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ONTOLOGY REPORT - ANNOTATIONS


Term:tipifarnib
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Accession:CHEBI:141969 term browser browse the term
Definition:A quinolone that is 1-methylquinolin-2-one which carries a 3-chlorophenyl and an amino(4-chlorophenyl)(1-methyl-imidazol-5-yl)methyl groups at the 4 and 6 positions, respectively (the R-isomer).
Synonyms:exact_synonym: 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one
 related_synonym: (R)-6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone;   Formula=C27H22Cl2N4O;   InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1;   InChIKey=PLHJCIYEEKOWNM-HHHXNRCGSA-N;   R-115777;   R115777;   SMILES=C1(C=C(C2=C(N1C)C=CC(=C2)[C@](C=3C=CC(=CC3)Cl)(C4=CN=CN4C)N)C=5C=C(C=CC5)Cl)=O;   Zarnestra;   tipifarnibum
 xref: CAS:192185-72-1 "ChemIDplus";   DrugBank:DB04960;   KEGG:D03720
 xref_mesh: MESH:C402769
 xref: PMID:12065441 "Europe PMC";   PMID:12769710 "Europe PMC";   PMID:16101130 "Europe PMC";   PMID:16885199 "Europe PMC";   PMID:22209975 "Europe PMC";   PMID:23672878 "Europe PMC";   PMID:24500418 "Europe PMC";   PMID:26323840 "Europe PMC";   PMID:28395021 "Europe PMC";   PMID:28988377 "Europe PMC";   PMID:29374384 "Europe PMC";   PMID:29760048 "Europe PMC";   Reaxys:9734901 "Reaxys";   Wikipedia:Tipifarnib


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tipifarnib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Ap1b1 adaptor related protein complex 1 subunit beta 1 JBrowse link 14 85,230,652 85,281,806 RGD:6480464
G Apc APC regulator of WNT signaling pathway JBrowse link 18 27,011,710 27,106,323 RGD:6480464
G Bmp6 bone morphogenetic protein 6 JBrowse link 17 26,955,142 27,112,820 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6480464
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Fgf14 fibroblast growth factor 14 JBrowse link 15 110,382,274 111,077,027 RGD:6480464
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:6480464
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 JBrowse link 5 62,276,100 62,621,737 RGD:6480464
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:6480464
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6480464
G Igf2 insulin-like growth factor 2 JBrowse link 1 215,828,102 215,839,081 RGD:6480464
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:6480464
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6480464
G Lpar1 lysophosphatidic acid receptor 1 JBrowse link 5 75,557,038 75,678,067 RGD:6480464
G Maf MAF bZIP transcription factor JBrowse link 19 48,179,826 48,200,995 RGD:6480464
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk12 mitogen-activated protein kinase 12 JBrowse link 7 130,109,214 130,120,918 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mos MOS proto-oncogene, serine/threonine kinase JBrowse link 5 16,746,085 16,747,392 RGD:6480464
G Mras muscle RAS oncogene homolog JBrowse link 8 107,629,028 107,656,851 RGD:6480464
G Mrgprf MAS related GPR family member F JBrowse link 1 218,465,642 218,476,228 RGD:6480464
G Mvk mevalonate kinase JBrowse link 12 47,904,266 47,920,457 RGD:6480464
G Mybbp1a MYB binding protein 1a JBrowse link 10 59,000,400 59,010,794 RGD:6480464
G Ndrg2 NDRG family member 2 JBrowse link 15 28,305,820 28,314,459 RGD:6480464
G Nf2 neurofibromin 2 JBrowse link 14 84,996,905 85,088,547 RGD:6480464
G Pgap2 post-GPI attachment to proteins 2 JBrowse link 1 167,309,021 167,335,550 RGD:6480464
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma JBrowse link 4 173,732,196 174,102,502 RGD:6480464
G Plaat3 phospholipase A and acyltransferase 3 JBrowse link 1 222,844,238 222,877,180 RGD:6480464
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:6480464
G Rab14 RAB14, member RAS oncogene family JBrowse link 3 14,373,270 14,395,357 RGD:6480464
G Rab29 RAB29, member RAS oncogene family JBrowse link 13 48,644,575 48,650,229 RGD:6480464
G Rab2a RAB2A, member RAS oncogene family JBrowse link 5 21,632,654 21,696,721 RGD:6480464
G Rab38 RAB38, member RAS oncogene family JBrowse link 1 152,072,716 152,153,449 RGD:6480464
G Rab3c RAB3C, member RAS oncogene family JBrowse link 2 41,570,955 41,786,681 RGD:6480464
G Rab8b RAB8B, member RAS oncogene family JBrowse link 8 72,641,680 72,714,646 RGD:6480464
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6480464
G Ralgds ral guanine nucleotide dissociation stimulator JBrowse link 3 7,090,134 7,130,548 RGD:6480464
G Rgs8 regulator of G-protein signaling 8 JBrowse link 13 71,086,654 71,141,820 RGD:6480464
G Rheb Ras homolog, mTORC1 binding JBrowse link 4 6,827,429 6,873,384 RGD:6480464
G Rin1 Ras and Rab interactor 1 JBrowse link 1 220,335,036 220,342,319 RGD:6480464
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:6480464
G Rock2 Rho-associated coiled-coil containing protein kinase 2 JBrowse link 6 42,180,864 42,289,910 RGD:6480464
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator JBrowse link 19 561,696 564,929 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Vav1 vav guanine nucleotide exchange factor 1 JBrowse link 9 9,617,551 9,675,167 RGD:6480464
G Zmat3 zinc finger, matrin type 3 JBrowse link 2 118,715,229 118,746,109 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        biochemical role 19138
          apoptosis inducer 10783
            tipifarnib 57
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  heteroarene 15146
                                    monocyclic heteroarene 11614
                                      azole 10473
                                        diazole 8040
                                          imidazoles 7591
                                            tipifarnib 57
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.