Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:24G7 epitope
go back to main search page
Accession:CHEBI:142163 term browser browse the term
Definition:An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22.
Synonyms:related_synonym: Formula=C7H6N2O;   SMILES=C(=CC(NC(=*)*)=*)(NC(C(C)=*)=O)*


show annotations for term's descendants           Sort by:
 
bilirubin IXalpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP Bilirubin analog inhibits the reaction [tert-Butylhydroperoxide affects the localization of and results in decreased activity of ABCB11 protein] CTD PMID:24306262 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects transport
multiple interactions
ISO ABCC1 protein affects the transport of Bilirubin
Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Bilirubin inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; Glutathione promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; verlukast inhibits the reaction [ABCC1 protein affects the transport of Bilirubin]
CTD PMID:15245331 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
multiple interactions
affects transport
EXP Bilirubin results in decreased activity of ABCC2 protein
Bilirubin analog inhibits the reaction [tert-Butylhydroperoxide affects the localization of and results in decreased activity of ABCC2 protein]
ABCC2 protein affects the transport of Bilirubin
CTD PMID:15374814 PMID:15901347 PMID:24306262 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO [[Bilirubin binds to and results in increased activity of AHR protein] which binds to CYP1A promoter] which results in increased expression of CYP1A mRNA CTD PMID:18187559 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Bilirubin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein] CTD PMID:18215737 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alad aminolevulinate dehydratase decreases expression ISO Bilirubin results in decreased expression of ALAD mRNA CTD PMID:20196124 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO
EXP
ALB protein binds to Bilirubin; Bilirubin binds to ALB protein
Folic Acid inhibits the reaction [Homocysteine inhibits the reaction [ALB protein binds to Bilirubin]]; Folic Acid inhibits the reaction [phenylhydrazine inhibits the reaction [ALB protein binds to Bilirubin]]; Homocysteine inhibits the reaction [ALB protein binds to Bilirubin]; phenylhydrazine inhibits the reaction [ALB protein binds to Bilirubin]
[homocysteine thiolactone results in increased metabolism of ALB protein] affects the reaction [ALB protein binds to Bilirubin]; Sulfisoxazole inhibits the reaction [Bilirubin binds to ALB protein]
CTD PMID:21280114 PMID:33788065 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Anxa1 annexin A1 decreases expression ISO Bilirubin results in decreased expression of ANXA1 mRNA CTD PMID:20196124 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Areg amphiregulin increases expression ISO Bilirubin results in increased expression of AREG mRNA CTD PMID:20196124 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Arhgap29 Rho GTPase activating protein 29 decreases expression ISO Bilirubin results in decreased expression of ARHGAP29 mRNA CTD PMID:20196124 NCBI chr 2:210,060,036...210,132,572
Ensembl chr 2:210,071,199...210,132,028
JBrowse link
G Asb13 ankyrin repeat and SOCS box-containing 13 decreases expression ISO Bilirubin results in decreased expression of ASB13 mRNA CTD PMID:20196124 NCBI chr17:66,564,653...66,583,365
Ensembl chr17:66,562,434...66,583,337
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Bilirubin results in increased expression of ATF3 mRNA CTD PMID:20196124 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions
ISO Bilirubin results in increased expression of ATF6 mRNA
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of ATF6 mRNA]
CTD PMID:27578021 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 decreases expression ISO Bilirubin results in decreased expression of ATP1A1 mRNA CTD PMID:20196124 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
JBrowse link
G Axin2 axin 2 decreases expression ISO Bilirubin results in decreased expression of AXIN2 mRNA CTD PMID:20196124 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Bilirubin promotes the reaction [Iron-Dextran Complex results in increased expression of BCL2L1 protein] CTD PMID:20709802 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bloc1s1 biogenesis of lysosomal organelles complex-1, subunit 1 decreases expression ISO Bilirubin results in decreased expression of BLOC1S1 mRNA CTD PMID:20196124 NCBI chr 7:1,347,495...1,351,103
Ensembl chr 7:1,340,934...1,351,558
JBrowse link
G C1d C1D nuclear receptor corepressor decreases expression ISO Bilirubin results in decreased expression of C1D mRNA CTD PMID:20196124 NCBI chr14:91,660,951...91,673,177
Ensembl chr14:91,660,989...91,672,852
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]; Bilirubin inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; CYP2A5 protein inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein] CTD PMID:20709802 PMID:23628428 PMID:27578021 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases expression ISO Bilirubin results in decreased expression of CAT mRNA CTD PMID:20196124 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccdc80 coiled-coil domain containing 80 decreases expression ISO Bilirubin results in decreased expression of CCDC80 mRNA CTD PMID:20196124 NCBI chr11:55,685,165...55,718,827
Ensembl chr11:55,685,872...55,719,137
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Bilirubin results in decreased expression of CCND1 mRNA CTD PMID:20196124 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd302 CD302 molecule decreases expression ISO Bilirubin results in decreased expression of CD302 mRNA CTD PMID:20196124 NCBI chr 3:44,722,324...44,756,045
Ensembl chr 3:44,722,325...44,756,045
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression ISO Bilirubin results in increased expression of CHAC1 mRNA CTD PMID:20196124 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
JBrowse link
G Chka choline kinase alpha increases expression ISO Bilirubin results in increased expression of CHKA mRNA CTD PMID:20196124 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
JBrowse link
G Clcc1 chloride channel CLIC-like 1 decreases expression ISO Bilirubin results in decreased expression of CLCC1 mRNA CTD PMID:20196124 NCBI chr 2:196,296,350...196,326,914
Ensembl chr 2:196,296,393...196,326,913
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 decreases expression ISO Bilirubin results in decreased expression of CLIP1 mRNA CTD PMID:20196124 NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO Bilirubin results in decreased expression of COL3A1 mRNA CTD PMID:20196124 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 decreases expression ISO Bilirubin results in decreased expression of COX15 mRNA CTD PMID:20196124 NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261
JBrowse link
G Cpd carboxypeptidase D decreases expression ISO Bilirubin results in decreased expression of CPD mRNA CTD PMID:20196124 NCBI chr10:61,623,528...61,687,491
Ensembl chr10:61,623,526...61,687,491
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Bilirubin results in increased expression of CSF2 mRNA CTD PMID:20196124 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Ctsh cathepsin H decreases expression ISO Bilirubin results in decreased expression of CTSH mRNA CTD PMID:20196124 NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Bilirubin results in increased expression of CXCL10 mRNA CTD PMID:20196124 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO Bilirubin results in increased expression of CXCL11 mRNA CTD PMID:20196124 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Bilirubin results in increased expression of CXCL2 mRNA CTD PMID:20196124 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Bilirubin results in increased expression of CYP1A1 mRNA; Bilirubin results in increased expression of CYP1A1 protein CTD PMID:20196124 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Bilirubin results in decreased activity of CYP1A2 protein CTD PMID:16183037 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 multiple interactions
affects degradation
increases oxidation
increases degradation
increases stability
decreases activity
increases expression
ISO [CYP2A5 protein results in increased oxidation of Bilirubin] which results in increased chemical synthesis of Biliverdine; Bilirubin promotes the reaction [NFE2L2 protein results in increased expression of CYP2A5 mRNA]; Bilirubin results in increased expression of and results in increased activity of CYP2A5 protein; CYP2A5 protein inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]
CYP2A5 protein affects the degradation of Bilirubin
CYP2A5 protein results in increased degradation of Bilirubin
Bilirubin results in increased stability of CYP2A5 protein
Bilirubin results in decreased activity of CYP2A5 protein
Bilirubin results in increased expression of CYP2A5 mRNA; Bilirubin results in increased expression of CYP2A5 protein
CTD PMID:16183037 PMID:21871474 PMID:22465937 PMID:23628428 PMID:25478736 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions
ISO Bilirubin results in increased expression of CYP2B6 mRNA
IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2B6 mRNA]
CTD PMID:15382119 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO Bilirubin results in increased expression of CYP3A4 mRNA
IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP3A4 mRNA]
CTD PMID:15382119 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
decreases activity
EXP [Manganese co-treated with Bilirubin] results in decreased activity of CYP7A1 protein
Bilirubin results in decreased activity of CYP7A1 protein
CTD PMID:12700418 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Bilirubin results in increased expression of DDIT3 mRNA
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of DDIT3 mRNA]; [Bilirubin co-treated with Rotenone] promotes the reaction [Cannabidiol results in increased expression of DDIT3 mRNA]; Bilirubin inhibits the reaction [Cannabidiol results in increased expression of DDIT3 mRNA]
CTD PMID:20196124 PMID:27578021 PMID:32033040 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Deptor DEP domain containing MTOR-interacting protein decreases expression ISO Bilirubin results in decreased expression of DEPTOR mRNA CTD PMID:20196124 NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773
JBrowse link
G Dmkn dermokine decreases expression ISO Bilirubin results in decreased expression of DMKN mRNA CTD PMID:20196124 NCBI chr 1:86,013,237...86,031,243
Ensembl chr 1:86,014,188...86,030,006
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 affects expression ISO Bilirubin affects the expression of DNAJB1 mRNA CTD PMID:20196124 NCBI chr19:24,522,717...24,526,458
Ensembl chr19:24,522,717...24,526,458
JBrowse link
G Dnpep aspartyl aminopeptidase decreases expression ISO Bilirubin results in decreased expression of DNPEP mRNA CTD PMID:20196124 NCBI chr 9:76,799,931...76,808,841
Ensembl chr 9:76,783,966...76,808,716
JBrowse link
G Dpy19l1 dpy-19 like C-mannosyltransferase 1 decreases expression ISO Bilirubin results in decreased expression of DPY19L1 mRNA CTD PMID:20196124 NCBI chr 8:22,933,163...23,021,461
Ensembl chr 8:22,933,163...23,021,751
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO Bilirubin results in increased expression of DUSP5 mRNA CTD PMID:20196124 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]; Bilirubin inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein] CTD PMID:27297870 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 decreases expression ISO Bilirubin results in decreased expression of EGLN1 mRNA CTD PMID:20196124 NCBI chr19:52,867,914...52,907,169 JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein decreases expression ISO Bilirubin results in decreased expression of EI24 mRNA CTD PMID:20196124 NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571
JBrowse link
G Eid1 EP300 interacting inhibitor of differentiation 1 decreases expression ISO Bilirubin results in decreased expression of EID1 mRNA CTD PMID:20196124 NCBI chr 3:112,922,961...112,924,680
Ensembl chr 3:112,922,668...112,924,752
JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 multiple interactions ISO [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Bilirubin CTD PMID:25411909 NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Bilirubin results in increased phosphorylation of and results in increased activity of EIF2AK3 protein; EIF2AK3 mRNA promotes the reaction [Bilirubin results in increased expression of CXCL8 mRNA] CTD PMID:20196124 PMID:27578021 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO Bilirubin results in increased phosphorylation of and results in increased activity of EIF2S1 protein CTD PMID:20196124 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Endod1 endonuclease domain containing 1 decreases expression ISO Bilirubin results in decreased expression of ENDOD1 mRNA CTD PMID:20196124 NCBI chr 8:11,209,123...11,238,680 JBrowse link
G Fam174a family with sequence similarity 174, member A decreases expression ISO Bilirubin results in decreased expression of FAM174A mRNA CTD PMID:20196124 NCBI chr 9:95,742,815...95,761,083
Ensembl chr 9:95,742,927...95,761,081
JBrowse link
G Fgf19 fibroblast growth factor 19 increases abundance ISO FGF15 gene mutant form results in increased abundance of Bilirubin CTD PMID:24699334 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO Bilirubin inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein] CTD PMID:25371888 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Bilirubin results in increased expression of FOSL1 mRNA CTD PMID:20196124 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Bilirubin results in increased expression of GADD45B mRNA CTD PMID:20196124 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Gas5 growth arrest specific 5 decreases expression ISO Bilirubin results in decreased expression of GAS5 mRNA CTD PMID:20196124 NCBI chr13:73,303,611...73,306,932 JBrowse link
G Gsn gelsolin decreases expression ISO Bilirubin results in decreased expression of GSN mRNA CTD PMID:20196124 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression
multiple interactions
ISO Bilirubin results in increased expression of GSTA1 mRNA
IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA1 mRNA]
CTD PMID:15382119 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression
affects binding
multiple interactions
ISO
EXP
Bilirubin results in increased expression of GSTA2 mRNA
Bilirubin binds to GSTA2 protein
IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA2 mRNA]
CTD PMID:1148165 PMID:2768223 PMID:15382119 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression ISO Bilirubin results in decreased expression of GSTA4 mRNA CTD PMID:20196124 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Bilirubin results in decreased expression of GSTK1 mRNA CTD PMID:20196124 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression ISO Bilirubin results in decreased expression of GSTM1 mRNA CTD PMID:20196124 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO Bilirubin results in decreased expression of GSTP1 mRNA CTD PMID:20196124 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G H1f4 H1.4 linker histone, cluster member increases expression ISO Bilirubin results in increased expression of H1-4 mRNA CTD PMID:20196124 NCBI chr17:41,486,634...41,487,293
Ensembl chr17:41,486,560...41,487,403
JBrowse link
G Hacd4 3-hydroxyacyl-CoA dehydratase 4 decreases expression ISO Bilirubin results in decreased expression of HACD4 mRNA CTD PMID:20196124 NCBI chr 5:102,887,597...102,915,376
Ensembl chr 5:102,887,588...102,915,338
JBrowse link
G Heph hephaestin decreases expression ISO Bilirubin results in decreased expression of HEPH mRNA CTD PMID:20196124 NCBI chr  X:61,151,131...61,402,980
Ensembl chr  X:61,296,345...61,402,980
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Bilirubin results in increased expression of HERPUD1 mRNA CTD PMID:20196124 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] CTD PMID:27297870 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hist1h4b histone cluster 1 H4 family member B increases expression ISO Bilirubin results in increased expression of H4C9 mRNA CTD PMID:20196124 NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein CTD PMID:12700418 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases chemical synthesis
increases expression
affects activity
increases abundance
EXP
ISO
[[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of HMOX1 mRNA] which results in increased chemical synthesis of Bilirubin; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin
HMOX1 protein results in increased chemical synthesis of Bilirubin
[Rotenone co-treated with Bilirubin] inhibits the reaction [Cannabidiol results in increased expression of HMOX1 mRNA]; Bilirubin inhibits the reaction [Cannabidiol results in increased expression of HMOX1 mRNA]; sodium arsenite promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]
Bilirubin results in increased expression of HMOX1 mRNA
Bilirubin affects the activity of HMOX1 protein
[Ethanol results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin; Atazanavir Sulfate promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Bilirubin inhibits the reaction [[tin protoporphyrin IX results in decreased activity of HMOX1 protein] which results in increased chemical synthesis of Reactive Oxygen Species]; Bilirubin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Lopinavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Ritonavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]
HMOX1 protein results in increased abundance of Bilirubin
CTD PMID:12690112 PMID:15226216 PMID:15602829 PMID:20196124 PMID:21401295 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hmox2 heme oxygenase 2 affects abundance ISO HMOX2 affects the abundance of Bilirubin CTD PMID:16181104 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO Bilirubin results in increased expression of HSPA5 mRNA; Bilirubin results in increased expression of HSPA5 protein
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of HSPA5 mRNA]; Bilirubin inhibits the reaction [[Cannabidiol co-treated with Rotenone] results in increased expression of HSPA5 mRNA]
CTD PMID:20196124 PMID:27578021 PMID:32033040 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression ISO Bilirubin results in decreased expression of IDH2 mRNA CTD PMID:20196124 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO Bilirubin results in increased expression of IFRD1 mRNA CTD PMID:20196124 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 decreases expression ISO Bilirubin results in decreased expression of IGFBP3 mRNA CTD PMID:20196124 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Il18 interleukin 18 multiple interactions
decreases response to substance
ISO Bilirubin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Bilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein]
Bilirubin results in decreased susceptibility to IL18 protein
CTD PMID:18215737 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2B6 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2C9 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP3A4 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA1 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA2 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of SLCO1B1 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA]
Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]
CTD PMID:15382119 PMID:18206168 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Bilirubin results in increased expression of IL6 mRNA
[Rotenone co-treated with Bilirubin] inhibits the reaction [Cannabidiol results in increased expression of IL6 mRNA]; Bilirubin inhibits the reaction [Cannabidiol results in increased expression of IL6 mRNA]
CTD PMID:20196124 PMID:32033040 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lamb1 laminin subunit beta 1 decreases expression ISO Bilirubin results in decreased expression of LAMB1 mRNA CTD PMID:20196124 NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 decreases expression ISO Bilirubin results in decreased expression of LAMP2 mRNA CTD PMID:20196124 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Leprot leptin receptor overlapping transcript decreases expression ISO Bilirubin results in decreased expression of LEPROT mRNA CTD PMID:20196124 NCBI chr 5:116,289,843...116,301,951
Ensembl chr 5:116,289,822...116,301,988
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Bilirubin results in increased expression of LIF mRNA CTD PMID:20196124 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G LOC690126 hypothetical protein LOC690126 increases expression ISO Bilirubin results in increased expression of H3C15 mRNA CTD PMID:20196124 NCBI chr 2:183,797,721...183,800,653 JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression ISO Bilirubin results in decreased expression of LRP1 mRNA CTD PMID:20196124 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Ly6h lymphocyte antigen 6 family member H decreases expression ISO Bilirubin results in decreased expression of LY6A mRNA CTD PMID:20196124 NCBI chr 7:107,258,779...107,261,270
Ensembl chr 7:107,258,779...107,261,454
JBrowse link
G Maf MAF bZIP transcription factor decreases expression ISO Bilirubin results in decreased expression of MAF mRNA CTD PMID:20196124 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Bilirubin results in decreased phosphorylation of MAPK1 protein CTD PMID:12690112 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Bilirubin results in decreased phosphorylation of MAPK3 protein CTD PMID:12690112 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 decreases expression ISO Bilirubin results in decreased expression of MAPRE2 mRNA CTD PMID:20196124 NCBI chr18:15,028,675...15,169,553 JBrowse link
G Me2 malic enzyme 2 decreases expression ISO Bilirubin results in decreased expression of ME2 mRNA CTD PMID:20196124 NCBI chr18:67,350,833...67,400,987
Ensembl chr18:67,355,795...67,400,987
JBrowse link
G Megf9 multiple EGF-like-domains 9 decreases expression ISO Bilirubin results in decreased expression of MEGF9 mRNA CTD PMID:20196124 NCBI chr 5:83,993,565...84,105,622
Ensembl chr 5:83,993,565...84,105,622
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases secretion ISO MET gene mutant form results in increased secretion of Bilirubin CTD PMID:27394961 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases expression ISO Bilirubin results in decreased expression of MGST2 mRNA CTD PMID:20196124 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Bilirubin results in increased expression of MMP13 mRNA CTD PMID:20196124 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mpzl2 myelin protein zero-like 2 decreases expression ISO Bilirubin results in decreased expression of MPZL2 mRNA CTD PMID:20196124 NCBI chr 8:45,348,285...45,359,298
Ensembl chr 8:45,348,285...45,359,298
JBrowse link
G Mrpl18 mitochondrial ribosomal protein L18 decreases expression ISO Bilirubin results in decreased expression of MRPL18 mRNA CTD PMID:20196124 NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
ISO Bilirubin affects the localization of NFE2L2 protein
Bilirubin promotes the reaction [NFE2L2 protein results in increased expression of CYP2A5 mRNA]
CTD PMID:23628428 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nid1 nidogen 1 decreases expression ISO Bilirubin results in decreased expression of NID1 mRNA CTD PMID:20196124 NCBI chr17:86,085,046...86,158,277
Ensembl chr17:86,085,077...86,158,267
JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase decreases expression ISO Bilirubin results in decreased expression of NNT mRNA CTD PMID:20196124 NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
JBrowse link
G Noct nocturnin increases expression ISO Bilirubin results in increased expression of NOCT mRNA CTD PMID:20196124 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 mRNA]; Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:18206168 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
affects abundance
affects transport
ISO Bilirubin results in increased expression of NR1I2 mRNA
NR1I2 protein affects the abundance of Bilirubin
NR1I2 protein affects the transport of Bilirubin
CTD PMID:15726644 PMID:18706437 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO Bilirubin results in increased expression of NR1I3 mRNA CTD PMID:18706437 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO Bilirubin results in increased expression of OSGIN1 mRNA CTD PMID:20196124 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions
ISO Bilirubin results in increased expression of PARP1 protein modified form
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of PARP1 protein modified form]
CTD PMID:27578021 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO Bilirubin results in decreased expression of PDK1 mRNA CTD PMID:20196124 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression ISO Bilirubin results in decreased expression of PGAP2 mRNA CTD PMID:20196124 NCBI chr 1:156,591,540...156,618,116
Ensembl chr 1:156,591,615...156,618,114
JBrowse link
G Phb prohibitin decreases expression ISO Bilirubin results in decreased expression of PHB mRNA CTD PMID:20196124 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 decreases expression ISO Bilirubin results in decreased expression of PIAS1 mRNA CTD PMID:20196124 NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression ISO Bilirubin results in decreased expression of PIK3R1 mRNA CTD PMID:20196124 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pla1a phospholipase A1 member A decreases expression ISO Bilirubin results in decreased expression of PLA1A mRNA CTD PMID:20196124 NCBI chr11:62,320,117...62,357,779
Ensembl chr11:62,320,493...62,357,779
JBrowse link
G Pmp22 peripheral myelin protein 22 decreases expression ISO Bilirubin results in decreased expression of PMP22 mRNA CTD PMID:20196124 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
JBrowse link
G Pon2 paraoxonase 2 decreases expression ISO Bilirubin results in decreased expression of PON2 mRNA CTD PMID:20196124 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
JBrowse link
G Prdx4 peroxiredoxin 4 decreases expression ISO Bilirubin results in decreased expression of PRDX4 mRNA CTD PMID:20196124 NCBI chr  X:40,026,762...40,044,066
Ensembl chr  X:40,026,651...40,044,066
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Bilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Rassf4 Ras association domain family member 4 increases expression ISO Bilirubin results in increased expression of RASSF4 mRNA CTD PMID:20196124 NCBI chr 4:149,897,525...149,932,658
Ensembl chr 4:149,897,543...149,932,411
JBrowse link
G Rbm39 RNA binding motif protein 39 decreases expression ISO Bilirubin results in decreased expression of RBM39 mRNA CTD PMID:20196124 NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213
JBrowse link
G Rbm5 RNA binding motif protein 5 decreases expression ISO Bilirubin results in decreased expression of RBM5 mRNA CTD PMID:20196124 NCBI chr 8:108,420,220...108,449,481
Ensembl chr 8:108,420,222...108,449,430
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Bilirubin results in increased expression of RELA mRNA CTD PMID:27578021 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rhobtb3 Rho-related BTB domain containing 3 decreases expression ISO Bilirubin results in decreased expression of RHOBTB3 mRNA CTD PMID:20196124 NCBI chr 2:5,363,388...5,419,164
Ensembl chr 2:5,363,388...5,419,041
JBrowse link
G Rnase4 ribonuclease A family member 4 decreases expression ISO Bilirubin results in decreased expression of RNASE4 mRNA CTD PMID:20196124 NCBI chr15:24,312,765...24,330,116
Ensembl chr15:24,312,464...24,330,117
JBrowse link
G S100a10 S100 calcium binding protein A10 decreases expression ISO Bilirubin results in decreased expression of S100A10 mRNA CTD PMID:20196124 NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661
JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression ISO Bilirubin results in decreased expression of S100A4 mRNA CTD PMID:20196124 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G Scp2 sterol carrier protein 2 decreases expression ISO Bilirubin results in decreased expression of SCP2 mRNA CTD PMID:20196124 NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287
JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Bilirubin results in decreased expression of SELENBP1 mRNA CTD PMID:20196124
G Serpinb1a serpin family B member 1A decreases expression ISO Bilirubin results in decreased expression of SERPINB1A mRNA CTD PMID:20196124 NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Bilirubin results in increased expression of SERPINE1 mRNA CTD PMID:20196124 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sesn1 sestrin 1 decreases expression ISO Bilirubin results in decreased expression of SESN1 mRNA CTD PMID:20196124 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 decreases expression ISO Bilirubin results in decreased expression of SGPP1 mRNA CTD PMID:20196124 NCBI chr 6:94,425,339...94,446,534
Ensembl chr 6:94,425,339...94,446,534
JBrowse link
G Slc16a12 solute carrier family 16, member 12 decreases expression ISO Bilirubin results in decreased expression of SLC16A12 mRNA CTD PMID:20196124 NCBI chr 1:232,184,004...232,262,170
Ensembl chr 1:232,185,907...232,262,141
JBrowse link
G Slc23a1 solute carrier family 23 member 1 increases expression ISO Bilirubin results in increased expression of SLC23A1 mRNA CTD PMID:18706437 NCBI chr18:27,214,940...27,230,564
Ensembl chr18:27,216,281...27,230,697
JBrowse link
G Slc23a2 solute carrier family 23 member 2 increases expression ISO Bilirubin results in increased expression of SLC23A2 mRNA CTD PMID:18706437 NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions
increases expression
ISO [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine; Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]
Bilirubin results in increased expression of SLC3A2 mRNA
CTD PMID:22216172 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions
increases expression
ISO [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine; Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]
Bilirubin results in increased expression of SLC7A11 mRNA
CTD PMID:22216172 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Snx14 sorting nexin 14 decreases expression ISO Bilirubin results in decreased expression of SNX14 mRNA CTD PMID:20196124 NCBI chr 8:89,283,673...89,390,597
Ensembl chr 8:89,298,114...89,390,580
JBrowse link
G Sost sclerostin decreases expression ISO Bilirubin results in decreased expression of SOST mRNA CTD PMID:20196124 NCBI chr10:86,912,517...86,915,561
Ensembl chr10:86,911,517...86,915,561
JBrowse link
G Sp5 Sp5 transcription factor decreases expression ISO Bilirubin results in decreased expression of SP5 mRNA CTD PMID:20196124 NCBI chr 3:55,274,931...55,277,733
Ensembl chr 3:55,274,931...55,277,733
JBrowse link
G Tapbp TAP binding protein decreases expression ISO Bilirubin results in decreased expression of TAPBP mRNA CTD PMID:20196124 NCBI chr20:4,956,937...4,966,191
Ensembl chr20:4,956,937...4,966,181
JBrowse link
G Tcf4 transcription factor 4 decreases expression ISO Bilirubin results in decreased expression of TCF4 mRNA CTD PMID:20196124 NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression ISO Bilirubin results in increased expression of TIPARP mRNA CTD PMID:20196124 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
JBrowse link
G Tm9sf2 transmembrane 9 superfamily member 2 decreases expression ISO Bilirubin results in decreased expression of TM9SF2 mRNA CTD PMID:20196124 NCBI chr15:99,201,556...99,254,054
Ensembl chr15:99,201,489...99,254,049
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of TNF mRNA]
Bilirubin results in increased expression of TNF mRNA; Bilirubin results in increased expression of TNF protein
CTD PMID:27578021 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf19 TNF receptor superfamily member 19 decreases expression ISO Bilirubin results in decreased expression of TNFRSF19 mRNA CTD PMID:20196124 NCBI chr15:35,092,206...35,158,472
Ensembl chr15:35,092,206...35,180,795
JBrowse link
G Tpp1 tripeptidyl peptidase 1 decreases expression ISO Bilirubin results in decreased expression of TPP1 mRNA CTD PMID:20196124 NCBI chr 1:160,097,984...160,104,108
Ensembl chr 1:160,096,833...160,104,129
JBrowse link
G Trib2 tribbles pseudokinase 2 decreases expression ISO Bilirubin results in decreased expression of TRIB2 mRNA CTD PMID:20196124 NCBI chr 6:38,545,971...38,570,349
Ensembl chr 6:38,545,975...38,569,370
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I decreases expression ISO Bilirubin results in decreased expression of UBE2I mRNA CTD PMID:20196124 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
increases glucuronidation
multiple interactions
increases metabolic processing
decreases glucuronidation
decreases activity
ISO
EXP
Bilirubin results in increased expression of UGT1A1 mRNA
UGT1A1 protein results in increased glucuronidation of Bilirubin
5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]
UGT1A1 protein results in increased metabolism of Bilirubin
UGT1A1 protein results in increased glucuronidation of Bilirubin; UGT1A1 results in increased glucuronidation of Bilirubin
UGT1A1 gene mutant form results in decreased glucuronidation of Bilirubin
5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA]; imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; UGT1A1 protein results in increased glucuronidation of and results in decreased activity of Bilirubin
Bilirubin results in decreased activity of UGT1A1 protein
CTD PMID:10950852 PMID:12153725 PMID:15334623 PMID:15382119 PMID:15557560 More... NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO Bilirubin results in decreased activity of UGT1A3 protein CTD PMID:15334623 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI decreases expression ISO Bilirubin results in decreased expression of UQCR mRNA CTD PMID:20196124 NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750
JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein decreases expression ISO Bilirubin results in decreased expression of UQCRB mRNA CTD PMID:20196124 NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150
JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 decreases expression ISO Bilirubin results in decreased expression of UQCRC1 mRNA CTD PMID:20196124 NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480
JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein decreases expression ISO Bilirubin results in decreased expression of UQCRH mRNA CTD PMID:20196124 NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242
JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 decreases expression ISO Bilirubin results in decreased expression of UXS1 mRNA CTD PMID:20196124 NCBI chr 9:653,740...731,121
Ensembl chr 9:653,659...756,334
JBrowse link
G Vldlr very low density lipoprotein receptor decreases expression ISO Bilirubin results in decreased expression of VLDLR mRNA CTD PMID:20196124 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
JBrowse link
G Xbp1 X-box binding protein 1 increases expression
multiple interactions
ISO Bilirubin results in increased expression of XBP1 mRNA
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of XBP1 mRNA]
CTD PMID:27578021 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 decreases expression ISO Bilirubin results in decreased expression of ZBTB20 mRNA CTD PMID:20196124 NCBI chr11:57,052,129...57,823,679
Ensembl chr11:57,072,880...57,510,210
JBrowse link
G Zbtb8os zinc finger and BTB domain containing 8 opposite strand decreases expression ISO Bilirubin results in decreased expression of ZBTB8OS mRNA CTD PMID:20196124 NCBI chr 5:141,675,502...141,687,148
Ensembl chr 5:141,675,857...141,688,660
JBrowse link
G Zcchc7 zinc finger CCHC-type containing 7 decreases expression ISO Bilirubin results in decreased expression of ZCCHC7 mRNA CTD PMID:20196124 NCBI chr 5:58,992,558...59,173,308
Ensembl chr 5:58,993,290...59,173,300
JBrowse link
G Zfand2a zinc finger AN1-type containing 2A increases expression ISO Bilirubin results in increased expression of ZFAND2A mRNA CTD PMID:20196124 NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677
JBrowse link
G Zfp207 zinc finger protein 207 decreases expression ISO Bilirubin results in decreased expression of ZFP207 mRNA CTD PMID:20196124 NCBI chr10:65,385,823...65,397,591
Ensembl chr10:65,385,740...65,397,386
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      group 19741
        24G7 epitope 167
          bilirubin IXalpha 167
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  group 19741
                    24G7 epitope 167
                      bilirubin IXalpha 167
paths to the root