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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:altenusin
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Accession:CHEBI:141340 term browser browse the term
Definition:A carboxybiphenyl that is [biphenyl]-2-carboxylic acid which is substituted by a hydroxy group at positions 3, 4' and 5', methoxy group at position 5 and a methyl group at position 2'. It is a a metabolite isolated from Alternaria and several other fungal species.
Synonyms:exact_synonym: 3,4',5'-trihydroxy-5-methoxy-2'-methyl[biphenyl]-2-carboxylic acid
 related_synonym: 2,4',5'-trihydroxy-5-methoxy-2'-methyl-(1,1'-biphenyl)-2-carboxylic acid;   2-(4,5-dihydroxy-2-methylphenyl)-6-hydroxy-4-methoxybenzoic acid;   Formula=C15H14O6;   InChI=1S/C15H14O6/c1-7-3-11(16)12(17)6-9(7)10-4-8(21-2)5-13(18)14(10)15(19)20/h3-6,16-18H,1-2H3,(H,19,20);   InChIKey=ADPBTBPPIIKLEH-UHFFFAOYSA-N;   MS-341;   SMILES=CC1=CC(=C(C=C1C=2C=C(C=C(C2C(=O)O)O)OC)O)O;   alutenusin
 xref: CAS:31186-12-6;   KNApSAcK:C00023666
 xref_mesh: MESH:C095643
 xref: PMID:10470682;   PMID:18494522;   PMID:19835393;   PMID:22366718;   PMID:22967766;   PMID:24385360;   PMID:24689437;   PMID:27450949;   PMID:28067492;   PMID:28300771;   PMID:28739572;   Reaxys:2223336



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altenusin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Top2a DNA topoisomerase II alpha decreases activity ISO altenusin results in decreased activity of TOP2A protein CTD PMID:27682608 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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  CHEBI ontology 19911
    role 19887
      biological role 19885
        antimicrobial agent 18156
          antifungal agent 16870
            altenusin 1
Path 2
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  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19909
          baryon 19909
            nucleon 19909
              atomic nucleus 19909
                atom 19909
                  main group element atom 19859
                    p-block element atom 19859
                      carbon group element atom 19803
                        carbon atom 19799
                          organic molecular entity 19799
                            organic group 18986
                              organic divalent group 18961
                                organodiyl group 18961
                                  carbonyl group 18917
                                    carbonyl compound 18917
                                      carboxylic acid 18641
                                        aromatic carboxylic acid 12255
                                          benzoic acids 12230
                                            carboxybiphenyl 125
                                              altenusin 1
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