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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(-)-noscapine hemiacetal
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Accession:CHEBI:141667 term browser browse the term
Definition:A lactol that is (-)-noscapine [which is also known as (-)-alpha-narcotine] in which the carbonyl group of the lactone moiety has been reduced to give the corresponding lactol. It is the biosynthetic precursor of (-)-noscapine.
Synonyms:exact_synonym: (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-1,3-dihydro-2-benzofuran-1-ol
 related_synonym: (-)-alpha-narcotine hemiacetal;   Formula=C22H25NO7;   InChI=1S/C22H25NO7/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18/h5-6,9,17-18,22,24H,7-8,10H2,1-4H3/t17-,18+,22?/m1/s1;   InChIKey=TZNFGVJRQISOHK-HVHHGIHYSA-N;   SMILES=C1N([C@@](C2=C(C1)C=C3OCOC3=C2OC)([H])[C@@]4(C=5C=CC(=C(C5C(O4)O)OC)OC)[H])C;   narcotine hemiacetal
 xref: KEGG:C20297;   MetaCyc:CPD-14833;   PMID:25485687;   PMID:26369413;   PMID:27634038;   PMID:29723437;   Reaxys:6547265


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(-)-noscapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO Noscapine promotes the reaction [Cisplatin results in increased expression of BAX protein]
Noscapine results in increased expression of BAX protein		 CTD PMID:20674069 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Noscapine results in decreased expression of BCL2 protein
Noscapine promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]		 CTD PMID:20674069 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases response to substance
multiple interactions
decreases expression
increases expression		 ISO BIRC5 protein results in decreased susceptibility to Noscapine
Noscapine promotes the reaction [Cisplatin results in decreased expression of BIRC5 protein]
Noscapine results in decreased expression of BIRC5 protein
Noscapine results in increased expression of BIRC5 mRNA; Noscapine results in increased expression of BIRC5 protein		 CTD PMID:20674069 PMID:22848370 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO [Noscapine co-treated with Cisplatin] results in increased cleavage of CASP3 protein; Noscapine promotes the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein]; Noscapine results in increased expression of and results in increased cleavage of CASP3 protein
Noscapine results in increased activity of CASP3 protein		 CTD PMID:20674069 PMID:22848370 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Noscapine promotes the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP9 protein]; Noscapine results in increased expression of and results in increased cleavage of CASP9 protein CTD PMID:20674069 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO Noscapine promotes the reaction [Cisplatin results in increased expression of CDKN1A protein]
Noscapine results in increased expression of CDKN1A protein		 CTD PMID:20674069 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Noscapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Noscapine results in increased degradation of and results in decreased expression of and results in decreased activity of HIF1A protein CTD PMID:16596621 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Noscapine results in increased cleavage of PARP1 protein CTD PMID:22848370 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Noscapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO Noscapine promotes the reaction [Cisplatin results in increased expression of TP53 protein]; Noscapine results in increased expression of and results in increased phosphorylation of TP53 protein
Noscapine results in increased expression of TP53 protein		 CTD PMID:20674069 PMID:22848370 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases secretion ISO Noscapine results in decreased secretion of VEGFA protein CTD PMID:16596621 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        NMR chemical shift reference compound 18090
          ammonia 17865
            organic amino compound 17888
              tertiary amino compound 10155
                (-)-noscapine hemiacetal 12
                  (-)-noscapine 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        tertiary amino compound 10155
                                          (-)-noscapine hemiacetal 12
                                            (-)-noscapine 12
paths to the root