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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:140427 term browser browse the term
Definition:A polypeptide with an amino acid sequence that is identical to natural hirudin variant 1, but which lacks the sulfate group on Tyr(63). (Hirudin is a salivary anticoagulant found in leeches, an almost irreversible inhibitor of thrombin in the clotting cascade; desirudin is a synthetic recombinant analogue used as an anticoagulant drug). Sequence: VVYTDCTESG QNLCLCEGSN VCGQGNKCIL GSDGEKNQCV TGEGTPKPQS HNDGDFEEIP EEYLQ (disulfide bridge: 6-14; 16-28; 22-39).
Synonyms:related_synonym: 63-desulfohirudin (Hirudo medicinalis isoform HV1);   CGP-39393;   Iprivask;   Revasc;   desirudina;   desirudine;   desirudinum;   desulphatohirudin HV1
 xref: CAS:120993-53-5;   Drug_Central:2990;   KEGG:D03692;   PMID:12090145;   PMID:21045759;   PMID:21646070;   PMID:21932952;   PMID:22672318;   PMID:23344102;   PMID:7719527;   PMID:7979736;   PMID:8596376;   PMID:8684139;   Pubchem:16129703

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      molecular entity 19808
        polyatomic entity 19721
          macromolecule 3323
            polypeptide 186
              desirudin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                peptide 9395
                                                  polypeptide 186
                                                    desirudin 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.