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ONTOLOGY REPORT - ANNOTATIONS


Term:solabegron
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Accession:CHEBI:141346 term browser browse the term
Definition:A carboxybiphenyl that is [biphenyl]-3-carboxylic acid carrying a (2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)nitrilo group at the 3' position. A selective beta3-adrenergic receptor agonist currently in clinical development for the treatment of overactive bladder and irritable bowel syndrome.
Synonyms:exact_synonym: 3'-[(2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)amino][biphenyl]-3-carboxylic acid
 related_synonym: (R)-3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-(1,1'-biphenyl)-3-carboxylic acid;   Formula=C23H23ClN2O3;   GW-427353;   GW427353;   InChI=1S/C23H23ClN2O3/c24-20-8-2-6-18(13-20)22(27)15-25-10-11-26-21-9-3-5-17(14-21)16-4-1-7-19(12-16)23(28)29/h1-9,12-14,22,25-27H,10-11,15H2,(H,28,29)/t22-/m0/s1;   InChIKey=LLDXOPKUNJTIRF-QFIPXVFZSA-N;   SMILES=C=1C(=CC=CC1Cl)[C@H](CNCCNC=2C=C(C=CC2)C=3C=CC=C(C3)C(=O)O)O;   solabegronum
 xref: CAS:252920-94-8 "ChemIDplus";   DrugBank:DB06190
 xref_mesh: MESH:C523977
 xref: PMID:16640337 "Europe PMC";   PMID:17026593 "Europe PMC";   PMID:17626794 "Europe PMC";   PMID:18372395 "Europe PMC";   PMID:19786030 "Europe PMC";   PMID:22695239 "Europe PMC";   PMID:25557359 "Europe PMC";   PMID:25689345 "Europe PMC";   PMID:26954275 "Europe PMC";   Patent:US8642661;   Reaxys:10484931 "Reaxys";   Wikipedia:Solabegron


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solabegron term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb3 adrenoceptor beta 3 JBrowse link 16 69,003,541 69,006,632 RGD:6480464

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        refrigerant 16994
          ammonia 16561
            organic amino compound 16560
              secondary amino compound 6358
                solabegron 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        aromatic carboxylic acid 10675
                                          benzoic acids 10639
                                            carboxybiphenyl 99
                                              solabegron 1
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