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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:anagrelide
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Accession:CHEBI:142290 term browser browse the term
Definition:A 1,5-dihydroimidazo[2,1-]quinazoline having an oxo substituent at the 2-position and chloro substituents at the 6- and 7-positions.
Synonyms:exact_synonym: 6,7-dichloro-1,5-dihydroimidazo[2,1-]quinazolin-2(3H)-one
 related_synonym: Formula=C10H7Cl2N3O;   InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16);   InChIKey=OTBXOEAOVRKTNQ-UHFFFAOYSA-N;   SMILES=Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl;   anagrelida;   anagrelidum
 xref: Beilstein:619582;   CAS:68475-42-3;   DrugBank:DB00261;   Drug_Central:209;   KEGG:D07455;   LINCS:LSM-3380
 xref_mesh: MESH:C021139
 xref: Wikipedia:Anagrelide


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anagrelide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fli1 Fli-1 proto-oncogene, ETS transcription factor multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of FLI1 mRNA] CTD PMID:20586925 NCBI chr 8:33,541,932...33,661,111
Ensembl chr 8:33,543,258...33,661,049
JBrowse link
G Gata1 GATA binding protein 1 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 protein] CTD PMID:20586925 NCBI chr  X:15,273,937...15,281,759
Ensembl chr  X:15,378,789...15,382,066
Ensembl chr  X:15,378,789...15,382,066
JBrowse link
G Itga2b integrin subunit alpha 2b multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of ITGA2B mRNA] CTD PMID:20586925 NCBI chr10:90,397,960...90,416,550
Ensembl chr10:90,398,132...90,415,070
JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of MPL mRNA] CTD PMID:20586925 NCBI chr 5:137,268,412...137,282,032
Ensembl chr 5:137,269,480...137,281,298
JBrowse link
G Nfe2 nuclear factor, erythroid 2 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of NF-E2 mRNA] CTD PMID:20586925 NCBI chr 7:144,872,739...144,880,092
Ensembl chr 7:144,872,747...144,880,092
JBrowse link
G Pdgfb platelet derived growth factor subunit B increases expression ISO anagrelide results in increased expression of PDGFB mRNA CTD PMID:15682418 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO anagrelide results in decreased expression of TGFB1 mRNA CTD PMID:15682418 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thpo thrombopoietin multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of FLI1 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 protein]; anagrelide inhibits the reaction [THPO protein results in increased expression of ITGA2B mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of MPL mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of NF-E2 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of ZFPM1 mRNA] CTD PMID:20586925 NCBI chr11:82,845,676...82,853,439
Ensembl chr11:83,868,655...83,873,910
Ensembl chr11:83,868,655...83,873,910
JBrowse link
G Zfpm1 zinc finger protein, multitype 1 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of ZFPM1 mRNA] CTD PMID:20586925 NCBI chr19:55,094,585...55,150,994
Ensembl chr19:55,094,585...55,150,686
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      application 19413
        pharmaceutical 19301
          drug 19301
            cardiovascular drug 7666
              anagrelide 9
                anagrelide hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic molecule 19505
                              organic cyclic compound 19332
                                organic heterocyclic compound 18519
                                  organic heteropolycyclic compound 17979
                                    organic heterotricyclic compound 14602
                                      imidazoquinazoline 9
                                        anagrelide 9
                                          anagrelide hydrochloride 0
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