CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: tert-butyl ethyl ether
Accession: CHEBI:141564
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Definition: An ether having ethyl and tert-butyl as the two alkyl components. It is used as an engine fuel additive to reduce emissions of carbon monoxide and soot.
Synonyms: exact_synonym: 2-ethoxy-2-methylpropane
related_synonym: 2-methyl-2-ethoxypropane; ETBE; Formula=C6H14O; InChI=1S/C6H14O/c1-5-7-6(2,3)4/h5H2,1-4H3; InChIKey=NUMQCACRALPSHD-UHFFFAOYSA-N; SMILES=CCOC(C)(C)C; t-BuOEt; t-butyl ethyl ether
xref: CAS:637-92-3; Chemspider:11996
xref_mesh: MESH:C098546
xref: PMID:20544807; PMID:21288640; PMID:22177017; PMID:23474617; PMID:25108826; PMID:25559863; PMID:25644031; PMID:26538808; PMID:28152311; PMID:28279869; PMID:29478141; Reaxys:1731469; Wikipedia:Ethyl_tert-butyl_ether
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Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
increases expression
ISO
ethyl tert-butyl ether results in increased expression of ACOX1 protein
CTD
PMID:24090815
NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871
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Aldh2
aldehyde dehydrogenase 2, mitochondrial
affects response to substance decreases response to substance
EXP
ALDH2 protein affects the susceptibility to ethyl tert-butyl ether ALDH2 results in decreased susceptibility to ethyl tert-butyl ether
CTD
PMID:22102104 PMID:23810710 PMID:24448831
NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887
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Ccnd1
cyclin D1
increases expression
ISO
ethyl tert-butyl ether results in increased expression of CCND1 mRNA
CTD
PMID:24090815
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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Ces3b
carboxylesterase 3B
increases expression
ISO
ethyl tert-butyl ether results in increased expression of CES3 protein
CTD
PMID:24090815
NCBI chr 8:105,810,365...105,820,561
Ensembl chr 8:105,810,385...105,820,561
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
ethyl tert-butyl ether results in increased expression of CYP1A1 mRNA; ethyl tert-butyl ether results in increased expression of CYP1A1 protein
CTD
PMID:24090815
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
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Cyp2a5
cytochrome P450, family 2, subfamily a, polypeptide 5
increases metabolic processing
ISO
CYP2A6 protein results in increased metabolism of ethyl tert-butyl ether
CTD
PMID:11504148
NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
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Cyp2b13
cytochrome P450, family 2, subfamily b, polypeptide 13
increases expression
ISO
ethyl tert-butyl ether results in increased expression of CYP2B2 mRNA
CTD
PMID:24090815
NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622
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Cyp2c29
cytochrome P450, family 2, subfamily c, polypeptide 29
increases expression
ISO
ethyl tert-butyl ether results in increased expression of CYP2C6V1 mRNA; ethyl tert-butyl ether results in increased expression of CYP2C6V1 protein
CTD
PMID:24090815
NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
ISO
ethyl tert-butyl ether results in increased expression of CYP2E1 mRNA; ethyl tert-butyl ether results in increased expression of CYP2E1 protein
CTD
PMID:24090815
NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
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Cyp2g1
cytochrome P450, family 2, subfamily g, polypeptide 1
increases expression
ISO
ethyl tert-butyl ether results in increased expression of CYP2G1 protein
CTD
PMID:24090815
NCBI chr 7:26,508,352...26,520,622
Ensembl chr 7:26,508,317...26,520,630
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Ech1
enoyl coenzyme A hydratase 1, peroxisomal
increases expression
ISO
ethyl tert-butyl ether results in increased expression of ECH1 protein
CTD
PMID:24090815
NCBI chr 7:28,524,763...28,531,664
Ensembl chr 7:28,524,642...28,531,672
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Ephx1
epoxide hydrolase 1, microsomal
increases expression
ISO
ethyl tert-butyl ether results in increased expression of EPHX1 protein
CTD
PMID:24090815
NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469
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Fdx1
ferredoxin 1
increases expression
ISO
ethyl tert-butyl ether results in increased expression of FDX1 protein
CTD
PMID:24090815
NCBI chr 9:51,854,323...51,874,902
Ensembl chr 9:51,854,606...51,874,856
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Gpx1
glutathione peroxidase 1
increases expression
ISO
ethyl tert-butyl ether results in increased expression of GPX1 protein
CTD
PMID:24090815
NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
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Gsta1
glutathione S-transferase, alpha 1 (Ya)
increases expression
ISO
ethyl tert-butyl ether results in increased expression of GSTA5 protein
CTD
PMID:24090815
NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966
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Ogg1
8-oxoguanine DNA-glycosylase 1
decreases expression
ISO
ethyl tert-butyl ether results in decreased expression of OGG1 mRNA
CTD
PMID:24090815
NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029
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Por
cytochrome p450 oxidoreductase
increases expression
ISO
ethyl tert-butyl ether results in increased expression of POR protein
CTD
PMID:24090815
NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180
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Ppara
peroxisome proliferator activated receptor alpha
increases expression
ISO
ethyl tert-butyl ether results in increased expression of PPARA mRNA
CTD
PMID:24090815
NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
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Pparg
peroxisome proliferator activated receptor gamma
increases expression
ISO
ethyl tert-butyl ether results in increased expression of PPARG mRNA
CTD
PMID:24090815
NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
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Rbp4
retinol binding protein 4, plasma
increases expression
ISO
ethyl tert-butyl ether results in increased expression of RBP4 protein
CTD
PMID:24090815
NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729
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Slc27a2
solute carrier family 27 (fatty acid transporter), member 2
increases expression
ISO
ethyl tert-butyl ether results in increased expression of SLC27A2 protein
CTD
PMID:24090815
NCBI chr 2:126,394,944...126,430,163
Ensembl chr 2:126,394,327...126,430,163
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Slc27a5
solute carrier family 27 (fatty acid transporter), member 5
increases expression
ISO
ethyl tert-butyl ether results in increased expression of SLC27A5 protein
CTD
PMID:24090815
NCBI chr 7:12,722,273...12,732,119
Ensembl chr 7:12,722,273...12,732,119
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Sod2
superoxide dismutase 2, mitochondrial
increases expression
ISO
ethyl tert-butyl ether results in increased expression of SOD2 protein
CTD
PMID:24090815
NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
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Ugdh
UDP-glucose dehydrogenase
increases expression
ISO
ethyl tert-butyl ether results in increased expression of UGDH protein
CTD
PMID:24090815
NCBI chr 5:65,570,550...65,593,185
Ensembl chr 5:65,570,564...65,593,292
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Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
decreases expression
ISO
ethyl tert-butyl ether results in decreased expression of UGT1A1 mRNA
CTD
PMID:24090815
NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
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Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
increases expression
ISO
ethyl tert-butyl ether results in increased expression of UGT2B1 protein
CTD
PMID:24090815
NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389
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Uqcrc1
ubiquinol-cytochrome c reductase core protein 1
increases expression
ISO
ethyl tert-butyl ether results in increased expression of UQCRC1 protein
CTD
PMID:24090815
NCBI chr 9:108,765,716...108,778,709
Ensembl chr 9:108,765,701...108,778,691
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