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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate
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Accession:CHEBI:141474 term browser browse the term
Definition:A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.
Synonyms:related_synonym: Formula=C10H19O6PS2;   InChI=1S/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3;   InChIKey=JXSJBGJIGXNWCI-UHFFFAOYSA-N;   SMILES=C(C(OCC)=O)C(C(OCC)=O)SP(OC)(OC)=S
 xref: Reaxys:5381514


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malathion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Malathion co-treated with Dichlorvos] results in decreased activity of ACHE protein; Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein]; Oximes analog inhibits the reaction [Malathion results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein]
[Endosulfan co-treated with Malathion] results in decreased activity of ACHE protein; [Malathion co-treated with Permethrin] results in decreased activity of ACHE protein; [Malathion co-treated with Permethrin] results in increased activity of ACHE protein; Taurine inhibits the reaction [Malathion results in decreased activity of ACHE protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein]
CTD PMID:2380476 PMID:4859365 PMID:14713564 PMID:18617161 PMID:19429256 More... NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 decreases expression ISO Malathion results in decreased expression of ACSM1 mRNA CTD PMID:17311802 NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495
JBrowse link
G Add3 adducin 3 increases expression EXP Malathion results in increased expression of ADD3 mRNA CTD PMID:19784758 NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124
JBrowse link
G Aff1 AF4/FMR2 family, member 1 increases expression ISO Malathion results in increased expression of AFF1 mRNA mutant form CTD PMID:28624474 NCBI chr14:5,861,188...6,024,196
Ensembl chr14:5,863,961...6,024,729
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO [prothioconazole co-treated with terbutylazine co-treated with bitertanol co-treated with cypermethrin co-treated with Malathion] results in increased activity of AHR protein CTD PMID:25684042 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Malathion results in increased expression of AKR1C2 mRNA CTD PMID:16079077 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Ar androgen receptor multiple interactions ISO [terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; [terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] results in decreased activity of AR protein CTD PMID:23871939 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 decreases expression ISO Malathion results in decreased expression of B4GALT1 mRNA CTD PMID:32069766 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
increases expression
EXP
ISO
Malathion results in decreased expression of BAX mRNA
Plant Extracts inhibits the reaction [Malathion results in increased expression of BAX protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of BAX protein]
Acetylcysteine inhibits the reaction [Malathion results in increased expression of BAX protein]
CTD PMID:23774768 PMID:30769050 PMID:32120800 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase multiple interactions
increases activity
decreases activity
ISO
EXP
Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of BCHE protein]
Malathion results in increased activity of BCHE protein
CTD PMID:17364237 PMID:18617161 PMID:21983245 PMID:25180440 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases expression
multiple interactions
EXP
ISO
Malathion results in decreased expression of BCL2 mRNA
Malathion results in increased expression of BCL2 mRNA
Malathion results in increased expression of BCL2 protein
Acetylcysteine inhibits the reaction [Malathion results in decreased expression of BCL2 protein]
CTD PMID:23774768 PMID:30673264 PMID:30769050 PMID:32120800 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger increases expression ISO Malathion results in increased expression of BMI1 mRNA CTD PMID:32069766 NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690
JBrowse link
G Brd7 bromodomain containing 7 increases expression ISO Malathion results in increased expression of BRD7 mRNA CTD PMID:18214912 NCBI chr19:18,708,792...18,737,500
Ensembl chr19:18,709,022...18,737,494
JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO Malathion results in decreased expression of BTG1 mRNA CTD PMID:32069766 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression ISO Malathion results in decreased expression of BUB1 mRNA CTD PMID:16079077 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Malathion promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA] CTD PMID:28385489 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta multiple interactions EXP Malathion promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA] CTD PMID:28385489 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
increases expression
ISO
EXP
Malathion results in increased activity of CASP3 protein
Malathion results in increased activity of and results in increased cleavage of CASP3 protein; Metoclopramide inhibits the reaction [Malathion results in increased activity of and results in increased cleavage of CASP3 protein]
Malathion results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]
Malathion results in increased expression of CASP3 mRNA
[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP3 mRNA]
CTD PMID:12505448 PMID:19815060 PMID:21628957 PMID:27941166 PMID:29027213 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 decreases expression ISO Malathion results in decreased expression of CASP4 mRNA CTD PMID:32069766 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp8 caspase 8 increases activity ISO Malathion results in increased activity of CASP8 protein CTD PMID:12505448 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage
multiple interactions
increases expression
ISO
EXP
Malathion results in increased activity of CASP9 protein
Malathion results in increased cleavage of CASP9 protein
Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]
[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP9 mRNA]
CTD PMID:12505448 PMID:21628957 PMID:27941166 PMID:30769050 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
decreases expression
decreases activity
increases activity
EXP
ISO
[Dimethoate co-treated with Malathion] results in increased activity of CAT protein; [Selenium co-treated with Vitamin E] inhibits the reaction [Malathion results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of CAT protein]; Pentoxifylline inhibits the reaction [Malathion results in increased activity of CAT protein]; Taurine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of CAT protein]
Malathion results in decreased expression of CAT protein
[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Malathion results in increased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Ascorbic Acid inhibits the reaction [Malathion results in increased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein]
[Malathion co-treated with 1,4-bis(4-hydroxyiminomethylpyridinium)butane dibromide] results in increased activity of CAT protein; [Malathion co-treated with pralidoxime] results in increased activity of CAT protein; lavender oil inhibits the reaction [Malathion results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Malathion results in decreased activity of CAT protein]; Polyphenols inhibits the reaction [Malathion results in decreased activity of CAT protein]
CTD PMID:11834209 PMID:18655177 PMID:19429256 PMID:20194575 PMID:21628957 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbfb core-binding factor subunit beta increases expression ISO Malathion results in increased expression of CBFB mRNA CTD PMID:32069766 NCBI chr19:33,049,162...33,092,752
Ensembl chr19:33,049,172...33,092,751
JBrowse link
G Cck cholecystokinin increases expression EXP Malathion results in increased expression of CCK mRNA CTD PMID:19784758 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Malathion results in decreased expression of CCNA2 protein CTD PMID:30769050 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Malathion results in decreased expression of CCNB1 protein CTD PMID:30769050 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Malathion results in decreased expression of CCNE1 protein CTD PMID:30769050 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cd14 CD14 molecule decreases expression ISO Malathion results in decreased expression of CD14 mRNA CTD PMID:32069766 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd36 CD36 molecule increases expression ISO Malathion results in increased expression of CD36 mRNA CTD PMID:32069766 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd5 Cd5 molecule decreases expression ISO Malathion results in decreased expression of CD5 mRNA CTD PMID:32069766 NCBI chr 1:207,365,337...207,386,313
Ensembl chr 1:207,365,337...207,386,313
JBrowse link
G Cdc20 cell division cycle 20 decreases expression ISO Malathion results in decreased expression of CDC20 mRNA CTD PMID:18214805 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
increases expression
ISO Malathion results in decreased expression of CDK2 protein
Malathion results in increased expression of CDK2 mRNA
CTD PMID:30769050 PMID:32069766 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma increases expression ISO Malathion results in increased expression of CEBPG mRNA CTD PMID:32069766 NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569
JBrowse link
G Cenpf centromere protein F decreases expression ISO Malathion results in decreased expression of CENPF mRNA CTD PMID:16079077 NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO Malathion results in increased expression of CES1 mRNA CTD PMID:17311802 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Cldn5 claudin 5 multiple interactions
decreases expression
EXP [Malathion co-treated with Lead] results in decreased expression of CLDN5 protein
Malathion results in decreased expression of CLDN5 protein
CTD PMID:20970449 NCBI chr11:82,212,822...82,214,248 JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO Malathion results in increased expression of COL1A2 mRNA CTD PMID:32069766 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
decreases expression
EXP caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA] CTD PMID:20233601 PMID:25404496 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crispld2 cysteine-rich secretory protein LCCL domain containing 2 decreases expression EXP Malathion results in decreased expression of CRISPLD2 mRNA CTD PMID:19784758 NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465
JBrowse link
G Ctsd cathepsin D increases expression ISO Malathion results in increased expression of CTSD protein CTD PMID:8812242 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
increases expression
ISO Plant Extracts inhibits the reaction [Malathion results in increased expression of NOX2 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of NOX2 protein] CTD PMID:32120800 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
multiple interactions
ISO Malathion results in decreased expression of CYP11A1 mRNA
lavender oil inhibits the reaction [Malathion results in decreased expression of CYP11A1 mRNA]
CTD PMID:30409133 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions EXP [bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion co-treated with terbutylazine] results in increased expression of CYP19A1 mRNA CTD PMID:23954766 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
increases expression
ISO CYP1A2 protein affects the metabolism of Malathion
Malathion results in increased expression of CYP1A2 mRNA
CTD PMID:15557345 PMID:22310298 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects metabolic processing
multiple interactions
increases expression
decreases activity
ISO CYP2B6 protein affects the metabolism of Malathion
Malathion promotes the reaction [isomalathion results in increased expression of CYP2B6 mRNA]
Malathion results in increased expression of CYP2B6 mRNA
Malathion results in decreased activity of CYP2B6 protein
CTD PMID:15557345 PMID:22310298 PMID:24333466 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO Malathion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Malathion results in decreased activity of CYP2E1 protein
CTD PMID:22634058 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
affects metabolic processing
ISO [Malathion co-treated with isomalathion] results in increased expression of CYP3A4 mRNA
Malathion results in increased expression of CYP3A4 mRNA
CYP3A4 protein affects the metabolism of Malathion
CTD PMID:15557345 PMID:17110060 PMID:22310298 PMID:24333466 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing ISO CYP3A5 protein affects the metabolism of Malathion CTD PMID:17110060 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Ddx11 DEAD/H-box helicase 11 increases expression ISO Malathion results in increased expression of DDX11 mRNA CTD PMID:32069766 NCBI chr 9:105,833,234...105,862,844
Ensembl chr 9:105,833,504...105,862,550
JBrowse link
G Duox1 dual oxidase 1 multiple interactions
increases expression
ISO Plant Extracts inhibits the reaction [Malathion results in increased expression of DUOX1 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of DUOX1 protein] CTD PMID:32120800 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression ISO Malathion results in decreased expression of DUSP1 mRNA CTD PMID:32069766 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dvl1 dishevelled segment polarity protein 1 increases expression ISO Malathion results in increased expression of DVL1 mRNA CTD PMID:18204794 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
JBrowse link
G Ehbp1 EH domain binding protein 1 increases response to substance ISO EHBP1 gene SNP results in increased susceptibility to Malathion CTD PMID:23593118 NCBI chr14:96,093,327...96,380,502
Ensembl chr14:96,093,327...96,345,332
JBrowse link
G Epha4 Eph receptor A4 increases expression ISO Malathion results in increased expression of EPHA4 mRNA CTD PMID:32069766 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression ISO Malathion results in decreased expression of EPHX1 mRNA CTD PMID:17311802 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Eps8l1 EPS8-like 1 increases expression ISO Malathion results in increased expression of EPS8L1 mRNA CTD PMID:32069766 NCBI chr 1:69,343,202...69,359,778
Ensembl chr 1:69,344,243...69,363,524
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO Malathion results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Etv6 ETS variant transcription factor 6 increases expression ISO Malathion results in increased expression of ETV6 mRNA mutant form CTD PMID:28624474 NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992
JBrowse link
G Fgf6 fibroblast growth factor 6 increases expression ISO Malathion results in increased expression of FGF6 mRNA CTD PMID:32069766 NCBI chr 4:159,854,913...159,863,447
Ensembl chr 4:159,854,913...159,863,447
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases expression ISO Malathion results in increased expression of FGFR1 mRNA CTD PMID:32069766 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Foxo4 forkhead box O4 increases expression ISO Malathion results in increased expression of FOXO4 mRNA CTD PMID:32069766 NCBI chr  X:66,385,241...66,392,115
Ensembl chr  X:66,385,558...66,392,115
JBrowse link
G Fshr follicle stimulating hormone receptor increases expression ISO Malathion results in increased expression of FSHR mRNA CTD PMID:32069766 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions
increases activity
EXP [Malathion co-treated with Carbaryl] results in increased activity of G6PD protein; Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein]
Malathion results in increased activity of G6PD protein
CTD PMID:27214522 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gk glycerol kinase multiple interactions
increases activity
EXP Acetylcysteine inhibits the reaction [Malathion results in increased activity of GK protein] CTD PMID:25449180 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631
JBrowse link
G Gk2 glycerol kinase 2 decreases expression EXP Malathion results in decreased expression of GK2 mRNA CTD PMID:25449180 NCBI chr14:12,107,071...12,108,923
Ensembl chr14:12,107,020...12,128,473
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression ISO Malathion results in decreased expression of GNAI2 mRNA CTD PMID:32069766 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Gps2 G protein pathway suppressor 2 decreases expression ISO Malathion results in decreased expression of GPS2 mRNA CTD PMID:32069766 NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Malathion results in increased activity of GPT protein CTD PMID:25180440 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gramd4 GRAM domain containing 4 decreases expression ISO Malathion results in decreased expression of GRAMD4 mRNA CTD PMID:32069766 NCBI chr 7:117,150,398...117,224,056
Ensembl chr 7:117,150,374...117,224,053
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression EXP Malathion results in increased expression of GSK3B mRNA CTD PMID:25449180 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
ISO
EXP
[Hexachlorocyclohexane co-treated with Malathion] results in decreased activity of GSR protein
zinc chloride inhibits the reaction [Malathion results in decreased activity of GSR protein]
CTD PMID:16718366 PMID:19429256 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO Malathion results in decreased expression of GSTP1 mRNA CTD PMID:32069766 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gzmb granzyme B decreases expression
multiple interactions
ISO Malathion results in decreased expression of GZMB protein
Plant Extracts inhibits the reaction [Malathion results in decreased expression of GZMB protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of GZMB protein]
CTD PMID:32120800 NCBI chr15:30,343,361...30,346,792 JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases expression
ISO [Malathion co-treated with Estrogens] results in increased expression of HRAS mRNA
Malathion results in increased expression of HRAS mRNA; Malathion results in increased expression of HRAS protein
CTD PMID:18204794 PMID:19787260 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions
decreases expression
ISO lavender oil inhibits the reaction [Malathion results in decreased expression of HSD17B3 mRNA] CTD PMID:30409133 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
JBrowse link
G Hspb2 heat shock protein family B (small) member 2 increases expression ISO Malathion results in increased expression of HSPB2 protein CTD PMID:19607909 NCBI chr 8:51,093,267...51,094,864 JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 decreases expression ISO Malathion results in decreased expression of HTATIP2 mRNA CTD PMID:32069766 NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Malathion inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:18177342 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
increases expression
EXP
ISO
Malathion results in decreased expression of IFNG protein
Plant Extracts inhibits the reaction [Malathion results in decreased expression of IFNG protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IFNG protein]
Malathion results in increased expression of IFNG mRNA
Acetylcysteine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]; Taurine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]
CTD PMID:19145326 PMID:24810974 PMID:25180440 PMID:28987951 PMID:32120800 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 increases expression ISO Malathion results in increased expression of IL13RA2 mRNA CTD PMID:32069766 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL1B mRNA]; Taurine inhibits the reaction [Malathion results in increased expression of IL1B mRNA] CTD PMID:24810974 PMID:25180440 PMID:28987951 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1r2 interleukin 1 receptor type 2 decreases expression EXP Malathion results in decreased expression of IL1R2 mRNA CTD PMID:19784758 NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases expression
ISO Plant Extracts inhibits the reaction [Malathion results in decreased expression of IL2 protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IL2 protein] CTD PMID:32120800 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions
ISO Malathion results in decreased expression of IL4 protein
Plant Extracts inhibits the reaction [Malathion results in decreased expression of IL4 protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IL4 protein]
CTD PMID:32120800 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL6 mRNA] CTD PMID:24810974 PMID:25180440 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 increases expression ISO Malathion results in increased expression of IRAK1 mRNA CTD PMID:32069766 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521
JBrowse link
G Kmt2a lysine methyltransferase 2A increases mutagenesis
increases expression
ISO Malathion results in increased mutagenesis of KMT2A gene
Malathion results in increased expression of KMT2A mRNA mutant form
CTD PMID:28624474 NCBI chr 8:45,116,771...45,193,320
Ensembl chr 8:45,118,814...45,193,181
JBrowse link
G Lat linker for activation of T cells increases expression EXP Malathion results in increased expression of LAT mRNA CTD PMID:19784758 NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578
JBrowse link
G Lgals1 galectin 1 decreases expression ISO Malathion results in decreased expression of LGALS1 mRNA CTD PMID:32069766 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
JBrowse link
G Lpcat4 lysophosphatidylcholine acyltransferase 4 increases expression ISO Malathion results in increased expression of LPCAT4 mRNA CTD PMID:32069766 NCBI chr 3:99,044,729...99,052,963
Ensembl chr 3:99,044,729...99,052,875
JBrowse link
G Lzts2 leucine zipper tumor suppressor 2 decreases expression ISO Malathion results in decreased expression of LZTS2 mRNA CTD PMID:32069766 NCBI chr 1:243,876,665...243,888,489
Ensembl chr 1:243,880,022...243,888,423
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 decreases expression ISO Malathion results in decreased expression of MAP2K3 mRNA CTD PMID:32069766 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions
increases expression
ISO [Malathion co-treated with Estrogens] results in increased expression of MCM2 mRNA
Malathion results in increased expression of MCM2 mRNA
CTD PMID:18204794 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
JBrowse link
G Mill1 MHC I like leukocyte 1 increases expression ISO Malathion results in increased expression of MICA mRNA CTD PMID:32069766 NCBI chr 1:78,372,138...78,398,932
Ensembl chr 1:78,372,802...78,398,930
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
EXP Acetylcysteine inhibits the reaction [Malathion results in increased activity of MPO protein] CTD PMID:24810974 PMID:25180440 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression ISO Malathion results in decreased expression of COX1 mRNA CTD PMID:18214912 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III decreases expression ISO Malathion results in decreased expression of COX3 mRNA CTD PMID:18214912 Ensembl chr MT:8,599...9,382 JBrowse link
G Nefh neurofilament heavy chain affects expression
increases expression
EXP Malathion affects the expression of NEFH mRNA
Malathion results in increased expression of NEFH mRNA
CTD PMID:22954530 PMID:28385489 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Malathion results in increased activity of NFE2L2 protein CTD PMID:30114225 PMID:30203046 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Malathion promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]; Malathion promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA] CTD PMID:28385489 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ninj1 ninjurin 1 decreases expression ISO Malathion results in decreased expression of NINJ1 mRNA CTD PMID:32069766 NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Malathion results in increased expression of NOS2 mRNA CTD PMID:20233601 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Malathion results in increased expression of NQO1 mRNA CTD PMID:17311802 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
increases activity
ISO Malathion results in increased expression of NR1I3 mRNA
Malathion results in increased activity of NR1I3 protein
CTD PMID:22310298 PMID:28927721 PMID:30203046 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression ISO Malathion results in increased expression of NTRK2 mRNA CTD PMID:32069766 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Ocln occludin multiple interactions
decreases expression
EXP [Malathion co-treated with Lead] results in decreased expression of OCLN protein
Malathion results in decreased expression of OCLN protein
CTD PMID:20970449 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G P2rx1 purinergic receptor P2X 1 increases expression EXP Malathion results in increased expression of P2RX1 mRNA CTD PMID:19784758 NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Malathion results in increased cleavage of PARP1 protein
Metoclopramide inhibits the reaction [Malathion results in increased cleavage of PARP1 protein]
CTD PMID:29027213 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pax1 paired box 1 increases expression ISO Malathion results in increased expression of PAX1 mRNA CTD PMID:32069766 NCBI chr 3:134,789,291...134,801,636
Ensembl chr 3:134,789,182...134,801,636
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Malathion results in increased expression of PCK1 mRNA] CTD PMID:25449180 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression
ISO Atropine inhibits the reaction [Malathion results in increased expression of PCNA] CTD PMID:12762645 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 decreases expression ISO Malathion results in decreased expression of PEBP1 mRNA CTD PMID:32069766 NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
JBrowse link
G Pfn1 profilin 1 decreases expression ISO Malathion results in decreased expression of PFN1 mRNA CTD PMID:32069766 NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
JBrowse link
G Phb prohibitin decreases expression ISO Malathion results in decreased expression of PHB mRNA CTD PMID:32069766 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
JBrowse link
G Plat plasminogen activator, tissue type decreases expression ISO Malathion results in decreased expression of PLAT mRNA CTD PMID:16079077 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO Malathion results in increased expression of PLAU mRNA CTD PMID:32069766 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Pml PML nuclear body scaffold decreases expression ISO Malathion results in decreased expression of PML mRNA CTD PMID:32069766 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Malathion results in decreased expression of PPARA mRNA CTD PMID:25689681 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Prkd1 protein kinase D1 increases expression ISO Malathion results in increased expression of PRKD1 mRNA CTD PMID:32069766 NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Malathion results in increased expression of PTGS2 mRNA; Malathion results in increased expression of PTGS2 protein CTD PMID:30673264 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pygl glycogen phosphorylase L multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Malathion results in increased expression of PYGL mRNA] CTD PMID:25449180 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
JBrowse link
G Rab11fip3 RAB11 family interacting protein 3 increases expression ISO Malathion results in increased expression of RAB11FIP3 mRNA CTD PMID:32069766 NCBI chr10:15,002,650...15,086,382
Ensembl chr10:15,002,926...15,118,479
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression
multiple interactions
EXP
ISO
Malathion results in increased expression of RELA mRNA
Taurine inhibits the reaction [Malathion results in increased expression of RELA mRNA]
CTD PMID:28987951 PMID:30673264 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rfc3 replication factor C subunit 3 decreases expression ISO Malathion results in decreased expression of RFC3 mRNA CTD PMID:16079077 NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778
JBrowse link
G Rnase6 ribonuclease A family member k6 increases expression EXP Malathion results in increased expression of RNASE6 mRNA CTD PMID:19784758 NCBI chr15:24,354,305...24,357,289
Ensembl chr15:24,354,303...24,357,328
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 decreases expression ISO Malathion results in decreased expression of HLA-E mRNA CTD PMID:32069766 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression ISO Malathion results in increased expression of RUNX1 mRNA mutant form CTD PMID:28624474 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G Shc1 SHC adaptor protein 1 increases expression ISO Malathion results in increased expression of SHC1 mRNA CTD PMID:32069766 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Malathion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:23770354 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Malathion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression ISO Malathion results in decreased expression of SOCS3 mRNA CTD PMID:32069766 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod1 superoxide dismutase 1 increases activity
decreases expression
multiple interactions
EXP
ISO
Malathion results in increased activity of SOD1 protein
Malathion results in decreased expression of SOD1 protein
lavender oil inhibits the reaction [Malathion results in decreased expression of SOD1 protein]
alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD1 protein]
CTD PMID:20194575 PMID:30409133 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
EXP
ISO
alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD2 protein]; Malathion results in increased expression of and results in increased activity of SOD2 protein
lavender oil inhibits the reaction [Malathion results in decreased expression of SOD2 protein]
CTD PMID:20194575 PMID:30409133 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 decreases expression EXP Malathion results in decreased expression of SRSF5 mRNA CTD PMID:19784758 NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
JBrowse link
G St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 increases expression EXP Malathion results in increased expression of ST8SIA1 mRNA CTD PMID:19784758 NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:175,789,947...175,920,708
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
multiple interactions
ISO Malathion results in decreased expression of STAR mRNA
lavender oil inhibits the reaction [Malathion results in decreased expression of STAR mRNA]
CTD PMID:30409133 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity ISO Malathion results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Tek TEK receptor tyrosine kinase increases expression ISO Malathion results in increased expression of TEK mRNA CTD PMID:32069766 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
JBrowse link
G Tfrc transferrin receptor increases expression ISO Malathion results in increased expression of TFRC mRNA CTD PMID:32069766 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tg thyroglobulin decreases expression EXP Malathion results in decreased expression of TG mRNA; Malathion results in decreased expression of TG protein CTD PMID:29143548 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 decreases expression EXP Malathion results in decreased expression of TIMP3 mRNA CTD PMID:19784758 NCBI chr 7:17,520,827...17,571,871
Ensembl chr 7:17,521,919...17,571,839
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions
decreases expression
EXP [Malathion co-treated with Lead] results in decreased expression of TJP1 protein
Malathion results in decreased expression of TJP1 protein
CTD PMID:20970449 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tjp2 tight junction protein 2 multiple interactions
decreases expression
EXP [Malathion co-treated with Lead] results in decreased expression of TJP2 protein
Malathion results in decreased expression of TJP2 protein
CTD PMID:20970449 NCBI chr 1:221,709,745...221,838,383
Ensembl chr 1:221,709,745...221,838,295
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression
ISO Plant Extracts inhibits the reaction [Malathion results in increased expression of TLR4 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of TLR4 protein] CTD PMID:32120800 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr8 toll-like receptor 8 increases expression ISO Malathion results in increased expression of TLR8 mRNA CTD PMID:32069766 NCBI chr  X:27,091,780...27,116,092
Ensembl chr  X:27,091,778...27,116,549
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP Malathion results in increased expression of TNF mRNA
Taurine inhibits the reaction [Malathion results in increased expression of TNF mRNA]
CTD PMID:28987951 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO
EXP
Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]
Plant Extracts inhibits the reaction [Malathion results in increased expression of TRP53 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of TRP53 protein]
[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of TP53 mRNA]
Malathion results in increased expression of TP53 mRNA; Malathion results in increased expression of TP53 protein
CTD PMID:12505448 PMID:12762645 PMID:18204794 PMID:19787260 PMID:21628957 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression
multiple interactions
ISO Malathion results in increased expression of TP53I3 mRNA
[Malathion co-treated with Estrogens] results in increased expression of TP53I3 mRNA
CTD PMID:18204794 NCBI chr13:69,612,605...69,655,018
Ensembl chr13:69,620,792...69,652,475
JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression ISO Malathion results in increased expression of TPR mRNA CTD PMID:32069766 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
JBrowse link
G Trim35 tripartite motif-containing 35 decreases expression ISO Malathion results in decreased expression of TRIM35 mRNA CTD PMID:32069766 NCBI chr15:40,493,697...40,510,246
Ensembl chr15:40,493,755...40,510,240
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 increases expression EXP Malathion results in increased expression of TRPC1 mRNA; Malathion results in increased expression of TRPC1 protein CTD PMID:22674931 NCBI chr 8:96,263,322...96,314,197
Ensembl chr 8:96,263,329...96,314,276
JBrowse link
G Trpc4 transient receptor potential cation channel, subfamily C, member 4 increases expression EXP Malathion results in increased expression of TRPC4 mRNA; Malathion results in increased expression of TRPC4 protein CTD PMID:22674931 NCBI chr 2:138,307,676...138,476,856
Ensembl chr 2:138,308,084...138,476,768
JBrowse link
G Tshr thyroid stimulating hormone receptor decreases expression EXP Malathion results in decreased expression of TSHR protein CTD PMID:29143548 NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538
JBrowse link
G Tusc2 tumor suppressor 2, mitochondrial calcium regulator decreases expression ISO Malathion results in decreased expression of TUSC2 mRNA CTD PMID:32069766 NCBI chr 8:108,236,838...108,240,056
Ensembl chr 8:108,236,838...108,240,056
JBrowse link
G Twist1 twist family bHLH transcription factor 1 increases expression ISO Malathion results in increased expression of TWIST1 mRNA CTD PMID:32069766 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Tyms thymidylate synthetase decreases expression ISO Malathion results in decreased expression of TYMS mRNA CTD PMID:16079077 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor decreases expression ISO Malathion results in decreased expression of VHL mRNA CTD PMID:32069766 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
JBrowse link
G Vpreb3 V-set pre-B cell surrogate light chain 3 increases expression ISO Malathion results in increased expression of VPREB3 mRNA CTD PMID:32069766 NCBI chr20:12,717,475...12,718,785
Ensembl chr20:12,716,779...12,719,520
JBrowse link
G Wt1 WT1 transcription factor increases expression ISO Malathion results in increased expression of WT1 mRNA CTD PMID:32069766 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        antimicrobial agent 17408
          disinfectant 12305
            ethanol 8182
              ethyl ester 3300
                diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate 159
                  (R)-malathion + 159
                  (S)-malathion + 159
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      chalcogen 19469
                        oxygen atom 19445
                          oxygen molecular entity 19445
                            hydroxides 19180
                              oxoacid 18498
                                pnictogen oxoacid 10685
                                  phosphorus oxoacid 9666
                                    phosphoric acids 8466
                                      phosphoric acid 8466
                                        phosphoric acid derivative 8172
                                          phosphate 8172
                                            organic phosphate 8171
                                              organic thiophosphate 3715
                                                diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate 159
                                                  (R)-malathion + 159
                                                  (S)-malathion + 159
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