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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea
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Accession:CHEBI:140936 term browser browse the term
Definition:A member of ther class of ureas that is urea in which a hydrogen attached to one of the nitrogens has been replaced by an N-methylindol-5-yl group, while a hydrogen attached to the other nitrogen has been replaced by a 3-methyl-1,2-thiazol-5-yl group. It is a potent and selective antagonist for the 5-hydroxytryptamine 2B (5-HT2B) receptor.
Synonyms:exact_synonym: 1-(1-methyl-1H-indol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea
 related_synonym: Formula=C14H14N4OS;   InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19);   InChIKey=USFUFHFQWXDVMH-UHFFFAOYSA-N;   N-(1-methyl-1H-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea;   N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea;   SB-204741;   SB204741;   SMILES=S1N=C(C=C1NC(=O)NC2=CC3=C(N(C=C3)C)C=C2)C
 xref: CAS:152239-46-8;   PMID:10821800;   PMID:20374255;   PMID:20472767;   PMID:20969855;   PMID:21860590;   PMID:22120177;   PMID:22210189;   PMID:23769718;   PMID:25544272;   PMID:25667920;   PMID:26293029;   PMID:27511837;   PMID:29649585;   PMID:7582481;   PMID:7699699;   Wikipedia:SB-204741


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  CHEBI ontology 21771
    role 21750
      application 21257
        pharmaceutical 20738
          drug 20738
            receptor modulator 19461
              1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea 0
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  CHEBI ontology 21771
    subatomic particle 21757
      composite particle 21757
        hadron 21757
          baryon 21757
            nucleon 21757
              atomic nucleus 21757
                atom 21757
                  main group element atom 21674
                    p-block element atom 21674
                      carbon group element atom 21487
                        carbon atom 21387
                          organic molecular entity 21387
                            organic group 19948
                              organic divalent group 19935
                                organodiyl group 19935
                                  carbonyl group 19920
                                    carbonyl compound 19920
                                      carboxylic acid 19248
                                        carboacyl group 18050
                                          univalent carboacyl group 18050
                                            carbamoyl group 17826
                                              carboxamide 17826
                                                monocarboxylic acid amide 15125
                                                  urea 5281
                                                    ureas 5280
                                                      1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea 0
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