Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rubimaillin
go back to main search page
Accession:CHEBI:141063 term browser browse the term
Definition:A benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-alpha-induced NF-kappaB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme.
Synonyms:exact_synonym: methyl 6-hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate
 related_synonym: Formula=C17H16O4;   InChI=1S/C17H16O4/c1-17(2)9-8-12-13(16(19)20-3)14(18)10-6-4-5-7-11(10)15(12)21-17/h4-9,18H,1-3H3;   InChIKey=VLGATXOTCNBWIT-UHFFFAOYSA-N;   SMILES=C12=CC=CC=C1C3=C(C(=C2O)C(OC)=O)C=CC(O3)(C)C;   mollugin
 xref: CAS:55481-88-4
 xref_mesh: MESH:C046245
 xref: PMID:19652367;   PMID:19716835;   PMID:19765578;   PMID:21077262;   PMID:21236252;   PMID:22997839;   PMID:23000442;   PMID:23065756;   PMID:23318249;   PMID:23466342;   PMID:23738323;   PMID:23845549;   PMID:24887566;   PMID:25310176;   PMID:25636867;   PMID:26126771;   PMID:26681510;   PMID:26697688;   PMID:27258244;   PMID:28933726;   PMID:29027119


show annotations for term's descendants           Sort by:
 
rubimaillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions
ISO rubimaillin results in decreased expression of ABCB1 mRNA; rubimaillin results in decreased expression of ABCB1 protein
dorsomorphin inhibits the reaction [rubimaillin results in decreased expression of ABCB1 mRNA]; rubimaillin inhibits the reaction [RELA protein results in increased expression of ABCB1 protein]
CTD PMID:23466342 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO rubimaillin results in increased phosphorylation of ACACA protein CTD PMID:23466342 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO rubimaillin results in decreased phosphorylation of AKT1 protein
dorsomorphin inhibits the reaction [rubimaillin results in decreased phosphorylation of AKT1 protein]
CTD PMID:23466342 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP12 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP9 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of BID protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of CFLAR protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein] CTD PMID:19716835 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage
multiple interactions
ISO rubimaillin results in increased cleavage of BID protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of BID protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased cleavage of BID protein]
CTD PMID:19716835 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp12 caspase 12 increases activity
multiple interactions
ISO rubimaillin results in increased activity of CASP12 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP12 protein]
CTD PMID:19716835 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO rubimaillin results in increased activity of CASP3 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone affects the reaction [rubimaillin results in increased activity of CASP3 protein]
CTD PMID:19716835 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO rubimaillin results in increased activity of CASP7 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]
CTD PMID:19716835 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO rubimaillin results in increased activity of CASP8 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]
CTD PMID:19716835 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO rubimaillin results in increased activity of CASP9 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone affects the reaction [rubimaillin results in increased activity of CASP9 protein]
CTD PMID:19716835 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases cleavage
multiple interactions
ISO rubimaillin results in increased cleavage of CFLAR protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of CFLAR protein]
CTD PMID:19716835 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression
decreases phosphorylation
ISO rubimaillin results in decreased expression of CREB1 mRNA
rubimaillin results in decreased phosphorylation of CREB1 protein
CTD PMID:23466342 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO rubimaillin results in increased phosphorylation of GSK3B protein CTD PMID:23466342 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation ISO rubimaillin results in increased phosphorylation of NFKBIA protein CTD PMID:23466342 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases degradation
multiple interactions
ISO rubimaillin results in increased degradation of PARP1 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein]
CTD PMID:19716835 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO rubimaillin results in decreased expression of PTGS2 mRNA; rubimaillin results in decreased expression of PTGS2 protein CTD PMID:23466342 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO rubimaillin inhibits the reaction [RELA protein results in increased expression of ABCB1 protein]
rubimaillin results in decreased expression of RELA protein
CTD PMID:23466342 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO rubimaillin results in increased phosphorylation of STK11 protein CTD PMID:23466342 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        anti-inflammatory agent 15836
          rubimaillin 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      chalcogen 19460
                        oxygen atom 19436
                          oxygen molecular entity 19436
                            hydroxides 19175
                              organic hydroxy compound 18668
                                alcohol 15081
                                  aliphatic alcohol 11325
                                    alkyl alcohol 11282
                                      methanol 3858
                                        methyl ester 3830
                                          rubimaillin 18
paths to the root