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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea
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Accession:CHEBI:140936 term browser browse the term
Definition:A member of ther class of ureas that is urea in which a hydrogen attached to one of the nitrogens has been replaced by an N-methylindol-5-yl group, while a hydrogen attached to the other nitrogen has been replaced by a 3-methyl-1,2-thiazol-5-yl group. It is a potent and selective antagonist for the 5-hydroxytryptamine 2B (5-HT2B) receptor.
Synonyms:exact_synonym: 1-(1-methyl-1H-indol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea
 related_synonym: Formula=C14H14N4OS;   InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19);   InChIKey=USFUFHFQWXDVMH-UHFFFAOYSA-N;   N-(1-methyl-1H-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea;   N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea;   SB-204741;   SB204741;   SMILES=S1N=C(C=C1NC(=O)NC2=CC3=C(N(C=C3)C)C=C2)C
 xref: CAS:152239-46-8;   PMID:10821800;   PMID:20374255;   PMID:20472767;   PMID:20969855;   PMID:21860590;   PMID:22120177;   PMID:22210189;   PMID:23769718;   PMID:25544272;   PMID:25667920;   PMID:26293029;   PMID:27511837;   PMID:29649585;   PMID:7582481;   PMID:7699699;   Wikipedia:SB-204741


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                                    carbonyl compound 313
                                      carboxylic acid 277
                                        carboacyl group 214
                                          univalent carboacyl group 214
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                                                monocarboxylic acid amide 185
                                                  urea 9
                                                    ureas 7
                                                      1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea 0
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