Term: | 16,16-dimethylprostaglandin E2 |
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Accession: | CHEBI:141046
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Definition: | A prostanoid that is prostaglandin E2 in which both of the hydrogens at position 16 have been replaced by methyl groups. A synthetic analogue of prostaglandin E2, it is a potent inhibitor of pancreatic function and growth of experimental tumors. It also protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. |
Synonyms: | exact_synonym: | (5Z,11alpha,13E,15R)-11,15-dihydroxy-16,16-dimethyl-9-oxoprosta-5,13-dien-1-oic acid |
| related_synonym: | 16,16-Dimethyl-pge2; 16,16-Dimethyl-prostaglandin E2; 9-oxo-11R,15R-dihydroxy-16,16-dimethyl-5Z,13E-prostadienoic acid; Formula=C22H36O5; InChI=1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6-,13-12+/t16-,17-,19-,20-/m1/s1; InChIKey=QAOBBBBDJSWHMU-WMBBNPMCSA-N; SMILES=C(\\[C@H]1[C@@H](CC([C@@H]1C/C=C\\CCCC(O)=O)=O)O)=C/[C@H](C(CCCC)(C)C)O; dmPGE(2); dmPGE2 |
| xref: | CAS:39746-25-3; LIPID_MAPS_instance:LMFA03010065 |
| xref_mesh: | MESH:D015064 |
| xref: | PMID:10630489; PMID:10669047; PMID:10952078; PMID:11208431; PMID:11991626; PMID:1372575; PMID:1373359; PMID:1604570; PMID:1629578; PMID:174967; PMID:19059888; PMID:2116342; PMID:23996087; PMID:3562785; PMID:7201834; PMID:7513369; PMID:7616483; PMID:7625885; PMID:7847837; PMID:7874263; PMID:8225563; PMID:8322025; PMID:8419232; PMID:8514255; PMID:8613460; PMID:9073153; PMID:9481403 |
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