrowse link
G S100a4 S100 calcium binding protein A4 increases expression
affects expression
EXP
ISO
Pravastatin results in increased expression of S100A4 mRNA
Pravastatin affects the expression of S100A4 mRNA
CTD PMID:27225895 NCBI chr 3:90,511,077...90,513,349
Ensembl chr 3:90,511,078...90,513,352
JBrowse link
G S100g S100 calcium binding protein G decreases expression ISO
EXP
Pravastatin results in decreased expression of S100G mRNA CTD PMID:27225895 NCBI chr  X:161,744,988...161,747,595
Ensembl chr  X:161,744,988...161,747,595
JBrowse link
G Sat2 spermidine/spermine N1-acetyl transferase 2 decreases expression EXP
ISO
Pravastatin results in decreased expression of SAT2 mRNA CTD PMID:27225895 NCBI chr11:69,512,824...69,514,857
Ensembl chr11:69,512,850...69,514,696
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 increases expression ISO Pravastatin results in increased expression of SCD mRNA CTD PMID:27225895 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression EXP Pravastatin results in increased expression of SCD2 mRNA CTD PMID:27225895 NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303
JBrowse link
G Selp selectin, platelet decreases expression ISO Pravastatin results in decreased expression of SELP protein CTD PMID:11189483 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595
JBrowse link
G Serpinb1a serine (or cysteine) peptidase inhibitor, clade B, member 1a decreases expression ISO
EXP
Pravastatin results in decreased expression of SERPINB1A mRNA CTD PMID:27225895 NCBI chr13:33,026,075...33,037,189
Ensembl chr13:33,026,075...33,035,168
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 increases expression EXP Pravastatin results in increased expression of SFRP1 mRNA CTD PMID:27225895 NCBI chr 8:23,901,401...23,939,648
Ensembl chr 8:23,901,518...23,939,648
JBrowse link
G Shisa4 shisa family member 4 increases expression ISO
EXP
Pravastatin results in increased expression of SHISA4 mRNA CTD PMID:27225895 NCBI chr 1:135,298,578...135,302,812
Ensembl chr 1:135,298,795...135,302,975
JBrowse link
G Sirt1 sirtuin 1 increases phosphorylation ISO Pravastatin results in increased phosphorylation of SIRT1 protein CTD PMID:33073877 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of SLC10A1 mRNA CTD PMID:27225895 NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479
JBrowse link
G Slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 decreases expression EXP Pravastatin results in decreased expression of SLC13A3 mRNA CTD PMID:27225895 NCBI chr 2:165,247,215...165,315,117
Ensembl chr 2:165,246,948...165,315,150
JBrowse link
G Slc15a3 solute carrier family 15, member 3 decreases expression ISO
EXP
Pravastatin results in decreased expression of SLC15A3 mRNA CTD PMID:27225895 NCBI chr19:10,819,908...10,835,279
Ensembl chr19:10,817,091...10,836,726
JBrowse link
G Slc16a5 solute carrier family 16 (monocarboxylic acid transporters), member 5 decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of SLC16A5 mRNA
Pravastatin affects the expression of SLC16A5 mRNA
CTD PMID:27225895 NCBI chr11:115,353,231...115,365,224
Ensembl chr11:115,353,300...115,365,224
JBrowse link
G Slc17a1 solute carrier family 17 (sodium phosphate), member 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of SLC17A1 mRNA CTD PMID:27225895 NCBI chr13:24,051,607...24,079,713
Ensembl chr13:24,051,733...24,079,713
JBrowse link
G Slc17a3 solute carrier family 17 (sodium phosphate), member 3 decreases expression EXP
ISO
Pravastatin results in decreased expression of SLC17A3 mRNA CTD PMID:27225895 NCBI chr13:24,020,905...24,044,701
Ensembl chr13:24,023,417...24,044,699
JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of SLC22A5 mRNA
Pravastatin affects the expression of SLC22A5 mRNA
CTD PMID:27225895 NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486
JBrowse link
G Slc23a1 solute carrier family 23 (nucleobase transporters), member 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of SLC23A1 mRNA CTD PMID:27225895 NCBI chr18:35,747,657...35,762,900
Ensembl chr18:35,747,657...35,760,297
JBrowse link
G Slc25a20 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 decreases expression EXP Pravastatin results in decreased expression of SLC25A20 mRNA CTD PMID:27225895 NCBI chr 9:108,539,335...108,561,841
Ensembl chr 9:108,539,287...108,561,840
JBrowse link
G Slc25a34 solute carrier family 25, member 34 affects expression ISO Pravastatin affects the expression of SLC25A34 mRNA CTD PMID:27225895 NCBI chr 4:141,346,130...141,351,202
Ensembl chr 4:141,346,135...141,351,132
JBrowse link
G Slc25a42 solute carrier family 25, member 42 decreases expression ISO
EXP
Pravastatin results in decreased expression of SLC25A42 mRNA CTD PMID:27225895 NCBI chr 8:70,636,990...70,664,931
Ensembl chr 8:70,636,990...70,664,955
JBrowse link
G Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 decreases expression EXP
ISO
Pravastatin results in decreased expression of SLC27A2 mRNA CTD PMID:27225895 NCBI chr 2:126,394,944...126,430,163
Ensembl chr 2:126,394,327...126,430,163
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 decreases expression ISO
EXP
Pravastatin results in decreased expression of SLC2A4 mRNA CTD PMID:27225895 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014
JBrowse link
G Slc34a2 solute carrier family 34 (sodium phosphate), member 2 decreases expression ISO
EXP
Pravastatin results in decreased expression of SLC34A2 mRNA CTD PMID:27225895 NCBI chr 5:53,206,695...53,229,006
Ensembl chr 5:53,195,423...53,229,006
JBrowse link
G Slc9b2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 increases expression
affects expression
EXP
ISO
Pravastatin results in increased expression of SLC9B2 mRNA
Pravastatin affects the expression of SLC9B2 mRNA
CTD PMID:27225895 NCBI chr 3:135,013,083...135,048,606
Ensembl chr 3:135,013,461...135,051,148
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects transport
decreases expression
EXP
ISO
SLCO1A4 protein affects the transport of Pravastatin
Pravastatin results in decreased expression of SLCO1A4 protein
CTD PMID:19833843 PMID:24909372 NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925
JBrowse link
G Slco1a5 solute carrier organic anion transporter family, member 1a5 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of SLCO1A5 mRNA
Pravastatin results in decreased expression of SLCO1A5 mRNA
CTD PMID:27225895 NCBI chr 6:142,179,953...142,268,707
Ensembl chr 6:142,179,953...142,268,707
JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions ISO Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]; Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein] CTD PMID:21430235 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Pravastatin inhibits the reaction [SLCO2B1 protein results in increased uptake of Mesalamine]; Pravastatin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein] CTD PMID:21430235 NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547
JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 increases expression ISO
EXP
Pravastatin results in increased expression of SLCO4A1 mRNA CTD PMID:27225895 NCBI chr 2:180,098,019...180,116,646
Ensembl chr 2:180,098,038...180,116,660
JBrowse link
G Smim3 small integral membrane protein 3 increases expression EXP Pravastatin results in increased expression of SMIM3 mRNA CTD PMID:27225895 NCBI chr18:60,607,263...60,635,055
Ensembl chr18:60,607,263...60,635,059
JBrowse link
G Snap25 synaptosomal-associated protein 25 multiple interactions EXP [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of SNAP25 protein CTD PMID:26875785 NCBI chr 2:136,555,359...136,624,348
Ensembl chr 2:136,555,373...136,624,348
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP Pravastatin results in increased expression of SOCS3 protein CTD PMID:19330073 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873
JBrowse link
G Spag5 sperm associated antigen 5 affects expression
decreases expression
EXP
ISO
Pravastatin affects the expression of SPAG5 mRNA
Pravastatin results in decreased expression of SPAG5 mRNA
CTD PMID:27225895 NCBI chr11:78,192,412...78,213,283
Ensembl chr11:78,192,355...78,213,283
JBrowse link
G Spic Spi-C transcription factor (Spi-1/PU.1 related) decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of SPIC mRNA
Pravastatin results in increased expression of SPIC mRNA
CTD PMID:27225895 NCBI chr10:88,511,131...88,518,885
Ensembl chr10:88,510,634...88,520,877
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression EXP Pravastatin results in decreased expression of SRD5A2 mRNA CTD PMID:27225895 NCBI chr17:74,321,886...74,354,855
Ensembl chr17:74,323,950...74,354,911
JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 decreases expression EXP
ISO
Pravastatin results in decreased expression of ST8SIA3 mRNA CTD PMID:27225895 NCBI chr18:64,387,430...64,409,217
Ensembl chr18:64,387,430...64,412,682
JBrowse link
G Stard4 StAR related lipid transfer domain containing 4 increases expression ISO
EXP
Pravastatin results in increased expression of STARD4 mRNA CTD PMID:27225895 NCBI chr18:33,332,191...33,346,937
Ensembl chr18:33,332,408...33,346,915
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions EXP Pravastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:18323514 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation EXP Pravastatin results in decreased phosphorylation of STAT3 protein CTD PMID:19330073 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Stx1a syntaxin 1A (brain) multiple interactions EXP [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of STX1A protein CTD PMID:26875785 NCBI chr 5:135,051,473...135,079,954
Ensembl chr 5:135,052,336...135,079,954
JBrowse link
G Sult1c2 sulfotransferase family, cytosolic, 1C, member 2 decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of SULT1C2 mRNA
Pravastatin affects the expression of SULT1C2 mRNA
CTD PMID:27225895 NCBI chr17:54,136,665...54,152,986
Ensembl chr17:54,136,665...54,153,367
JBrowse link
G Sult1e1 sulfotransferase family 1E, member 1 decreases expression EXP Pravastatin results in decreased expression of SULT1E1 mRNA CTD PMID:27225895 NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453
JBrowse link
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of SULT2A1 mRNA CTD PMID:27225895 NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334
JBrowse link
G Tex12 testis expressed 12 decreases expression ISO
EXP
Pravastatin results in decreased expression of TEX12 mRNA CTD PMID:27225895 NCBI chr 9:50,468,448...50,472,568
Ensembl chr 9:50,468,119...50,472,625
JBrowse link
G Thbd thrombomodulin increases expression
affects expression
EXP
ISO
Pravastatin results in increased expression of THBD mRNA
Pravastatin affects the expression of THBD mRNA
CTD PMID:27225895 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 decreases expression ISO Pravastatin results in decreased expression of TIMP1 mRNA CTD PMID:16935385 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 decreases expression ISO Pravastatin results in decreased expression of TIMP2 mRNA CTD PMID:16935385 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566
JBrowse link
G Tlcd4 TLC domain containing 4 decreases expression EXP Pravastatin results in decreased expression of TLCD4 mRNA CTD PMID:27225895 NCBI chr 3:120,995,657...121,076,756
Ensembl chr 3:120,995,410...121,076,747
JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 increases expression EXP
ISO
Pravastatin results in increased expression of TM7SF2 mRNA CTD PMID:27225895 NCBI chr19:6,112,851...6,117,880
Ensembl chr19:6,112,851...6,118,403
JBrowse link
G Tmem139 transmembrane protein 139 increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of TMEM139 mRNA
Pravastatin results in decreased expression of TMEM139 mRNA
CTD PMID:27225895 NCBI chr 6:42,238,866...42,241,489
Ensembl chr 6:42,238,893...42,241,489
JBrowse link
G Tmem164 transmembrane protein 164 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of TMEM164 mRNA
Pravastatin results in decreased expression of TMEM164 mRNA
CTD PMID:27225895 NCBI chr  X:141,463,343...141,626,490
Ensembl chr  X:141,464,402...141,626,490
JBrowse link
G Tmem205 transmembrane protein 205 decreases expression ISO
EXP
Pravastatin results in decreased expression of TMEM205 mRNA CTD PMID:27225895 NCBI chr 9:21,832,305...21,838,831
Ensembl chr 9:21,832,304...21,838,852
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA]; Pravastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Pravastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]; Pravastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]
Pravastatin results in increased expression of TNF mRNA
CTD PMID:17729120 PMID:18323514 PMID:27225895 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfsf18 tumor necrosis factor (ligand) superfamily, member 18 affects expression ISO
EXP
Pravastatin affects the expression of TNFSF18 mRNA CTD PMID:27225895 NCBI chr 1:161,322,221...161,333,903
Ensembl chr 1:161,322,224...161,332,859
JBrowse link
G Tnnt2 troponin T2, cardiac increases expression EXP Pravastatin results in increased expression of TNNT2 mRNA CTD PMID:27225895 NCBI chr 1:135,763,933...135,780,006
Ensembl chr 1:135,764,092...135,779,998
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO [Pravastatin results in increased phosphorylation of MDM2 protein] which results in increased degradation of TP53 protein; Pravastatin inhibits the reaction [Fluorouracil results in decreased degradation of TP53 protein]; Pravastatin inhibits the reaction [leptomycin B results in decreased degradation of TP53 protein]; Pravastatin inhibits the reaction [lopinavir-ritonavir drug combination results in increased expression of TP53 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased expression of TP53 protein]
Pravastatin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
CTD PMID:15625077 PMID:20650967 PMID:20884875 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Tspan13 tetraspanin 13 increases expression ISO
EXP
Pravastatin results in increased expression of TSPAN13 mRNA CTD PMID:27225895 NCBI chr12:36,064,554...36,092,477
Ensembl chr12:36,064,556...36,092,499
JBrowse link
G Ttc41 tetratricopeptide repeat domain 41 decreases expression EXP Pravastatin results in decreased expression of TTC41 mRNA CTD PMID:27225895 NCBI chr10:86,541,675...86,612,708
Ensembl chr10:86,541,675...86,612,708
JBrowse link
G Tuba1a tubulin, alpha 1A increases expression EXP
ISO
Pravastatin results in increased expression of TUBA1A mRNA CTD PMID:27225895 NCBI chr15:98,847,728...98,851,382
Ensembl chr15:98,847,718...98,851,584
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 decreases expression EXP
ISO
Pravastatin results in decreased expression of UGT2B1 mRNA CTD PMID:27225895 NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389
JBrowse link
G Uroc1 urocanase domain containing 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of UROC1 mRNA CTD PMID:27225895 NCBI chr 6:90,310,221...90,341,533
Ensembl chr 6:90,310,266...90,341,533
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 multiple interactions EXP [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of VAMP2 protein CTD PMID:26875785 NCBI chr11:68,979,354...68,983,207
Ensembl chr11:68,979,316...68,983,210
JBrowse link
G Vnn1 vanin 1 decreases expression EXP Pravastatin results in decreased expression of VNN1 mRNA CTD PMID:27225895 NCBI chr10:23,770,586...23,781,242
Ensembl chr10:23,770,586...23,781,241
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of ZC3H12A mRNA
Pravastatin results in increased expression of ZC3H12A mRNA
CTD PMID:27225895 NCBI chr 4:125,012,207...125,021,674
Ensembl chr 4:125,012,216...125,021,633
JBrowse link
simvastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression ISO Simvastatin results in decreased expression of A2M mRNA CTD PMID:16414398 NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186
JBrowse link
G Abca1 ATP-binding cassette, sub-family A member 1 decreases expression
increases expression
ISO
EXP
Simvastatin results in decreased expression of ABCA1; Simvastatin results in decreased expression of ABCA1 mRNA
Simvastatin results in increased expression of ABCA1 mRNA
Simvastatin results in increased expression of ABCA1 mRNA; Simvastatin results in increased expression of ABCA1 protein
CTD PMID:16282522 PMID:18270459 PMID:19383813 PMID:19461118 PMID:21241519 More... NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions
decreases activity
decreases expression
ISO Simvastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Simvastatin results in decreased activity of ABCB11 protein
Simvastatin results in decreased expression of ABCB11 mRNA
CTD PMID:20829430 PMID:23956101 PMID:24014644 PMID:27765674 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A increases transport
multiple interactions
decreases activity
affects response to substance
ISO ABCB1 protein results in increased transport of Simvastatin
ABCB1 alternative form affects the reaction [CYP3A4 polymorphism affects the susceptibility to Simvastatin]; Simvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]
Simvastatin analog results in decreased activity of ABCB1 protein
ABCB1 polymorphism affects the susceptibility to Simvastatin
CTD PMID:15616150 PMID:16321621 PMID:19802823 PMID:19891551 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 increases expression
decreases expression
EXP
ISO
Simvastatin results in increased expression of ABCB4 mRNA
Simvastatin results in decreased expression of ABCB4 mRNA
CTD PMID:21241519 PMID:27765674 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 multiple interactions
decreases activity
affects response to substance
decreases expression
ISO ABCC2 protein binds to and results in increased uptake of Simvastatin analog; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
Simvastatin analog results in decreased activity of ABCC2 protein
ABCC2 polymorphism affects the susceptibility to Simvastatin
Simvastatin results in decreased expression of ABCC2 mRNA
CTD PMID:15616150 PMID:22186618 PMID:23562342 PMID:27765674 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 multiple interactions
increases nitrosation
ISO artemisinin inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein]; parthenolide inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein]; Simvastatin promotes the reaction [Doxorubicin results in increased nitrosation of ABCC3 protein] CTD PMID:18463201 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression EXP
ISO
Simvastatin results in decreased expression of ABCG1 mRNA CTD PMID:19383813 PMID:22120639 NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Simvastatin results in increased expression of ABCG5 mRNA CTD PMID:21241519 NCBI chr17:84,965,602...84,990,439
Ensembl chr17:84,965,662...84,990,439
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression ISO Simvastatin results in decreased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr17:84,983,730...85,007,761
Ensembl chr17:84,983,730...85,007,761
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 decreases expression
multiple interactions
ISO Simvastatin results in decreased expression of ACAA2 mRNA
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of ACAA2 mRNA
CTD PMID:25055962 NCBI chr18:74,912,283...74,939,278
Ensembl chr18:74,912,268...74,939,279
JBrowse link
G Acacb acetyl-Coenzyme A carboxylase beta increases expression ISO Simvastatin results in increased expression of ACACB mRNA CTD PMID:12056585 NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822
JBrowse link
G Acan aggrecan multiple interactions
increases expression
ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of ACAN mRNA]; NOG inhibits the reaction [Simvastatin results in increased expression of ACAN mRNA] CTD PMID:18628692 PMID:19912653 NCBI chr 7:78,702,974...78,764,847
Ensembl chr 7:78,703,231...78,764,847
JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Simvastatin results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions
decreases expression
ISO Simvastatin inhibits the reaction [TGFB1 results in increased expression of ACTA2 mRNA]
Simvastatin results in decreased expression of ACTA2 protein
CTD PMID:15677772 PMID:15855201 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Actb actin, beta increases expression ISO Simvastatin results in increased expression of ACTB mRNA CTD PMID:25055962 NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509
JBrowse link
G Actn4 actinin alpha 4 increases expression ISO Simvastatin results in increased expression of ACTN4 mRNA CTD PMID:16710349 NCBI chr 7:28,592,673...28,661,799
Ensembl chr 7:28,592,673...28,661,765
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP
ISO
Simvastatin promotes the reaction [Lipopolysaccharides results in increased expression of ADIPOQ mRNA]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of ADIPOQ protein]
carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]]; Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]
CTD PMID:17641834 PMID:29071762 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
JBrowse link
G Adora2b adenosine A2b receptor multiple interactions ISO Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of ADORA2B mRNA]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of ADORA2B protein] CTD PMID:33774062 NCBI chr11:62,139,810...62,157,278
Ensembl chr11:62,139,810...62,157,279
JBrowse link
G Adrb1 adrenergic receptor, beta 1 increases expression EXP Simvastatin results in increased expression of ADRB1 mRNA; Simvastatin results in increased expression of ADRB1 protein CTD PMID:19262002 NCBI chr19:56,710,549...56,713,582
Ensembl chr19:56,710,631...56,721,545
JBrowse link
G Afp alpha fetoprotein increases expression ISO Simvastatin results in increased expression of AFP mRNA CTD PMID:10365819 NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions
decreases expression
ISO Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]
Simvastatin results in decreased expression of AGER protein
CTD PMID:17038636 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910
JBrowse link
G Agt angiotensinogen multiple interactions
decreases expression
ISO [Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Simvastatin inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [AGT results in increased activity of RAC1 protein]; Simvastatin promotes the reaction [Glucose promotes the reaction [AGT protein results in increased expression of PTGS2 mRNA]]
Simvastatin results in decreased expression of AGT mRNA
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of PXN protein]]; Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of and affects the localization of PXN protein]; Simvastatin inhibits the reaction [CTF1 results in increased expression of AGT mRNA]
CTD PMID:17513949 PMID:18400235 PMID:18475152 PMID:19100119 PMID:19225232 More... NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression ISO Simvastatin results in decreased expression of AGTR1 mRNA CTD PMID:17513949 PMID:18475152 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 decreases expression ISO Simvastatin results in decreased expression of AKR1C3 mRNA CTD PMID:18192897 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 decreases expression ISO Simvastatin results in decreased expression of AKR1D1 mRNA CTD PMID:25055962 NCBI chr 6:37,506,913...37,551,856
Ensembl chr 6:37,507,108...37,545,750
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases expression
multiple interactions
decreases activity
increases phosphorylation
decreases phosphorylation
ISO
EXP
Simvastatin results in decreased expression of AKT1 mRNA; Simvastatin results in decreased expression of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; [Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein; [Simvastatin co-treated with Metformin] results in decreased phosphorylation of AKT1 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of AKT1 mRNA]; Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]; Simvastatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of AKT1 protein]; Simvastatin results in increased phosphorylation of and results in increased activity of AKT1 protein; Wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]
Simvastatin inhibits the reaction [Glucose results in decreased expression of AKT1 protein modified form]; Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]; Simvastatin inhibits the reaction [Smoke analog results in increased phosphorylation of AKT1 protein]; Simvastatin results in increased phosphorylation of and results in increased activity of AKT1 protein
Simvastatin results in decreased activity of AKT1 protein
Simvastatin results in increased phosphorylation of AKT1 protein
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; Simvastatin inhibits the reaction [IGF1 results in increased activity of AKT1 protein]
CTD PMID:12438947 PMID:17327694 PMID:17335931 PMID:18004065 PMID:18031796 More... NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Aldh3a1 aldehyde dehydrogenase family 3, subfamily A1 increases expression ISO Simvastatin results in increased expression of ALDH3A1 mRNA CTD PMID:17428261 NCBI chr11:61,099,336...61,109,244
Ensembl chr11:61,098,363...61,109,247
JBrowse link
G Alk anaplastic lymphoma kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA CTD PMID:28263720 NCBI chr17:72,174,206...72,911,719
Ensembl chr17:72,175,967...72,911,622
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression ISO Simvastatin results in increased expression of ALOX5AP mRNA CTD PMID:17183729 NCBI chr 5:149,201,814...149,224,963
Ensembl chr 5:149,201,577...149,224,963
JBrowse link
G Alpi alkaline phosphatase, intestinal increases expression EXP Simvastatin results in increased expression of ALPI mRNA CTD PMID:14973129 NCBI chr 1:87,025,724...87,029,328
Ensembl chr 1:87,025,724...87,029,328
JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney increases expression
multiple interactions
affects expression
EXP
ISO
Simvastatin results in increased expression of ALPL mRNA
Hydroxychloroquine affects the reaction [Simvastatin affects the expression of ALPL mRNA]
CTD PMID:20417880 PMID:28975700 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
JBrowse link
G Angpt1 angiopoietin 1 increases expression ISO Simvastatin results in increased expression of ANGPT1; Simvastatin results in increased expression of ANGPT1 mRNA; Simvastatin results in increased expression of ANGPT1 protein CTD PMID:18544044 NCBI chr15:42,288,063...42,540,373
Ensembl chr15:42,288,119...42,540,373
JBrowse link
G Angpt2 angiopoietin 2 multiple interactions ISO Simvastatin inhibits the reaction [Streptozocin results in increased expression of ANGPT2 protein] CTD PMID:20821229 NCBI chr 8:18,740,279...18,791,578
Ensembl chr 8:18,740,279...18,791,578
JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO Simvastatin results in decreased expression of ANGPTL3 mRNA CTD PMID:25055962 NCBI chr 4:98,919,191...98,926,429
Ensembl chr 4:98,919,191...98,934,348
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression EXP Simvastatin results in increased expression of ANGPTL4 mRNA CTD PMID:19262002 NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804
JBrowse link
G Ankra2 ankyrin repeat family A member 2 increases expression ISO Simvastatin results in increased expression of ANKRA2 mRNA CTD PMID:25055962 NCBI chr13:98,399,584...98,411,262
Ensembl chr13:98,399,582...98,411,262
JBrowse link
G Anpep alanyl aminopeptidase, membrane increases expression EXP Simvastatin results in increased expression of ANPEP mRNA CTD PMID:19262002 NCBI chr 7:79,471,551...79,497,958
Ensembl chr 7:79,471,551...79,510,807
JBrowse link
G Anxa1 annexin A1 increases expression EXP Simvastatin results in increased expression of ANXA1 protein CTD PMID:14973129 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308
JBrowse link
G Anxa3 annexin A3 decreases expression ISO
EXP
Simvastatin results in decreased expression of ANXA3 mRNA
Simvastatin results in decreased expression of ANXA3 protein
CTD PMID:14973129 PMID:17428261 NCBI chr 5:96,941,257...96,993,825
Ensembl chr 5:96,941,198...96,993,825
JBrowse link
G Aoc1 amine oxidase, copper-containing 1 multiple interactions EXP Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of AOC1 mRNA] CTD PMID:16373842 NCBI chr 6:48,872,189...48,886,122
Ensembl chr 6:48,849,830...48,886,122
JBrowse link
G Apmap adipocyte plasma membrane associated protein decreases expression ISO Simvastatin results in decreased expression of APMAP protein CTD PMID:20217863 NCBI chr 2:150,425,000...150,450,487
Ensembl chr 2:150,425,000...150,450,487
JBrowse link
G Apoa1 apolipoprotein A-I multiple interactions
increases expression
decreases expression
EXP
ISO
MTHFR gene mutant form inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]
Polystyrenes analog promotes the reaction [Simvastatin results in increased expression of APOA1 mRNA]; Simvastatin promotes the reaction [Polystyrenes analog results in increased expression of APOA1 mRNA]
Simvastatin results in increased expression of APOA1 mRNA; Simvastatin results in increased expression of APOA1 protein
[Niacin co-treated with Ezetimibe co-treated with Simvastatin] results in increased expression of APOA1 protein; [Simvastatin co-treated with Ezetimibe] results in increased expression of APOA1 protein; Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 mRNA]; Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]; Niacin promotes the reaction [[Simvastatin co-treated with Ezetimibe] results in increased expression of APOA1 protein]; Simvastatin results in increased expression of and results in increased secretion of APOA1 protein
Simvastatin results in decreased expression of APOA1 mRNA; Simvastatin results in decreased expression of APOA1 protein
CTD PMID:8289597 PMID:8461338 PMID:12048122 PMID:12633795 PMID:18270459 More... NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764
JBrowse link
G Apoa2 apolipoprotein A-II decreases expression ISO Simvastatin results in decreased expression of APOA2 mRNA CTD PMID:25055962 NCBI chr 1:171,049,133...171,053,948
Ensembl chr 1:171,052,623...171,053,948
JBrowse link
G Apoa4 apolipoprotein A-IV multiple interactions
increases expression
decreases expression
EXP
ISO
Simvastatin inhibits the reaction [[APOA4 protein co-treated with CBS protein] affects the abundance of Nitrogen Compounds]; Simvastatin promotes the reaction [[APOA4 protein co-treated with CBS protein] affects the expression of CAV1 protein]
Simvastatin results in increased expression of APOA4 protein
Polystyrenes analog promotes the reaction [Simvastatin results in decreased expression of APOA4 protein]; Simvastatin promotes the reaction [Polystyrenes analog results in decreased expression of APOA4 protein]
Simvastatin results in decreased expression of APOA4 mRNA; Simvastatin results in decreased expression of APOA4 protein
CTD PMID:8289597 PMID:8461338 PMID:18224302 PMID:25055962 NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757
JBrowse link
G Apob apolipoprotein B multiple interactions
affects response to substance
decreases expression
decreases secretion
ISO [LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB; [Niacin co-treated with Simvastatin] results in decreased expression of APOB protein; HMGCR polymorphism promotes the reaction [[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB]
APOB polymorphism affects the susceptibility to Simvastatin
Simvastatin promotes the reaction [Polystyrenes analog results in decreased expression of APOB protein]
Simvastatin results in decreased expression of APOB mRNA; Simvastatin results in decreased expression of APOB protein
Simvastatin results in decreased secretion of APOB protein
CTD PMID:1627634 PMID:8289597 PMID:8461338 PMID:9512650 PMID:10498134 More... NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835
JBrowse link
G Apoc1 apolipoprotein C-I decreases expression ISO Simvastatin results in decreased expression of APOC1 mRNA CTD PMID:25055962 NCBI chr 7:19,423,405...19,426,584
Ensembl chr 7:19,423,406...19,426,585
JBrowse link
G Apoc3 apolipoprotein C-III decreases expression ISO Simvastatin results in decreased expression of APOC3 mRNA CTD PMID:25055962 NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934
JBrowse link
G Apoe apolipoprotein E decreases expression
affects response to substance
multiple interactions
ISO
EXP
Simvastatin results in decreased expression of APOE; Simvastatin results in decreased expression of APOE mRNA
APOE affects the susceptibility to Simvastatin
Polystyrenes analog inhibits the reaction [Simvastatin results in decreased expression of APOE protein]
APOE polymorphism affects the susceptibility to Simvastatin
Simvastatin results in decreased expression of APOE mRNA; Simvastatin results in decreased expression of APOE protein
CTD PMID:8289597 PMID:8461338 PMID:11849659 PMID:11947894 PMID:12901521 More... NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
JBrowse link
G Apof apolipoprotein F decreases expression ISO Simvastatin results in decreased expression of APOF mRNA CTD PMID:25055962 NCBI chr10:128,104,568...128,107,119
Ensembl chr10:128,103,866...128,106,022
JBrowse link
G Apom apolipoprotein M decreases expression
increases expression
multiple interactions
ISO
EXP
Simvastatin results in decreased expression of APOM mRNA
Simvastatin results in increased expression of APOM mRNA; Simvastatin results in increased expression of APOM protein
T0901317 inhibits the reaction [Simvastatin results in increased expression of APOM mRNA]; T0901317 inhibits the reaction [Simvastatin results in increased expression of APOM protein]; Ursodeoxycholic Acid inhibits the reaction [Simvastatin results in increased expression of APOM mRNA]; Ursodeoxycholic Acid inhibits the reaction [Simvastatin results in increased expression of APOM protein]
CTD PMID:21729290 PMID:22160096 NCBI chr17:35,347,973...35,350,777
Ensembl chr17:35,347,973...35,351,026
JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases activity
ISO oblimersen inhibits the reaction [Simvastatin results in decreased activity of APP protein alternative form]; Simvastatin inhibits the reaction [APP protein alternative form results in decreased expression of CASP3 protein]; Simvastatin inhibits the reaction [APP protein alternative form results in increased activity of CASP3 protein]
Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein]
CTD PMID:17241114 PMID:28734741 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Arhgap29 Rho GTPase activating protein 29 decreases expression ISO Simvastatin results in decreased expression of ARHGAP29 mRNA CTD PMID:17428261 NCBI chr 3:121,746,752...121,810,326
Ensembl chr 3:121,746,190...121,810,402
JBrowse link
G Arhgap4 Rho GTPase activating protein 4 increases expression ISO Simvastatin results in increased expression of ARHGAP4 mRNA CTD PMID:14630613 NCBI chr  X:72,937,958...72,954,945
Ensembl chr  X:72,935,048...72,965,476
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 increases expression ISO Simvastatin results in increased expression of ARHGEF2 mRNA CTD PMID:14630613 NCBI chr 3:88,500,427...88,556,839
Ensembl chr 3:88,513,273...88,555,359
JBrowse link
G Ass1 argininosuccinate synthetase 1 decreases expression ISO Simvastatin results in decreased expression of ASS1 mRNA CTD PMID:16414398 NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684
JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation ISO Simvastatin results in increased phosphorylation of ATF2 protein CTD PMID:15488325 NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Simvastatin results in increased expression of ATF3 mRNA CTD PMID:17428261 NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Simvastatin results in increased expression of ATF6 mRNA; Simvastatin results in increased expression of ATF6 protein CTD PMID:18807172 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340
JBrowse link
G Atm ataxia telangiectasia mutated multiple interactions ISO Simvastatin results in increased phosphorylation of and results in increased activity of ATM protein CTD PMID:20499237 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
JBrowse link
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 increases expression ISO Simvastatin results in increased expression of ATP2A2 mRNA; Simvastatin results in increased expression of ATP2A2 protein CTD PMID:15916736 NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288
JBrowse link
G Atp6v1e1 ATPase, H+ transporting, lysosomal V1 subunit E1 increases expression EXP Simvastatin results in increased expression of ATP6V1E1 mRNA CTD PMID:19262002 NCBI chr 6:120,772,205...120,799,659
Ensembl chr 6:120,771,266...120,799,754
JBrowse link
G Aurka aurora kinase A decreases expression ISO Simvastatin results in decreased expression of AURKA mRNA CTD PMID:17428261 NCBI chr 2:172,198,116...172,212,825
Ensembl chr 2:172,198,110...172,212,455
JBrowse link
G Axin2 axin 2 affects expression ISO Simvastatin affects the expression of AXIN2 mRNA CTD PMID:19968183 NCBI chr11:108,808,687...108,841,609
Ensembl chr11:108,811,175...108,841,609
JBrowse link
G Axl AXL receptor tyrosine kinase decreases expression ISO Simvastatin results in decreased expression of AXL mRNA CTD PMID:17428261 NCBI chr 7:25,455,925...25,488,502
Ensembl chr 7:25,456,698...25,488,130
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
decreases phosphorylation
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased phosphorylation of BAD protein]
IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of BAD protein]
CTD PMID:12438947 PMID:27734117 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267
JBrowse link
G Bax BCL2-associated X protein affects localization
increases expression
ISO
EXP
Simvastatin affects the localization of BAX protein
Simvastatin results in increased expression of BAX mRNA; Simvastatin results in increased expression of BAX protein
CTD PMID:12557325 PMID:17901590 PMID:20045437 PMID:25300705 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bbc3 BCL2 binding component 3 multiple interactions
affects localization
increases expression
ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 mRNA]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 protein]
Simvastatin affects the localization of BBC3 protein
Simvastatin results in increased expression of BBC3 mRNA; Simvastatin results in increased expression of BBC3 protein
CTD PMID:17428261 PMID:20045437 PMID:21199873 PMID:37956312 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
increases expression
ISO
EXP
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of BCL2 mRNA]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Simvastatin promotes the reaction [NFATC3 protein binds to BCL2 promoter]
Simvastatin results in decreased expression of BCL2 mRNA; Simvastatin results in decreased expression of BCL2 protein
Simvastatin results in increased expression of BCL2 protein
Simvastatin results in increased expression of BCL2 mRNA; Simvastatin results in increased expression of BCL2 protein
CTD PMID:17241114 PMID:17277159 PMID:17901590 PMID:18031796 PMID:18521906 More... NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions
decreases expression
ISO Simvastatin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]
Simvastatin results in decreased expression of BCL2L1 protein
CTD PMID:17277159 PMID:18521906 PMID:20060890 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Bdnf brain derived neurotrophic factor increases expression
multiple interactions
ISO Simvastatin results in increased expression of BDNF
Simvastatin promotes the reaction [Lipopolysaccharides results in increased expression of BDNF mRNA]
CTD PMID:18047562 PMID:20851742 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Bglap bone gamma carboxyglutamate protein increases secretion
increases expression
multiple interactions
ISO
EXP
Simvastatin results in increased secretion of BGLAP protein
Simvastatin results in increased expression of BGLAP; Simvastatin results in increased expression of BGLAP mRNA
CTNNB1 mutant form inhibits the reaction [Simvastatin results in increased expression of BGLAP protein]; DKK1 inhibits the reaction [Simvastatin results in increased expression of BGLAP mRNA]
Simvastatin results in increased expression of BGLAP; Simvastatin results in increased expression of BGLAP mRNA; Simvastatin results in increased expression of BGLAP protein
[Simvastatin co-treated with Dexamethasone] results in increased expression of BGLAP
CTD PMID:12914771 PMID:14601315 PMID:14973129 PMID:15953866 PMID:17252541 More... NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771
JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA CTD PMID:28263720 NCBI chr 5:144,127,104...144,131,259
Ensembl chr 5:144,127,104...144,131,259
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions
decreases expression
ISO Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 mRNA]; Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]
Simvastatin results in decreased expression of BIRC2 protein
CTD PMID:17277159 PMID:18521906 PMID:19343037 NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC3 mRNA]; Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC3 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BIRC3 protein] CTD PMID:17277159 PMID:19343037 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Simvastatin results in decreased expression of BIRC5 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; Simvastatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC5 protein]
Simvastatin results in decreased expression of BIRC5 mRNA; Simvastatin results in decreased expression of BIRC5 protein
CTD PMID:17277159 PMID:20464445 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
JBrowse link
G Bmp1 bone morphogenetic protein 1 increases expression ISO Simvastatin results in increased expression of BMP1 mRNA CTD PMID:12963647 NCBI chr14:70,711,998...70,758,280
Ensembl chr14:70,711,998...70,757,674
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases secretion
multiple interactions
increases expression
ISO
EXP
Simvastatin results in increased secretion of BMP2 protein
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BMP2 mRNA]
Simvastatin results in increased expression of BMP2; Simvastatin results in increased expression of BMP2 mRNA
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; Simvastatin inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]; Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD1 protein]]; Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD5 protein]]; Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD9 protein]]; Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]
Simvastatin results in increased expression of BMP2 mRNA; Simvastatin results in increased expression of BMP2 protein
CTD PMID:10814523 PMID:11162604 PMID:12914771 PMID:16470222 PMID:17252541 More... NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 affects expression
increases expression
increases stability
ISO Simvastatin affects the expression of BMPR2 mRNA
Simvastatin results in increased expression of BMPR2 protein
Simvastatin results in increased stability of BMPR2 mRNA
CTD PMID:16297860 NCBI chr 1:59,802,721...59,917,240
Ensembl chr 1:59,802,559...59,918,173
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 increases expression ISO Simvastatin results in increased expression of BNIP3 mRNA CTD PMID:17428261 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248
JBrowse link
G C5ar1 complement component 5a receptor 1 decreases expression ISO Simvastatin results in decreased expression of C5AR1 mRNA CTD PMID:16414398 NCBI chr 7:15,980,668...15,993,465
Ensembl chr 7:15,980,668...15,993,465
JBrowse link
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit multiple interactions
decreases expression
ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C protein]
Simvastatin results in decreased expression of CACNA1C mRNA; Simvastatin results in decreased expression of CACNA1C protein
CTD PMID:19791473 NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851
JBrowse link
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit multiple interactions
decreases expression
ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H protein]
Simvastatin results in decreased expression of CACNA1H mRNA; Simvastatin results in decreased expression of CACNA1H protein
CTD PMID:19791473 NCBI chr17:25,593,259...25,655,308
Ensembl chr17:25,593,259...25,652,759
JBrowse link
G Calb1 calbindin 1 multiple interactions EXP Simvastatin inhibits the reaction [Oxygen deficiency results in decreased expression of CALB1 mRNA] CTD PMID:16373842 NCBI chr 4:15,881,264...15,906,709
Ensembl chr 4:15,881,264...15,908,064
JBrowse link
G Calb2 calbindin 2 decreases expression ISO Simvastatin results in decreased expression of CALB2 protein CTD PMID:20217863 NCBI chr 8:110,869,158...110,894,844
Ensembl chr 8:110,864,134...110,894,842
JBrowse link
G Cald1 caldesmon 1 decreases expression ISO Simvastatin results in decreased expression of CALD1 mRNA; Simvastatin results in decreased expression of CALD1 protein CTD PMID:14630613 NCBI chr 6:34,575,433...34,752,404
Ensembl chr 6:34,575,435...34,752,408
JBrowse link
G Calml3 calmodulin-like 3 increases expression ISO Simvastatin results in increased expression of CALML3 mRNA CTD PMID:17428261 NCBI chr13:3,852,893...3,854,318
Ensembl chr13:3,852,896...3,854,316
JBrowse link
G Capn1 calpain 1 increases expression ISO Simvastatin results in increased expression of CAPN1 mRNA CTD PMID:18664198 PMID:19253821 NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927
JBrowse link
G Capza1 capping actin protein of muscle Z-line subunit alpha 1 decreases expression ISO Simvastatin results in decreased expression of CAPZA1 protein CTD PMID:20217863 NCBI chr 3:104,730,097...104,771,821
Ensembl chr 3:104,730,095...104,771,821
JBrowse link
G Capza2 capping actin protein of muscle Z-line subunit alpha 2 decreases expression ISO Simvastatin results in decreased expression of CAPZA2 protein CTD PMID:20217863 NCBI chr 6:17,637,009...17,666,971
Ensembl chr 6:17,636,233...17,666,971
JBrowse link
G Casp1 caspase 1 decreases activity
multiple interactions
ISO Simvastatin results in decreased activity of CASP1 protein
Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of CASP1 protein]]; Simvastatin inhibits the reaction [Acetic Acid results in increased expression of CASP1 protein]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of CASP1 protein]
CTD PMID:16054375 PMID:30408459 PMID:35762198 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp12 caspase 12 multiple interactions ISO Simvastatin results in increased cleavage of and results in increased activity of CASP12 protein CTD PMID:19253821 NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
increases expression
decreases activity
ISO
EXP
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of CASP3 protein]; Simvastatin inhibits the reaction [APP protein alternative form results in decreased expression of CASP3 protein]; Simvastatin inhibits the reaction [APP protein alternative form results in increased activity of CASP3 protein]; Simvastatin inhibits the reaction [Coal Ash results in increased expression of CASP3 protein modified form]; Simvastatin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]; Simvastatin results in increased cleavage of and results in increased activity of CASP3 protein
[Glucose deficiency co-treated with Simvastatin] results in increased cleavage of CASP3 protein; [Lipopolysaccharides co-treated with Simvastatin] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [[Glucose deficiency co-treated with Simvastatin] results in increased cleavage of CASP3 protein]
carvacrol inhibits the reaction [Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP3 protein]]; PD 150606 inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP3 protein]; Simvastatin inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of CASP3 mRNA]; Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]; Simvastatin results in decreased expression of and results in decreased activity of CASP3 protein; Simvastatin results in increased cleavage of and results in increased activity of CASP3 protein; Verapamil inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]
Simvastatin results in increased expression of CASP3 mRNA; Simvastatin results in increased expression of CASP3 protein
Simvastatin results in decreased activity of CASP3 protein
CTD PMID:11868908 PMID:12557325 PMID:12962723 PMID:14527821 PMID:15200425 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp6 caspase 6 multiple interactions ISO Simvastatin results in increased cleavage of and results in increased activity of CASP6 protein CTD PMID:19253821 NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP7 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of CASP7 protein]; Simvastatin results in increased cleavage of and results in increased activity of CASP7 protein CTD PMID:19253821 PMID:20045437 PMID:20427495 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
increases cleavage
ISO
EXP
Simvastatin results in increased activity of CASP8 protein
Acetylcysteine inhibits the reaction [Simvastatin results in increased activity of CASP8 protein]
Simvastatin results in increased cleavage of CASP8 protein
Simvastatin results in increased cleavage of and results in increased activity of CASP8 protein
CTD PMID:12962723 PMID:15705602 PMID:20464445 PMID:20883752 PMID:21910007 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
decreases activity
increases activity
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased activity of CASP9 protein]; DIABLO protein promotes the reaction [Simvastatin results in increased activity of CASP9 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of CASP9 protein]; Simvastatin results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:12438947 PMID:12962723 PMID:15705602 PMID:16470222 PMID:19253821 More... NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase decreases expression
increases activity
multiple interactions
EXP
ISO
Simvastatin results in decreased expression of CAT mRNA
Simvastatin results in increased activity of CAT protein
carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein]]; Simvastatin inhibits the reaction [Diazepam results in decreased activity of CAT protein]; Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein]
CTD PMID:17479860 PMID:20883752 PMID:27111380 PMID:29071762 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cav1 caveolin 1, caveolae protein multiple interactions
decreases expression
ISO
EXP
Simvastatin inhibits the reaction [Glucose results in decreased expression of CAV1 mRNA]
Simvastatin promotes the reaction [[APOA4 protein co-treated with CBS protein] affects the expression of CAV1 protein]
Simvastatin results in decreased expression of CAV1 protein
Simvastatin inhibits the reaction [[Semaxinib co-treated with Oxygen deficiency] results in decreased expression of CAV1 protein]
CTD PMID:16698853 PMID:18224302 PMID:19816600 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451
JBrowse link
G Cav2 caveolin 2 multiple interactions ISO Simvastatin inhibits the reaction [[Semaxinib co-treated with Oxygen deficiency] results in decreased expression of CAV2 protein] CTD PMID:16698853 NCBI chr 6:17,281,184...17,289,129
Ensembl chr 6:17,281,184...17,289,114
JBrowse link
G Cbs cystathionine beta-synthase multiple interactions EXP Simvastatin inhibits the reaction [[APOA4 protein co-treated with CBS protein] affects the abundance of Nitrogen Compounds]; Simvastatin promotes the reaction [[APOA4 protein co-treated with CBS protein] affects the expression of CAV1 protein] CTD PMID:18224302 NCBI chr17:31,831,602...31,856,170
Ensembl chr17:31,827,868...31,856,212
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
decreases response to substance
affects expression
ISO
EXP
[Simvastatin co-treated with Ramipril] results in decreased expression of CCL2 protein; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL2 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [TNF results in increased secretion of CCL2 protein]; Simvastatin results in decreased expression of and results in decreased secretion of CCL2 protein
Simvastatin results in decreased expression of CCL2 mRNA; Simvastatin results in decreased expression of CCL2 protein
Simvastatin results in decreased susceptibility to CCL2 protein
Simvastatin affects the expression of CCL2 mRNA
CTD PMID:12117737 PMID:12818400 PMID:15184351 PMID:15781755 PMID:15824212 More... NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression ISO Simvastatin results in decreased expression of CCL20 mRNA CTD PMID:22305382 NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases expression
ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL3 mRNA]
Simvastatin results in decreased expression of CCL3 mRNA
CTD PMID:16321392 PMID:16414398 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL4 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL4 mRNA]; Simvastatin inhibits the reaction [TNF results in increased secretion of CCL4 mRNA] CTD PMID:16321392 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression
decreases expression
ISO Simvastatin results in increased expression of CCL5 mRNA
Simvastatin results in decreased expression of CCL5 mRNA
Simvastatin results in decreased expression of CCL5 protein
CTD PMID:17112859 PMID:17183729 PMID:17449418 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
decreases expression
ISO Simvastatin inhibits the reaction [CCN1 results in increased expression of IL1B]; Simvastatin inhibits the reaction [CCN1 results in increased expression of OSM]; Simvastatin inhibits the reaction [CCN1 results in increased expression of TNF]; Simvastatin inhibits the reaction [OSM results in increased expression of CCN1 mRNA]
Simvastatin results in decreased expression of CCN1 mRNA
CTD PMID:17428261 PMID:20191585 NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
decreases expression
ISO
EXP
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]]; Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]; Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 protein]
Simvastatin inhibits the reaction [Bleomycin results in increased expression of CCN2 mRNA]; Simvastatin inhibits the reaction [Bleomycin results in increased expression of CCN2 protein]
Simvastatin inhibits the reaction [lysophosphatidic acid results in increased expression of CCN2 protein]
Simvastatin results in decreased expression of CCN2 mRNA; Simvastatin results in decreased expression of CCN2 protein
CTD PMID:15200425 PMID:15298857 PMID:15677772 PMID:19080365 PMID:19099753 More... NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581
JBrowse link
G Ccna2 cyclin A2 decreases expression
multiple interactions
ISO Simvastatin results in decreased expression of CCNA2 mRNA
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CCNA2 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCNA2 protein]
CTD PMID:17428261 PMID:26577051 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Simvastatin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]
Simvastatin results in decreased expression of CCND1 mRNA; Simvastatin results in decreased expression of CCND1 protein
CTD PMID:17277159 PMID:17428261 PMID:20878096 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccne1 cyclin E1 multiple interactions
decreases expression
ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein] CTD PMID:26577051 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 multiple interactions
decreases expression
ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]
Simvastatin results in decreased expression of CCR1 mRNA
CTD PMID:16321392 PMID:16414398 NCBI chr 9:123,762,163...123,768,729
Ensembl chr 9:123,762,161...123,768,729
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions
decreases expression
ISO [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Simvastatin results in decreased expression of CCR2 mRNA]; [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Simvastatin results in decreased expression of CCR2 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]
Simvastatin results in decreased expression of CCR2 mRNA; Simvastatin results in decreased expression of CCR2 protein
CTD PMID:15781755 PMID:16321392 PMID:16414398 PMID:16781696 PMID:17449418 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR4 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA] CTD PMID:16321392 NCBI chr 9:114,319,384...114,334,544
Ensembl chr 9:114,319,384...114,333,984
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions
decreases expression
ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]
Simvastatin results in decreased expression of CCR5 mRNA
Simvastatin results in decreased expression of CCR5 protein
CTD PMID:16321392 PMID:17112859 PMID:17449418 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736
JBrowse link
G Cd14 CD14 antigen decreases expression ISO Simvastatin results in decreased expression of CD14 mRNA CTD PMID:16414398 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851
JBrowse link
G Cd151 CD151 antigen decreases expression ISO Simvastatin results in decreased expression of CD151 mRNA CTD PMID:16414398 NCBI chr 7:141,047,275...141,051,394
Ensembl chr 7:141,047,305...141,051,386
JBrowse link
G Cd24a CD24a antigen increases expression ISO Simvastatin results in increased expression of CD24 mRNA CTD PMID:18192897 NCBI chr10:43,454,433...43,460,261
Ensembl chr10:43,454,280...43,460,261
JBrowse link
G Cd27 CD27 antigen decreases expression ISO Simvastatin results in decreased expression of CD27 mRNA CTD PMID:18453621 NCBI chr 6:125,209,583...125,214,014
Ensembl chr 6:125,209,585...125,213,973
JBrowse link
G Cd2ap CD2-associated protein increases expression ISO Simvastatin results in increased expression of CD2AP mRNA CTD PMID:16710349 NCBI chr17:43,059,857...43,187,593
Ensembl chr17:43,103,842...43,187,556
JBrowse link
G Cd40 CD40 antigen decreases expression
multiple interactions
ISO
EXP
Simvastatin results in decreased expression of CD40 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]; Simvastatin inhibits the reaction [IFNG promotes the reaction [STAT1 binds to CD40 promoter]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]; Simvastatin promotes the reaction [IFNG promotes the reaction [RELA binds to CD40 promoter]]
CTD PMID:16387846 PMID:17169357 PMID:17507688 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
JBrowse link
G Cd40lg CD40 ligand decreases expression
increases expression
multiple interactions
EXP
ISO
Simvastatin results in decreased expression of CD40LG protein; Simvastatin results in decreased expression of CD40LG protein modified form
Simvastatin results in increased expression of CD40LG protein
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]]; Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]
CTD PMID:17169357 PMID:18269829 PMID:21330348 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402
JBrowse link
G Cd44 CD44 antigen multiple interactions
decreases expression
ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CD44 protein]; Simvastatin promotes the reaction [TP53 protein binds to CD44 promoter]
Simvastatin results in decreased expression of CD44 mRNA; Simvastatin results in decreased expression of CD44 protein
CTD PMID:21199873 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010
JBrowse link
G Cd80 CD80 antigen decreases expression ISO Simvastatin results in decreased expression of CD80 mRNA CTD PMID:22305382 NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697
JBrowse link
G Cd83 CD83 antigen decreases expression ISO Simvastatin results in decreased expression of CD83 protein CTD PMID:16387846 NCBI chr13:43,938,661...43,956,608
Ensembl chr13:43,938,251...43,956,608
JBrowse link
G Cd86 CD86 antigen decreases expression ISO Simvastatin results in decreased expression of CD86 protein CTD PMID:16387846 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
JBrowse link
G Cdc25b cell division cycle 25B affects expression ISO Simvastatin affects the expression of CDC25B mRNA; Simvastatin affects the expression of CDC25B protein CTD PMID:19110722 NCBI chr 2:131,028,356...131,040,431
Ensembl chr 2:131,028,869...131,040,417
JBrowse link
G Cdc42 cell division cycle 42 decreases activity EXP Simvastatin results in decreased activity of CDC42 protein CTD PMID:17169357 NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031
JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO Simvastatin results in decreased expression of CDC45 mRNA CTD PMID:17428261 NCBI chr16:18,599,202...18,632,371
Ensembl chr16:18,599,197...18,630,737
JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO Simvastatin results in decreased expression of CDC6 mRNA CTD PMID:17428261 NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766
JBrowse link
G Cdh5 cadherin 5 increases expression ISO Simvastatin results in increased expression of CDH5 mRNA; Simvastatin results in increased expression of CDH5 protein CTD PMID:19109527 NCBI chr 8:104,828,247...104,871,136
Ensembl chr 8:104,828,257...104,871,143
JBrowse link
G Cdk1 cyclin dependent kinase 1 decreases expression
multiple interactions
ISO Simvastatin results in decreased expression of CDK1 mRNA; Simvastatin results in decreased expression of CDK1 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein]
CTD PMID:17428261 PMID:20878096 PMID:26577051 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases expression
decreases activity
ISO [Simvastatin results in decreased degradation of CDKN1A protein] which results in decreased activity of CDK2 protein; [Simvastatin results in decreased degradation of CDKN1B protein] which results in decreased activity of CDK2 protein
Simvastatin results in decreased expression of CDK2 protein
Simvastatin results in decreased activity of CDK2 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein]
CTD PMID:10412745 PMID:17928568 PMID:18804536 PMID:20878096 PMID:26577051 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cdk4 cyclin dependent kinase 4 decreases expression
decreases activity
ISO Simvastatin results in decreased expression of CDK4 protein
Simvastatin results in decreased activity of CDK4 protein
CTD PMID:18804536 PMID:20878096 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
JBrowse link
G Cdk5 cyclin dependent kinase 5 increases expression ISO Simvastatin results in increased expression of CDK5 CTD PMID:19461118 NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions
increases expression
ISO [Simvastatin results in decreased degradation of CDKN1A protein] which results in decreased activity of CDK2 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of CDKN1A protein]; Simvastatin inhibits the reaction [Fluorouracil results in decreased degradation of CDKN1A protein]
Simvastatin results in increased expression of CDKN1A mRNA; Simvastatin results in increased expression of CDKN1A protein
CTD PMID:15625077 PMID:17428261 PMID:17928568 PMID:18337644 PMID:18625202 More... NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B multiple interactions
increases expression
ISO [Simvastatin results in decreased degradation of CDKN1B protein] which results in decreased activity of CDK2 protein
Simvastatin results in increased expression of CDKN1B mRNA; Simvastatin results in increased expression of CDKN1B protein
CTD PMID:12963647 PMID:17428261 PMID:17928568 PMID:18337644 PMID:18804536 More... NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Cdkn1c cyclin dependent kinase inhibitor 1C increases expression ISO Simvastatin results in increased expression of CDKN1C mRNA CTD PMID:17428261 NCBI chr 7:143,012,076...143,014,735
Ensembl chr 7:143,012,076...143,014,787
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A increases expression ISO Simvastatin results in increased expression of CDKN2A protein CTD PMID:18804536 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D increases expression ISO Simvastatin results in increased expression of CDKN2D mRNA; Simvastatin results in increased expression of CDKN2D protein CTD PMID:20878096 NCBI chr 9:21,199,759...21,202,553
Ensembl chr 9:21,199,706...21,202,703
JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 decreases expression ISO Simvastatin results in decreased expression of CDT1 mRNA CTD PMID:17428261 NCBI chr 8:123,294,754...123,299,869
Ensembl chr 8:123,294,754...123,300,293
JBrowse link
G Cebpz CCAAT/enhancer binding protein zeta multiple interactions ISO Simvastatin inhibits the reaction [CEBPZ binds to COL1A1 promoter] CTD PMID:16575855 NCBI chr17:79,226,432...79,244,499
Ensembl chr17:79,226,435...79,244,495
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Simvastatin affects the reaction [Dietary Fats affects the expression of CES1 mRNA]; Simvastatin affects the reaction [Dietary Fats affects the expression of CES1 protein]
Simvastatin inhibits the reaction [CES1 protein results in increased hydrolysis of remdesivir]
CTD PMID:33383043 PMID:34774545 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression
increases expression
ISO
EXP
Simvastatin inhibits the reaction [TNF protein results in increased expression of CFLAR protein]
Simvastatin results in decreased expression of CFLAR protein; Simvastatin results in decreased expression of CFLAR protein alternative form
Simvastatin results in increased expression of CFLAR mRNA; Simvastatin results in increased expression of CFLAR protein
CTD PMID:17277159 PMID:18521906 PMID:19262002 PMID:21910007 NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of CFTR mRNA]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of CFTR protein] CTD PMID:33774062 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767
JBrowse link
G Chat choline acetyltransferase multiple interactions ISO Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the activity of CHAT protein]; Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHAT mRNA] CTD PMID:16828882 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHRM5 mRNA] CTD PMID:16828882 NCBI chr 2:112,306,055...112,365,487
Ensembl chr 2:112,309,516...112,311,114
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions
increases phosphorylation
increases expression
ISO
EXP
artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein]; parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein]; Simvastatin promotes the reaction [Doxorubicin results in increased phosphorylation of CHUK protein]
Simvastatin results in increased expression of CHUK mRNA
CTD PMID:18463201 PMID:19262002 NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919
JBrowse link
G Ciita class II transactivator multiple interactions ISO Simvastatin inhibits the reaction [IFNG results in increased expression of CIITA protein] CTD PMID:11219190 NCBI chr16:10,297,877...10,348,928
Ensembl chr16:10,297,923...10,346,282
JBrowse link
G Ckm creatine kinase, muscle multiple interactions
decreases expression
increases secretion
ISO [Clarithromycin co-treated with Simvastatin] results in increased expression of CKM protein
Simvastatin results in decreased expression of CKM protein
carvacrol inhibits the reaction [Simvastatin results in increased secretion of CKM protein]; Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of CKM protein]]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of CKM protein]
CTD PMID:8611662 PMID:19252767 PMID:29071762 PMID:35762198 NCBI chr 7:19,145,019...19,155,508
Ensembl chr 7:19,138,701...19,156,766
JBrowse link
G Clcn3 chloride channel, voltage-sensitive 3 multiple interactions
decreases expression
ISO Simvastatin inhibits the reaction [EDN1 protein results in increased expression of CLCN3 protein]
Simvastatin results in decreased expression of CLCN3 protein
CTD PMID:20644009 NCBI chr 8:61,363,423...61,436,351
Ensembl chr 8:61,363,423...61,436,334
JBrowse link
G Cldn18 claudin 18 multiple interactions ISO Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of CLDN18 mRNA]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of CLDN18 protein] CTD PMID:33774062 NCBI chr 9:99,572,849...99,599,320
Ensembl chr 9:99,571,514...99,599,320
JBrowse link
G Cldn4 claudin 4 multiple interactions ISO Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CLDN4 mRNA]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CLDN4 protein] CTD PMID:33774062 NCBI chr 5:134,973,977...134,975,788
Ensembl chr 5:134,973,973...134,975,788
JBrowse link
G Col11a1 collagen, type XI, alpha 1 increases expression EXP Simvastatin results in increased expression of COL11A1 mRNA CTD PMID:16274305 NCBI chr 3:113,823,933...114,014,405
Ensembl chr 3:113,824,189...114,014,367
JBrowse link
G Col12a1 collagen, type XII, alpha 1 increases expression EXP Simvastatin results in increased expression of COL12A1 mRNA CTD PMID:16274305 NCBI chr 9:79,506,269...79,628,423
Ensembl chr 9:79,506,273...79,626,113
JBrowse link
G Col13a1 collagen, type XIII, alpha 1 decreases response to substance ISO COL13A1 SNP results in decreased susceptibility to Simvastatin CTD PMID:21483694 NCBI chr10:61,674,013...61,814,985
Ensembl chr10:61,674,015...61,814,887
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions
decreases expression
increases expression
ISO
EXP
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of COL1A1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of COL1A1 mRNA]; Simvastatin inhibits the reaction [CEBPZ binds to COL1A1 promoter]; Simvastatin inhibits the reaction [SP1 binds to COL1A1 promoter]
Simvastatin results in increased expression of COL1A1 mRNA
CTD PMID:10412775 PMID:14973129 PMID:16274305 PMID:16575855 PMID:17252541 More... NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Col2a1 collagen, type II, alpha 1 multiple interactions
increases expression
ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of COL2A1 mRNA]; NOG inhibits the reaction [Simvastatin results in increased expression of COL2A1 mRNA] CTD PMID:18628692 PMID:19912653 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576
JBrowse link
G Col3a1 collagen, type III, alpha 1 increases expression
decreases expression
ISO
EXP
Simvastatin results in increased expression of COL3A1 mRNA
Simvastatin results in decreased expression of COL3A1 mRNA
CTD PMID:10412775 PMID:16274305 PMID:16414398 PMID:17183729 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866
JBrowse link
G Col4a1 collagen, type IV, alpha 1 decreases expression EXP Simvastatin results in decreased expression of COL4A1 mRNA CTD PMID:10412775 NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826
JBrowse link
G Col5a1 collagen, type V, alpha 1 increases expression EXP Simvastatin results in increased expression of COL5A1 mRNA CTD PMID:16274305 NCBI chr 2:27,776,393...27,929,522
Ensembl chr 2:27,776,437...27,929,526
JBrowse link
G Col6a2 collagen, type VI, alpha 2 increases expression EXP Simvastatin results in increased expression of COL6A2 mRNA CTD PMID:16274305 NCBI chr10:76,431,590...76,459,464
Ensembl chr10:76,431,596...76,459,464
JBrowse link
G Col7a1 collagen, type VII, alpha 1 increases expression ISO Simvastatin results in increased expression of COL7A1 mRNA CTD PMID:17428261 NCBI chr 9:108,782,654...108,813,943
Ensembl chr 9:108,782,654...108,813,943
JBrowse link
G Coro1a coronin, actin binding protein 1A decreases expression ISO Simvastatin results in decreased expression of CORO1A protein CTD PMID:20217863 NCBI chr 7:126,298,946...126,303,925
Ensembl chr 7:126,298,945...126,306,959
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Simvastatin inhibits the reaction [OSM results in increased phosphorylation of CREB1 protein] CTD PMID:20191585 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Crp C-reactive protein, pentraxin-related decreases expression
multiple interactions
ISO Simvastatin results in decreased expression of CRP protein
[Ezetimibe co-treated with Simvastatin] results in decreased expression of CRP protein; [Simvastatin co-treated with Ezetimibe] promotes the reaction [Niacin results in decreased expression of CRP protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]]; Simvastatin inhibits the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in increased expression of CRP protein]; Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]; Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]; Simvastatin inhibits the reaction [ethinyl estradiol-desogestrel combination results in increased expression of CRP protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CRP protein]
CTD PMID:15184351 PMID:15824212 PMID:17105841 PMID:18023360 PMID:18420099 More... NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
JBrowse link
G Csn1s2a casein alpha s2-like A increases expression EXP Simvastatin results in increased expression of CSN1S2A mRNA CTD PMID:19262002 NCBI chr 5:87,922,309...87,936,657
Ensembl chr 5:87,922,426...87,936,656
JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 increases expression EXP Simvastatin results in increased expression of CSPG4 mRNA CTD PMID:19262002 NCBI chr 9:56,772,388...56,807,154
Ensembl chr 9:56,772,317...56,807,154
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]]; Simvastatin inhibits the reaction [CTF1 results in increased expression of AGT mRNA]; Simvastatin inhibits the reaction [CTF1 results in increased expression of FOS mRNA]; Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]; Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein modified form]; Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]; Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein modified form]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]; Simvastatin inhibits the reaction [CTF1 results in increased phosphorylation of JAK2 protein]; Simvastatin inhibits the reaction [CTF1 results in increased phosphorylation of STAT3 protein] CTD PMID:16534557 PMID:18400235 PMID:19100119 NCBI chr 7:127,311,872...127,317,360
Ensembl chr 7:127,311,908...127,317,364
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 decreases expression ISO Simvastatin results in decreased expression of CTLA4 mRNA CTD PMID:18453621 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991
JBrowse link
G Ctnnal1 catenin alpha like 1 decreases expression ISO Simvastatin results in decreased expression of CTNNAL1 mRNA CTD PMID:17428261 NCBI chr 4:56,810,935...56,865,370
Ensembl chr 4:56,810,935...56,865,188
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
EXP
ISO
CTNNB1 mutant form inhibits the reaction [Simvastatin results in increased expression of BGLAP protein]; CTNNB1 mutant form inhibits the reaction [Simvastatin results in increased expression of SP7 protein]
Simvastatin inhibits the reaction [Glucose results in decreased expression of CTNNB1 protein]
Simvastatin results in increased expression of CTNNB1 protein
CTD PMID:18004065 PMID:22058016 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Ctsl cathepsin L increases expression ISO Simvastatin results in increased expression of CTSL mRNA CTD PMID:19001041 NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704
JBrowse link
G Ctss cathepsin S multiple interactions EXP Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of CTSS mRNA]; Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of CTSS protein] CTD PMID:20835264 NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714
JBrowse link
G Cttn cortactin affects localization
multiple interactions
ISO Simvastatin affects the localization of CTTN protein
Simvastatin affects the reaction [F2 affects the localization of CTTN protein]
CTD PMID:14630613 NCBI chr 7:143,989,468...144,024,743
Ensembl chr 7:143,989,470...144,024,746
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 decreases expression ISO Simvastatin results in decreased expression of CX3CR1 mRNA CTD PMID:18359719 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
decreases expression
EXP
ISO
Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL10 mRNA]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL10 protein]
Simvastatin results in decreased expression of CXCL10 mRNA; Simvastatin results in decreased expression of CXCL10 protein
CTD PMID:15187114 PMID:16414398 PMID:17449418 PMID:22305382 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO Simvastatin results in increased expression of CXCL12 CTD PMID:19591934 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions
decreases secretion
decreases expression
ISO
EXP
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CXCL8 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]; Simvastatin inhibits the reaction [TNF results in increased secretion of CXCL8 protein]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; Simvastatin results in decreased expression of and results in decreased secretion of CXCL8 protein
Simvastatin results in decreased secretion of CXCL8 protein
Simvastatin inhibits the reaction [TNF results in increased expression of CXCL15 mRNA]
Simvastatin results in decreased expression of CXCL8 mRNA; Simvastatin results in decreased expression of CXCL8 protein
CTD PMID:12117737 PMID:16387846 PMID:16511915 PMID:17178392 PMID:18203325 More... NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcl16 C-X-C motif chemokine ligand 16 decreases expression ISO Simvastatin results in decreased expression of CXCL16 mRNA CTD PMID:25055962 NCBI chr11:70,345,215...70,350,810
Ensembl chr11:70,344,809...70,350,810
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression EXP Simvastatin results in decreased expression of CXCL2 mRNA; Simvastatin results in decreased expression of CXCL2 protein CTD PMID:21330348 PMID:21441352 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression EXP Simvastatin results in decreased expression of CXCL1 mRNA; Simvastatin results in decreased expression of CXCL1 protein CTD PMID:21330348 PMID:21441352 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO Simvastatin results in decreased expression of CXCR2 mRNA CTD PMID:16414398 NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression
increases expression
ISO Simvastatin results in decreased expression of CXCR4 mRNA
Simvastatin results in increased expression of CXCR4
CTD PMID:16414398 PMID:19591934 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030
JBrowse link
G Cyba cytochrome b-245, alpha polypeptide affects response to substance ISO CYBA gene SNP affects the susceptibility to Simvastatin CTD PMID:15936011 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO Simvastatin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein] CTD PMID:30513525 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11A1 mRNA; [Simvastatin co-treated with resveratrol] results in decreased expression of CYP11A1 mRNA CTD PMID:24524197 PMID:25055962 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions ISO [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11B2 mRNA CTD PMID:25055962 NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,859...74,728,167
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression
multiple interactions
ISO Simvastatin results in decreased expression of CYP17A1 mRNA
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP17A1 mRNA; farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]; resveratrol promotes the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]; Simvastatin promotes the reaction [resveratrol results in decreased expression of CYP17A1 mRNA]
CTD PMID:21918126 PMID:24524197 PMID:25055962 NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Simvastatin results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Simvastatin results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions ISO Simvastatin promotes the reaction [Dietary Fats results in increased expression of CYP27A1 mRNA] CTD PMID:33383043 NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression ISO Simvastatin results in increased expression of CYP2B6 mRNA CTD PMID:15802384 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases activity ISO Simvastatin results in decreased activity of CYP2C8 protein CTD PMID:15601807 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO Simvastatin affects the reaction [CYP2C9 polymorphism affects the susceptibility to Warfarin] CTD PMID:22594507 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 affects response to substance ISO CYP2D6 polymorphism affects the susceptibility to Simvastatin CTD PMID:11753271 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 decreases expression ISO Simvastatin results in decreased expression of CYP39A1 mRNA CTD PMID:25055962 NCBI chr17:43,978,263...44,062,322
Ensembl chr17:43,978,316...44,062,322
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 affects response to substance ISO CYP3A5 polymorphism affects the susceptibility to Simvastatin CTD PMID:17192506 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 decreases expression ISO Simvastatin results in decreased expression of CYP46A1 mRNA CTD PMID:25055962 NCBI chr12:108,300,568...108,328,497
Ensembl chr12:108,300,640...108,328,493
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression ISO Simvastatin results in increased expression of CYP51 mRNA CTD PMID:25055962 NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 multiple interactions ISO Simvastatin promotes the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]; Simvastatin promotes the reaction [Dietary Fats results in increased expression of CYP7A1 protein] CTD PMID:33383043 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Dbf4 DBF4 zinc finger decreases expression ISO Simvastatin results in decreased expression of DBF4 mRNA CTD PMID:17428261 NCBI chr 5:8,446,969...8,472,789
Ensembl chr 5:8,446,973...8,472,716
JBrowse link
G Dbp D site albumin promoter binding protein multiple interactions EXP Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of DBP mRNA] CTD PMID:16373842 NCBI chr 7:45,354,658...45,359,579
Ensembl chr 7:45,354,512...45,359,627
JBrowse link
G Dcx doublecortin increases expression ISO Simvastatin results in increased expression of DCX CTD PMID:18544044 NCBI chr  X:142,638,838...142,716,392
Ensembl chr  X:142,638,838...142,716,307
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 decreases expression ISO Simvastatin results in decreased expression of DDAH1 mRNA CTD PMID:16414398 NCBI chr 3:145,464,447...145,600,032
Ensembl chr 3:145,464,430...145,600,032
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 increases expression
increases activity
ISO Simvastatin results in increased expression of DGAT1 mRNA
Simvastatin results in increased activity of DGAT1 protein
CTD PMID:12056585 NCBI chr15:76,386,215...76,396,167
Ensembl chr15:76,386,215...76,396,153
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO
EXP
Simvastatin results in increased expression of DHCR24
Simvastatin results in increased expression of DHCR24 mRNA; Simvastatin results in increased expression of DHCR24 protein
CTD PMID:21987590 PMID:25055962 NCBI chr 4:106,418,279...106,446,310
Ensembl chr 4:106,418,235...106,446,310
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase affects response to substance
multiple interactions
affects expression
ISO
EXP
DHCR7 mutant form affects the susceptibility to Simvastatin
Hydroxychloroquine affects the reaction [Simvastatin affects the expression of DHCR7 mRNA]; Simvastatin promotes the reaction [DHCR7 results in increased chemical synthesis of Cholesterol]
Simvastatin inhibits the reaction [DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol]
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of DHCR7 mRNA
CTD PMID:15896653 PMID:16446309 PMID:19365639 PMID:25055962 PMID:28975700 NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein affects localization
multiple interactions
ISO Simvastatin affects the localization of DIABLO protein
DIABLO protein promotes the reaction [Simvastatin results in increased activity of CASP9 protein]
CTD PMID:20045437 NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions EXP DKK1 inhibits the reaction [Simvastatin results in increased expression of BGLAP mRNA]; DKK1 inhibits the reaction [Simvastatin results in increased expression of RUNX2 mRNA]; DKK1 inhibits the reaction [Simvastatin results in increased expression of SP7 mRNA] CTD PMID:22058016 NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065
JBrowse link
G Dll4 delta like canonical Notch ligand 4 increases expression ISO Simvastatin results in increased expression of DLL4 mRNA CTD PMID:19109527 NCBI chr 2:119,156,286...119,166,145
Ensembl chr 2:119,156,265...119,166,443
JBrowse link
G Dnm1l dynamin 1-like affects localization
increases expression
ISO Simvastatin affects the localization of DNM1L protein
Simvastatin results in increased expression of DNM1L protein
CTD PMID:20045437 NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions
increases expression
ISO SCH 23390 inhibits the reaction [Simvastatin promotes the reaction [[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP]]; SCH 23390 inhibits the reaction [Simvastatin promotes the reaction [SK&F 82958 analog results in increased activity of DRD1 protein]]; Simvastatin promotes the reaction [[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP]; Simvastatin promotes the reaction [SK&F 82958 analog results in increased activity of DRD1 protein]
Simvastatin results in increased expression of DRD1 mRNA; Simvastatin results in increased expression of DRD1 protein
CTD PMID:15711596 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
JBrowse link
G Drd2 dopamine receptor D2 increases expression ISO Simvastatin results in increased expression of DRD2 mRNA; Simvastatin results in increased expression of DRD2 protein CTD PMID:15711596 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
JBrowse link
G Dspp dentin sialophosphoprotein increases expression ISO Simvastatin results in increased expression of DSPP mRNA CTD PMID:19249597 NCBI chr 5:104,318,569...104,327,993
Ensembl chr 5:104,318,578...104,327,993
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression ISO Simvastatin results in decreased expression of DUSP1 mRNA; Simvastatin results in decreased expression of DUSP1 protein CTD PMID:21080865 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Simvastatin results in decreased expression of E2F1 mRNA CTD PMID:17428261 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
JBrowse link
G Eaf2 ELL associated factor 2 decreases response to substance ISO EAF2 SNP results in decreased susceptibility to Simvastatin CTD PMID:21483694 NCBI chr16:36,613,246...36,695,275
Ensembl chr16:36,613,246...36,695,365
JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions
decreases secretion
ISO Simvastatin results in decreased expression of EDN1 mRNA; Simvastatin results in decreased expression of EDN1 protein
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 protein]; Simvastatin results in increased expression of and results in increased secretion of EDN1 protein
Simvastatin results in decreased secretion of EDN1 protein
Simvastatin inhibits the reaction [EDN1 protein results in increased expression of CLCN3 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]
CTD PMID:16375908 PMID:18390205 PMID:19099753 PMID:20369390 PMID:20644009 More... NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Ednra endothelin receptor type A multiple interactions ISO Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA mRNA]; Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDNRA mRNA] CTD PMID:19505368 PMID:22022327 NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein]]; Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein] CTD PMID:20359552 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Egr1 early growth response 1 decreases expression EXP Simvastatin results in decreased expression of EGR1 protein CTD PMID:12818400 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions
EXP Simvastatin results in decreased phosphorylation of EIF4EBP1 protein
IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of EIF4EBP1 protein]
CTD PMID:22144680 PMID:27734117 NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702
JBrowse link
G Eno1 enolase 1, alpha non-neuron decreases expression ISO Simvastatin results in decreased expression of ENO1 protein CTD PMID:20217863 NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336
JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 multiple interactions ISO Simvastatin inhibits the reaction [F2 protein results in decreased expression of ENTPD1 protein] CTD PMID:12067895 NCBI chr19:40,600,810...40,730,046
Ensembl chr19:40,600,810...40,730,046
JBrowse link
G Epha3 Eph receptor A3 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA CTD PMID:28263720 NCBI chr16:63,363,895...63,684,538
Ensembl chr16:63,363,897...63,684,538
JBrowse link
G Epha8 Eph receptor A8 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA8 mRNA CTD PMID:28263720 NCBI chr 4:136,656,729...136,684,170
Ensembl chr 4:136,656,730...136,684,127
JBrowse link
G Epo erythropoietin multiple interactions ISO Simvastatin inhibits the reaction [Streptozocin results in decreased expression of EPO protein]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of EPO mRNA] CTD PMID:20821229 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504
JBrowse link
G Epor erythropoietin receptor multiple interactions ISO Simvastatin inhibits the reaction [Streptozocin results in decreased expression of EPOR protein]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA] CTD PMID:20821229 NCBI chr 9:21,870,193...21,874,915
Ensembl chr 9:21,870,193...21,874,802
JBrowse link
G F2 coagulation factor II multiple interactions
decreases activity
ISO Cycloheximide inhibits the reaction [Simvastatin results in decreased activity of F2 protein]; Simvastatin affects the reaction [F2 affects the localization of CTTN protein]; Simvastatin inhibits the reaction [F2 protein results in decreased expression of ENTPD1 protein] CTD PMID:12067895 PMID:14630613 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759
JBrowse link
G F3 coagulation factor III multiple interactions
decreases expression
increases expression
affects response to substance
decreases activity
ISO
EXP
geranylgeraniol inhibits the reaction [Simvastatin results in decreased expression of F3]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of F3 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of F3]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]
Simvastatin results in decreased expression of F3; Simvastatin results in decreased expression of F3 mRNA; Simvastatin results in decreased expression of F3 protein
Simvastatin results in increased expression of F3 mRNA; Simvastatin results in increased expression of F3 protein
F3 polymorphism affects the susceptibility to Simvastatin
Simvastatin results in decreased activity of F3 protein
CTD PMID:9081680 PMID:10830219 PMID:12753293 PMID:12818400 PMID:15824212 More... NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
JBrowse link
G Fasn fatty acid synthase increases expression ISO Simvastatin results in increased expression of FASN mRNA CTD PMID:11728391 PMID:12056585 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
JBrowse link
G Fbxo32 F-box protein 32 increases expression
multiple interactions
EXP
ISO
Simvastatin results in increased expression of FBXO32 mRNA; Simvastatin results in increased expression of FBXO32 protein
FST protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 mRNA]; FST protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 mRNA]
CTD PMID:19001041 PMID:25300705 PMID:27734117 PMID:33034787 NCBI chr15:58,039,275...58,078,288
Ensembl chr15:58,039,275...58,078,328
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression
increases activity
multiple interactions
ISO Simvastatin results in increased expression of FDFT1 protein
Simvastatin results in increased activity of FDFT1 protein
resveratrol inhibits the reaction [Simvastatin results in increased expression of FDFT1 mRNA]
CTD PMID:8517861 PMID:12518039 PMID:23386644 NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027
JBrowse link
G Fdps farnesyl diphosphate synthetase increases expression
multiple interactions
ISO Simvastatin results in increased expression of FDPS mRNA
resveratrol inhibits the reaction [Simvastatin results in increased expression of FDPS mRNA]
CTD PMID:23386644 NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266
JBrowse link
G Fgf15 fibroblast growth factor 15 multiple interactions ISO Simvastatin inhibits the reaction [Dietary Fats results in increased expression of FGF19 mRNA] CTD PMID:33383043 NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Simvastatin results in increased expression of FGF2 CTD PMID:20381859 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
JBrowse link
G Fkbp1a FK506 binding protein 1a decreases expression ISO Simvastatin results in decreased expression of FKBP1A mRNA CTD PMID:16414398 NCBI chr 2:151,384,403...151,403,611
Ensembl chr 2:151,384,403...151,403,612
JBrowse link
G Fkbp4 FK506 binding protein 4 increases expression EXP Simvastatin results in increased expression of FKBP4 mRNA CTD PMID:19262002 NCBI chr 6:128,407,066...128,415,619
Ensembl chr 6:128,406,698...128,415,640
JBrowse link
G Flot1 flotillin 1 decreases expression EXP Simvastatin results in decreased expression of FLOT1 protein CTD PMID:12628479 NCBI chr17:36,134,243...36,143,674
Ensembl chr17:36,134,122...36,143,683
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 multiple interactions
increases expression
ISO Simvastatin inhibits the reaction [Streptozocin results in increased expression of FLT1 mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased expression of FLT1 protein]
Simvastatin results in increased expression of FLT1 mRNA
CTD PMID:19109527 PMID:20821229 NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821
JBrowse link
G Fn1 fibronectin 1 decreases expression
increases expression
EXP
ISO
Simvastatin results in decreased expression of FN1 mRNA
Simvastatin results in increased expression of FN1 mRNA
CTD PMID:10412775 PMID:15855201 PMID:16274305 PMID:16414398 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
decreases localization
decreases expression
ISO
EXP
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of FOS mRNA]
Simvastatin results in decreased localization of FOS protein
FOS inhibits the reaction [Simvastatin results in increased expression of IL12B mRNA]; Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FOS protein]
Simvastatin inhibits the reaction [CTF1 results in increased expression of FOS mRNA]
CTD PMID:12753293 PMID:12963647 PMID:15187114 PMID:16005304 PMID:19100119 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Fosb FBJ osteosarcoma oncogene B multiple interactions EXP Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]] CTD PMID:15187114 NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976
JBrowse link
G Fosl1 fos-like antigen 1 increases expression EXP Simvastatin results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974
JBrowse link
G Fosl2 fos-like antigen 2 multiple interactions EXP Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]] CTD PMID:15187114 NCBI chr 5:32,292,599...32,315,184
Ensembl chr 5:32,293,145...32,315,186
JBrowse link
G Foxo1 forkhead box O1 affects localization
decreases phosphorylation
increases phosphorylation
multiple interactions
decreases localization
ISO
EXP
Simvastatin affects the localization of FOXO1 protein
Simvastatin results in decreased phosphorylation of FOXO1 protein
Simvastatin results in increased phosphorylation of FOXO1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased localization of FOXO1 protein]
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of FOXO1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of and affects the localization of FOXO1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of and affects the localization of FOXO1 protein]
CTD PMID:12438947 PMID:18826357 PMID:19001041 PMID:33034787 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
JBrowse link
G Foxo3 forkhead box O3 multiple interactions
increases phosphorylation
decreases expression
decreases phosphorylation
affects localization
EXP
ISO
Acetylcysteine inhibits the reaction [Simvastatin results in increased phosphorylation of FOXO3 protein]; IGF1 protein inhibits the reaction [Simvastatin affects the localization of FOXO3 protein]
Simvastatin results in decreased expression of FOXO3 protein
Simvastatin results in decreased phosphorylation of FOXO3 protein
CTD PMID:19001041 PMID:20883752 PMID:27734117 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751
JBrowse link
G Foxp3 forkhead box P3 increases expression
multiple interactions
affects methylation
decreases expression
ISO
EXP
Simvastatin results in increased expression of FOXP3
IL2 affects the reaction [Simvastatin results in increased expression of FOXP3]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of FOXP3]
Simvastatin affects the methylation of FOXP3 promoter
Simvastatin results in decreased expression of FOXP3 mRNA
CTD PMID:20408897 PMID:20491794 PMID:22305382 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484
JBrowse link
G Fst follistatin multiple interactions EXP FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of MTOR protein]; FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6KB1 protein]; FST protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 mRNA]; FST protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 protein]; FST protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 mRNA]; FST protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 protein]; FST protein inhibits the reaction [Simvastatin results in increased phosphorylation of SMAD2 protein]; FST protein inhibits the reaction [Simvastatin results in increased phosphorylation of SMAD3 protein] CTD PMID:33034787 NCBI chr13:114,588,798...114,595,522
Ensembl chr13:114,588,826...114,595,487
JBrowse link
G Fzd2 frizzled class receptor 2 increases expression ISO Simvastatin results in increased expression of FZD2 mRNA CTD PMID:19968183 NCBI chr11:102,495,257...102,498,884
Ensembl chr11:102,495,222...102,498,884
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO [Simvastatin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA CTD PMID:24204015 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression ISO Simvastatin results in decreased expression of GAPDH mRNA CTD PMID:16414398 NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430
JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO Simvastatin results in increased expression of GATA6 mRNA; Simvastatin results in increased expression of GATA6 protein CTD PMID:19842842 NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635
JBrowse link
G Gdi2 GDP dissociation inhibitor 2 decreases expression ISO Simvastatin results in decreased expression of GDI2 protein CTD PMID:20217863 NCBI chr13:3,588,075...3,616,261
Ensembl chr13:3,588,063...3,617,871
JBrowse link
G Gdnf glial cell line derived neurotrophic factor increases expression ISO Simvastatin results in increased expression of GDNF CTD PMID:20851742 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056
JBrowse link
G Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA CTD PMID:28263720 NCBI chr19:58,224,013...58,444,387
Ensembl chr19:58,224,036...58,444,341
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP GJA1 protein affects the reaction [Simvastatin results in increased susceptibility to Etoposide]; Simvastatin affects the localization of and results in decreased phosphorylation of GJA1 protein CTD PMID:23978459 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression ISO Simvastatin results in increased expression of GJB2 mRNA CTD PMID:17428261 NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO Simvastatin inhibits the reaction [Coal Ash results in increased expression of GLB1 protein] CTD PMID:26773838 NCBI chr 9:114,230,146...114,303,447
Ensembl chr 9:114,230,144...114,303,966
JBrowse link
G Gm7030 predicted gene 7030 affects expression ISO Simvastatin affects the expression of HLA-F mRNA CTD PMID:25811541 NCBI chr17:36,438,501...36,440,317
Ensembl chr17:36,420,611...36,440,317
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
multiple interactions
EXP
ISO
Simvastatin results in decreased expression of GPX1 mRNA
Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]
CTD PMID:20883752 PMID:28734741 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO Simvastatin results in increased expression of GPX2 mRNA CTD PMID:18787804 NCBI chr12:76,839,109...76,842,328
Ensembl chr12:76,839,107...76,842,273
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression
multiple interactions
ISO Simvastatin results in increased expression of GSK3B
Simvastatin inhibits the reaction [Glucose results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of GSK3B protein]
Simvastatin results in increased expression of GSK3B protein modified form
CTD PMID:18004065 PMID:18047562 PMID:19461118 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Simvastatin inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 affects expression ISO Simvastatin affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393
JBrowse link
G H2-DMa histocompatibility 2, class II, locus DMa decreases expression ISO Simvastatin results in decreased expression of RT1-DMA mRNA CTD PMID:16414398 NCBI chr17:34,338,667...34,358,075
Ensembl chr17:34,338,515...34,358,075
JBrowse link
G H2-Ea histocompatibility 2, class II antigen E alpha multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]]; Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein] CTD PMID:11219190 NCBI chr17:34,560,926...34,563,619
Ensembl chr17:34,560,926...34,563,618
JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 affects expression ISO Simvastatin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr17:36,340,869...36,343,593
Ensembl chr17:36,340,665...36,343,747
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Simvastatin results in increased phosphorylation of H2AX protein CTD PMID:20499237 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
JBrowse link
G Hes5 hes family bHLH transcription factor 5 increases expression ISO Simvastatin results in increased expression of HES5 mRNA CTD PMID:19109527 NCBI chr 4:155,042,358...155,046,829
Ensembl chr 4:155,045,380...155,046,828
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases expression
multiple interactions
decreases expression
ISO Simvastatin results in increased expression of HIF1A protein
HIF1A mutant form inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA]
Simvastatin results in decreased expression of HIF1A mRNA
CTD PMID:18356691 PMID:21844074 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholecalciferol] results in increased expression of HMGB1 mRNA]
[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein]
CTD PMID:20519084 PMID:25412314 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase decreases response to substance
affects response to substance
increases activity
multiple interactions
increases expression
decreases activity
ISO
EXP
HMGCR exon alternative form results in decreased susceptibility to Simvastatin
HMGCR intron polymorphism affects the susceptibility to Simvastatin; HMGCR polymorphism affects the susceptibility to Simvastatin
Simvastatin results in increased activity of HMGCR protein
[HMGCR intron polymorphism affects the expression of HMGCR exon alternative form] which results in decreased susceptibility to Simvastatin; [MVK gene mutant form results in increased activity of HMGCR protein] which results in increased susceptibility to Simvastatin; [Simvastatin co-treated with Ezetimibe] results in increased expression of HMGCR mRNA; HMGCR polymorphism promotes the reaction [[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB]; MVK gene mutant form promotes the reaction [Simvastatin results in decreased activity of HMGCR protein]; Resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]; Resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR protein]; Resveratrol promotes the reaction [Simvastatin results in decreased activity of HMGCR protein]; Simvastatin affects the reaction [Hydroxychloroquine affects the expression of HMGCR mRNA]; Simvastatin results in increased expression of and results in increased activity of HMGCR protein
Colesevelam Hydrochloride promotes the reaction [Simvastatin results in increased expression of HMGCR mRNA]
Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of HMGCR protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]; resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]; resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR protein]; resveratrol promotes the reaction [Simvastatin results in decreased activity of HMGCR protein]; Simvastatin results in increased expression of and results in decreased activity of HMGCR protein; Simvastatin results in increased expression of and results in increased activity of HMGCR protein
Simvastatin results in increased expression of HMGCR mRNA; Simvastatin results in increased expression of HMGCR protein
CTD PMID:1627634 PMID:8517861 PMID:8593127 PMID:9512650 PMID:10357840 More... NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases stability
decreases expression
increases activity
increases expression
increases response to substance
EXP
ISO
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which affects the localization of RELA protein; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased phosphorylation of NFKBIA protein; [Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein; Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 protein]]
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which affects the localization of RELA protein; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased phosphorylation of NFKBIA protein; [Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein; tin protoporphyrin IX inhibits the reaction [Simvastatin results in increased expression of HMOX1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased stability of HMOX1 mRNA]; MAPK1 promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Simvastatin results in increased expression of HMOX1 mRNA]
Simvastatin results in decreased expression of HMOX1 mRNA
Simvastatin results in increased activity of HMOX1 protein
Simvastatin results in increased expression of HMOX1 mRNA; Simvastatin results in increased expression of HMOX1 protein
HMOX1 gene mutant form results in increased susceptibility to Simvastatin
CTD PMID:16375908 PMID:16414398 PMID:16628357 PMID:17928392 PMID:18073186 More... NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hnf1a HNF1 homeobox A increases expression EXP Simvastatin results in increased expression of HNF1A mRNA CTD PMID:22160096 NCBI chr 5:115,087,039...115,109,121
Ensembl chr 5:115,087,039...115,109,153
JBrowse link
G Hras Harvey rat sarcoma virus oncogene multiple interactions
decreases activity
ISO
EXP
Farnesol inhibits the reaction [Simvastatin results in decreased farnesylation of and affects the localization of HRAS protein]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]; MVK gene mutant form promotes the reaction [Simvastatin results in decreased farnesylation of and affects the localization of HRAS protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased prenylation of HRAS protein]; Simvastatin results in decreased prenylation of and results in decreased localization of HRAS protein
Simvastatin results in decreased activity of HRAS
CTD PMID:11914545 PMID:12477733 PMID:18625914 PMID:19360310 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO [Simvastatin co-treated with resveratrol] results in decreased expression of HSD3B1 mRNA CTD PMID:24524197 NCBI chr 3:98,749,672...98,767,110
Ensembl chr 3:98,759,510...98,767,110
JBrowse link
G Hsf1 heat shock factor 1 affects localization ISO Simvastatin affects the localization of HSF1 protein CTD PMID:16375908 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 increases expression ISO Simvastatin results in increased expression of HSP90AA1 protein CTD PMID:16375908 NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162
JBrowse link
G Hspa4 heat shock protein 4 increases expression ISO Simvastatin results in increased expression of HSPA4 protein CTD PMID:16375908 NCBI chr11:53,150,641...53,191,306
Ensembl chr11:53,150,641...53,191,284
JBrowse link
G Hspa5 heat shock protein 5 increases expression ISO Simvastatin results in increased expression of HSPA5 mRNA; Simvastatin results in increased expression of HSPA5 protein CTD PMID:18664198 PMID:19253821 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Hspa8 heat shock protein 8 decreases expression ISO Simvastatin results in decreased expression of HSPA8 protein CTD PMID:20217863 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383
JBrowse link
G Htra2 HtrA serine peptidase 2 affects localization ISO Simvastatin affects the localization of HTRA2 protein CTD PMID:20045437 NCBI chr 6:83,028,247...83,031,552
Ensembl chr 6:83,028,247...83,032,254
JBrowse link
G Ibsp integrin binding sialoprotein increases expression EXP Simvastatin results in increased expression of IBSP mRNA CTD PMID:20417880 NCBI chr 5:104,447,153...104,459,338
Ensembl chr 5:104,447,037...104,459,335
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; Simvastatin affects the expression of and affects the secretion of ICAM1 protein; Simvastatin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1]; Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]; Vitamin E inhibits the reaction [Simvastatin results in decreased expression of ICAM1 protein modified form]
Simvastatin results in decreased expression of ICAM1 mRNA; Simvastatin results in decreased expression of ICAM1 protein; Simvastatin results in decreased expression of ICAM1 protein modified form
CTD PMID:10946302 PMID:12615677 PMID:14602771 PMID:15234187 PMID:16054375 More... NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression EXP Simvastatin results in increased expression of ID1 mRNA CTD PMID:19262002 NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase increases expression ISO Simvastatin results in increased expression of IDI1 mRNA CTD PMID:25055962 NCBI chr13:8,935,642...8,942,432
Ensembl chr13:8,935,537...8,942,487
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression ISO Simvastatin results in increased expression of IDO1 CTD PMID:20491794 NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
increases secretion
ISO
EXP
IFNG affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IFNG affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; IFNG affects the reaction [Simvastatin results in decreased secretion of IL17A protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR4 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CIITA protein]; Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]; Simvastatin inhibits the reaction [IFNG results in increased expression of PTGS2]; Simvastatin inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL2 protein]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL3 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL4 mRNA]
Simvastatin results in increased expression of IFNG mRNA
Simvastatin results in increased secretion of IFNG protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]; Simvastatin inhibits the reaction [IFNG promotes the reaction [STAT1 binds to CD40 promoter]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]; Simvastatin inhibits the reaction [IFNG results in increased expression of IRF1 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased phosphorylation of STAT1 protein]; Simvastatin promotes the reaction [IFNG promotes the reaction [RELA binds to CD40 promoter]]; Simvastatin promotes the reaction [IFNG results in increased expression of PTGS2]
CTD PMID:11219190 PMID:16321392 PMID:17507688 PMID:18453621 PMID:19589242 More... NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP [Simvastatin co-treated with NVP-AEW541] inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]; IGF1 protein inhibits the reaction [Simvastatin affects the localization of FOXO3 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of BAD protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of EIF4EBP1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6KB1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased cleavage of CASP3 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 mRNA]; IGF1 protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 mRNA]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein]; Simvastatin inhibits the reaction [IGF1 results in increased activity of AKT1 protein]; Simvastatin inhibits the reaction [IGF1 results in increased activity of MAPK1 protein]; Simvastatin inhibits the reaction [IGF1 results in increased activity of MAPK3 protein] CTD PMID:17327694 PMID:27734117 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Igf1r insulin-like growth factor I receptor decreases expression
increases expression
multiple interactions
ISO
EXP
Simvastatin results in decreased expression of IGF1R; Simvastatin results in decreased expression of IGF1R mRNA; Simvastatin results in decreased expression of IGF1R protein
Simvastatin results in increased expression of IGF1R protein alternative form
[Simvastatin co-treated with NVP-AEW541] inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]
CTD PMID:17158816 PMID:17327694 PMID:18489904 PMID:27734117 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416
JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 increases expression ISO Simvastatin results in increased expression of IGFBP6 mRNA CTD PMID:17428261 NCBI chr15:102,052,621...102,057,947
Ensembl chr15:102,052,797...102,057,946
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta multiple interactions
decreases expression
increases phosphorylation
ISO artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein]; parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein]; Simvastatin promotes the reaction [Doxorubicin results in increased phosphorylation of IKBKB protein]
Simvastatin results in decreased expression of IKBKB mRNA
CTD PMID:17277159 PMID:18463201 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
ISO
EXP
Simvastatin results in increased expression of IL10
Simvastatin results in increased expression of IL10 mRNA; Simvastatin results in increased expression of IL10 protein
Simvastatin promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein]
1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of IL10 protein]]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of IL10 protein]
CTD PMID:15883752 PMID:20491794 PMID:21925249 PMID:33774062 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il12b interleukin 12b multiple interactions
increases expression
EXP FOS inhibits the reaction [Simvastatin results in increased expression of IL12B mRNA]; JUN promotes the reaction [Simvastatin results in increased expression of IL12B mRNA]; Simvastatin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B mRNA]; Simvastatin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein]; Simvastatin promotes the reaction [Pam(3)CSK(4) peptide results in increased expression of IL12B protein]; Simvastatin promotes the reaction [resiquimod results in increased expression of IL12B protein] CTD PMID:15187114 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
JBrowse link
G Il13 interleukin 13 decreases expression EXP Simvastatin results in decreased expression of IL13 mRNA; Simvastatin results in decreased expression of IL13 protein CTD PMID:17169357 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
JBrowse link
G Il16 interleukin 16 multiple interactions EXP [Lipopolysaccharides co-treated with Simvastatin] results in increased expression of IL16 mRNA CTD PMID:15665042 NCBI chr 7:83,292,027...83,395,479
Ensembl chr 7:83,292,033...83,394,934
JBrowse link
G Il17a interleukin 17A multiple interactions
decreases expression
decreases secretion
ISO IFNG affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IFNG affects the reaction [Simvastatin results in decreased secretion of IL17A protein]; IL27 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IL27 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]; IL4 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IL4 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL17A mRNA] CTD PMID:18453621 PMID:21856936 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Il17f interleukin 17F decreases secretion ISO Simvastatin results in decreased secretion of IL17F protein CTD PMID:21856936 NCBI chr 1:20,847,370...20,855,498
Ensembl chr 1:20,847,370...20,860,841
JBrowse link
G Il18 interleukin 18 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]]; Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]
Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]
CTD PMID:18660453 PMID:27377765 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]]; Simvastatin inhibits the reaction [IL1A results in decreased expression of NFKBIA protein modified form]; Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]; Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]; Simvastatin inhibits the reaction [IL1A results in increased expression of NOS2 mRNA]; Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]; Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]
CTD PMID:15705589 PMID:15728660 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
decreases secretion
ISO 1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]; Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]]; Simvastatin affects the reaction [Doxorubicin results in increased expression of IL1B mRNA]; Simvastatin affects the reaction [Doxorubicin results in increased expression of IL1B protein]; Simvastatin inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]
farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]; Simvastatin affects the reaction [IL1B protein results in increased activity of MMP2 protein]; Simvastatin inhibits the reaction [CCN1 results in increased expression of IL1B]; Simvastatin inhibits the reaction [IL1B protein results in increased activity of MMP9 protein]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP2 mRNA]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [TNF results in increased localization of IL1B protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]; Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]; Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE mRNA]; Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]; Simvastatin promotes the reaction [IL1B protein results in increased expression of VCAM1 protein]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Simvastatin results in decreased expression of IL1B mRNA; Simvastatin results in decreased expression of IL1B protein
Simvastatin results in decreased secretion of IL1B protein
CTD PMID:10946302 PMID:12829860 PMID:15883752 PMID:16054375 PMID:17075836 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il1r2 interleukin 1 receptor, type II decreases expression ISO Simvastatin results in decreased expression of IL1R2 mRNA CTD PMID:16414398 NCBI chr 1:40,123,872...40,164,390
Ensembl chr 1:40,113,239...40,164,391
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression ISO Simvastatin results in decreased expression of IL1RL1 mRNA CTD PMID:16414398 NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575
JBrowse link
G Il2 interleukin 2 multiple interactions EXP IL2 affects the reaction [Simvastatin results in increased expression of FOXP3] CTD PMID:20408897 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Il20rb interleukin 20 receptor beta increases expression ISO Simvastatin results in increased expression of IL20RB mRNA CTD PMID:17428261 NCBI chr 9:100,339,772...100,368,526
Ensembl chr 9:100,339,772...100,368,841
JBrowse link
G Il21 interleukin 21 decreases expression
decreases secretion
ISO Simvastatin results in decreased expression of IL21 mRNA
Simvastatin results in decreased secretion of IL21 protein
CTD PMID:18453621 PMID:21856936 NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785
JBrowse link
G Il22b interleukin 22B decreases secretion ISO Simvastatin results in decreased secretion of IL22 protein CTD PMID:21856936 NCBI chr10:118,125,534...118,130,943
Ensembl chr10:118,125,534...118,130,943
JBrowse link
G Il23a interleukin 23, alpha subunit p19 decreases expression ISO Simvastatin results in decreased expression of IL23A mRNA CTD PMID:18453621 PMID:22305382 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621
JBrowse link
G Il25 interleukin 25 decreases expression ISO Simvastatin results in decreased expression of IL25 mRNA CTD PMID:22305382 NCBI chr14:55,170,152...55,173,294
Ensembl chr14:55,170,152...55,173,294
JBrowse link
G Il27 interleukin 27 increases expression
multiple interactions
increases secretion
ISO Simvastatin results in increased expression of IL27 mRNA
IL27 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IL27 affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; IL27 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]
Simvastatin results in increased secretion of IL27 protein
CTD PMID:18453621 NCBI chr 7:126,188,181...126,194,197
Ensembl chr 7:126,188,182...126,194,113
JBrowse link
G Il2ra interleukin 2 receptor, alpha chain affects expression
decreases expression
ISO Simvastatin affects the expression of IL2RA protein
Simvastatin results in decreased expression of IL2RA mRNA
CTD PMID:16387846 PMID:18453621 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
increases secretion
decreases expression
ISO
EXP
IL4 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IL4 affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; IL4 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]
Simvastatin results in increased expression of IL4 mRNA
Simvastatin results in increased secretion of IL4 protein
Simvastatin results in decreased expression of IL4 mRNA; Simvastatin results in decreased expression of IL4 protein
CTD PMID:17169357 PMID:18453621 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Il4ra interleukin 4 receptor, alpha decreases expression ISO Simvastatin results in decreased expression of IL4R mRNA
Simvastatin results in decreased expression of IL4RA mRNA
CTD PMID:16414398 PMID:18453621 NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
decreases expression
decreases secretion
affects secretion
ISO
EXP
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL6 mRNA]; Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]; Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]; Simvastatin inhibits the reaction [TNF results in increased localization of IL6 protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Simvastatin results in decreased expression of and results in decreased secretion of IL6 protein
Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]
Simvastatin results in increased expression of IL6 mRNA
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]
Simvastatin results in decreased expression of IL6 mRNA; Simvastatin results in decreased expression of IL6 protein
Simvastatin results in decreased secretion of IL6 protein
Simvastatin affects the secretion of IL6 protein
CTD PMID:12117737 PMID:15665042 PMID:15883752 PMID:16387846 PMID:16424782 More... NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Inha inhibin alpha multiple interactions ISO [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of INHA mRNA CTD PMID:25055962 NCBI chr 1:75,483,872...75,487,010
Ensembl chr 1:75,483,721...75,487,010
JBrowse link
G Insig2 insulin induced gene 2 decreases expression ISO Simvastatin results in decreased expression of INSIG2 mRNA CTD PMID:25055962 NCBI chr 1:121,232,082...121,260,391
Ensembl chr 1:121,232,082...121,260,318
JBrowse link
G Insl3 insulin-like 3 multiple interactions ISO [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of INSL3 mRNA CTD PMID:25055962 NCBI chr 8:72,141,896...72,143,221
Ensembl chr 8:72,141,858...72,143,219
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions EXP Simvastatin inhibits the reaction [IFNG results in increased expression of IRF1 mRNA] CTD PMID:17507688 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200
JBrowse link
G Irf4 interferon regulatory factor 4 decreases expression
multiple interactions
ISO
EXP
Simvastatin results in decreased expression of IRF4 protein
Simvastatin results in decreased expression of IRF4 mRNA; Simvastatin results in decreased expression of IRF4 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of IRF4 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of IRF4 protein]; IRF4 protein inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; IRF4 protein inhibits the reaction [Simvastatin results in increased expression of MSTN protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IRF4 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IRF4 protein]
CTD PMID:21856936 PMID:33034787 NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:27734117 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137
JBrowse link
G Itgal integrin alpha L affects binding
multiple interactions
decreases expression
ISO Simvastatin binds to [ITGAL protein binds to ITGB2 protein]
Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the activity of CHAT protein]; Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHAT mRNA]; Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHRM5 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of ITGAL]
Simvastatin results in decreased expression of ITGAL mRNA
CTD PMID:12615677 PMID:15041742 PMID:16828882 NCBI chr 7:126,895,404...126,934,309
Ensembl chr 7:126,895,432...126,934,310
JBrowse link
G Itgam integrin alpha M multiple interactions
decreases expression
EXP
ISO
Simvastatin results in decreased expression of [ITGAM protein binds to ITGB2 protein]
Simvastatin results in decreased expression of ITGAM mRNA; Simvastatin results in decreased expression of ITGAM protein
CTD PMID:16414398 PMID:21330348 PMID:21441352 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) decreases expression ISO Simvastatin results in decreased expression of ITGB1 mRNA; Simvastatin results in decreased expression of ITGB1 protein CTD PMID:17428261 PMID:21874229 NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681
JBrowse link
G Itgb2 integrin beta 2 affects binding
multiple interactions
decreases expression
ISO
EXP
Simvastatin binds to [ITGAL protein binds to ITGB2 protein]
Simvastatin results in decreased expression of [ITGAM protein binds to ITGB2 protein]
Simvastatin inhibits the reaction [TNF results in increased expression of ITGB2]
Simvastatin results in decreased expression of ITGB2 mRNA
CTD PMID:12615677 PMID:15041742 PMID:21330348 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542
JBrowse link
G Itgb3bp integrin beta 3 binding protein (beta3-endonexin) decreases expression ISO Simvastatin results in decreased expression of ITGB3BP mRNA CTD PMID:17428261 NCBI chr 4:99,655,643...99,717,403
Ensembl chr 4:99,653,639...99,787,010
JBrowse link
G Itgb4 integrin beta 4 affects expression
increases expression
ISO Simvastatin affects the expression of ITGB4 mRNA; Simvastatin affects the expression of ITGB4 protein
Simvastatin results in increased expression of ITGB4 mRNA; Simvastatin results in increased expression of ITGB4 protein
CTD PMID:14630613 PMID:19110722 NCBI chr11:115,865,556...115,899,238
Ensembl chr11:115,865,535...115,899,238
JBrowse link
G Itgbl1 integrin, beta-like 1 decreases expression ISO Simvastatin results in decreased expression of ITGBL1 mRNA CTD PMID:17428261 NCBI chr14:123,897,331...124,215,173
Ensembl chr14:123,897,383...124,213,030
JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]]; Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein] CTD PMID:16534557 NCBI chr 4:101,009,171...101,122,493
Ensembl chr 4:101,009,564...101,122,479
JBrowse link
G Jak2 Janus kinase 2 multiple interactions
decreases expression
decreases phosphorylation
ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]]; Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein modified form]; Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]; Simvastatin inhibits the reaction [CTF1 results in increased phosphorylation of JAK2 protein]
Simvastatin results in decreased expression of JAK2 mRNA
Simvastatin results in decreased phosphorylation of JAK2 protein
CTD PMID:16414398 PMID:16534557 PMID:18400235 PMID:19100119 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480
JBrowse link
G Jun jun proto-oncogene multiple interactions
increases phosphorylation
decreases localization
decreases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [Simvastatin results in increased phosphorylation of JUN protein]
JUN promotes the reaction [Simvastatin results in increased expression of IL12B mRNA]; Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]]; Simvastatin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of JUN protein]
Simvastatin results in decreased localization of JUN protein
Simvastatin results in decreased expression of JUN mRNA
CTD PMID:12753293 PMID:12963647 PMID:15187114 PMID:15488325 PMID:17125918 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Junb jun B proto-oncogene multiple interactions EXP Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]] CTD PMID:15187114 NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases localization
multiple interactions
decreases activity
ISO Simvastatin results in decreased localization of KCNH2 protein
Berberine promotes the reaction [Simvastatin results in decreased activity of KCNH2 protein]
CTD PMID:21525004 PMID:30086269 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Kdr kinase insert domain protein receptor increases expression
multiple interactions
ISO
EXP
Simvastatin results in increased expression of KDR mRNA; Simvastatin results in increased expression of KDR protein
Simvastatin inhibits the reaction [Streptozocin results in increased expression of KDR mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased expression of KDR protein]
CTD PMID:15572054 PMID:19109527 PMID:20821229 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of KIT mRNA CTD PMID:28263720 NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382
JBrowse link
G Klf10 Kruppel-like transcription factor 10 multiple interactions ISO [Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA] CTD PMID:19225232 NCBI chr15:38,291,702...38,300,950
Ensembl chr15:38,291,707...38,300,950
JBrowse link
G Klf16 Kruppel-like transcription factor 16 increases expression EXP Simvastatin results in increased expression of KLF16 mRNA CTD PMID:19262002 NCBI chr10:80,402,955...80,413,130
Ensembl chr10:80,402,958...80,413,155
JBrowse link
G Klf2 Kruppel-like transcription factor 2 (lung) increases expression
multiple interactions
decreases expression
ISO Simvastatin results in increased expression of KLF2 mRNA
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of KLF2 mRNA]
Simvastatin results in decreased expression of KLF2 mRNA
CTD PMID:17428261 PMID:20493886 PMID:20737288 PMID:22305382 NCBI chr 8:73,072,906...73,075,498
Ensembl chr 8:73,072,877...73,075,500
JBrowse link
G Klf6 Kruppel-like transcription factor 6 increases expression ISO Simvastatin results in increased expression of KLF6 mRNA CTD PMID:17428261 NCBI chr13:5,911,488...5,920,392
Ensembl chr13:5,911,481...5,920,393
JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog decreases prenylation ISO Simvastatin results in decreased prenylation of KRAS protein CTD PMID:8063617 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965
JBrowse link
G Krt13 keratin 13 increases expression ISO Simvastatin results in increased expression of KRT13 mRNA CTD PMID:17428261 NCBI chr11:100,008,153...100,012,392
Ensembl chr11:100,008,153...100,012,392
JBrowse link
G Krt15 keratin 15 increases expression ISO Simvastatin results in increased expression of KRT15 mRNA CTD PMID:17428261 NCBI chr11:100,022,585...100,026,775
Ensembl chr11:100,022,584...100,026,754
JBrowse link
G Krt17 keratin 17 increases expression ISO Simvastatin results in increased expression of KRT17 mRNA CTD PMID:17428261 NCBI chr11:100,147,041...100,151,855
Ensembl chr11:100,147,043...100,151,855
JBrowse link
G Lbh limb-bud and heart increases expression EXP Simvastatin results in increased expression of LBH mRNA CTD PMID:19262002 NCBI chr17:73,225,300...73,248,941
Ensembl chr17:73,225,300...73,248,942
JBrowse link
G Lbp lipopolysaccharide binding protein decreases expression ISO Simvastatin results in decreased expression of LBP mRNA CTD PMID:16414398 NCBI chr 2:158,148,413...158,174,772
Ensembl chr 2:158,148,413...158,174,772
JBrowse link
G Lcat lecithin cholesterol acyltransferase increases activity
decreases expression
EXP
ISO
Simvastatin results in increased activity of LCAT protein
Simvastatin results in decreased expression of LCAT mRNA
CTD PMID:21241519 PMID:25055962 NCBI chr 8:106,666,183...106,670,034
Ensembl chr 8:106,666,183...106,670,014
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
affects response to substance
increases expression
increases activity
ISO
EXP
[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB; [Simvastatin co-treated with Ezetimibe] results in increased expression of LDLR mRNA; HMGCR polymorphism promotes the reaction [[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB]
LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin; LDLR mutant form affects the susceptibility to Simvastatin
Simvastatin results in increased expression of LDLR mRNA
Berberine promotes the reaction [Simvastatin results in increased expression of LDLR mRNA]; Simvastatin promotes the reaction [Berberine results in increased expression of LDLR mRNA]
Simvastatin results in increased activity of LDLR protein
Simvastatin results in increased expression of LDLR mRNA; Simvastatin results in increased expression of LDLR protein
CTD PMID:1627634 PMID:8457250 PMID:8593127 PMID:9633944 PMID:10208479 More... NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 increases expression ISO Simvastatin results in increased expression of LEF1 mRNA CTD PMID:19968183 NCBI chr 3:130,903,972...131,018,006
Ensembl chr 3:130,904,120...131,018,005
JBrowse link
G Lep leptin multiple interactions
decreases expression
decreases secretion
EXP
ISO
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]; GGTI 298 inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]; GGTI 298 inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]
Simvastatin results in decreased expression of LEP mRNA; Simvastatin results in decreased expression of LEP mRNA alternative form
Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein]
CTD PMID:19254925 PMID:29071762 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
JBrowse link
G Lepr leptin receptor affects response to substance ISO LEPR polymorphism affects the susceptibility to Simvastatin CTD PMID:14625131 PMID:18854995 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Lhb luteinizing hormone beta multiple interactions ISO Simvastatin promotes the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of LHB protein]; Simvastatin promotes the reaction [ethinyl estradiol-desogestrel combination results in decreased expression of LHB protein] CTD PMID:17105841 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
JBrowse link
G Lif leukemia inhibitory factor multiple interactions ISO [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]] CTD PMID:19225232 NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514
JBrowse link
G Litaf LPS-induced TN factor decreases expression ISO Simvastatin results in decreased expression of LITAF mRNA CTD PMID:16414398 NCBI chr16:10,777,137...10,810,985
Ensembl chr16:10,777,139...10,884,021
JBrowse link
G Lox lysyl oxidase decreases expression ISO Simvastatin results in decreased expression of LOX mRNA CTD PMID:16414398 NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939
JBrowse link
G Lpl lipoprotein lipase decreases expression
increases expression
ISO Simvastatin results in decreased expression of LPL
Simvastatin results in increased expression of LPL protein
CTD PMID:2009092 PMID:19216230 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100
JBrowse link
G Lrp6 low density lipoprotein receptor-related protein 6 decreases expression ISO Simvastatin results in decreased expression of LRP6 mRNA CTD PMID:25055962 NCBI chr 6:134,423,439...134,543,876
Ensembl chr 6:134,423,439...134,543,928
JBrowse link
G Lrrc2 leucine rich repeat containing 2 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of LRRC2 mRNA CTD PMID:28263720 NCBI chr 9:110,780,613...110,813,134
Ensembl chr 9:110,780,613...110,813,134
JBrowse link
G Ltb lymphotoxin B decreases expression ISO Simvastatin results in decreased expression of LTB mRNA CTD PMID:17428261 NCBI chr17:35,413,483...35,415,281
Ensembl chr17:35,413,415...35,415,296
JBrowse link
G Mad2l1 MAD2 mitotic arrest deficient-like 1 decreases expression ISO Simvastatin results in decreased expression of MAD2L1 mRNA CTD PMID:17428261 NCBI chr 6:66,512,205...66,518,091
Ensembl chr 6:66,512,374...66,524,204
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions
EXP
ISO
Simvastatin results in increased expression of MAP1LC3B protein
[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form; Chloroquine promotes the reaction [[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form]
CTD PMID:23817226 PMID:25412314 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 decreases expression ISO Simvastatin results in decreased expression of MAP3K14 mRNA CTD PMID:17277159 NCBI chr11:103,110,590...103,158,227
Ensembl chr11:103,110,588...103,158,298
JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 multiple interactions ISO Simvastatin results in decreased activity of [MAP3K7 protein co-treated with TAB1 protein] CTD PMID:17277159 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases activity
increases phosphorylation
decreases phosphorylation
ISO
EXP
[tipifarnib co-treated with Simvastatin] results in decreased phosphorylation of MAPK1 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; MAPK1 promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; MAPK1 promotes the reaction [Simvastatin results in increased expression of NFE2L2 mRNA]; MAPK1 promotes the reaction [Simvastatin results in increased expression of NQO1 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; Simvastatin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
Simvastatin results in decreased activity of MAPK1 protein
Simvastatin results in increased phosphorylation of MAPK1 protein
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]]; Simvastatin inhibits the reaction [IGF1 results in increased activity of MAPK1 protein]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]; Simvastatin results in increased phosphorylation of and results in increased activity of MAPK1 protein
Simvastatin results in decreased phosphorylation of MAPK1 protein
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]]; Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; Simvastatin inhibits the reaction [Smoke analog results in increased phosphorylation of MAPK1 protein]; Simvastatin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
CTD PMID:17169357 PMID:17327694 PMID:17428261 PMID:17928392 PMID:18047562 More... NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions
decreases expression
EXP
ISO
Simvastatin results in increased phosphorylation of and results in increased activity of MAPK14 protein
Simvastatin results in decreased expression of MAPK14 mRNA
CTD PMID:16414398 PMID:17928392 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
decreases activity
increases phosphorylation
decreases phosphorylation
ISO
EXP
[tipifarnib co-treated with Simvastatin] results in decreased phosphorylation of MAPK3 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; Simvastatin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
Simvastatin results in decreased activity of MAPK3 protein
Simvastatin results in increased phosphorylation of MAPK3 protein
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]]; Simvastatin inhibits the reaction [IGF1 results in increased activity of MAPK3 protein]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]; Simvastatin results in increased phosphorylation of and results in increased activity of MAPK3 protein
Simvastatin results in decreased phosphorylation of MAPK3 protein
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]]; Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; Simvastatin inhibits the reaction [Smoke analog results in increased phosphorylation of MAPK3 protein]; Simvastatin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
CTD PMID:17169357 PMID:17327694 PMID:17428261 PMID:17928392 PMID:18047562 More... NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases activity
EXP
ISO
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]
Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
Simvastatin results in increased activity of MAPK8 protein
CTD PMID:15187114 PMID:18047562 PMID:18310456 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases activity EXP Simvastatin results in increased activity of MAPK9 protein CTD PMID:15187114 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Mapt microtubule-associated protein tau affects expression ISO Simvastatin affects the expression of MAPT CTD PMID:19461118 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Mb myoglobin multiple interactions ISO Simvastatin inhibits the reaction [Poloxamer results in increased secretion of MB protein] CTD PMID:29071762 NCBI chr15:76,899,687...76,934,868
Ensembl chr15:76,899,687...76,934,870
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO Simvastatin results in decreased expression of MCM4 mRNA CTD PMID:17428261 NCBI chr16:15,441,761...15,455,264
Ensembl chr16:15,441,761...15,455,264
JBrowse link
G Mdh1 malate dehydrogenase 1, NAD (soluble) decreases expression ISO Simvastatin results in decreased expression of MDH1 protein CTD PMID:20217863 NCBI chr11:21,506,692...21,521,934
Ensembl chr11:21,506,692...21,522,367
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 increases phosphorylation
multiple interactions
ISO Simvastatin results in increased phosphorylation of MDM2 protein
Simvastatin promotes the reaction [Benzo(a)pyrene promotes the reaction [TP53 protein binds to MDM2 protein]]
CTD PMID:15625077 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
JBrowse link
G Mertk MER proto-oncogene tyrosine kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA CTD PMID:28263720 NCBI chr 2:128,540,836...128,645,082
Ensembl chr 2:128,540,876...128,644,814
JBrowse link
G Mir221 microRNA 221 decreases expression ISO Simvastatin results in decreased expression of MIR221 CTD PMID:25517390 NCBI chr  X:19,012,533...19,012,627
Ensembl chr  X:19,012,533...19,012,627
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 decreases expression ISO Simvastatin results in decreased expression of MKI67 protein CTD PMID:26577051 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression ISO Simvastatin results in increased expression of MMP10 mRNA CTD PMID:17428261 NCBI chr 9:7,502,343...7,510,243
Ensembl chr 9:7,502,353...7,510,241
JBrowse link
G Mmp12 matrix metallopeptidase 12 increases expression ISO Simvastatin results in increased expression of MMP12 mRNA CTD PMID:17428261 NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression
multiple interactions
ISO
EXP
Simvastatin results in increased expression of MMP13 mRNA
Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
CTD PMID:16274305 PMID:17428261 PMID:31260663 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) decreases secretion
increases expression
decreases expression
multiple interactions
ISO Simvastatin results in decreased secretion of MMP1 mRNA; Simvastatin results in decreased secretion of MMP1 protein
Simvastatin results in increased expression of MMP1 mRNA
Simvastatin results in decreased expression of MMP1 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP1]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of MMP1 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of MMP1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of MMP1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of MMP1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of MMP1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of MMP1 protein]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP1 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]
CTD PMID:17303772 PMID:17428261 PMID:18625914 PMID:31260663 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity
increases activity
multiple interactions
decreases expression
ISO
EXP
Simvastatin results in decreased activity of MMP2 protein
Simvastatin results in increased activity of MMP2 protein
Simvastatin inhibits the reaction [Monocrotaline results in increased expression of MMP2 mRNA]; Simvastatin results in decreased expression of and results in decreased activity of MMP2 protein
Simvastatin affects the reaction [IL1B protein results in increased activity of MMP2 protein]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP2 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]
Simvastatin results in decreased expression of MMP2 mRNA
Simvastatin results in decreased expression of MMP2 protein
CTD PMID:15210533 PMID:17038636 PMID:17158816 PMID:17169357 PMID:18309148 More... NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp28 matrix metallopeptidase 28 (epilysin) increases expression ISO Simvastatin results in increased expression of MMP28 mRNA CTD PMID:17428261 NCBI chr11:83,331,594...83,353,890
Ensembl chr11:83,331,594...83,353,897
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression
multiple interactions
ISO Simvastatin results in decreased expression of MMP3 mRNA
Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]
CTD PMID:16414398 PMID:31260663 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Mmp8 matrix metallopeptidase 8 multiple interactions ISO Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP8 mRNA] CTD PMID:18625914 NCBI chr 9:7,558,430...7,568,487
Ensembl chr 9:7,558,457...7,568,486
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases activity
decreases activity
decreases expression
ISO
EXP
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]]; Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]; Simvastatin inhibits the reaction [IL1B protein results in increased activity of MMP9 protein]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of MMP9 protein]; Simvastatin promotes the reaction [TNF results in increased expression of MMP9 mRNA]
Simvastatin results in increased activity of MMP9 protein
Simvastatin results in decreased activity of MMP9 protein
Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of MMP9 protein]
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]]; Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of MMP9 protein]; Simvastatin inhibits the reaction [Smoke analog results in increased activity of MMP9 protein]; Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of MMP9 mRNA]; Simvastatin results in decreased expression of and results in decreased activity of MMP9 protein
Simvastatin results in decreased expression of MMP9 protein
Simvastatin results in decreased expression of MMP9 mRNA; Simvastatin results in decreased expression of MMP9 protein
CTD PMID:15107580 PMID:15210533 PMID:15537504 PMID:15728660 PMID:16002570 More... NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases expression
decreases activity
ISO
EXP
Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]
Simvastatin results in decreased expression of MPO protein
Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]
Simvastatin results in decreased activity of MPO protein
1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of MPO protein]]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of MPO protein]
CTD PMID:15665042 PMID:17038636 PMID:21764683 PMID:33774062 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Mras muscle and microspikes RAS multiple interactions ISO Simvastatin inhibits the reaction [Glucose results in increased activity of MRAS protein]; Simvastatin inhibits the reaction [Smoke analog results in increased activity of MRAS protein] CTD PMID:18569938 PMID:19299917 NCBI chr 9:99,267,473...99,319,505
Ensembl chr 9:99,267,473...99,319,434
JBrowse link
G Mrps31 mitochondrial ribosomal protein S31 decreases response to substance ISO MRPS31 SNP results in decreased susceptibility to Simvastatin CTD PMID:21483694 NCBI chr 8:22,901,356...22,919,685
Ensembl chr 8:22,901,377...22,919,681
JBrowse link
G Mstn myostatin multiple interactions
increases expression
EXP 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid inhibits the reaction [Simvastatin results in increased expression of MSTN protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of MSTN protein]; IRF4 protein inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; IRF4 protein inhibits the reaction [Simvastatin results in increased expression of MSTN protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of MSTN protein]; Simvastatin results in increased expression of and results in increased secretion of MSTN protein
Simvastatin results in increased expression of MSTN mRNA; Simvastatin results in increased expression of MSTN protein
CTD PMID:33034787 NCBI chr 1:53,100,799...53,107,238
Ensembl chr 1:53,100,799...53,107,238
JBrowse link
G Mthfr methylenetetrahydrofolate reductase multiple interactions
increases expression
affects response to substance
ISO
EXP
Homocysteine inhibits the reaction [Simvastatin results in increased expression of MTHFR protein modified form]; Simvastatin promotes the reaction [Homocysteine results in increased expression of MTHFR protein]
MTHFR affects the susceptibility to Simvastatin
MTHFR gene mutant form inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]; MTHFR inhibits the reaction [Simvastatin results in increased expression of NOS2 mRNA]; MTHFR inhibits the reaction [Simvastatin results in increased expression of NOS2 protein]
CTD PMID:18540024 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions
EXP Simvastatin results in decreased phosphorylation of MTOR protein
FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of MTOR protein]
CTD PMID:22144680 PMID:33034787 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric multiple interactions ISO Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]; Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MUC5AC protein]
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]]; Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]
CTD PMID:19024099 PMID:20359552 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968
JBrowse link
G Mvd mevalonate (diphospho) decarboxylase increases expression ISO Simvastatin results in increased expression of MVD mRNA CTD PMID:25055962 NCBI chr 8:123,160,335...123,170,161
Ensembl chr 8:123,160,340...123,170,161
JBrowse link
G Mvk mevalonate kinase increases expression
multiple interactions
ISO Simvastatin results in increased expression of MVK mRNA
[MVK gene mutant form results in increased activity of HMGCR protein] which results in increased susceptibility to Simvastatin; MVK gene mutant form promotes the reaction [Simvastatin results in decreased activity of HMGCR protein]; MVK gene mutant form promotes the reaction [Simvastatin results in decreased farnesylation of and affects the localization of HRAS protein]; MVK gene mutant form promotes the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]
CTD PMID:12477733 PMID:25055962 NCBI chr 5:114,582,324...114,598,652
Ensembl chr 5:114,582,330...114,598,652
JBrowse link
G Mybph myosin binding protein H increases expression ISO Simvastatin results in increased expression of MYBPH mRNA CTD PMID:17183729 NCBI chr 1:134,121,159...134,128,975
Ensembl chr 1:134,121,186...134,128,970
JBrowse link
G Myh10 myosin, heavy polypeptide 10, non-muscle decreases expression ISO Simvastatin results in decreased expression of MYH10 protein CTD PMID:16005304 NCBI chr11:68,581,228...68,707,451
Ensembl chr11:68,582,385...68,707,458
JBrowse link
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha increases expression EXP Simvastatin results in increased expression of MYH6 mRNA CTD PMID:19262002 NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384
JBrowse link
G Ndrg1 N-myc downstream regulated gene 1 decreases expression ISO Simvastatin results in decreased expression of NDRG1 protein CTD PMID:20217863 NCBI chr15:66,801,167...66,841,490
Ensembl chr15:66,801,167...66,841,489
JBrowse link
G Neat1 nuclear paraspeckle assembly transcript 1 (non-protein coding) increases expression ISO Simvastatin results in increased expression of NEAT1 mRNA; Simvastatin results in increased expression of NEAT1 mRNA alternative form CTD PMID:31311324 NCBI chr19:5,874,736...5,895,508
Ensembl chr19:5,874,736...5,895,898
JBrowse link
G Nfatc3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 multiple interactions
decreases localization
increases localization
ISO Simvastatin promotes the reaction [NFATC3 protein binds to BCL2 promoter]
Simvastatin results in decreased localization of NFATC3 protein alternative form
Simvastatin results in increased localization of NFATC3 protein
CTD PMID:20369390 NCBI chr 8:106,785,450...106,857,169
Ensembl chr 8:106,785,472...106,857,169
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases localization
multiple interactions
increases expression
EXP
ISO
Simvastatin results in increased localization of NFE2L2 protein
NFE2L2 mutant form inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]]
Mevalonic Acid affects the reaction [Simvastatin results in increased localization of NFE2L2 protein]
Simvastatin results in increased expression of NFE2L2 mRNA
MAPK1 promotes the reaction [Simvastatin results in increased expression of NFE2L2 mRNA]; Simvastatin results in increased expression of and affects the localization of NFE2L2 protein
CTD PMID:17928392 PMID:18787804 PMID:30513525 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions
increases localization
decreases localization
decreases activity
decreases expression
ISO
EXP
artemisinin inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein]; RHOA protein affects the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Simvastatin promotes the reaction [Doxorubicin results in increased localization of and results in increased activity of NFKB1 protein]; Simvastatin promotes the reaction [Doxorubicin results in increased localization of NFKB1 protein]; Simvastatin results in increased localization of and results in increased activity of NFKB1 protein
Simvastatin results in decreased localization of NFKB1 protein
Simvastatin results in decreased activity of NFKB1 protein
Simvastatin results in decreased expression of NFKB1 mRNA
Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]]
CTD PMID:12753293 PMID:17038636 PMID:17277159 PMID:18463201 PMID:21465237 More... NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions
increases phosphorylation
ISO
EXP
artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]]; parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]; Simvastatin promotes the reaction [Doxorubicin results in increased phosphorylation of NFKBIA protein]
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased phosphorylation of NFKBIA protein; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]]
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased phosphorylation of NFKBIA protein; Simvastatin inhibits the reaction [IL1A results in decreased expression of NFKBIA protein modified form]; Simvastatin inhibits the reaction [Smoke analog results in increased phosphorylation of NFKBIA protein]
CTD PMID:15705589 PMID:17075836 PMID:17178392 PMID:17277159 PMID:18073186 More... NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nlgn3 neuroligin 3 multiple interactions EXP Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of NLGN3 mRNA] CTD PMID:16373842 NCBI chr  X:100,342,785...100,364,956
Ensembl chr  X:100,342,774...100,369,569
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of NLRP3 protein]]; Simvastatin inhibits the reaction [Acetic Acid results in increased expression of NLRP3 mRNA]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of NLRP3 protein] CTD PMID:30408459 PMID:35762198 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
JBrowse link
G Nog noggin multiple interactions ISO NOG inhibits the reaction [Simvastatin results in increased expression of ACAN mRNA]; NOG inhibits the reaction [Simvastatin results in increased expression of COL2A1 mRNA] CTD PMID:18628692 NCBI chr11:89,191,464...89,193,385
Ensembl chr11:89,191,464...89,193,158
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression
decreases expression
ISO
EXP
Simvastatin promotes the reaction [Doxorubicin results in increased expression of NOS2 protein]
Simvastatin results in increased expression of NOS2 mRNA; Simvastatin results in increased expression of NOS2 protein
Homocysteine affects the reaction [Simvastatin results in increased expression of NOS2 protein]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]]; MTHFR inhibits the reaction [Simvastatin results in increased expression of NOS2 mRNA]; MTHFR inhibits the reaction [Simvastatin results in increased expression of NOS2 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]; Simvastatin promotes the reaction [Homocysteine results in increased expression of NOS2 mRNA]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in decreased expression of NOS2 protein]]; Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of NOS2 mRNA]; Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of NOS2 protein]; Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]; Simvastatin inhibits the reaction [IL1A results in increased expression of NOS2 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]; Simvastatin inhibits the reaction [TNF results in decreased expression of NOS2 protein]; Simvastatin inhibits the reaction [TNF results in increased expression of NOS2 mRNA]; Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]
Simvastatin results in decreased expression of NOS2 mRNA; Simvastatin results in decreased expression of NOS2 protein
CTD PMID:10188333 PMID:11470468 PMID:15705589 PMID:16414398 PMID:17729120 More... NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases expression
multiple interactions
increases phosphorylation
decreases expression
ISO
EXP
Simvastatin results in increased expression of NOS3; Simvastatin results in increased expression of NOS3 mRNA; Simvastatin results in increased expression of NOS3 protein
Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in decreased expression of NOS3 protein]]; Simvastatin inhibits the reaction [Cyclophosphamide results in decreased expression of NOS3 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of NOS3 mRNA]; Simvastatin inhibits the reaction [Smoke analog affects the expression of NOS3 mRNA]; Simvastatin results in increased expression of and results in increased phosphorylation of and results in increased activity of NOS3 protein
Simvastatin results in increased phosphorylation of NOS3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; [Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of NOS3 mRNA]; Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]; Nifedipine promotes the reaction [Simvastatin inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; Simvastatin inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]; Simvastatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]; Simvastatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]; Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]]; wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]]
Simvastatin results in decreased expression of NOS3 mRNA
Simvastatin results in decreased expression of NOS3 mRNA; Simvastatin results in decreased expression of NOS3 protein
CTD PMID:10188333 PMID:11470468 PMID:11947894 PMID:12379581 PMID:12406854 More... NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G Notch1 notch 1 increases cleavage
increases expression
ISO Simvastatin results in increased cleavage of NOTCH1 protein
Simvastatin results in increased expression of NOTCH1 mRNA
CTD PMID:19109527 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675
JBrowse link
G Notch4 notch 4 increases expression ISO Simvastatin results in increased expression of NOTCH4 mRNA CTD PMID:19109527 NCBI chr17:34,783,257...34,807,517
Ensembl chr17:34,783,242...34,807,477
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 decreases expression ISO Simvastatin results in decreased expression of NPC1L1 mRNA CTD PMID:17980884 NCBI chr11:6,161,011...6,180,245
Ensembl chr11:6,161,013...6,180,143
JBrowse link
G Nphs2 nephrosis 2, podocin increases expression ISO Simvastatin results in increased expression of NPHS2 mRNA CTD PMID:16710349 NCBI chr 1:156,138,105...156,155,605
Ensembl chr 1:156,138,297...156,155,605
JBrowse link
G Nppa natriuretic peptide type A multiple interactions
decreases expression
ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]]; Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]
Simvastatin results in decreased expression of NPPA mRNA
CTD PMID:16029635 PMID:16534557 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536
JBrowse link
G Nppb natriuretic peptide type B decreases expression ISO Simvastatin results in decreased expression of NPPB; Simvastatin results in decreased expression of NPPB protein CTD PMID:16628357 PMID:21124329 NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression
multiple interactions
ISO
EXP
Simvastatin results in increased expression of NQO1 mRNA; Simvastatin results in increased expression of NQO1 protein
MAPK1 promotes the reaction [Simvastatin results in increased expression of NQO1 mRNA]
CTD PMID:30513525 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 multiple interactions ISO [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of NR0B1 mRNA CTD PMID:25055962 NCBI chr  X:85,235,381...85,239,553
Ensembl chr  X:85,235,370...85,239,553
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 multiple interactions EXP Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of NR1D1 mRNA] CTD PMID:16373842 NCBI chr11:98,658,758...98,666,233
Ensembl chr11:98,658,758...98,666,159
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 decreases expression EXP Simvastatin results in decreased expression of NR1H3 mRNA CTD PMID:22160096 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Simvastatin affects the reaction [Dietary Fats affects the expression of NR1H4 mRNA]; Simvastatin affects the reaction [Dietary Fats affects the expression of NR1H4 protein] CTD PMID:33383043 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Simvastatin results in increased activity of NR1I2 protein
[Simvastatin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA; [Simvastatin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA; [Simvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA; [Simvastatin co-treated with NR1I2 protein] results in increased secretion of Glucose; [Simvastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; SGK2 mutant form inhibits the reaction [[Simvastatin co-treated with NR1I2 protein] results in increased secretion of Glucose]; Simvastatin promotes the reaction [NR1I2 protein binds to SGK2 promoter]
CTD PMID:15802384 PMID:17041008 PMID:24204015 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO
EXP
Simvastatin results in increased activity of NR1I3 protein CTD PMID:15802384 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of NR4A3 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of NR4A3 mRNA] CTD PMID:16005304 NCBI chr 4:48,045,098...48,086,446
Ensembl chr 4:48,045,153...48,086,447
JBrowse link
G Nrp1 neuropilin 1 decreases response to substance ISO NRP1 SNP results in decreased susceptibility to Simvastatin CTD PMID:21483694 NCBI chr 8:129,085,553...129,231,957
Ensembl chr 8:129,085,085...129,229,844
JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like decreases expression ISO Simvastatin results in decreased expression of NSDHL mRNA CTD PMID:25055962 NCBI chr  X:71,962,127...72,002,134
Ensembl chr  X:71,962,163...72,002,120
JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA CTD PMID:28263720 NCBI chr 3:87,685,551...87,702,549
Ensembl chr 3:87,685,551...87,702,469
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA CTD PMID:28263720 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784
JBrowse link
G Ocln occludin increases expression ISO Simvastatin results in increased expression of OCLN CTD PMID:18544044 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226
JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 decreases expression ISO Simvastatin results in decreased expression of OLR1 mRNA CTD PMID:16414398 NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128
JBrowse link
G Osbpl1a oxysterol binding protein-like 1A decreases expression ISO Simvastatin results in decreased expression of OSBPL1A mRNA CTD PMID:25055962 NCBI chr18:12,886,955...13,074,933
Ensembl chr18:12,888,371...13,074,898
JBrowse link
G Osm oncostatin M multiple interactions ISO Simvastatin inhibits the reaction [CCN1 results in increased expression of OSM]; Simvastatin inhibits the reaction [OSM results in increased expression of CCN1 mRNA]; Simvastatin inhibits the reaction [OSM results in increased phosphorylation of CREB1 protein] CTD PMID:20191585 NCBI chr11:4,186,831...4,191,027
Ensembl chr11:4,186,420...4,191,026
JBrowse link
G P4hb prolyl 4-hydroxylase, beta polypeptide decreases expression ISO Simvastatin results in decreased expression of P4HB mRNA CTD PMID:16414398 NCBI chr11:120,451,124...120,464,079
Ensembl chr11:120,451,124...120,464,079
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
decreases cleavage
increases cleavage
ISO
EXP
[Simvastatin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; Mevalonic Acid inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]]; pifithrin inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; Simvastatin inhibits the reaction [Coal Ash results in increased expression of PARP1 protein modified form]; Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]
Simvastatin results in decreased cleavage of PARP1 mRNA
Simvastatin inhibits the reaction [Glucose results in increased activity of PARP1 protein]
IGF1 protein inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]
CTD PMID:16054375 PMID:18004065 PMID:20045437 PMID:20464445 PMID:21910007 More... NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Simvastatin results in decreased expression of PCNA mRNA; Simvastatin results in decreased expression of PCNA protein CTD PMID:17428261 PMID:18824851 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 multiple interactions ISO [Simvastatin co-treated with Ezetimibe] results in increased expression of PCSK9 mRNA CTD PMID:17980884 NCBI chr 4:106,299,531...106,321,522
Ensembl chr 4:106,299,526...106,321,526
JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific multiple interactions EXP Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of PDE4B mRNA] CTD PMID:16373842 NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456
JBrowse link
G Pdgfa platelet derived growth factor, alpha decreases expression ISO Simvastatin results in decreased expression of PDGFA mRNA CTD PMID:16414398 NCBI chr 5:138,961,761...138,986,336
Ensembl chr 5:138,961,769...138,983,125
JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide decreases expression
multiple interactions
decreases activity
ISO
EXP
Simvastatin results in decreased expression of PDGFB protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of PDGFB protein]; Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]
Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of PDGFB mRNA]
Simvastatin results in decreased expression of PDGFB mRNA
CTD PMID:8231022 PMID:10412745 PMID:10412775 PMID:15728660 PMID:16373842 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178
JBrowse link
G Pdgfra platelet derived growth factor receptor, alpha polypeptide decreases expression ISO Simvastatin results in decreased expression of PDGFRA mRNA CTD PMID:16414398 NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876
JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide decreases expression
multiple interactions
EXP
ISO
Simvastatin results in decreased expression of PDGFRB mRNA
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA
CTD PMID:10412775 PMID:28263720 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 increases expression ISO Simvastatin results in increased expression of PDK2 mRNA CTD PMID:19001041 NCBI chr11:94,917,084...94,932,197
Ensembl chr11:94,917,084...94,932,180
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 increases expression ISO
EXP
Simvastatin results in increased expression of PDK4 mRNA CTD PMID:19001041 PMID:19262002 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309
JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 increases expression ISO Simvastatin results in increased expression of PECAM1 mRNA CTD PMID:19109527 NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454
JBrowse link
G Phb2 prohibitin 2 decreases expression ISO Simvastatin results in decreased expression of PHB2 protein CTD PMID:20217863 NCBI chr 6:124,689,252...124,693,908
Ensembl chr 6:124,689,299...124,693,913
JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C decreases expression EXP Simvastatin results in decreased expression of PIGC mRNA CTD PMID:19262002 NCBI chr 1:161,796,757...161,801,029
Ensembl chr 1:161,796,755...161,801,004
JBrowse link
G Pitx2 paired-like homeodomain transcription factor 2 decreases expression EXP Simvastatin results in decreased expression of PITX2 mRNA CTD PMID:19262002 NCBI chr 3:128,993,527...129,013,243
Ensembl chr 3:128,993,527...129,013,240
JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 decreases expression ISO Simvastatin results in decreased expression of PKMYT1 mRNA CTD PMID:17428261 NCBI chr17:23,945,385...23,955,709
Ensembl chr17:23,945,310...23,955,709
JBrowse link
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) multiple interactions ISO Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of PLA2G2A protein] CTD PMID:19237014 NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497
JBrowse link
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) multiple interactions ISO Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G7 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G7 mRNA] CTD PMID:21176638 NCBI chr17:43,879,009...43,923,093
Ensembl chr17:43,878,989...43,923,092
JBrowse link
G Plat plasminogen activator, tissue multiple interactions
increases expression
increases activity
decreases expression
ISO geranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA]; geranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT]; Simvastatin inhibits the reaction [TNF results in decreased expression of PLAT]
Simvastatin results in increased expression of PLAT; Simvastatin results in increased expression of PLAT mRNA; Simvastatin results in increased expression of PLAT protein
Simvastatin results in increased activity of PLAT protein
Simvastatin results in decreased expression of PLAT mRNA
CTD PMID:12371961 PMID:12753293 PMID:16414398 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860
JBrowse link
G Plau plasminogen activator, urokinase decreases expression EXP Simvastatin results in decreased expression of PLAU mRNA CTD PMID:10412775 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453
JBrowse link
G Plcg2 phospholipase C, gamma 2 increases expression ISO Simvastatin results in increased expression of PLCG2 mRNA CTD PMID:17428261 NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881
JBrowse link
G Plk2 polo like kinase 2 decreases expression EXP Simvastatin results in decreased expression of PLK2 mRNA CTD PMID:19262002 NCBI chr13:110,531,578...110,537,378
Ensembl chr13:110,531,580...110,537,378
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 decreases expression ISO Simvastatin results in decreased expression of PLOD3 mRNA CTD PMID:16414398 NCBI chr 5:137,015,873...137,025,500
Ensembl chr 5:137,015,873...137,025,502
JBrowse link
G Plxnd1 plexin D1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of PLXND1 mRNA CTD PMID:28263720 NCBI chr 6:115,931,772...115,972,300
Ensembl chr 6:115,931,772...115,971,966
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 affects localization
multiple interactions
increases expression
ISO Simvastatin affects the localization of PMAIP1 protein
pifithrin inhibits the reaction [Simvastatin results in increased expression of PMAIP1 mRNA]
Simvastatin results in increased expression of PMAIP1 mRNA; Simvastatin results in increased expression of PMAIP1 protein
CTD PMID:20045437 NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636
JBrowse link
G Pmvk phosphomevalonate kinase increases expression ISO Simvastatin results in increased expression of PMVK mRNA CTD PMID:25055962 NCBI chr 3:89,361,848...89,376,321
Ensembl chr 3:89,361,848...89,376,320
JBrowse link
G Pomt1 protein-O-mannosyltransferase 1 increases expression EXP Simvastatin results in increased expression of POMT1 mRNA CTD PMID:19262002 NCBI chr 2:32,126,321...32,145,017
Ensembl chr 2:32,126,602...32,145,017
JBrowse link
G Pon1 paraoxonase 1 multiple interactions
increases expression
ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA]; PON1 gene polymorphism affects the reaction [Simvastatin results in increased abundance of Cholesterol, HDL]; PON1 gene SNP affects the reaction [Simvastatin results in increased abundance of Cholesterol, HDL]; PON1 protein affects the reaction [Simvastatin results in increased abundance of Cholesterol, HDL]; Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]; Simvastatin results in increased expression of and results in increased activity of PON1 protein; Squalene inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] CTD PMID:14500290 PMID:15690306 PMID:16238680 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression
multiple interactions
ISO
EXP
Simvastatin results in increased expression of PPARA mRNA
PPARA mutant form inhibits the reaction [Simvastatin results in increased expression of SCARB1]; Simvastatin promotes the reaction [TNF results in increased expression of PPARA]
Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of PPARA mRNA]; Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of PPARA protein]; Simvastatin promotes the reaction [Zymosan results in increased expression of PPARA]
CTD PMID:15234187 PMID:18981156 PMID:19001041 PMID:20835264 PMID:21323892 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
decreases expression
ISO
EXP
[2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Simvastatin results in decreased expression of CCR2 mRNA]; [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Simvastatin results in decreased expression of CCR2 protein]
Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of PPARG mRNA]; Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of PPARG protein]
Simvastatin results in decreased expression of PPARG
CTD PMID:15781755 PMID:19216230 PMID:20835264 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions ISO geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein] CTD PMID:24449418 NCBI chr10:107,997,913...108,115,846
Ensembl chr10:107,998,054...108,120,336
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory inhibitor subunit 14A multiple interactions ISO geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein] CTD PMID:24449418 NCBI chr 7:28,988,732...28,992,817
Ensembl chr 7:28,988,733...28,993,226
JBrowse link
G Prim1 DNA primase, p49 subunit decreases expression ISO Simvastatin results in decreased expression of PRIM1 mRNA CTD PMID:17428261 NCBI chr10:127,851,084...127,865,899
Ensembl chr10:127,851,041...127,865,906
JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit increases expression ISO Simvastatin results in increased expression of PRKAA1 mRNA CTD PMID:25055962 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380
JBrowse link
G Psen1 presenilin 1 increases expression ISO Simvastatin results in increased expression of PSEN1 mRNA CTD PMID:19109527 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973
JBrowse link
G Ptafr platelet-activating factor receptor decreases expression ISO Simvastatin results in decreased expression of PTAFR mRNA CTD PMID:16414398 NCBI chr 4:132,291,378...132,309,994
Ensembl chr 4:132,291,378...132,309,994
JBrowse link
G Pten phosphatase and tensin homolog increases expression EXP Simvastatin results in increased expression of PTEN mRNA; Simvastatin results in increased expression of PTEN protein CTD PMID:20060890 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560
JBrowse link
G Ptges prostaglandin E synthase multiple interactions
decreases expression
ISO Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES protein]
Simvastatin results in decreased expression of PTGES protein
CTD PMID:17038636 NCBI chr 2:30,779,483...30,793,309
Ensembl chr 2:30,779,483...30,819,875
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
decreases expression
ISO
EXP
JTE 013 inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased expression of PTGS2]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Simvastatin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Simvastatin inhibits the reaction [TNF results in increased expression of PTGS2 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of PTGS2 protein]; Simvastatin promotes the reaction [Glucose promotes the reaction [AGT protein results in increased expression of PTGS2 mRNA]]; Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]
Simvastatin results in increased expression of PTGS2 mRNA
Simvastatin promotes the reaction [IFNG results in increased expression of PTGS2]
Simvastatin results in decreased expression of PTGS2 protein
Simvastatin inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein]
CTD PMID:17038636 PMID:17277159 PMID:17901590 PMID:18612546 PMID:19225232 More... NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 decreases activity ISO Simvastatin results in decreased activity of PTK2 protein CTD PMID:17428261 NCBI chr15:73,076,951...73,297,192
Ensembl chr15:73,076,951...73,295,129
JBrowse link
G Pxn paxillin multiple interactions
affects localization
decreases phosphorylation
ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of PXN protein]]; Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of and affects the localization of PXN protein]
Simvastatin affects the localization of PXN protein
Simvastatin results in decreased phosphorylation of PXN protein
CTD PMID:22306966 NCBI chr 5:115,630,035...115,694,046
Ensembl chr 5:115,644,735...115,694,046
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions
affects localization
increases expression
decreases activity
decreases expression
increases activity
ISO
EXP
Cholesterol inhibits the reaction [Simvastatin affects the localization of and results in decreased activity of RAC1 protein]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]]; Simvastatin affects the localization of and results in decreased activity of RAC1 protein; Simvastatin inhibits the reaction [AGT results in increased activity of RAC1 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased prenylation of RAC1 protein]
Simvastatin affects the localization of RAC1 protein
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of RAC1 protein]
Simvastatin results in decreased activity of RAC1 protein
Simvastatin results in decreased expression of RAC1
Simvastatin results in increased activity of RAC1 protein
CTD PMID:16698853 PMID:17169357 PMID:17303772 PMID:17513949 PMID:18625914 More... NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791
JBrowse link
G Rac2 Rac family small GTPase 2 affects localization
decreases activity
ISO
EXP
Simvastatin affects the localization of RAC2 protein
Simvastatin results in decreased activity of RAC2 protein
CTD PMID:17169357 PMID:20045437 NCBI chr15:78,443,369...78,456,983
Ensembl chr15:78,443,367...78,456,983
JBrowse link
G Rac3 Rac family small GTPase 3 affects localization ISO Simvastatin affects the localization of RAC3 protein CTD PMID:20045437 NCBI chr11:120,612,294...120,614,795
Ensembl chr11:120,612,296...120,614,795
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO Simvastatin results in decreased expression of RACGAP1 mRNA CTD PMID:17428261 NCBI chr15:99,518,377...99,549,504
Ensembl chr15:99,518,377...99,549,537
JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 decreases activity
multiple interactions
ISO Simvastatin results in decreased activity of RAF1 protein
Simvastatin inhibits the reaction [Streptozocin results in increased expression of RAF1 protein]
CTD PMID:18569938 PMID:19360310 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596
JBrowse link
G Rap1a RAS-related protein 1a decreases prenylation
multiple interactions
decreases geranoylation
decreases expression
ISO
EXP
Simvastatin results in decreased prenylation of RAP1A protein
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased geranoylation of RAP1A protein]; Simvastatin results in decreased geranoylation of and results in decreased prenylation of RAP1A protein
Simvastatin results in decreased expression of RAP1A protein alternative form
CTD PMID:20018177 PMID:22120639 PMID:25578243 PMID:37956312 NCBI chr 3:105,634,576...105,708,740
Ensembl chr 3:105,634,583...105,708,652
JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 affects localization
affects phosphorylation
EXP Simvastatin affects the localization of RASGRF1 protein
Simvastatin affects the phosphorylation of RASGRF1 protein
CTD PMID:20417880 NCBI chr 9:89,791,565...89,909,032
Ensembl chr 9:89,791,961...89,909,030
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Simvastatin results in decreased phosphorylation of RB1 protein CTD PMID:17928568 PMID:18804536 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases localization
decreases localization
decreases expression
ISO
EXP
artemisinin inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of RELA protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of RELA protein]; RHOA protein affects the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Simvastatin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; Simvastatin inhibits the reaction [TNF results in increased localization of RELA protein]; Simvastatin promotes the reaction [Doxorubicin results in increased localization of and results in increased activity of RELA protein]; Simvastatin promotes the reaction [Doxorubicin results in increased localization of RELA protein]; Simvastatin results in increased localization of and results in increased activity of RELA protein
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which affects the localization of RELA protein; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]]; Simvastatin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]; Simvastatin inhibits the reaction [Smoke analog results in increased phosphorylation of RELA protein]
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which affects the localization of RELA protein; Homocysteine inhibits the reaction [Simvastatin results in decreased expression of RELA protein]; Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]; Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein modified form]; Simvastatin promotes the reaction [IFNG promotes the reaction [RELA binds to CD40 promoter]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein modified form]]
Simvastatin results in decreased localization of RELA protein
Simvastatin results in decreased expression of RELA mRNA; Simvastatin results in decreased expression of RELA protein
CTD PMID:12753293 PMID:15705589 PMID:16414398 PMID:17038636 PMID:17075836 More... NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Ret ret proto-oncogene multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA CTD PMID:28263720 NCBI chr 6:118,128,709...118,174,705
Ensembl chr 6:118,128,706...118,174,679
JBrowse link
G Retn resistin multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]]; Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]; Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein] CTD PMID:18023360 NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110
JBrowse link
G Rfc5 replication factor C (activator 1) 5 decreases expression ISO Simvastatin results in decreased expression of RFC5 mRNA CTD PMID:17428261 NCBI chr 5:117,517,210...117,527,088
Ensembl chr 5:117,516,168...117,527,112
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO Simvastatin results in increased expression of RGS2 mRNA CTD PMID:17428261 NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899
JBrowse link
G Rhoa ras homolog family member A multiple interactions
decreases activity
decreases expression
increases expression
increases localization
affects localization
decreases prenylation
ISO
EXP
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]; geranylgeraniol inhibits the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin affects the localization of and results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased localization of RHOA protein]; MVK gene mutant form promotes the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]; RHOA inhibits the reaction [Simvastatin results in increased expression of SCARB1]; RHOA protein affects the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; RHOA protein affects the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; Simvastatin affects the localization of and results in decreased activity of RHOA protein; Simvastatin inhibits the reaction [geranylgeranyl pyrophosphate affects the localization of RHOA protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]; Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]; Simvastatin results in decreased localization of and results in decreased activity of RHOA protein; Simvastatin results in increased localization of and results in decreased prenylation of RHOA protein
geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RHOA protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of RHOA]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]; Simvastatin results in decreased geranoylation of and results in decreased prenylation of RHOA protein
Simvastatin results in decreased expression of RHOA; Simvastatin results in decreased expression of RHOA protein
Simvastatin results in increased expression of RHOA mRNA
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]
Simvastatin results in increased expression of RHOA protein
Simvastatin affects the localization of RHOA protein
Simvastatin results in decreased prenylation of RHOA protein
CTD PMID:12477733 PMID:14630613 PMID:15200425 PMID:16005304 PMID:16470222 More... NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
JBrowse link
G Rhoc ras homolog family member C increases expression ISO Simvastatin results in increased expression of RHOC mRNA CTD PMID:14630613 NCBI chr 3:104,696,350...104,701,775
Ensembl chr 3:104,695,691...104,701,775
JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 multiple interactions ISO [Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]; [Simvastatin co-treated with Metformin] results in increased expression of RIPK1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]; RIPK3 protein affects the reaction [necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]] CTD PMID:25412314 NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO [Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]; RIPK3 protein affects the reaction [necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]] CTD PMID:25412314 NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322
JBrowse link
G Rorc RAR-related orphan receptor gamma multiple interactions
decreases expression
ISO IFNG affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; IL27 affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; IL4 affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RORC mRNA] CTD PMID:18453621 NCBI chr 3:94,280,106...94,305,583
Ensembl chr 3:94,280,101...94,305,583
JBrowse link
G Rpl39 ribosomal protein L39 increases expression EXP Simvastatin results in increased expression of RPL39 mRNA CTD PMID:19262002 NCBI chr  X:36,346,169...36,348,852
Ensembl chr  X:36,346,173...36,349,055
JBrowse link
G Rps10 ribosomal protein S10 increases expression EXP Simvastatin results in increased expression of RPS10 mRNA CTD PMID:19262002 NCBI chr17:27,849,389...27,854,218
Ensembl chr17:27,849,392...27,855,643
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
multiple interactions
EXP Simvastatin results in decreased phosphorylation of RPS6 protein
IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6 protein]
CTD PMID:27734117 NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 decreases phosphorylation
multiple interactions
EXP Simvastatin results in decreased phosphorylation of RPS6KB1 protein
FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6KB1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6KB1 protein]
CTD PMID:27734117 PMID:33034787 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631
JBrowse link
G Runx2 runt related transcription factor 2 increases expression
multiple interactions
ISO
EXP
Simvastatin results in increased expression of RUNX2
DKK1 inhibits the reaction [Simvastatin results in increased expression of RUNX2 mRNA]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; Simvastatin inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]; Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]
CTD PMID:18310456 PMID:20381859 PMID:20417880 PMID:22058016 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684
JBrowse link
G Ryr2 ryanodine receptor 2, cardiac increases expression ISO Simvastatin results in increased expression of RYR2 mRNA; Simvastatin results in increased expression of RYR2 protein CTD PMID:15916736 NCBI chr13:11,567,985...12,121,831
Ensembl chr13:11,567,988...12,121,831
JBrowse link
G S100a6 S100 calcium binding protein A6 (calcyclin) increases expression
multiple interactions
ISO
EXP
Simvastatin results in increased expression of S100A6 mRNA
Simvastatin results in increased expression of and results in increased localization of S100A6 protein
Simvastatin results in increased expression of S100A6 mRNA; Simvastatin results in increased expression of S100A6 protein
CTD PMID:14973129 PMID:17428261 NCBI chr 3:90,520,491...90,531,797
Ensembl chr 3:90,520,189...90,531,488
JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) increases expression ISO Simvastatin results in increased expression of S100A8 mRNA CTD PMID:17428261 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342
JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) increases expression ISO Simvastatin results in increased expression of S100A9 mRNA CTD PMID:17428261 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 increases expression ISO Simvastatin results in increased expression of S1PR1 mRNA CTD PMID:18612546 NCBI chr 3:115,504,082...115,508,704
Ensembl chr 3:115,504,082...115,508,721
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 increases expression
decreases expression
ISO Simvastatin results in increased expression of S1PR3 mRNA
Simvastatin results in decreased expression of S1PR3 mRNA
CTD PMID:18612546 PMID:18981156 NCBI chr13:51,562,654...51,576,833
Ensembl chr13:51,562,675...51,576,833
JBrowse link
G Scap SREBF chaperone affects response to substance ISO SCAP polymorphism affects the susceptibility to Simvastatin CTD PMID:16158080 NCBI chr 9:110,162,356...110,214,017
Ensembl chr 9:110,162,356...110,214,018
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
increases expression
ISO
EXP
PPARA mutant form inhibits the reaction [Simvastatin results in increased expression of SCARB1]; RHOA inhibits the reaction [Simvastatin results in increased expression of SCARB1]
Simvastatin results in increased expression of SCARB1; Simvastatin results in increased expression of SCARB1 mRNA; Simvastatin results in increased expression of SCARB1 protein
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of SCARB1 mRNA; Simvastatin inhibits the reaction [Dietary Fats results in decreased expression of SCARB1 mRNA]; Simvastatin inhibits the reaction [Dietary Fats results in decreased expression of SCARB1 protein]
CTD PMID:18981156 PMID:20025956 PMID:21241519 PMID:25055962 PMID:33383043 NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158
JBrowse link
G Sdc1 syndecan 1 decreases expression ISO Simvastatin results in decreased expression of SDC1 mRNA CTD PMID:16414398 NCBI chr12:8,821,396...8,843,716
Ensembl chr12:8,821,323...8,843,715
JBrowse link
G Sdc4 syndecan 4 decreases expression ISO Simvastatin results in decreased expression of SDC4 mRNA CTD PMID:16414398 NCBI chr 2:164,266,167...164,285,512
Ensembl chr 2:164,266,167...164,285,807
JBrowse link
G Sele selectin, endothelial cell multiple interactions
decreases expression
affects expression
ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]; geranylgeraniol inhibits the reaction [Simvastatin promotes the reaction [TNF protein results in increased expression of SELE protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]; Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE mRNA]; Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]; Simvastatin promotes the reaction [TNF protein results in increased expression of SELE protein]; Vitamin E inhibits the reaction [Simvastatin results in decreased expression of SELE protein modified form]
Simvastatin affects the expression of SELE protein
CTD PMID:10946302 PMID:14602771 PMID:16740276 PMID:21994025 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246
JBrowse link
G Selp selectin, platelet multiple interactions
decreases expression
ISO Simvastatin inhibits the reaction [staphylococcal alpha-toxin results in increased expression of SELP protein]
Simvastatin results in decreased expression of SELP mRNA
CTD PMID:12379581 PMID:16414398 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 decreases expression
multiple interactions
decreases activity
decreases secretion
ISO Simvastatin results in decreased expression of SERPINE1 mRNA; Simvastatin results in decreased expression of SERPINE1 protein
[Simvastatin co-treated with Dexamethasone] results in increased secretion of SERPINE1 protein
Simvastatin results in decreased activity of SERPINE1 protein
Simvastatin results in decreased secretion of SERPINE1 protein
CTD PMID:16375908 PMID:16414398 PMID:17513194 PMID:21524281 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
JBrowse link
G Sesn2 sestrin 2 increases expression EXP Simvastatin results in increased expression of SESN2 mRNA CTD PMID:19262002 NCBI chr 4:132,220,115...132,237,767
Ensembl chr 4:132,219,343...132,237,812
JBrowse link
G Sesn3 sestrin 3 decreases expression EXP Simvastatin results in decreased expression of SESN3 mRNA CTD PMID:20883752 NCBI chr 9:14,187,597...14,237,430
Ensembl chr 9:14,186,363...14,244,397
JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 multiple interactions ISO [Simvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA; SGK2 mutant form inhibits the reaction [[Simvastatin co-treated with NR1I2 protein] results in increased secretion of Glucose]; Simvastatin promotes the reaction [NR1I2 protein binds to SGK2 promoter] CTD PMID:24204015 NCBI chr 2:162,829,249...162,856,059
Ensembl chr 2:162,829,250...162,856,047
JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 decreases expression ISO Simvastatin results in decreased expression of SLC10A1 mRNA CTD PMID:27765674 NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479
JBrowse link
G Slc38a4 solute carrier family 38, member 4 increases expression EXP Simvastatin results in increased expression of SLC38A4 mRNA CTD PMID:19262002 NCBI chr15:96,892,701...96,953,837
Ensembl chr15:96,892,701...96,953,837
JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 increases activity ISO Simvastatin results in increased activity of SLC6A4 protein CTD PMID:15740995 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166
JBrowse link
G Smad1 SMAD family member 1 multiple interactions
increases expression
increases phosphorylation
EXP Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD1 protein]]
Simvastatin results in increased expression of SMAD1 mRNA
Simvastatin results in increased phosphorylation of SMAD1 protein
CTD PMID:18310456 PMID:20417880 NCBI chr 8:80,065,024...80,126,057
Ensembl chr 8:80,065,024...80,126,147
JBrowse link
G Smad2 SMAD family member 2 decreases phosphorylation
increases expression
increases phosphorylation
multiple interactions
ISO
EXP
Simvastatin results in decreased phosphorylation of SMAD2 protein
Simvastatin results in increased expression of SMAD2 mRNA
Simvastatin results in increased phosphorylation of SMAD2 protein
FST protein inhibits the reaction [Simvastatin results in increased phosphorylation of SMAD2 protein]
CTD PMID:18310456 PMID:19659652 PMID:33034787 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034
JBrowse link
G Smad3 SMAD family member 3 increases expression
decreases phosphorylation
multiple interactions
increases phosphorylation
EXP
ISO
Simvastatin results in increased expression of SMAD3 mRNA
Simvastatin results in decreased phosphorylation of SMAD3 protein
FST protein inhibits the reaction [Simvastatin results in increased phosphorylation of SMAD3 protein]
CTD PMID:18310456 PMID:19659652 PMID:33034787 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276
JBrowse link
G Smad5 SMAD family member 5 multiple interactions EXP Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD5 protein]] CTD PMID:18310456 NCBI chr13:56,850,804...56,890,191
Ensembl chr13:56,850,823...56,890,190
JBrowse link
G Smad9 SMAD family member 9 multiple interactions EXP Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD9 protein]] CTD PMID:18310456 NCBI chr 3:54,662,873...54,709,162
Ensembl chr 3:54,663,003...54,708,678
JBrowse link
G Snx17 sorting nexin 17 decreases expression
multiple interactions
ISO Simvastatin results in decreased expression of SNX17 mRNA
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of SNX17 mRNA
CTD PMID:25055962 NCBI chr 5:31,350,634...31,356,244
Ensembl chr 5:31,350,571...31,356,487
JBrowse link
G Soat1 sterol O-acyltransferase 1 increases expression ISO Simvastatin results in increased expression of SOAT1 mRNA CTD PMID:12056585 NCBI chr 1:156,255,678...156,301,898
Ensembl chr 1:156,252,095...156,301,901
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Simvastatin results in increased expression of SOCS3 mRNA CTD PMID:18453621 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873
JBrowse link
G Socs4 suppressor of cytokine signaling 4 increases expression EXP Simvastatin results in increased expression of SOCS4 mRNA; Simvastatin results in increased expression of SOCS4 protein CTD PMID:19262002 NCBI chr14:47,514,377...47,533,559
Ensembl chr14:47,514,388...47,533,559
JBrowse link
G Socs7 suppressor of cytokine signaling 7 increases expression ISO Simvastatin results in increased expression of SOCS7 mRNA CTD PMID:18453621 NCBI chr11:97,253,044...97,289,368
Ensembl chr11:97,253,261...97,289,368
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases expression EXP
ISO
Simvastatin results in decreased expression of SOD2 mRNA CTD PMID:16414398 PMID:20883752 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Sod3 superoxide dismutase 3, extracellular multiple interactions ISO Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA] CTD PMID:28734741 NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760
JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions ISO Simvastatin inhibits the reaction [SP1 binds to COL1A1 promoter] CTD PMID:16575855 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839
JBrowse link
G Sp7 Sp7 transcription factor 7 multiple interactions
increases expression
EXP CTNNB1 mutant form inhibits the reaction [Simvastatin results in increased expression of SP7 protein]; DKK1 inhibits the reaction [Simvastatin results in increased expression of SP7 mRNA]
Simvastatin results in increased expression of SP7; Simvastatin results in increased expression of SP7 mRNA; Simvastatin results in increased expression of SP7 protein
CTD PMID:20564244 PMID:22058016 NCBI chr15:102,265,038...102,275,498
Ensembl chr15:102,265,041...102,275,617
JBrowse link
G Spon2 spondin 2, extracellular matrix protein increases expression ISO Simvastatin results in increased expression of SPON2 mRNA CTD PMID:17428261 NCBI chr 5:33,370,862...33,375,596
Ensembl chr 5:33,355,528...33,375,799
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression
increases expression
ISO
EXP
Simvastatin results in decreased expression of SPP1 mRNA
Simvastatin results in increased expression of SPP1 protein
CTD PMID:12914771 PMID:14601315 PMID:21076490 PMID:21109955 PMID:22058016 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [Simvastatin co-treated with Metformin] results in decreased expression of SQSTM1 protein; Chloroquine inhibits the reaction [[Simvastatin co-treated with Metformin] results in decreased expression of SQSTM1 protein] CTD PMID:25412314 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases localization
decreases expression
ISO Simvastatin results in increased localization of SREBF1 protein
Simvastatin results in decreased expression of SREBF1 mRNA
CTD PMID:17655842 PMID:25055962 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
JBrowse link
G Srebf2 sterol regulatory element binding factor 2 multiple interactions
increases expression
ISO Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]]; Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]
Simvastatin results in increased expression of SREBF2 protein modified form
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of SREBF2 mRNA]; Simvastatin results in increased activity of and results in increased localization of SREBF2 protein
CTD PMID:12056585 PMID:14500290 PMID:20018177 NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580
JBrowse link
G Star steroidogenic acute regulatory protein increases expression
multiple interactions
ISO Simvastatin results in increased expression of STAR mRNA
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of STAR mRNA
CTD PMID:24524197 PMID:25055962 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions
decreases expression
decreases activity
decreases phosphorylation
ISO
EXP
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT1 protein]; Simvastatin inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]
Simvastatin results in decreased expression of STAT1 mRNA
Simvastatin results in decreased activity of STAT1 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein]; Simvastatin inhibits the reaction [IFNG promotes the reaction [STAT1 binds to CD40 promoter]]; Simvastatin inhibits the reaction [IFNG results in increased phosphorylation of STAT1 protein]
Simvastatin results in decreased expression of STAT1 mRNA; Simvastatin results in decreased expression of STAT1 protein
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]
CTD PMID:16534557 PMID:17507688 PMID:18453621 PMID:19886038 PMID:21268089 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases activity
multiple interactions
affects expression
decreases phosphorylation
ISO
EXP
Simvastatin results in decreased activity of STAT3 protein
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT3 protein]
Simvastatin affects the expression of STAT3 protein
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein modified form]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]; Simvastatin inhibits the reaction [CTF1 results in increased phosphorylation of STAT3 protein]; Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of STAT3 protein]
CTD PMID:16534557 PMID:17507688 PMID:18400235 PMID:18453621 PMID:19100119 More... NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Stat5a signal transducer and activator of transcription 5A affects expression EXP Simvastatin affects the expression of STAT5A protein CTD PMID:17507688 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995
JBrowse link
G Stat6 signal transducer and activator of transcription 6 affects expression EXP Simvastatin affects the expression of STAT6 protein CTD PMID:17507688 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826
JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation EXP Simvastatin results in increased phosphorylation of STK11 protein CTD PMID:19332549 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516
JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 multiple interactions ISO Simvastatin results in decreased activity of [MAP3K7 protein co-treated with TAB1 protein] CTD PMID:17277159 NCBI chr15:80,017,333...80,045,908
Ensembl chr15:80,017,328...80,045,908
JBrowse link
G Tank TRAF family member-associated Nf-kappa B activator multiple interactions EXP [Lipopolysaccharides co-treated with Simvastatin] results in increased expression of TANK mRNA CTD PMID:15665042 NCBI chr 2:61,408,901...61,484,515
Ensembl chr 2:61,408,929...61,484,515
JBrowse link
G Tbxas1 thromboxane A synthase 1, platelet decreases expression
increases expression
ISO Simvastatin results in decreased expression of TBXAS1 mRNA
Simvastatin results in increased expression of TBXAS1 mRNA
CTD PMID:16414398 PMID:20659230 NCBI chr 6:38,817,897...39,061,524
Ensembl chr 6:38,852,338...39,061,519
JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions
increases expression
ISO Simvastatin inhibits the reaction [Streptozocin results in increased expression of TEK mRNA]; Simvastatin results in increased expression of and results in increased activity of TEK protein
Simvastatin results in increased expression of TEK; Simvastatin results in increased expression of TEK mRNA
CTD PMID:18544044 PMID:20821229 NCBI chr 4:94,627,322...94,763,213
Ensembl chr 4:94,627,526...94,763,213
JBrowse link
G Tfrc transferrin receptor affects expression ISO Simvastatin affects the expression of TFRC protein CTD PMID:16387846 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
increases activity
decreases expression
ISO
EXP
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]]; Simvastatin inhibits the reaction [TGFB1 results in increased expression of ACTA2 mRNA]; Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]; Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 protein]
Simvastatin inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Simvastatin inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]
Simvastatin results in increased expression of TGFB1 mRNA
Simvastatin results in increased activity of TGFB1 protein
Simvastatin results in decreased expression of TGFB1 mRNA; Simvastatin results in decreased expression of TGFB1 protein
CTD PMID:15298857 PMID:15677772 PMID:15855201 PMID:16320597 PMID:19080365 More... NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II multiple interactions
decreases expression
EXP
ISO
Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of TGFBR2 mRNA]
Simvastatin results in decreased expression of TGFBR2 mRNA
CTD PMID:16320597 PMID:16373842 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428
JBrowse link
G Thbd thrombomodulin increases expression
multiple interactions
ISO Simvastatin results in increased expression of THBD mRNA; Simvastatin results in increased expression of THBD protein
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of THBD mRNA]
CTD PMID:14630613 PMID:16375908 PMID:20493886 PMID:20737288 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108
JBrowse link
G Thbs1 thrombospondin 1 decreases expression ISO Simvastatin results in decreased expression of THBS1 mRNA CTD PMID:17428261 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions
decreases expression
ISO Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP1 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP1 mRNA]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of TIMP1 mRNA] CTD PMID:16414398 PMID:20137537 PMID:22022327 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 multiple interactions
decreases expression
ISO Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP2 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP2 mRNA] CTD PMID:20137537 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566
JBrowse link
G Tlr2 toll-like receptor 2 increases expression
multiple interactions
ISO Simvastatin results in increased expression of TLR2 protein
Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]
CTD PMID:16387846 PMID:16443229 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074
JBrowse link
G Tlr4 toll-like receptor 4 increases expression
decreases expression
multiple interactions
ISO Simvastatin results in increased expression of TLR4 protein
Simvastatin results in decreased expression of TLR4 mRNA; Simvastatin results in decreased expression of TLR4 protein
Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]
CTD PMID:16387846 PMID:16443229 PMID:19166837 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 increases expression ISO Simvastatin results in increased expression of TM7SF2 mRNA CTD PMID:25055962 NCBI chr19:6,112,851...6,117,880
Ensembl chr19:6,112,851...6,118,403
JBrowse link
G Tnc tenascin C decreases expression ISO Simvastatin results in decreased expression of TNC mRNA CTD PMID:16414398 NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
decreases activity
decreases expression
increases secretion
decreases secretion
affects secretion
ISO
EXP
geranylgeraniol inhibits the reaction [Simvastatin promotes the reaction [TNF protein results in increased expression of SELE protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]; Simvastatin inhibits the reaction [CCN1 results in increased expression of TNF]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Simvastatin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Simvastatin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Simvastatin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; Simvastatin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF results in decreased expression of PLAT]; Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]; Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1]; Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of ITGAL]; Simvastatin inhibits the reaction [TNF results in increased expression of ITGB2]; Simvastatin inhibits the reaction [TNF results in increased expression of PTGS2 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of PTGS2 protein]; Simvastatin inhibits the reaction [TNF results in increased expression of TF]; Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]; Simvastatin inhibits the reaction [TNF results in increased localization of IL1B protein]; Simvastatin inhibits the reaction [TNF results in increased localization of IL6 protein]; Simvastatin inhibits the reaction [TNF results in increased localization of RELA protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of CCL2 protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of CCL4 mRNA]; Simvastatin inhibits the reaction [TNF results in increased secretion of CXCL8 protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of MMP9 protein]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Simvastatin promotes the reaction [TNF protein results in increased expression of SELE protein]; Simvastatin promotes the reaction [TNF results in increased expression of MMP9 mRNA]; Simvastatin promotes the reaction [TNF results in increased expression of PPARA]
Simvastatin results in increased expression of TNF mRNA
1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased secretion of TNF protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in decreased expression of NOS2 protein]]; Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]]; Simvastatin inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Simvastatin inhibits the reaction [Acrolein results in increased secretion of TNF protein]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]; Simvastatin inhibits the reaction [TNF results in decreased expression of NOS2 protein]; Simvastatin inhibits the reaction [TNF results in increased expression of NOS2 mRNA]
Simvastatin results in decreased activity of TNF; Simvastatin results in decreased activity of TNF protein
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]; Guanidines inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]]; Simvastatin inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]; Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD1 protein]]; Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD5 protein]]; Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD9 protein]]; Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]; Simvastatin inhibits the reaction [TNF results in increased expression of CXCL15 mRNA]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]; Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]; Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]; Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Simvastatin results in decreased expression of TNF mRNA; Simvastatin results in decreased expression of TNF protein
Simvastatin results in increased secretion of TNF protein
Simvastatin results in decreased secretion of TNF protein
Simvastatin affects the secretion of TNF protein
CTD PMID:10946302 PMID:12117737 PMID:12615677 PMID:12753293 PMID:12829860 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) increases expression ISO Simvastatin results in increased expression of TNFRSF11B mRNA CTD PMID:21431270 NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880
JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a decreases expression EXP Simvastatin results in decreased expression of TNFRSF1A mRNA CTD PMID:18310456 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447
JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b decreases expression EXP Simvastatin results in decreased expression of TNFRSF1B mRNA CTD PMID:18310456 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440
JBrowse link
G Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 multiple interactions
decreases expression
ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]
Simvastatin results in decreased expression of TNFRSF4 mRNA; Simvastatin results in decreased expression of TNFRSF4 protein
CTD PMID:19589242 NCBI chr 4:156,098,049...156,101,070
Ensembl chr 4:156,098,300...156,101,069
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions
increases response to substance
ISO [Simvastatin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Mevalonic Acid inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]]; Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]
TNFSF10 protein results in increased susceptibility to Simvastatin
CTD PMID:21910007 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576
JBrowse link
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 multiple interactions
decreases expression
ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]
Simvastatin results in decreased expression of TNFSF4 mRNA; Simvastatin results in decreased expression of TNFSF4 protein
CTD PMID:19589242 NCBI chr 1:161,223,009...161,245,777
Ensembl chr 1:161,222,980...161,245,981
JBrowse link
G Tnni3 troponin I, cardiac 3 multiple interactions ISO Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of TNNI3 protein]]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of TNNI3 protein] CTD PMID:35762198 NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 decreases expression ISO Simvastatin results in decreased expression of TPT1 protein CTD PMID:20217863 NCBI chr14:76,082,771...76,085,743
Ensembl chr14:76,082,533...76,085,965
JBrowse link
G Tradd TNFRSF1A-associated via death domain decreases expression ISO Simvastatin results in decreased expression of TRADD mRNA CTD PMID:17277159 NCBI chr 8:105,985,207...105,991,226
Ensembl chr 8:105,984,918...105,991,241
JBrowse link
G Traf2 TNF receptor-associated factor 2 decreases expression ISO Simvastatin results in decreased expression of TRAF2 mRNA CTD PMID:17277159 NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952
JBrowse link
G Trf transferrin multiple interactions ISO Simvastatin inhibits the reaction [TNF results in increased expression of TF] CTD PMID:12753293 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
JBrowse link
G Trim63 tripartite motif-containing 63 increases expression
multiple interactions
ISO
EXP
Simvastatin results in increased expression of TRIM63 mRNA
Simvastatin results in increased expression of TRIM63 mRNA; Simvastatin results in increased expression of TRIM63 protein
FST protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 mRNA]; FST protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 mRNA]
CTD PMID:19001041 PMID:27734117 PMID:33034787 NCBI chr 4:134,042,431...134,056,940
Ensembl chr 4:134,042,431...134,056,940
JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases phosphorylation
increases expression
ISO pifithrin inhibits the reaction [Simvastatin results in increased expression of TP53 protein]; Simvastatin promotes the reaction [Benzo(a)pyrene promotes the reaction [TP53 protein binds to MDM2 protein]]; Simvastatin promotes the reaction [TP53 protein binds to CD44 promoter]; Simvastatin results in increased expression of and results in increased phosphorylation of TP53 protein
Simvastatin results in increased phosphorylation of TP53 protein
Simvastatin results in increased expression of TP53 mRNA; Simvastatin results in increased expression of TP53 mutant form; Simvastatin results in increased expression of TP53 protein
CTD PMID:15625077 PMID:18804536 PMID:20045437 PMID:21199873 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression ISO Simvastatin results in decreased expression of TXNRD1 mRNA CTD PMID:16414398 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
JBrowse link
G Tyms thymidylate synthase decreases expression ISO Simvastatin results in decreased expression of TYMS mRNA; Simvastatin results in decreased expression of TYMS protein CTD PMID:17428261 NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein decreases phosphorylation EXP Simvastatin results in decreased phosphorylation of VASP protein CTD PMID:19332549 NCBI chr 7:18,990,854...19,005,779
Ensembl chr 7:18,990,854...19,005,742
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
ISO
EXP
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]]; Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]; Simvastatin promotes the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of VCAM1 protein]; Simvastatin promotes the reaction [ethinyl estradiol-desogestrel combination results in decreased expression of VCAM1 protein]; Simvastatin promotes the reaction [IL1B protein results in increased expression of VCAM1 protein]; Vitamin E inhibits the reaction [Simvastatin results in decreased expression of VCAM1 protein modified form]
Simvastatin results in decreased expression of VCAM1 mRNA; Simvastatin results in decreased expression of VCAM1 protein; Simvastatin results in decreased expression of VCAM1 protein modified form
CTD PMID:10946302 PMID:14602771 PMID:15234187 PMID:17105841 PMID:17169357 More... NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
G Vcl vinculin affects localization ISO Simvastatin affects the localization of VCL protein CTD PMID:22306966 NCBI chr14:20,979,436...21,083,744
Ensembl chr14:20,979,466...21,083,744
JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression ISO Simvastatin results in decreased expression of VDAC1 protein CTD PMID:20217863 NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor increases expression EXP Simvastatin results in increased expression of VDR mRNA CTD PMID:19262002 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
increases expression
increases secretion
ISO
EXP
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA]; HIF1A mutant form inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of VEGFA protein]
Simvastatin results in decreased expression of VEGFA protein
Simvastatin results in increased expression of VEGFA; Simvastatin results in increased expression of VEGFA mRNA
Simvastatin results in increased secretion of VEGFA protein
Simvastatin results in increased expression of VEGFA mRNA; Simvastatin results in increased expression of VEGFA protein
Simvastatin inhibits the reaction [Glucose results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]
CTD PMID:15572054 PMID:16424782 PMID:17277159 PMID:18316203 PMID:18356691 More... NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Vim vimentin decreases expression EXP
ISO
Simvastatin results in decreased expression of VIM protein CTD PMID:14973129 PMID:15855201 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link
G Vwf Von Willebrand factor increases expression ISO Simvastatin results in increased expression of VWF mRNA; Simvastatin results in increased expression of VWF protein CTD PMID:19109527 NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642
JBrowse link
G Wnt4 wingless-type MMTV integration site family, member 4 multiple interactions
increases expression
ISO Simvastatin inhibits the reaction [Glucose results in decreased expression of WNT4 mRNA]
Simvastatin results in increased expression of WNT4 protein
CTD PMID:18004065 NCBI chr 4:137,004,946...137,026,812
Ensembl chr 4:137,004,800...137,027,037
JBrowse link
G Wnt5a wingless-type MMTV integration site family, member 5A multiple interactions
increases expression
ISO Simvastatin inhibits the reaction [Glucose results in decreased expression of WNT5A mRNA]
Simvastatin results in increased expression of WNT5A mRNA; Simvastatin results in increased expression of WNT5A protein
CTD PMID:18004065 PMID:19968183 NCBI chr14:28,224,962...28,249,405
Ensembl chr14:28,226,707...28,249,405
JBrowse link
G Xbp1 X-box binding protein 1 decreases expression ISO Simvastatin results in decreased expression of XBP1 protein CTD PMID:18807172 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression EXP Simvastatin results in decreased expression of XIAP mRNA; Simvastatin results in decreased expression of XIAP protein CTD PMID:19262002 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533
JBrowse link
G Zfp810 zinc finger protein 810 decreases expression EXP Simvastatin results in decreased expression of ZFP810 mRNA CTD PMID:19262002 NCBI chr 9:22,188,044...22,218,973
Ensembl chr 9:22,188,044...22,218,944
JBrowse link
G Zfp997 zinc finger protein 997 decreases expression ISO Simvastatin results in decreased expression of CXCL5 mRNA CTD PMID:16414398 NCBI chr13:66,258,188...66,271,523
Ensembl chr13:66,261,294...66,271,953
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22188
    chemical entity 22187
      molecular entity 22179
        polyatomic entity 22082
          molecule 21679
            cyclic compound 21260
              bicyclic compound 18278
                carbobicyclic compound 5949
                  hexahydronaphthalenes 959
                    (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid + 316
                    (4R,6R)-6-\{2-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl\}-4-hydroxyoxan-2-one 0
                    (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one 0
                    3-\{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene\}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one 0
                    9-hydroxy hedychenone 0
                    ML-236C + 0
                    alpha-cadinene 0
                    compactin diol lactone 0
                    cytosporic acid 0
                    delta-cadinene + 0
                    dihydroserrulatene 0
                    epizonarene 0
                    lamesticumin F 0
                    lovastatin + 725
                    mevastatin + 729
                    mevinic acid 0
                    monacolin J + 0
                    monacolin J acid 0
                    monacolin L + 0
                    monacolin L acid 0
                    myceliothermophin E + 0
                    pravastatin lactone 0
                    simvastatin 583
                    zonarene 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    p-block element atom 22114
                      carbon group element atom 21915
                        carbon group molecular entity 21915
                          organic molecular entity 21840
                            organic molecule 21654
                              organic cyclic compound 21259
                                carbocyclic compound 19665
                                  carbopolycyclic compound 17891
                                    carbobicyclic compound 5949
                                      hexahydronaphthalenes 959
                                        (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid + 316
                                        (4R,6R)-6-\{2-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl\}-4-hydroxyoxan-2-one 0
                                        (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one 0
                                        3-\{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene\}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one 0
                                        9-hydroxy hedychenone 0
                                        ML-236C + 0
                                        alpha-cadinene 0
                                        compactin diol lactone 0
                                        cytosporic acid 0
                                        delta-cadinene + 0
                                        dihydroserrulatene 0
                                        epizonarene 0
                                        lamesticumin F 0
                                        lovastatin + 725
                                        mevastatin + 729
                                        mevinic acid 0
                                        monacolin J + 0
                                        monacolin J acid 0
                                        monacolin L + 0
                                        monacolin L acid 0
                                        myceliothermophin E + 0
                                        pravastatin lactone 0
                                        simvastatin 583
                                        zonarene 0
paths to the root