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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tipifarnib
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Accession:CHEBI:141969 term browser browse the term
Definition:A quinolone that is 1-methylquinolin-2-one which carries a 3-chlorophenyl and an amino(4-chlorophenyl)(1-methyl-imidazol-5-yl)methyl groups at the 4 and 6 positions, respectively (the R-isomer).
Synonyms:exact_synonym: 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one
 related_synonym: (R)-6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone;   Formula=C27H22Cl2N4O;   InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1;   InChIKey=PLHJCIYEEKOWNM-HHHXNRCGSA-N;   R-115777;   R115777;   SMILES=C1(C=C(C2=C(N1C)C=CC(=C2)[C@](C=3C=CC(=CC3)Cl)(C4=CN=CN4C)N)C=5C=C(C=CC5)Cl)=O;   Zarnestra;   tipifarnibum
 xref: CAS:192185-72-1;   DrugBank:DB04960;   KEGG:D03720
 xref_mesh: MESH:C402769
 xref: PMID:12065441;   PMID:12769710;   PMID:16101130;   PMID:16885199;   PMID:22209975;   PMID:23672878;   PMID:24500418;   PMID:26323840;   PMID:28395021;   PMID:28988377;   PMID:29374384;   PMID:29760048;   Reaxys:9734901;   Wikipedia:Tipifarnib


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tipifarnib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1 gene SNP affects the susceptibility to tipifarnib CTD PMID:15122075 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO tipifarnib inhibits the reaction [CSF2 protein results in increased phosphorylation of AKT1 protein] CTD PMID:22315502 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ap1b1 adaptor related protein complex 1 subunit beta 1 increases expression EXP tipifarnib results in increased expression of AP1B1 mRNA CTD PMID:16403772 NCBI chr14:79,879,482...79,930,778
Ensembl chr14:79,879,533...79,930,778
JBrowse link
G Apc APC regulator of WNT signaling pathway increases expression EXP tipifarnib results in increased expression of APC mRNA CTD PMID:16403772 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression EXP tipifarnib results in increased expression of BMP6 mRNA CTD PMID:16403772 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [tipifarnib co-treated with Paclitaxel] results in increased activity of CASP3 protein CTD PMID:15728126 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Tamoxifen co-treated with tipifarnib] results in decreased expression of CCND1 protein CTD PMID:17876043 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [Tamoxifen co-treated with tipifarnib] results in increased expression of CDKN1B protein CTD PMID:17876043 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases activity
ISO tipifarnib inhibits the reaction [CSF2 protein results in decreased phosphorylation of MAPK1 protein]; tipifarnib inhibits the reaction [CSF2 protein results in decreased phosphorylation of MAPK3 protein]; tipifarnib inhibits the reaction [CSF2 protein results in increased phosphorylation of AKT1 protein]
tipifarnib results in decreased activity of CSF2 protein
CTD PMID:22315502 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [tipifarnib co-treated with Paclitaxel] affects the localization of CYCS protein CTD PMID:15728126 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Fgf14 fibroblast growth factor 14 increases expression EXP tipifarnib results in increased expression of FGF14 mRNA CTD PMID:16403772 NCBI chr15:101,045,038...101,679,888
Ensembl chr15:101,045,036...101,679,900
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression EXP tipifarnib results in increased expression of FGFR2 mRNA CTD PMID:16403772 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 increases expression EXP tipifarnib results in increased expression of GABBR2 mRNA CTD PMID:16403772 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP tipifarnib results in decreased expression of GNAI2 mRNA CTD PMID:16403772 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Hras HRas proto-oncogene, GTPase increases response to substance
decreases metabolic processing
EXP
ISO
HRAS gene mutant form results in increased susceptibility to tipifarnib
tipifarnib results in decreased metabolism of HRAS protein
CTD PMID:15728126 PMID:16403772 PMID:16648579 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Igf2 insulin-like growth factor 2 increases expression EXP tipifarnib results in increased expression of IGF2 mRNA CTD PMID:16403772 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Il18 interleukin 18 multiple interactions ISO geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tipifarnib inhibits the reaction [[MVK protein mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased secretion of IL1B protein]
geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]
CTD PMID:21430599 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Jak3 Janus kinase 3 increases expression EXP tipifarnib results in increased expression of JAK3 mRNA CTD PMID:16403772 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Kras KRAS proto-oncogene, GTPase increases expression EXP tipifarnib results in increased expression of KRAS mRNA CTD PMID:16403772 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 increases expression EXP tipifarnib results in increased expression of LPAR1 mRNA CTD PMID:16403772 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895
JBrowse link
G Maf MAF bZIP transcription factor increases expression EXP tipifarnib results in increased expression of MAF mRNA CTD PMID:16403772 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression EXP tipifarnib results in increased expression of MAP3K1 mRNA CTD PMID:16403772 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [tipifarnib co-treated with Simvastatin] results in decreased phosphorylation of MAPK1 protein; tipifarnib inhibits the reaction [CSF2 protein results in decreased phosphorylation of MAPK1 protein] CTD PMID:19383813 PMID:22315502 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 increases expression EXP tipifarnib results in increased expression of MAPK12 mRNA CTD PMID:16403772 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [tipifarnib co-treated with Simvastatin] results in decreased phosphorylation of MAPK3 protein; tipifarnib inhibits the reaction [CSF2 protein results in decreased phosphorylation of MAPK3 protein] CTD PMID:19383813 PMID:22315502 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mos MOS proto-oncogene, serine/threonine kinase increases expression EXP tipifarnib results in increased expression of MOS mRNA CTD PMID:16403772 NCBI chr 5:16,859,957...16,861,264
Ensembl chr 5:16,859,957...16,861,264
JBrowse link
G Mras muscle RAS oncogene homolog increases expression EXP tipifarnib results in increased expression of MRAS mRNA CTD PMID:16403772 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408
JBrowse link
G Mrgprf MAS related GPR family member F increases expression EXP tipifarnib results in increased expression of MRGPRF mRNA CTD PMID:16403772 NCBI chr 1:200,464,100...200,473,588
Ensembl chr 1:200,463,973...200,473,660
JBrowse link
G Mvk mevalonate kinase multiple interactions ISO tipifarnib inhibits the reaction [[MVK protein mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased secretion of IL1B protein]; tipifarnib inhibits the reaction [MVK protein mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] CTD PMID:21430599 NCBI chr12:42,141,391...42,158,858
Ensembl chr12:42,141,384...42,158,882
JBrowse link
G Mybbp1a MYB binding protein 1a increases expression EXP tipifarnib results in increased expression of MYBBP1A mRNA CTD PMID:16403772 NCBI chr10:57,056,913...57,067,263
Ensembl chr10:57,056,874...57,067,255
JBrowse link
G Ndrg2 NDRG family member 2 decreases expression EXP tipifarnib results in decreased expression of NDRG2 mRNA CTD PMID:16403772 NCBI chr15:24,600,981...24,609,621
Ensembl chr15:24,600,982...24,609,626
JBrowse link
G Nf2 neurofibromin 2 increases expression EXP tipifarnib results in increased expression of NF2 mRNA CTD PMID:16403772 NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667
JBrowse link
G Pgap2 post-GPI attachment to proteins 2 increases expression EXP tipifarnib results in increased expression of PGAP2 mRNA CTD PMID:16403772 NCBI chr 1:156,591,540...156,618,116
Ensembl chr 1:156,591,615...156,618,114
JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma increases expression EXP tipifarnib results in increased expression of PIK3C2G mRNA CTD PMID:16403772 NCBI chr 4:172,483,752...172,851,623
Ensembl chr 4:172,484,345...172,850,544
JBrowse link
G Plaat3 phospholipase A and acyltransferase 3 increases expression EXP tipifarnib results in increased expression of PLAAT3 mRNA CTD PMID:16403772 NCBI chr 1:204,782,608...204,816,397
Ensembl chr 1:204,782,729...204,817,667
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions ISO tipifarnib promotes the reaction [PTPN11 protein mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] CTD PMID:22315502 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Rab14 RAB14, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB14 mRNA CTD PMID:16403772 NCBI chr 3:18,501,953...18,523,253
Ensembl chr 3:18,501,963...18,523,172
JBrowse link
G Rab29 RAB29, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB29 mRNA CTD PMID:16403772 NCBI chr13:43,307,757...43,313,420
Ensembl chr13:43,307,775...43,313,417
JBrowse link
G Rab2a RAB2A, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB2 mRNA CTD PMID:16403772 NCBI chr 5:21,676,219...21,738,833
Ensembl chr 5:21,676,129...21,739,899
JBrowse link
G Rab38 RAB38, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB38 mRNA CTD PMID:16403772 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924
JBrowse link
G Rab3c RAB3C, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB3C mRNA CTD PMID:16403772 NCBI chr 2:41,627,720...41,843,541
Ensembl chr 2:41,627,720...41,843,749
JBrowse link
G Rab8b RAB8B, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB8B mRNA CTD PMID:16403772 NCBI chr 8:67,458,921...67,536,466
Ensembl chr 8:67,458,923...67,536,384
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression EXP tipifarnib results in increased expression of RAF1 mRNA CTD PMID:16403772 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Ralgds ral guanine nucleotide dissociation stimulator decreases expression EXP tipifarnib results in decreased expression of RALGDS mRNA CTD PMID:16403772 NCBI chr 3:11,839,686...11,880,059
Ensembl chr 3:11,839,416...11,880,059
JBrowse link
G Rgs8 regulator of G-protein signaling 8 increases expression EXP tipifarnib results in increased expression of RGS8 mRNA CTD PMID:16403772 NCBI chr13:65,804,703...65,848,953
Ensembl chr13:65,804,797...65,846,807
JBrowse link
G Rheb Ras homolog, mTORC1 binding multiple interactions
decreases activity
ISO [tipifarnib results in decreased activity of RHEB protein] which results in increased susceptibility to Cisplatin CTD PMID:20554106 NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160
JBrowse link
G Rin1 Ras and Rab interactor 1 increases expression EXP tipifarnib results in increased expression of RIN1 mRNA CTD PMID:16403772 NCBI chr 1:202,355,729...202,362,731
Ensembl chr 1:202,355,890...202,362,729
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 increases expression EXP tipifarnib results in increased expression of ROCK1 mRNA CTD PMID:16403772 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 increases expression EXP tipifarnib results in increased expression of ROCK2 mRNA CTD PMID:16403772 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator increases expression EXP tipifarnib results in increased expression of RRAD mRNA CTD PMID:16403772 NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP tipifarnib results in decreased expression of TGFB1 mRNA CTD PMID:16403772 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression EXP tipifarnib results in increased expression of TGFBR2 mRNA CTD PMID:16403772 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]] CTD PMID:21430599 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP tipifarnib results in decreased expression of TP53 mRNA CTD PMID:16403772 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vav1 vav guanine nucleotide exchange factor 1 increases expression EXP tipifarnib results in increased expression of VAV1 mRNA CTD PMID:16403772 NCBI chr 9:2,161,985...2,209,951
Ensembl chr 9:2,157,900...2,208,937
JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression EXP tipifarnib results in increased expression of ZMAT3 mRNA CTD PMID:16403772 NCBI chr 2:115,106,050...115,136,863
Ensembl chr 2:115,106,966...115,136,863
JBrowse link

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  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          apoptosis inducer 13237
            tipifarnib 57
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  heteroarene 16534
                                    monocyclic heteroarene 13436
                                      azole 12624
                                        diazole 8394
                                          imidazoles 7688
                                            tipifarnib 57
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