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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:24G7 epitope
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Accession:CHEBI:142163 term browser browse the term
Definition:An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22.
Synonyms:related_synonym: Formula=C7H6N2O;   SMILES=C(=CC(NC(=*)*)=*)(NC(C(C)=*)=O)*


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bilirubin IXalpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 multiple interactions ISO Bilirubin analog inhibits the reaction [tert-Butylhydroperoxide affects the localization of and results in decreased activity of ABCB11 protein] CTD PMID:24306262 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 affects transport
multiple interactions
ISO ABCC1 protein affects the transport of Bilirubin
Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Bilirubin inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; Glutathione promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; verlukast inhibits the reaction [ABCC1 protein affects the transport of Bilirubin]
CTD PMID:15245331 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 decreases activity
multiple interactions
affects transport
ISO Bilirubin results in decreased activity of ABCC2 protein
Bilirubin analog inhibits the reaction [tert-Butylhydroperoxide affects the localization of and results in decreased activity of ABCC2 protein]
ABCC2 protein affects the transport of Bilirubin
CTD PMID:15374814 PMID:15901347 PMID:24306262 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions EXP [[Bilirubin binds to and results in increased activity of AHR protein] which binds to CYP1A promoter] which results in increased expression of CYP1A mRNA CTD PMID:18187559 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Bilirubin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein] CTD PMID:18215737 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Alad aminolevulinate, delta-, dehydratase decreases expression ISO Bilirubin results in decreased expression of ALAD mRNA CTD PMID:20196124 NCBI chr 4:62,505,984...62,520,063
Ensembl chr 4:62,509,169...62,519,918
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO ALB protein binds to Bilirubin; Bilirubin binds to ALB protein
Folic Acid inhibits the reaction [Homocysteine inhibits the reaction [ALB protein binds to Bilirubin]]; Folic Acid inhibits the reaction [phenylhydrazine inhibits the reaction [ALB protein binds to Bilirubin]]; Homocysteine inhibits the reaction [ALB protein binds to Bilirubin]; phenylhydrazine inhibits the reaction [ALB protein binds to Bilirubin]
[homocysteine thiolactone results in increased metabolism of ALB protein] affects the reaction [ALB protein binds to Bilirubin]; Sulfisoxazole inhibits the reaction [Bilirubin binds to ALB protein]
CTD PMID:21280114 PMID:33788065 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Anxa1 annexin A1 decreases expression ISO Bilirubin results in decreased expression of ANXA1 mRNA CTD PMID:20196124 NCBI chr19:20,373,434...20,390,671
Ensembl chr19:20,373,428...20,390,944
JBrowse link
G Areg amphiregulin increases expression ISO Bilirubin results in increased expression of AREG mRNA CTD PMID:20196124 NCBI chr 5:91,139,599...91,148,432
Ensembl chr 5:91,139,599...91,148,432
JBrowse link
G Arhgap29 Rho GTPase activating protein 29 decreases expression ISO Bilirubin results in decreased expression of ARHGAP29 mRNA CTD PMID:20196124 NCBI chr 3:121,953,113...122,016,677
Ensembl chr 3:121,952,541...122,016,753
JBrowse link
G Asb13 ankyrin repeat and SOCS box-containing 13 decreases expression ISO Bilirubin results in decreased expression of ASB13 mRNA CTD PMID:20196124 NCBI chr13:3,633,589...3,653,822
Ensembl chr13:3,634,032...3,653,822
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Bilirubin results in increased expression of ATF3 mRNA CTD PMID:20196124 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
increases expression
EXP
ISO
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of ATF6 mRNA] CTD PMID:27578021 NCBI chr 1:170,704,457...170,868,585
Ensembl chr 1:170,704,674...170,867,771
JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide decreases expression ISO Bilirubin results in decreased expression of ATP1A1 mRNA CTD PMID:20196124 NCBI chr 3:101,576,219...101,604,707
Ensembl chr 3:101,576,219...101,604,684
JBrowse link
G Axin2 axin 2 decreases expression ISO Bilirubin results in decreased expression of AXIN2 mRNA CTD PMID:20196124 NCBI chr11:108,917,828...108,950,783
Ensembl chr11:108,920,349...108,950,783
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions EXP Bilirubin promotes the reaction [Iron-Dextran Complex results in increased expression of BCL2L1 protein] CTD PMID:20709802 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bloc1s1 biogenesis of lysosomal organelles complex-1, subunit 1 decreases expression ISO Bilirubin results in decreased expression of BLOC1S1 mRNA CTD PMID:20196124 NCBI chr10:128,919,914...128,923,524
Ensembl chr10:128,917,882...128,924,035
JBrowse link
G C1d C1D nuclear receptor co-repressor decreases expression ISO Bilirubin results in decreased expression of C1D mRNA CTD PMID:20196124 NCBI chr11:17,257,547...17,269,176
Ensembl chr11:17,257,579...17,269,176
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP
ISO
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]; Bilirubin inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; CYP2A5 protein inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein] CTD PMID:20709802 PMID:23628428 PMID:27578021 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cat catalase decreases expression ISO Bilirubin results in decreased expression of CAT mRNA CTD PMID:20196124 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccdc80 coiled-coil domain containing 80 decreases expression ISO Bilirubin results in decreased expression of CCDC80 mRNA CTD PMID:20196124 NCBI chr16:45,093,407...45,127,924
Ensembl chr16:45,093,402...45,128,077
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Bilirubin results in decreased expression of CCND1 mRNA CTD PMID:20196124 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cd302 CD302 antigen decreases expression ISO Bilirubin results in decreased expression of CD302 mRNA CTD PMID:20196124 NCBI chr 2:60,251,993...60,284,484
Ensembl chr 2:60,251,993...60,284,488
JBrowse link
G Chac1 ChaC, cation transport regulator 1 increases expression ISO Bilirubin results in increased expression of CHAC1 mRNA CTD PMID:20196124 NCBI chr 2:119,351,242...119,354,326
Ensembl chr 2:119,351,229...119,354,381
JBrowse link
G Chka choline kinase alpha increases expression ISO Bilirubin results in increased expression of CHKA mRNA CTD PMID:20196124 NCBI chr19:3,851,585...3,894,369
Ensembl chr19:3,851,773...3,894,369
JBrowse link
G Clcc1 chloride channel CLIC-like 1 decreases expression ISO Bilirubin results in decreased expression of CLCC1 mRNA CTD PMID:20196124 NCBI chr 3:108,653,878...108,678,840
Ensembl chr 3:108,653,913...108,678,840
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 decreases expression ISO Bilirubin results in decreased expression of CLIP1 mRNA CTD PMID:20196124 NCBI chr 5:123,577,794...123,684,606
Ensembl chr 5:123,577,795...123,684,618
JBrowse link
G Col3a1 collagen, type III, alpha 1 decreases expression ISO Bilirubin results in decreased expression of COL3A1 mRNA CTD PMID:20196124 NCBI chr 1:45,311,538...45,349,706
Ensembl chr 1:45,311,538...45,349,706
JBrowse link
G Cox15 cytochrome c oxidase assembly protein 15 decreases expression ISO Bilirubin results in decreased expression of COX15 mRNA CTD PMID:20196124 NCBI chr19:43,733,254...43,753,000
Ensembl chr19:43,733,254...43,753,000
JBrowse link
G Cpd carboxypeptidase D decreases expression ISO Bilirubin results in decreased expression of CPD mRNA CTD PMID:20196124 NCBI chr11:76,777,208...76,847,008
Ensembl chr11:76,778,424...76,847,018
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) increases expression ISO Bilirubin results in increased expression of CSF2 mRNA CTD PMID:20196124 NCBI chr11:54,247,270...54,249,899
Ensembl chr11:54,247,271...54,249,667
JBrowse link
G Ctsh cathepsin H decreases expression ISO Bilirubin results in decreased expression of CTSH mRNA CTD PMID:20196124 NCBI chr 9:90,054,267...90,076,095
Ensembl chr 9:90,054,152...90,076,089
JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 increases expression ISO Bilirubin results in increased expression of CXCL10 mRNA CTD PMID:20196124 NCBI chr 5:92,346,638...92,348,889
Ensembl chr 5:92,346,638...92,348,889
JBrowse link
G Cxcl11 chemokine (C-X-C motif) ligand 11 increases expression ISO Bilirubin results in increased expression of CXCL11 mRNA CTD PMID:20196124 NCBI chr 5:92,359,544...92,363,296
Ensembl chr 5:92,359,544...92,365,485
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
increases expression
ISO EIF2AK3 mRNA promotes the reaction [Bilirubin results in increased expression of CXCL8 mRNA]; prolinedithiocarbamate inhibits the reaction [Bilirubin results in increased expression of CXCL8 mRNA]
Bilirubin results in increased expression of CXCL8 mRNA; Bilirubin results in increased expression of CXCL8 protein
CTD PMID:27578021 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 increases expression ISO Bilirubin results in increased expression of CXCL2 mRNA CTD PMID:20196124 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Bilirubin results in increased expression of CYP1A1 mRNA; Bilirubin results in increased expression of CYP1A1 protein CTD PMID:20196124 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP Bilirubin results in decreased activity of CYP1A2 protein CTD PMID:16183037 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 decreases activity
multiple interactions
increases stability
increases oxidation
affects degradation
increases degradation
increases expression
EXP
ISO
Bilirubin results in decreased activity of CYP2A5 protein
[CYP2A6 protein results in increased oxidation of Bilirubin] which results in increased chemical synthesis of Biliverdine; Bilirubin inhibits the reaction [Cycloheximide results in decreased expression of CYP2A6 protein]; Bilirubin results in increased expression of and results in increased activity of CYP2A6 protein
Bilirubin results in increased stability of CYP2A6 protein
Bilirubin results in decreased activity of CYP2A6 protein
CYP2A5 protein affects the degradation of Bilirubin
CYP2A5 protein results in increased degradation of Bilirubin
Bilirubin results in increased expression of CYP2A5 mRNA; Bilirubin results in increased expression of CYP2A5 protein
CYP2A5 protein results in increased oxidation of Bilirubin
Bilirubin results in increased stability of CYP2A5 protein
[CYP2A5 protein results in increased oxidation of Bilirubin] which results in increased chemical synthesis of Biliverdine; Bilirubin promotes the reaction [NFE2L2 protein results in increased expression of CYP2A5 mRNA]; Bilirubin results in increased expression of and results in increased activity of CYP2A5 protein; CYP2A5 protein inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]
CTD PMID:16183037 PMID:21871474 PMID:22465937 PMID:23628428 PMID:25478736 NCBI chr 7:26,835,339...26,843,264
Ensembl chr 7:26,835,305...26,843,548
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression
multiple interactions
ISO Bilirubin results in increased expression of CYP2B6 mRNA
IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2B6 mRNA]
CTD PMID:15382119 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions
increases expression
ISO IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2C9 mRNA] CTD PMID:15382119 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 multiple interactions
increases expression
ISO IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2C9 mRNA] CTD PMID:15382119 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO [Manganese co-treated with Bilirubin] results in decreased activity of CYP7A1 protein
Bilirubin results in decreased activity of CYP7A1 protein
CTD PMID:12700418 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO
EXP
Bilirubin results in increased expression of DDIT3 mRNA
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of DDIT3 mRNA]; [Bilirubin co-treated with Rotenone] promotes the reaction [Cannabidiol results in increased expression of DDIT3 mRNA]; Bilirubin inhibits the reaction [Cannabidiol results in increased expression of DDIT3 mRNA]
CTD PMID:20196124 PMID:27578021 PMID:32033040 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Deptor DEP domain containing MTOR-interacting protein decreases expression ISO Bilirubin results in decreased expression of DEPTOR mRNA CTD PMID:20196124 NCBI chr15:55,112,317...55,259,273
Ensembl chr15:55,112,317...55,259,271
JBrowse link
G Dmkn dermokine decreases expression ISO Bilirubin results in decreased expression of DMKN mRNA CTD PMID:20196124 NCBI chr 7:30,763,756...30,781,066
Ensembl chr 7:30,763,756...30,781,063
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 affects expression ISO Bilirubin affects the expression of DNAJB1 mRNA CTD PMID:20196124 NCBI chr 8:83,608,175...83,612,653
Ensembl chr 8:83,608,193...83,612,653
JBrowse link
G Dnpep aspartyl aminopeptidase decreases expression ISO Bilirubin results in decreased expression of DNPEP mRNA CTD PMID:20196124 NCBI chr 1:75,308,565...75,317,654
Ensembl chr 1:75,307,896...75,317,990
JBrowse link
G Dpy19l1 dpy-19-like 1 (C. elegans) decreases expression ISO Bilirubin results in decreased expression of DPY19L1 mRNA CTD PMID:20196124 NCBI chr 9:24,411,778...24,503,140
Ensembl chr 9:24,411,776...24,503,140
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO Bilirubin results in increased expression of DUSP5 mRNA CTD PMID:20196124 NCBI chr19:53,529,145...53,541,809
Ensembl chr19:53,529,109...53,542,431
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]; Bilirubin inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein] CTD PMID:27297870 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 decreases expression ISO Bilirubin results in decreased expression of EGLN1 mRNA CTD PMID:20196124 NCBI chr 8:124,908,587...124,949,254
Ensembl chr 8:124,908,587...124,949,324
JBrowse link
G Ei24 etoposide induced 2.4 mRNA decreases expression ISO Bilirubin results in decreased expression of EI24 mRNA CTD PMID:20196124 NCBI chr 9:36,779,153...36,797,334
Ensembl chr 9:36,779,159...36,797,393
JBrowse link
G Eid1 EP300 interacting inhibitor of differentiation 1 decreases expression ISO Bilirubin results in decreased expression of EID1 mRNA CTD PMID:20196124 NCBI chr 2:125,673,100...125,675,643
Ensembl chr 2:125,673,095...125,674,785
JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 multiple interactions EXP [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Bilirubin CTD PMID:25411909 NCBI chr 5:143,817,792...143,902,717
Ensembl chr 5:143,817,788...143,904,251
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Bilirubin results in increased phosphorylation of and results in increased activity of EIF2AK3 protein; EIF2AK3 mRNA promotes the reaction [Bilirubin results in increased expression of CXCL8 mRNA] CTD PMID:20196124 PMID:27578021 NCBI chr 6:70,844,484...70,905,241
Ensembl chr 6:70,844,515...70,905,245
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha multiple interactions ISO Bilirubin results in increased phosphorylation of and results in increased activity of EIF2S1 protein CTD PMID:20196124 NCBI chr12:78,862,072...78,887,010
Ensembl chr12:78,861,819...78,887,010
JBrowse link
G Endod1 endonuclease domain containing 1 decreases expression ISO Bilirubin results in decreased expression of ENDOD1 mRNA CTD PMID:20196124 NCBI chr 9:14,353,990...14,381,242
Ensembl chr 9:14,353,990...14,381,507
JBrowse link
G Fam174a family with sequence similarity 174, member A decreases expression ISO Bilirubin results in decreased expression of FAM174A mRNA CTD PMID:20196124 NCBI chr 1:95,313,628...95,335,284
Ensembl chr 1:95,313,623...95,335,284
JBrowse link
G Fgf15 fibroblast growth factor 15 increases abundance EXP FGF15 gene mutant form results in increased abundance of Bilirubin CTD PMID:24699334 NCBI chr 7:144,896,532...144,900,953
Ensembl chr 7:144,896,531...144,900,953
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 multiple interactions ISO Bilirubin inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein] CTD PMID:25371888 NCBI chr 5:147,561,604...147,726,438
Ensembl chr 5:147,561,604...147,726,011
JBrowse link
G Fosl1 fos-like antigen 1 increases expression ISO Bilirubin results in increased expression of FOSL1 mRNA CTD PMID:20196124 NCBI chr19:5,447,698...5,455,938
Ensembl chr19:5,447,547...5,455,946
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta increases expression ISO Bilirubin results in increased expression of GADD45B mRNA CTD PMID:20196124 NCBI chr10:80,930,091...80,932,204
Ensembl chr10:80,930,073...80,932,204
JBrowse link
G Gas5 growth arrest specific 5 decreases expression ISO Bilirubin results in decreased expression of GAS5 mRNA CTD PMID:20196124 NCBI chr 1:161,034,601...161,038,539
Ensembl chr 1:161,034,422...161,038,539
JBrowse link
G Gsn gelsolin decreases expression ISO Bilirubin results in decreased expression of GSN mRNA CTD PMID:20196124 NCBI chr 2:35,256,359...35,307,902
Ensembl chr 2:35,256,380...35,307,892
JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) affects binding ISO Bilirubin binds to GSTA2 protein CTD PMID:1148165 PMID:2768223 NCBI chr 9:78,331,018...78,347,192
Ensembl chr 9:78,331,018...78,355,788
JBrowse link
G Gsta3 glutathione S-transferase, alpha 3 decreases expression ISO Bilirubin results in decreased expression of GSTA3 mRNA CTD PMID:20196124 NCBI chr 1:21,240,565...21,265,575
Ensembl chr 1:21,240,589...21,265,661
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Bilirubin results in decreased expression of GSTK1 mRNA CTD PMID:20196124 NCBI chr 6:42,245,935...42,250,441
Ensembl chr 6:42,245,935...42,250,447
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 decreases expression ISO Bilirubin results in decreased expression of GSTM1 mRNA CTD PMID:20196124 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases expression ISO Bilirubin results in decreased expression of GSTP1 mRNA CTD PMID:20196124 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G H1f4 H1.4 linker histone, cluster member increases expression ISO Bilirubin results in increased expression of H1-4 mRNA CTD PMID:20196124 NCBI chr13:23,621,777...23,622,558
Ensembl chr13:23,620,629...23,622,558
JBrowse link
G H2aw H2A.W histone increases expression ISO Bilirubin results in increased expression of H2AW mRNA CTD PMID:20196124 NCBI chr11:58,954,685...58,955,192
Ensembl chr11:58,954,685...58,956,830
JBrowse link
G H2bc4 H2B clustered histone 4 increases expression ISO Bilirubin results in increased expression of H2BC4 mRNA CTD PMID:20196124 NCBI chr13:23,684,199...23,692,480
Ensembl chr13:23,684,199...23,692,908
JBrowse link
G H3c7 H3 clustered histone 7 increases expression ISO Bilirubin results in increased expression of H3C15 mRNA CTD PMID:20196124 NCBI chr13:23,544,052...23,544,954
Ensembl chr13:23,544,052...23,545,312
JBrowse link
G H4c8 H4 clustered histone 8 increases expression ISO Bilirubin results in increased expression of H4C9 mRNA CTD PMID:20196124 NCBI chr13:23,531,044...23,531,478
Ensembl chr13:23,531,050...23,531,519
JBrowse link
G Hacd4 3-hydroxyacyl-CoA dehydratase 4 decreases expression ISO Bilirubin results in decreased expression of HACD4 mRNA CTD PMID:20196124 NCBI chr 4:88,407,687...88,438,936
Ensembl chr 4:88,396,144...88,438,928
JBrowse link
G Heph hephaestin decreases expression ISO Bilirubin results in decreased expression of HEPH mRNA CTD PMID:20196124 NCBI chr  X:96,455,436...96,574,485
Ensembl chr  X:96,455,359...96,574,485
JBrowse link
G Herpud1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 increases expression ISO Bilirubin results in increased expression of HERPUD1 mRNA CTD PMID:20196124 NCBI chr 8:94,386,429...94,395,371
Ensembl chr 8:94,386,438...94,395,377
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] CTD PMID:27297870 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions ISO [Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein CTD PMID:12700418 NCBI chr13:96,648,962...96,670,936
Ensembl chr13:96,648,967...96,670,936
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases chemical synthesis
increases expression
affects activity
increases abundance
ISO
EXP
[[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of HMOX1 mRNA] which results in increased chemical synthesis of Bilirubin; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin
HMOX1 protein results in increased chemical synthesis of Bilirubin
[Rotenone co-treated with Bilirubin] inhibits the reaction [Cannabidiol results in increased expression of HMOX1 mRNA]; Bilirubin inhibits the reaction [Cannabidiol results in increased expression of HMOX1 mRNA]; sodium arsenite promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]
Bilirubin results in increased expression of HMOX1 mRNA
Bilirubin affects the activity of HMOX1 protein
[Ethanol results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin; Atazanavir Sulfate promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Bilirubin inhibits the reaction [[tin protoporphyrin IX results in decreased activity of HMOX1 protein] which results in increased chemical synthesis of Reactive Oxygen Species]; Bilirubin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Lopinavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Ritonavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]
HMOX1 protein results in increased abundance of Bilirubin
CTD PMID:12690112 PMID:15226216 PMID:15602829 PMID:20196124 PMID:21401295 More... NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hmox2 heme oxygenase 2 affects abundance EXP HMOX2 affects the abundance of Bilirubin CTD PMID:16181104 NCBI chr16:4,726,361...4,766,742
Ensembl chr16:4,726,361...4,766,742
JBrowse link
G Hspa5 heat shock protein 5 increases expression
multiple interactions
ISO
EXP
Bilirubin results in increased expression of HSPA5 mRNA; Bilirubin results in increased expression of HSPA5 protein
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of HSPA5 mRNA]; Bilirubin inhibits the reaction [[Cannabidiol co-treated with Rotenone] results in increased expression of HSPA5 mRNA]
CTD PMID:20196124 PMID:27578021 PMID:32033040 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial decreases expression ISO Bilirubin results in decreased expression of IDH2 mRNA CTD PMID:20196124 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO Bilirubin results in increased expression of IFRD1 mRNA CTD PMID:20196124 NCBI chr12:40,203,129...40,223,189
Ensembl chr12:40,201,567...40,248,504
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 decreases expression ISO Bilirubin results in decreased expression of IGFBP3 mRNA CTD PMID:20196124 NCBI chr11:7,206,086...7,215,498
Ensembl chr11:7,206,086...7,213,923
JBrowse link
G Il18 interleukin 18 multiple interactions
decreases response to substance
ISO Bilirubin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Bilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein]
Bilirubin results in decreased susceptibility to IL18 protein
CTD PMID:18215737 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2B6 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2C9 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP3A4 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA1 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA2 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of SLCO1B1 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA]
Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]
CTD PMID:15382119 PMID:18206168 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO
EXP
Bilirubin results in increased expression of IL6 mRNA
[Rotenone co-treated with Bilirubin] inhibits the reaction [Cannabidiol results in increased expression of IL6 mRNA]; Bilirubin inhibits the reaction [Cannabidiol results in increased expression of IL6 mRNA]
CTD PMID:20196124 PMID:32033040 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Lamb1 laminin B1 decreases expression ISO Bilirubin results in decreased expression of LAMB1 mRNA CTD PMID:20196124 NCBI chr12:31,265,146...31,329,644
Ensembl chr12:31,265,234...31,329,644
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 decreases expression ISO Bilirubin results in decreased expression of LAMP2 mRNA CTD PMID:20196124 NCBI chr  X:38,399,647...38,456,460
Ensembl chr  X:38,401,357...38,456,454
JBrowse link
G Leprot leptin receptor overlapping transcript decreases expression ISO Bilirubin results in decreased expression of LEPROT mRNA CTD PMID:20196124 NCBI chr 4:101,647,783...101,659,364
Ensembl chr 4:101,647,718...101,659,364
JBrowse link
G Lif leukemia inhibitory factor increases expression ISO Bilirubin results in increased expression of LIF mRNA CTD PMID:20196124 NCBI chr11:4,257,568...4,272,514
Ensembl chr11:4,257,557...4,272,514
JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 decreases expression ISO Bilirubin results in decreased expression of LRP1 mRNA CTD PMID:20196124 NCBI chr10:127,538,157...127,621,148
Ensembl chr10:127,538,161...127,621,148
JBrowse link
G Ly6h lymphocyte antigen 6 complex, locus H decreases expression ISO Bilirubin results in decreased expression of LY6A mRNA CTD PMID:20196124 NCBI chr15:75,564,745...75,569,470
Ensembl chr15:75,551,268...75,567,255
JBrowse link
G Maf avian musculoaponeurotic fibrosarcoma oncogene homolog decreases expression ISO Bilirubin results in decreased expression of MAF mRNA CTD PMID:20196124 NCBI chr 8:115,703,253...115,706,894
Ensembl chr 8:115,682,942...115,707,794
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO Bilirubin results in decreased phosphorylation of MAPK1 protein CTD PMID:12690112 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation ISO Bilirubin results in decreased phosphorylation of MAPK3 protein CTD PMID:12690112 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 decreases expression ISO Bilirubin results in decreased expression of MAPRE2 mRNA CTD PMID:20196124 NCBI chr18:23,752,333...23,893,861
Ensembl chr18:23,752,333...23,893,861
JBrowse link
G Me2 malic enzyme 2, NAD(+)-dependent, mitochondrial decreases expression ISO Bilirubin results in decreased expression of ME2 mRNA CTD PMID:20196124 NCBI chr18:73,764,954...73,815,438
Ensembl chr18:73,769,903...73,815,449
JBrowse link
G Megf9 multiple EGF-like-domains 9 decreases expression ISO Bilirubin results in decreased expression of MEGF9 mRNA CTD PMID:20196124 NCBI chr 4:70,431,927...70,534,928
Ensembl chr 4:70,427,065...70,534,995
JBrowse link
G Met met proto-oncogene increases secretion EXP MET gene mutant form results in increased secretion of Bilirubin CTD PMID:27394961 NCBI chr 6:17,463,349...17,573,980
Ensembl chr 6:17,463,800...17,573,980
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases expression ISO Bilirubin results in decreased expression of MGST2 mRNA CTD PMID:20196124 NCBI chr 3:51,636,912...51,682,675
Ensembl chr 3:51,660,360...51,682,677
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Bilirubin results in increased expression of MMP13 mRNA CTD PMID:20196124 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mpzl2 myelin protein zero-like 2 decreases expression ISO Bilirubin results in decreased expression of MPZL2 mRNA CTD PMID:20196124 NCBI chr 9:45,042,344...45,054,043
Ensembl chr 9:45,039,799...45,054,015
JBrowse link
G Mrpl18 mitochondrial ribosomal protein L18 decreases expression ISO Bilirubin results in decreased expression of MRPL18 mRNA CTD PMID:20196124 NCBI chr17:12,911,345...12,917,787
Ensembl chr17:12,911,349...12,916,345
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization
multiple interactions
EXP Bilirubin affects the localization of NFE2L2 protein
Bilirubin promotes the reaction [NFE2L2 protein results in increased expression of CYP2A5 mRNA]
CTD PMID:23628428 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nid1 nidogen 1 decreases expression ISO Bilirubin results in decreased expression of NID1 mRNA CTD PMID:20196124 NCBI chr13:13,437,602...13,512,275
Ensembl chr13:13,437,551...13,512,269
JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase decreases expression ISO Bilirubin results in decreased expression of NNT mRNA CTD PMID:20196124 NCBI chr13:119,335,527...119,409,257
Ensembl chr13:119,335,448...119,408,997
Ensembl chr13:119,335,448...119,408,997
JBrowse link
G Noct nocturnin increases expression ISO Bilirubin results in increased expression of NOCT mRNA CTD PMID:20196124 NCBI chr 3:51,224,447...51,251,654
Ensembl chr 3:51,224,447...51,251,644
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 mRNA]; Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:18206168 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
affects transport
affects abundance
ISO
EXP
Bilirubin results in increased expression of NR1I2 mRNA
NR1I2 protein affects the transport of Bilirubin
NR1I2 protein affects the abundance of Bilirubin
CTD PMID:15726644 PMID:18706437 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO Bilirubin results in increased expression of NR1I3 mRNA CTD PMID:18706437 NCBI chr 1:171,213,934...171,218,845
Ensembl chr 1:171,213,970...171,220,701
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO Bilirubin results in increased expression of OSGIN1 mRNA CTD PMID:20196124 NCBI chr 8:119,425,882...119,446,257
Ensembl chr 8:119,434,124...119,446,256
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases expression
EXP
ISO
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of PARP1 protein modified form] CTD PMID:27578021 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 decreases expression ISO Bilirubin results in decreased expression of PDK1 mRNA CTD PMID:20196124 NCBI chr 2:71,873,215...71,903,858
Ensembl chr 2:71,873,224...71,903,858
JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression ISO Bilirubin results in decreased expression of PGAP2 mRNA CTD PMID:20196124 NCBI chr 7:102,209,933...102,238,564
Ensembl chr 7:102,210,208...102,238,567
JBrowse link
G Phb prohibitin decreases expression ISO Bilirubin results in decreased expression of PHB mRNA CTD PMID:20196124 NCBI chr11:95,666,957...95,680,773
Ensembl chr11:95,666,957...95,680,773
JBrowse link
G Pias1 protein inhibitor of activated STAT 1 decreases expression ISO Bilirubin results in decreased expression of PIAS1 mRNA CTD PMID:20196124 NCBI chr 9:62,878,366...62,980,879
Ensembl chr 9:62,878,368...62,987,924
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression ISO Bilirubin results in decreased expression of PIK3R1 mRNA CTD PMID:20196124 NCBI chr13:101,680,761...101,768,217
Ensembl chr13:101,680,563...101,768,217
JBrowse link
G Pla1a phospholipase A1 member A decreases expression ISO Bilirubin results in decreased expression of PLA1A mRNA CTD PMID:20196124 NCBI chr16:38,396,117...38,433,191
Ensembl chr16:38,396,117...38,433,145
JBrowse link
G Pmp22 peripheral myelin protein 22 decreases expression ISO Bilirubin results in decreased expression of PMP22 mRNA CTD PMID:20196124 NCBI chr11:63,128,982...63,159,547
Ensembl chr11:63,128,982...63,159,547
JBrowse link
G Pon2 paraoxonase 2 decreases expression ISO Bilirubin results in decreased expression of PON2 mRNA CTD PMID:20196124 NCBI chr 6:5,264,620...5,298,345
Ensembl chr 6:5,264,147...5,298,455
JBrowse link
G Prdx4 peroxiredoxin 4 decreases expression ISO Bilirubin results in decreased expression of PRDX4 mRNA CTD PMID:20196124 NCBI chr  X:155,323,918...155,342,272
Ensembl chr  X:155,323,918...155,340,754
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Bilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr19:32,757,577...32,826,160
Ensembl chr19:32,757,497...32,826,160
JBrowse link
G Rassf4 Ras association (RalGDS/AF-6) domain family member 4 increases expression ISO Bilirubin results in increased expression of RASSF4 mRNA CTD PMID:20196124 NCBI chr 6:116,633,008...116,673,836
Ensembl chr 6:116,633,008...116,673,952
JBrowse link
G Rbm39 RNA binding motif protein 39 decreases expression ISO Bilirubin results in decreased expression of RBM39 mRNA CTD PMID:20196124 NCBI chr 2:156,147,239...156,180,238
Ensembl chr 2:156,147,239...156,180,238
JBrowse link
G Rbm5 RNA binding motif protein 5 decreases expression ISO Bilirubin results in decreased expression of RBM5 mRNA CTD PMID:20196124 NCBI chr 9:107,740,495...107,771,007
Ensembl chr 9:107,740,371...107,770,996
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) increases expression ISO Bilirubin results in increased expression of RELA mRNA CTD PMID:27578021 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rhobtb3 Rho-related BTB domain containing 3 decreases expression ISO Bilirubin results in decreased expression of RHOBTB3 mRNA CTD PMID:20196124 NCBI chr13:75,869,537...75,943,824
Ensembl chr13:75,869,537...75,943,925
JBrowse link
G Rnase4 ribonuclease, RNase A family 4 decreases expression ISO Bilirubin results in decreased expression of RNASE4 mRNA CTD PMID:20196124 NCBI chr14:51,091,077...51,106,151
Ensembl chr14:51,091,077...51,106,151
JBrowse link
G S100a10 S100 calcium binding protein A10 (calpactin) decreases expression ISO Bilirubin results in decreased expression of S100A10 mRNA CTD PMID:20196124 NCBI chr 3:93,555,117...93,564,645
Ensembl chr 3:93,555,080...93,564,643
JBrowse link
G S100a4 S100 calcium binding protein A4 decreases expression ISO Bilirubin results in decreased expression of S100A4 mRNA CTD PMID:20196124 NCBI chr 3:90,603,770...90,606,045
Ensembl chr 3:90,603,771...90,606,045
JBrowse link
G Scp2 sterol carrier protein 2, liver decreases expression ISO Bilirubin results in decreased expression of SCP2 mRNA CTD PMID:20196124 NCBI chr 4:108,043,830...108,144,971
Ensembl chr 4:108,043,839...108,144,998
JBrowse link
G Selenbp2 selenium binding protein 2 decreases expression ISO Bilirubin results in decreased expression of SELENBP1 mRNA CTD PMID:20196124 NCBI chr 3:94,693,573...94,704,406
Ensembl chr 3:94,693,556...94,704,413
JBrowse link
G Serpinb1a serine (or cysteine) peptidase inhibitor, clade B, member 1a decreases expression ISO Bilirubin results in decreased expression of SERPINB1A mRNA CTD PMID:20196124 NCBI chr13:32,842,092...32,853,206
Ensembl chr13:32,842,092...32,851,185
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 increases expression ISO Bilirubin results in increased expression of SERPINE1 mRNA CTD PMID:20196124 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Sesn1 sestrin 1 decreases expression ISO Bilirubin results in decreased expression of SESN1 mRNA CTD PMID:20196124 NCBI chr10:41,810,574...41,908,436
Ensembl chr10:41,809,935...41,908,424
JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 decreases expression ISO Bilirubin results in decreased expression of SGPP1 mRNA CTD PMID:20196124 NCBI chr12:75,714,248...75,735,729
Ensembl chr12:75,714,249...75,735,729
JBrowse link
G Slc16a12 solute carrier family 16 (monocarboxylic acid transporters), member 12 decreases expression ISO Bilirubin results in decreased expression of SLC16A12 mRNA CTD PMID:20196124 NCBI chr19:34,668,401...34,747,493
Ensembl chr19:34,668,403...34,747,289
JBrowse link
G Slc23a1 solute carrier family 23 (nucleobase transporters), member 1 increases expression ISO Bilirubin results in increased expression of SLC23A1 mRNA CTD PMID:18706437 NCBI chr18:35,604,224...35,629,845
Ensembl chr18:35,614,604...35,627,244
JBrowse link
G Slc23a2 solute carrier family 23 (nucleobase transporters), member 2 increases expression ISO Bilirubin results in increased expression of SLC23A2 mRNA CTD PMID:18706437 NCBI chr 2:132,052,496...132,145,320
Ensembl chr 2:132,052,496...132,145,108
JBrowse link
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 multiple interactions
increases expression
ISO [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine; Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]
Bilirubin results in increased expression of SLC3A2 mRNA
CTD PMID:22216172 NCBI chr19:8,706,882...8,723,369
Ensembl chr19:8,706,882...8,723,369
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 multiple interactions
increases expression
ISO [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine; Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]
Bilirubin results in increased expression of SLC7A11 mRNA
CTD PMID:22216172 NCBI chr 3:50,364,936...50,499,087
Ensembl chr 3:49,892,526...50,443,614
JBrowse link
G Snx14 sorting nexin 14 decreases expression ISO Bilirubin results in decreased expression of SNX14 mRNA CTD PMID:20196124 NCBI chr 9:88,376,755...88,438,929
Ensembl chr 9:88,376,750...88,438,958
Ensembl chr 9:88,376,750...88,438,958
JBrowse link
G Sost sclerostin decreases expression ISO Bilirubin results in decreased expression of SOST mRNA CTD PMID:20196124 NCBI chr11:101,962,458...101,967,015
Ensembl chr11:101,962,458...101,967,015
JBrowse link
G Sp5 trans-acting transcription factor 5 decreases expression ISO Bilirubin results in decreased expression of SP5 mRNA CTD PMID:20196124 NCBI chr 2:70,474,923...70,477,726
Ensembl chr 2:70,474,923...70,477,729
JBrowse link
G Tapbp TAP binding protein decreases expression ISO Bilirubin results in decreased expression of TAPBP mRNA CTD PMID:20196124 NCBI chr17:33,919,478...33,929,290
Ensembl chr17:33,915,899...33,929,292
JBrowse link
G Tcf4 transcription factor 4 decreases expression ISO Bilirubin results in decreased expression of TCF4 mRNA CTD PMID:20196124 NCBI chr18:69,343,429...69,687,967
Ensembl chr18:69,343,356...69,689,079
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression ISO Bilirubin results in increased expression of TIPARP mRNA CTD PMID:20196124 NCBI chr 3:65,528,447...65,555,518
Ensembl chr 3:65,528,410...65,555,518
JBrowse link
G Tm9sf2 transmembrane 9 superfamily member 2 decreases expression ISO Bilirubin results in decreased expression of TM9SF2 mRNA CTD PMID:20196124 NCBI chr14:122,107,082...122,159,603
Ensembl chr14:122,107,038...122,159,604
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP
ISO
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of TNF mRNA]
Bilirubin results in increased expression of TNF mRNA; Bilirubin results in increased expression of TNF protein
CTD PMID:27578021 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf19 tumor necrosis factor receptor superfamily, member 19 decreases expression ISO Bilirubin results in decreased expression of TNFRSF19 mRNA CTD PMID:20196124 NCBI chr14:60,963,834...61,046,855
Ensembl chr14:60,963,875...61,046,490
JBrowse link
G Tpp1 tripeptidyl peptidase I decreases expression ISO Bilirubin results in decreased expression of TPP1 mRNA CTD PMID:20196124 NCBI chr 7:105,744,811...105,752,282
Ensembl chr 7:105,744,811...105,752,235
JBrowse link
G Trib2 tribbles pseudokinase 2 decreases expression ISO Bilirubin results in decreased expression of TRIB2 mRNA CTD PMID:20196124 NCBI chr12:15,791,725...15,816,962
Ensembl chr12:15,791,727...15,816,922
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I decreases expression ISO Bilirubin results in decreased expression of UBE2I mRNA CTD PMID:20196124 NCBI chr17:25,260,510...25,275,799
Ensembl chr17:25,261,916...25,274,622
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases expression
increases glucuronidation
multiple interactions
increases metabolic processing
decreases glucuronidation
decreases activity
ISO Bilirubin results in increased expression of UGT1A1 mRNA
UGT1A1 protein results in increased glucuronidation of Bilirubin
5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]
UGT1A1 protein results in increased metabolism of Bilirubin
UGT1A1 protein results in increased glucuronidation of Bilirubin; UGT1A1 results in increased glucuronidation of Bilirubin
UGT1A1 gene mutant form results in decreased glucuronidation of Bilirubin
5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA]; imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; UGT1A1 protein results in increased glucuronidation of and results in decreased activity of Bilirubin
Bilirubin results in decreased activity of UGT1A1 protein
CTD PMID:10950852 PMID:12153725 PMID:15334623 PMID:15382119 PMID:15557560 More... NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO Bilirubin results in decreased activity of UGT1A3 protein CTD PMID:15334623 NCBI chr 1:88,200,611...88,220,002
Ensembl chr 1:88,200,601...88,218,997
JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI decreases expression ISO Bilirubin results in decreased expression of UQCR mRNA CTD PMID:20196124 NCBI chr10:80,402,997...80,406,821
Ensembl chr10:80,402,997...80,406,830
JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein decreases expression ISO Bilirubin results in decreased expression of UQCRB mRNA CTD PMID:20196124 NCBI chr13:66,900,576...66,905,350
Ensembl chr13:66,900,617...66,905,378
JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 decreases expression ISO Bilirubin results in decreased expression of UQCRC1 mRNA CTD PMID:20196124 NCBI chr 9:108,936,648...108,949,641
Ensembl chr 9:108,936,633...108,949,623
JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein decreases expression ISO Bilirubin results in decreased expression of UQCRH mRNA CTD PMID:20196124 NCBI chr 4:116,066,965...116,075,070
Ensembl chr 4:116,066,965...116,075,071
JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 decreases expression ISO Bilirubin results in decreased expression of UXS1 mRNA CTD PMID:20196124 NCBI chr 1:43,746,961...43,827,839
Ensembl chr 1:43,746,966...43,827,800
JBrowse link
G Vldlr very low density lipoprotein receptor decreases expression ISO Bilirubin results in decreased expression of VLDLR mRNA CTD PMID:20196124 NCBI chr19:27,216,480...27,254,231
Ensembl chr19:27,216,484...27,254,231
JBrowse link
G Xbp1 X-box binding protein 1 increases expression
multiple interactions
ISO
EXP
Bilirubin results in increased expression of XBP1 mRNA
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of XBP1 mRNA]
CTD PMID:27578021 NCBI chr11:5,520,641...5,525,993
Ensembl chr11:5,520,659...5,525,893
JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 decreases expression ISO Bilirubin results in decreased expression of ZBTB20 mRNA CTD PMID:20196124 NCBI chr16:42,875,689...43,634,392
Ensembl chr16:42,875,881...43,642,602
JBrowse link
G Zbtb8os zinc finger and BTB domain containing 8 opposite strand decreases expression ISO Bilirubin results in decreased expression of ZBTB8OS mRNA CTD PMID:20196124 NCBI chr 4:129,335,532...129,349,871
Ensembl chr 4:129,335,695...129,354,547
JBrowse link
G Zcchc7 zinc finger, CCHC domain containing 7 decreases expression ISO Bilirubin results in decreased expression of ZCCHC7 mRNA CTD PMID:20196124 NCBI chr 4:44,756,558...44,932,215
Ensembl chr 4:44,755,877...44,932,215
JBrowse link
G Zfand2a zinc finger, AN1-type domain 2A increases expression ISO Bilirubin results in increased expression of ZFAND2A mRNA CTD PMID:20196124 NCBI chr 5:139,471,216...139,484,491
Ensembl chr 5:139,471,211...139,484,549
JBrowse link
G Zfp207 zinc finger protein 207 decreases expression ISO Bilirubin results in decreased expression of ZFP207 mRNA CTD PMID:20196124 NCBI chr11:80,383,279...80,408,561
Ensembl chr11:80,383,279...80,405,733
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21788
    chemical entity 21786
      group 21667
        24G7 epitope 170
          bilirubin IXalpha 170
Path 2
Term Annotations click to browse term
  CHEBI ontology 21788
    subatomic particle 21774
      composite particle 21774
        hadron 21774
          baryon 21774
            nucleon 21774
              atomic nucleus 21774
                atom 21774
                  group 21667
                    24G7 epitope 170
                      bilirubin IXalpha 170
paths to the root