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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:imidazobenzodiazepine
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Accession:CHEBI:142118 term browser browse the term
Definition:Any organic heterotricyclic compound that is any benzodiazepine which is ortho-fused with a imidazole.
Synonyms:related_synonym: imidazobenzodiazepines


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1-hydroxymidazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases chemical synthesis ISO CYP3A5 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam CTD PMID:18191104, PMID:26958860 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Tspo translocator protein affects binding EXP 1-hydroxymethylmidazolam binds to TSPO protein; 1-hydroxymethylmidazolam metabolite binds to TSPO protein CTD PMID:7603229 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
4-hydroxymidazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases chemical synthesis
multiple interactions
ISO CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam
diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Luteolin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam]
CTD PMID:18191104 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
flumazenil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP Flumazenil inhibits the reaction [Ethanol deficiency results in decreased expression of GABRA1 mRNA]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]] CTD PMID:1977069, PMID:17403139 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 multiple interactions EXP Flumazenil inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 mRNA]; Flumazenil inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 protein] CTD PMID:17403139 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions
affects binding
ISO Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]
Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]
CTD PMID:8632757 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions EXP Flumazenil promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]] CTD PMID:1977069 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 affects binding
multiple interactions
ISO Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]
Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]
CTD PMID:8632757 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
affects binding
ISO Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]
Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]
CTD PMID:8632757 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Flumazenil inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tspo translocator protein multiple interactions ISO [Flumazenil binds to and results in decreased activity of TSPO protein] which results in decreased susceptibility to Nicotine CTD PMID:7862733 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
midazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Midazolam results in decreased activity of ABCB11 protein
Midazolam inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:20829430, PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Midazolam results in increased expression of ABCB1 protein CTD PMID:8632764 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 multiple interactions
decreases metabolic processing
ISO [ABCB6 gene mutant form results in decreased expression of CYP3A11 mRNA] inhibits the reaction [CYP3A11 protein results in increased metabolism of Midazolam]; [ABCB6 gene mutant form results in decreased expression of CYP3A11 protein] inhibits the reaction [CYP3A11 protein results in increased metabolism of Midazolam]
ABCB6 gene mutant form results in decreased metabolism of Midazolam
CTD PMID:25623066 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Midazolam results in increased expression of BCL2 CTD PMID:17715682 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Midazolam results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Midazolam results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity ISO Midazolam results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Midazolam results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Midazolam results in decreased activity of CYP2D6 protein CTD PMID:18420780 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of Midazolam CTD PMID:17590308 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation
affects metabolic processing
multiple interactions
EXP CYP3A2 protein results in increased hydroxylation of Midazolam
CYP3A4 protein affects the metabolism of Midazolam
shikonin inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Midazolam]
CTD PMID:11911841, PMID:15801540, PMID:28941798 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases hydroxylation EXP CYP3A23-3A1 protein results in increased hydroxylation of Midazolam CTD PMID:11911841 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing
increases hydroxylation
multiple interactions
increases metabolic processing
ISO
EXP
CYP3A5 gene polymorphism affects the metabolism of Midazolam; CYP3A5 protein affects the metabolism of Midazolam
CYP3A5 protein results in increased hydroxylation of Midazolam
fructus schizandrae, radix ginseng, radix ophiopogonis drug combination affects the reaction [CYP3A5 protein affects the metabolism of Midazolam]
CYP3A5 protein results in increased metabolism of Midazolam
CTD PMID:15383492, PMID:15499178, PMID:15801540, PMID:15900284, PMID:19557931, PMID:26958860 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression ISO Midazolam results in increased expression of GABRA4 mRNA CTD PMID:16733821 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 decreases response to substance ISO GABRA6 protein mutant form results in decreased susceptibility to Midazolam CTD PMID:12031754 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases response to substance ISO GABRB3 protein results in increased susceptibility to Midazolam CTD PMID:9523823 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon decreases response to substance EXP GABRE protein results in decreased susceptibility to Midazolam CTD PMID:11691872 NCBI chr  X:152,220,180...152,237,347
Ensembl chr  X:152,218,707...152,237,361
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 affects response to substance
affects binding
ISO GABRG2 protein alternative form affects the susceptibility to Midazolam
GABRG2 protein mutant form binds to Midazolam
CTD PMID:10880692 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gast gastrin multiple interactions EXP [fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:10864877 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects response to substance ISO GRIN2A protein affects the susceptibility to Midazolam CTD PMID:15731593 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Midazolam results in increased activity of NR1I2 protein
NR1I2 gene promotes the reaction [Rifampin results in increased metabolism of Midazolam]
CTD PMID:18799805, PMID:20080160 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases metabolic processing ISO NR1I3 gene mutant form results in decreased metabolism of Midazolam CTD PMID:27434302 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO Midazolam results in increased expression of STAR protein CTD PMID:19857560 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Syn1 synapsin I decreases expression EXP Midazolam results in decreased expression of SYN1 protein CTD PMID:21920406 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Midazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Midazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
G Tspo translocator protein increases expression
affects binding
ISO
EXP
Midazolam results in increased expression of TSPO protein
Midazolam binds to TSPO protein
CTD PMID:7603229, PMID:19857560 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biophysical role 12282
          membrane transport modulator 12063
            GABA modulator 4648
              benzodiazepine 542
                imidazobenzodiazepine 30
                  1',4-dihydroxymidazolam 0
                  1-hydroxymidazolam + 2
                  1-hydroxymidazolam beta-D-glucuronide 0
                  4-hydroxymidazolam + 1
                  4-hydroxymidazolam beta-D-glucuronide 0
                  flumazenil 8
                  iomazenil ((123)I) 0
                  loprazolam 0
                  midazolam + 27
                  midazolam hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organonitrogen heterocyclic compound 17460
                                    benzodiazepine 542
                                      imidazobenzodiazepine 30
                                        1',4-dihydroxymidazolam 0
                                        1-hydroxymidazolam + 2
                                        1-hydroxymidazolam beta-D-glucuronide 0
                                        4-hydroxymidazolam + 1
                                        4-hydroxymidazolam beta-D-glucuronide 0
                                        flumazenil 8
                                        iomazenil ((123)I) 0
                                        loprazolam 0
                                        midazolam + 27
                                        midazolam hydrochloride 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.