Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:rubimaillin
go back to main search page
Accession:CHEBI:141063 term browser browse the term
Definition:A benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-alpha-induced NF-kappaB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme.
Synonyms:exact_synonym: methyl 6-hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate
 related_synonym: Formula=C17H16O4;   InChI=1S/C17H16O4/c1-17(2)9-8-12-13(16(19)20-3)14(18)10-6-4-5-7-11(10)15(12)21-17/h4-9,18H,1-3H3;   InChIKey=VLGATXOTCNBWIT-UHFFFAOYSA-N;   SMILES=C12=CC=CC=C1C3=C(C(=C2O)C(OC)=O)C=CC(O3)(C)C;   mollugin
 xref: CAS:55481-88-4 "ChemIDplus"
 xref_mesh: MESH:C046245
 xref: PMID:19652367 "Europe PMC";   PMID:19716835 "Europe PMC";   PMID:19765578 "Europe PMC";   PMID:21077262 "Europe PMC";   PMID:21236252 "Europe PMC";   PMID:22997839 "Europe PMC";   PMID:23000442 "Europe PMC";   PMID:23065756 "Europe PMC";   PMID:23318249 "Europe PMC";   PMID:23466342 "Europe PMC";   PMID:23738323 "Europe PMC";   PMID:23845549 "Europe PMC";   PMID:24887566 "Europe PMC";   PMID:25310176 "Europe PMC";   PMID:25636867 "Europe PMC";   PMID:26126771 "Europe PMC";   PMID:26681510 "Europe PMC";   PMID:26697688 "Europe PMC";   PMID:27258244 "Europe PMC";   PMID:28933726 "Europe PMC";   PMID:29027119 "Europe PMC"


show annotations for term's descendants       view all columns           Sort by:
 
rubimaillin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Acaca acetyl-CoA carboxylase alpha JBrowse link 10 71,519,392 71,719,910 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:6480464
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        anti-inflammatory agent 14907
          rubimaillin 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      chalcogen 19233
                        oxygen atom 19188
                          oxygen molecular entity 19188
                            hydroxides 18965
                              organic hydroxy compound 18507
                                alcohol 14902
                                  aliphatic alcohol 11050
                                    alkyl alcohol 11003
                                      methanol 2945
                                        methyl ester 2937
                                          rubimaillin 18
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.