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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cefiderocol
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Accession:CHEBI:140376 term browser browse the term
Definition:A fourth-generation siderophore cephalosporin antibiotic having {1-[2-(2-chloro-3,4-dihydroxybenzamido)ethyl]pyrrolidinium-1-yl}methyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino side groups located at positions 3 and 7 respectively, developed to combat a variety of bacterial pathogens, including beta-lactam- and carbapenem-resistant organisms.
Synonyms:exact_synonym: (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-({1-[2-(2-chloro-3,4-dihydroxybenzamido)ethyl]pyrrolidinium-1-yl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
 related_synonym: Formula=C30H34ClN7O10S2;   GSK-2696266;   GSK2696266;   InChI=1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1;   InChIKey=DBPPRLRVDVJOCL-FQRUVTKNSA-N;   RSC 649266;   S-649266;   S649266;   SMILES=[H][C@]12SCC(C[N+]3(CCNC(=O)C4=CC=C(O)C(O)=C4Cl)CCCC3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC(C)(C)C(O)=O)\\C1=CSC(N)=N1)C([O-])=O;   cefiderocolum
 xref: CAS:1225208-94-5;   Chemspider:52084902;   DrugBank:DB14879;   Drug_Central:5352;   KEGG:D11302;   PMCID:PMC6253113;   PMCID:PMC7776597;   PMCID:PMC7777002;   PMID:27139465;   PMID:28369471;   PMID:28748397;   PMID:28848004;   PMID:29017833;   PMID:29061741;   PMID:29111435;   PMID:29311072;   PMID:29318906;   PMID:29471305;   PMID:29960205;   PMID:30323050;   PMID:30730562;   PMID:32522005;   PMID:32727829;   PMID:33068441;   PMID:33164837;   PMID:33199383;   PMID:33313656;   PMID:33393598;   PMID:33532823;   PMID:33573148;   PMID:33670891;   PMID:33677539;   PMID:33849355;   PMID:33894839;   PMID:33915286;   Patent:EP2341053;   Reaxys:21605074;   Wikipedia:Cefiderocol

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  CHEBI ontology 0
    role 0
      biological role 0
        biochemical role 0
          cofactor 0
            siderophore 0
              cefiderocol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 0
    subatomic particle 0
      composite particle 0
        hadron 0
          baryon 0
            nucleon 0
              atomic nucleus 0
                atom 0
                  main group element atom 0
                    p-block element atom 0
                      carbon group element atom 0
                        carbon atom 0
                          organic molecular entity 0
                            heteroorganic entity 0
                              organochalcogen compound 0
                                organooxygen compound 0
                                  carbon oxoacid 0
                                    carboxylic acid 0
                                      carboacyl group 0
                                        univalent carboacyl group 0
                                          carbamoyl group 0
                                            carboxamide 0
                                              lactam 0
                                                beta-lactam 0
                                                  beta-lactam antibiotic 0
                                                    cephem 0
                                                      cephalosporin 0
                                                        cefiderocol 0
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