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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:anagrelide
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Accession:CHEBI:142290 term browser browse the term
Definition:A 1,5-dihydroimidazo[2,1-]quinazoline having an oxo substituent at the 2-position and chloro substituents at the 6- and 7-positions.
Synonyms:exact_synonym: 6,7-dichloro-1,5-dihydroimidazo[2,1-]quinazolin-2(3H)-one
 related_synonym: Formula=C10H7Cl2N3O;   InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16);   InChIKey=OTBXOEAOVRKTNQ-UHFFFAOYSA-N;   SMILES=Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl;   anagrelida;   anagrelidum
 xref: Beilstein:619582;   CAS:68475-42-3;   DrugBank:DB00261;   Drug_Central:209;   KEGG:D07455;   LINCS:LSM-3380
 xref_mesh: MESH:C021139
 xref: Wikipedia:Anagrelide



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anagrelide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fli1 Fli-1 proto-oncogene, ETS transcription factor multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of FLI1 mRNA] CTD PMID:20586925 NCBI chr 8:30,831,422...30,950,468
Ensembl chr 8:30,832,753...30,950,433
JBrowse link
G Gata1 GATA binding protein 1 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 protein] CTD PMID:20586925 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530
JBrowse link
G Itga2b integrin subunit alpha 2b multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of ITGA2B mRNA] CTD PMID:20586925 NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168
JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of MPL mRNA] CTD PMID:20586925 NCBI chr 5:131,973,897...131,987,472
Ensembl chr 5:131,973,895...131,986,797
JBrowse link
G Nfe2 nuclear factor, erythroid 2 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of NF-E2 mRNA] CTD PMID:20586925 NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108
JBrowse link
G Pdgfb platelet derived growth factor subunit B increases expression ISO anagrelide results in increased expression of PDGFB mRNA CTD PMID:15682418 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO anagrelide results in decreased expression of TGFB1 mRNA CTD PMID:15682418 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thpo thrombopoietin multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of FLI1 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 protein]; anagrelide inhibits the reaction [THPO protein results in increased expression of ITGA2B mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of MPL mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of NF-E2 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of ZFPM1 mRNA] CTD PMID:20586925 Ensembl chr11:80,182,820...80,188,167 JBrowse link
G Zfpm1 zinc finger protein, multitype 1 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of ZFPM1 mRNA] CTD PMID:20586925 NCBI chr19:50,334,352...50,391,029
Ensembl chr19:50,334,682...50,390,591
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      application 19747
        pharmaceutical 19619
          drug 19619
            cardiovascular drug 7728
              anagrelide 9
                anagrelide hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic molecule 19819
                              organic cyclic compound 19581
                                organic heterocyclic compound 18804
                                  organic heteropolycyclic compound 18274
                                    organic heterotricyclic compound 15606
                                      imidazoquinazoline 12
                                        anagrelide 9
                                          anagrelide hydrochloride 0
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