Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rubimaillin
go back to main search page
Accession:CHEBI:141063 term browser browse the term
Definition:A benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-alpha-induced NF-kappaB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme.
Synonyms:exact_synonym: methyl 6-hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate
 related_synonym: Formula=C17H16O4;   InChI=1S/C17H16O4/c1-17(2)9-8-12-13(16(19)20-3)14(18)10-6-4-5-7-11(10)15(12)21-17/h4-9,18H,1-3H3;   InChIKey=VLGATXOTCNBWIT-UHFFFAOYSA-N;   SMILES=C12=CC=CC=C1C3=C(C(=C2O)C(OC)=O)C=CC(O3)(C)C;   mollugin
 xref: CAS:55481-88-4
 xref_mesh: MESH:C046245
 xref: PMID:19652367;   PMID:19716835;   PMID:19765578;   PMID:21077262;   PMID:21236252;   PMID:22997839;   PMID:23000442;   PMID:23065756;   PMID:23318249;   PMID:23466342;   PMID:23738323;   PMID:23845549;   PMID:24887566;   PMID:25310176;   PMID:25636867;   PMID:26126771;   PMID:26681510;   PMID:26697688;   PMID:27258244;   PMID:28933726;   PMID:29027119


show annotations for term's descendants           Sort by:
 
rubimaillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions
ISO rubimaillin results in decreased expression of ABCB1 mRNA; rubimaillin results in decreased expression of ABCB1 protein
dorsomorphin inhibits the reaction [rubimaillin results in decreased expression of ABCB1 mRNA]; rubimaillin inhibits the reaction [RELA protein results in increased expression of ABCB1 protein]
CTD PMID:23466342 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO rubimaillin results in increased phosphorylation of ACACA protein CTD PMID:23466342 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO rubimaillin results in decreased phosphorylation of AKT1 protein
dorsomorphin inhibits the reaction [rubimaillin results in decreased phosphorylation of AKT1 protein]
CTD PMID:23466342 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP12 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP9 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of BID protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of CFLAR protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein] CTD PMID:19716835 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage
multiple interactions
ISO rubimaillin results in increased cleavage of BID protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of BID protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased cleavage of BID protein]
CTD PMID:19716835 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp12 caspase 12 increases activity
multiple interactions
ISO rubimaillin results in increased activity of CASP12 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP12 protein]
CTD PMID:19716835 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO rubimaillin results in increased activity of CASP3 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone affects the reaction [rubimaillin results in increased activity of CASP3 protein]
CTD PMID:19716835 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO rubimaillin results in increased activity of CASP7 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]
CTD PMID:19716835 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO rubimaillin results in increased activity of CASP8 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]
CTD PMID:19716835 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO rubimaillin results in increased activity of CASP9 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone affects the reaction [rubimaillin results in increased activity of CASP9 protein]
CTD PMID:19716835 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases cleavage
multiple interactions
ISO rubimaillin results in increased cleavage of CFLAR protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of CFLAR protein]
CTD PMID:19716835 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression
decreases phosphorylation
ISO rubimaillin results in decreased expression of CREB1 mRNA
rubimaillin results in decreased phosphorylation of CREB1 protein
CTD PMID:23466342 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO rubimaillin results in increased phosphorylation of GSK3B protein CTD PMID:23466342 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation ISO rubimaillin results in increased phosphorylation of NFKBIA protein CTD PMID:23466342 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases degradation
multiple interactions
ISO rubimaillin results in increased degradation of PARP1 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein]
CTD PMID:19716835 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO rubimaillin results in decreased expression of PTGS2 mRNA; rubimaillin results in decreased expression of PTGS2 protein CTD PMID:23466342 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO rubimaillin inhibits the reaction [RELA protein results in increased expression of ABCB1 protein]
rubimaillin results in decreased expression of RELA protein
CTD PMID:23466342 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO rubimaillin results in increased phosphorylation of STK11 protein CTD PMID:23466342 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        anti-inflammatory agent 14950
          rubimaillin 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      chalcogen 19362
                        oxygen atom 19323
                          oxygen molecular entity 19323
                            hydroxides 19068
                              organic hydroxy compound 18634
                                alcohol 14987
                                  aliphatic alcohol 11105
                                    alkyl alcohol 11059
                                      methanol 3062
                                        methyl ester 3051
                                          rubimaillin 18
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.