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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxy polyunsaturated fatty acid
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Accession:CHEBI:140345 term browser browse the term
Definition:Any polyunsaturated fatty acid carrying one or more hydroxy substituents.
Synonyms:cyclic_relationship: is_conjugate_acid_of CHEBI:131871


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(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase decreases expression ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid results in decreased expression of ALOX5 protein CTD PMID:17056761 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:21724996 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of CXCL2 protein] CTD PMID:21724996 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of CXCL1 protein] CTD PMID:21724996 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA] CTD PMID:21724996 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein] CTD PMID:21724996 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] CTD PMID:21724996 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:21724996 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of ITGAL mRNA] CTD PMID:21724996 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:21724996 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of NFKBIA mRNA] CTD PMID:21724996 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid binds to and affects the activity of PPARG protein CTD PMID:17056761 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21724996 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased activity of RELA protein] CTD PMID:21724996 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid results in decreased secretion of TNF protein
CTD PMID:17056761, PMID:21724996 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of VCAM1 mRNA] CTD PMID:21724996 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
(5Z,8Z,11Z,13E)-15-HETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15 arachidonate 15-lipoxygenase multiple interactions
increases abundance
increases chemical synthesis
EXP
ISO
[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA; [[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 protein; [Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid; cinnamyl-3,4-dihydroxycyanocinnamate inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]; Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]
ALOX15 protein results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid
[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid
ALOX15 protein results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid
CTD PMID:18984061, PMID:21193584, PMID:23872364 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO [benoxaprofen results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid; [Masoprocol results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid; [RS 43179 results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid; [tenidap results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid CTD PMID:2849922 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Egf epidermal growth factor multiple interactions
increases chemical synthesis
ISO 15-hydroxy-5,8,11,13-eicosatetraenoic acid promotes the reaction [EGF protein affects the localization of PRKCA protein]
EGF protein results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid
CTD PMID:15613483 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Ephx2 epoxide hydrolase 2 increases activity ISO 15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased activity of EPHX2 protein CTD PMID:25600587 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO 15-hydroxy-5,8,11,13-eicosatetraenoic acid promotes the reaction [HGF protein affects the localization of PRKCA protein] CTD PMID:15613483 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
ISO 15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of IL1B protein
IL1B protein affects the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; IL1B protein affects the reaction [TNF protein affects the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]]; TNF protein affects the reaction [IL1B protein affects the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]]
CTD PMID:23355332 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 multiple interactions
affects activity
EXP [[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA; [[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 protein; cinnamyl-3,4-dihydroxycyanocinnamate inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]; Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]
15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the activity of KCNA5 protein
CTD PMID:18984061 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 affects activity EXP 15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the activity of KCNB1 protein CTD PMID:18984061 NCBI chr 3:163,850,785...163,935,610
Ensembl chr 3:163,850,785...163,935,617
JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 affects activity EXP 15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the activity of KCNC4 protein CTD PMID:18984061 NCBI chr 2:210,220,908...210,241,447
Ensembl chr 2:210,220,908...210,241,455
JBrowse link
G Krt1 keratin 1 multiple interactions ISO 15-hydroxy-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA] CTD PMID:12069687 NCBI chr 7:143,448,318...143,453,544
Ensembl chr 7:143,448,318...143,453,544
JBrowse link
G Lyz2 lysozyme 2 increases secretion
multiple interactions
ISO 15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein
[parthenolide co-treated with artemisinine co-treated with Quercetin] inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; artemisinine inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; IL1B protein affects the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; IL1B protein affects the reaction [TNF protein affects the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]]; parthenolide inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; Quercetin inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; SB 203580 inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; TNF protein affects the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; TNF protein affects the reaction [IL1B protein affects the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]]
CTD PMID:23355332 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased phosphorylation of MAPK1 protein CTD PMID:25600587 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased phosphorylation of MAPK3 protein CTD PMID:25600587 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases activity
affects localization
multiple interactions
ISO 15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased activity of NFKB1 protein
15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of NFKB1 protein
artemisinine inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of NFKB1 protein]
CTD PMID:23355332, PMID:25600587 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased phosphorylation of and results in increased degradation of NFKBIA protein; calphostin C inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased phosphorylation of and results in increased degradation of NFKBIA protein; Quercetin inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD PMID:15451026, PMID:23355332 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nppa natriuretic peptide A increases expression ISO 15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased expression of NPPA mRNA CTD PMID:25600587 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B increases expression ISO 15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased expression of NPPB mRNA CTD PMID:25600587 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO 15-hydroxy-5,8,11,13-eicosatetraenoic acid binds to and results in increased activity of PPARD protein CTD PMID:12069687 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
increases activity
affects localization
ISO 15-hydroxy-5,8,11,13-eicosatetraenoic acid promotes the reaction [EGF protein affects the localization of PRKCA protein]; 15-hydroxy-5,8,11,13-eicosatetraenoic acid promotes the reaction [HGF protein affects the localization of PRKCA protein]
calphostin C inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased activity of PRKCA protein]
15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of PRKCA protein
CTD PMID:15451026, PMID:15613483 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity
multiple interactions
affects localization
ISO 15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased activity of RELA protein
artemisinine inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of RELA protein]
CTD PMID:23355332, PMID:25600587 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO IL1B protein affects the reaction [TNF protein affects the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]]; TNF protein affects the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; TNF protein affects the reaction [IL1B protein affects the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]]
15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of TNF protein
CTD PMID:23355332 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 15-hydroxy-5,8,11,13-eicosatetraenoic acid CTD PMID:15231852 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 15-hydroxy-5,8,11,13-eicosatetraenoic acid CTD PMID:15231852 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of 15-hydroxy-5,8,11,13-eicosatetraenoic acid CTD PMID:15231852 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 15-hydroxy-5,8,11,13-eicosatetraenoic acid CTD PMID:15231852 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of 15-hydroxy-5,8,11,13-eicosatetraenoic acid CTD PMID:15231852 NCBI chr14:22,597,103...22,619,968 JBrowse link
12-HHTrE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid; arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid] CTD PMID:20933508 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Tbxas1 thromboxane A synthase 1 multiple interactions ISO [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid CTD PMID:2572437 NCBI chr 4:66,624,181...66,846,745
Ensembl chr 4:66,670,618...66,846,805
JBrowse link
19(S)-HETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects metabolic processing EXP CYP2E1 protein affects the metabolism of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:15205388 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases chemical synthesis ISO CYP4F3 protein alternative form results in increased chemical synthesis of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr16:19,501,680...19,528,935
Ensembl chr16:19,410,810...19,528,999
JBrowse link
19-HETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects metabolic processing EXP CYP2E1 protein affects the metabolism of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:15205388 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases chemical synthesis ISO CYP4F3 protein alternative form results in increased chemical synthesis of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr16:19,501,680...19,528,935
Ensembl chr16:19,410,810...19,528,999
JBrowse link
20-HETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clock clock circadian regulator affects abundance ISO CLOCK protein affects the abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:22440902 NCBI chr14:34,418,226...34,502,218
Ensembl chr14:34,446,616...34,502,218
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions
increases chemical synthesis
EXP 20-hydroxy-5,8,11,14-eicosatetraenoic acid affects the reaction [CYP4A1 protein affects the susceptibility to Phenylephrine]; 20-hydroxy-5,8,11,14-eicosatetraenoic acid inhibits the reaction [DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]]
CYP4A1 protein results in increased chemical synthesis of 20-hydroxy-5,8,11,14-eicosatetraenoic acid
CTD PMID:11124159, PMID:12388396 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 increases expression EXP 20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased expression of CYP4A2 mRNA CTD PMID:22442195 NCBI chr 5:134,196,910...134,207,888
Ensembl chr 5:134,196,912...134,207,863
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases chemical synthesis ISO CYP4F3 protein alternative form results in increased chemical synthesis of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr16:19,501,680...19,528,935
Ensembl chr16:19,410,810...19,528,999
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 multiple interactions
increases localization
ISO
EXP
Cyclosporine inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein] CTD PMID:16055480 NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases abundance
EXP N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine inhibits the reaction [POMC protein affects the abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid]
POMC protein results in increased abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid
CTD PMID:18067589, PMID:19458537 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:15231852 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:15231852 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:15231852 NCBI chr14:22,597,103...22,619,968 JBrowse link
leptomycin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO leptomycin B inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein] CTD PMID:10497241 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO leptomycin B inhibits the reaction [gefitinib results in decreased phosphorylation of AKT1 protein]
leptomycin B results in increased phosphorylation of AKT1 protein
CTD PMID:28942004 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of APAF1 mRNA CTD PMID:20803015 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Ar androgen receptor multiple interactions ISO leptomycin B inhibits the reaction [SB 216763 results in decreased localization of AR protein] CTD PMID:21980429 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bach1 BTB domain and CNC homolog 1 affects localization
multiple interactions
ISO leptomycin B affects the localization of BACH1 protein
leptomycin B inhibits the reaction [Cadmium Chloride affects the localization of BACH1 protein]; leptomycin B inhibits the reaction [Cadmium results in decreased activity of BACH1 protein]
CTD PMID:14504288 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO leptomycin B inhibits the reaction [Tretinoin results in increased expression of BAX protein] CTD PMID:14592536 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO leptomycin B inhibits the reaction [Tretinoin results in decreased expression of BCL2 protein] CTD PMID:14592536 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO leptomycin B inhibits the reaction [Tretinoin results in decreased expression of BCL2L1 protein] CTD PMID:14592536 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 affects localization ISO leptomycin B affects the localization of BIRC2 protein CTD PMID:15265700 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 affects localization ISO leptomycin B affects the localization of BIRC3 protein CTD PMID:15265700 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO [epigallocatechin gallate co-treated with leptomycin B] results in decreased expression of BIRC5 mRNA; [epigallocatechin gallate co-treated with leptomycin B] results in decreased expression of BIRC5 protein; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of BIRC5 mRNA; leptomycin B promotes the reaction [gefitinib results in decreased expression of BIRC5 protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in decreased expression of BIRC5 protein]
leptomycin B results in decreased expression of BIRC5 mRNA; leptomycin B results in decreased expression of BIRC5 protein
CTD PMID:20803015, PMID:25922640, PMID:28942004 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions
decreases expression
ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of BRCA1 mRNA
leptomycin B results in decreased expression of BRCA1 mRNA
CTD PMID:20803015 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO leptomycin B results in increased expression of BTG2 mRNA CTD PMID:20803015 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Casp1 caspase 1 multiple interactions ISO leptomycin B inhibits the reaction [[Lipopolysaccharides co-treated with aluminum sulfate] results in increased activity of CASP1 protein] CTD PMID:23430110 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion
multiple interactions
ISO leptomycin B results in increased secretion of CCL2 protein
polydatin inhibits the reaction [leptomycin B results in increased secretion of CCL2 protein]
CTD PMID:21967610 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO leptomycin B results in decreased expression of CCNB2 mRNA CTD PMID:20803015 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO leptomycin B inhibits the reaction [kahweol results in increased degradation of CCND1 protein] CTD PMID:27424123 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO leptomycin B results in decreased expression of CCNE2 mRNA CTD PMID:20803015 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO leptomycin B results in decreased expression of CDC25A mRNA CTD PMID:20803015 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO leptomycin B results in decreased expression of CDC25C mRNA CTD PMID:20803015 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO leptomycin B results in decreased expression of CDK1 mRNA CTD PMID:20803015 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CDKN1A mRNA; [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CDKN1A protein; leptomycin B inhibits the reaction [gefitinib results in decreased expression of CDKN1A protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in increased expression of CDKN1A protein]
leptomycin B results in increased expression of CDKN1A mRNA; leptomycin B results in increased expression of CDKN1A protein
CTD PMID:20803015, PMID:25922640, PMID:28942004 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO leptomycin B results in decreased expression of CHEK1 mRNA CTD PMID:20803015 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of CHEK2 mRNA CTD PMID:20803015 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion
multiple interactions
ISO leptomycin B results in decreased secretion of CXCL10 protein
acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]; Quercetin promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]
CTD PMID:21967610 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions
decreases expression
ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of DNMT1 mRNA
leptomycin B results in decreased expression of DNMT1 mRNA
CTD PMID:20803015 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO leptomycin B results in decreased expression of E2F1 mRNA CTD PMID:20803015 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G E2f3 E2F transcription factor 3 increases expression ISO leptomycin B results in increased expression of E2F3 mRNA CTD PMID:20803015 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein increases expression ISO leptomycin B results in increased expression of EI24 mRNA CTD PMID:20803015 NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO leptomycin B inhibits the reaction [Estradiol results in increased degradation of ESR1 protein] CTD PMID:15899841 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO leptomycin B results in decreased localization of and results in increased phosphorylation of FGF1 protein CTD PMID:15574884 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Foxo1 forkhead box O1 affects localization ISO leptomycin B affects the localization of FOXO1 protein CTD PMID:26026911 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO leptomycin B results in increased expression of GADD45A mRNA CTD PMID:20803015 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions
ISO leptomycin B results in increased expression of GPX1 mRNA
[epigallocatechin gallate co-treated with leptomycin B] results in increased expression of GPX1 mRNA
CTD PMID:25922640 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO leptomycin B promotes the reaction [Bortezomib results in increased expression of H2AX protein modified form] CTD PMID:16778179 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hax1 HCLS1 associated protein X-1 affects localization ISO leptomycin B affects the localization of HAX1 protein CTD PMID:23164465 NCBI chr 2:189,330,900...189,333,305
Ensembl chr 2:189,330,902...189,333,322
JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of HK2 mRNA CTD PMID:20803015 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein multiple interactions ISO leptomycin B inhibits the reaction [sodium arsenite affects the localization of ID3 protein] CTD PMID:23523789 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO leptomycin B inhibits the reaction [[Lipopolysaccharides co-treated with aluminum sulfate] results in increased expression of IL1B protein] CTD PMID:23430110 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of IL6 mRNA CTD PMID:20803015 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO leptomycin B results in increased phosphorylation of MAPK1 protein
leptomycin B inhibits the reaction [gefitinib results in decreased phosphorylation of MAPK1 protein]
CTD PMID:28942004 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO leptomycin B inhibits the reaction [gefitinib results in decreased phosphorylation of MAPK3 protein]
leptomycin B results in increased phosphorylation of MAPK3 protein
CTD PMID:28942004 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO leptomycin B results in increased expression of MDM2 mRNA CTD PMID:20803015 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mdm4 MDM4 regulator of p53 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of MDM4 mRNA CTD PMID:20803015 NCBI chr13:49,786,776...49,828,780
Ensembl chr13:49,792,794...49,828,720
JBrowse link
G Myh4 myosin heavy chain 4 multiple interactions EXP leptomycin B promotes the reaction [Potassium Chloride affects the localization of MYH4 protein] CTD PMID:29293066 NCBI chr10:53,778,456...53,801,605
Ensembl chr10:53,713,938...53,848,347
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of NFKB1 mRNA CTD PMID:20803015 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP leptomycin B inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:25341891 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO leptomycin B inhibits the reaction [Tretinoin affects the localization of [NR4A1 protein binds to RXRA protein]] CTD PMID:14592536 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO leptomycin B inhibits the reaction [sodium arsenite affects the localization of NR4A2 protein] CTD PMID:23283970 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nup62 nucleoporin 62 multiple interactions EXP leptomycin B inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein] CTD PMID:25341891 NCBI chr 1:100,811,140...100,827,119
Ensembl chr 1:100,811,755...100,827,111
JBrowse link
G Pidd1 p53-induced death domain protein 1 increases expression ISO leptomycin B results in increased expression of PIDD1 mRNA CTD PMID:20803015 NCBI chr 1:214,418,751...214,423,959
Ensembl chr 1:214,419,240...214,423,881
JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO leptomycin B inhibits the reaction [Lipopolysaccharides results in increased localization of PML protein] CTD PMID:23430110 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO leptomycin B results in decreased expression of PRC1 mRNA CTD PMID:20803015 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of PRKCA mRNA CTD PMID:20803015 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin decreases expression ISO leptomycin B results in decreased expression of PTTG1 mRNA CTD PMID:20803015 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Ranbp1 RAN binding protein 1 affects localization
multiple interactions
EXP leptomycin B affects the localization of RANBP1 protein
leptomycin B inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]
CTD PMID:10421839, PMID:25341891 NCBI chr11:86,890,585...86,898,818
Ensembl chr11:86,890,585...86,898,818
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO leptomycin B affects the localization of RELA protein CTD PMID:25704882 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 decreases activity ISO leptomycin B results in decreased activity of RPS6KB2 protein CTD PMID:12087098 NCBI chr 1:219,406,201...219,412,888
Ensembl chr 1:219,406,202...219,412,888
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO leptomycin B inhibits the reaction [Tretinoin affects the localization of [NR4A1 protein binds to RXRA protein]] CTD PMID:14592536 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Sesn1 sestrin 1 increases expression ISO leptomycin B results in increased expression of SESN1 mRNA CTD PMID:20803015 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]] CTD PMID:26354774 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]] CTD PMID:26354774 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad4 SMAD family member 4 multiple interactions ISO [leptomycin B results in decreased activity of XPO1 protein] which results in decreased export of SMAD4 protein CTD PMID:26354774 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
ISO leptomycin B results in increased expression of SOD2 mRNA
[epigallocatechin gallate co-treated with leptomycin B] results in increased expression of SOD2 mRNA
CTD PMID:25922640 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat4 signal transducer and activator of transcription 4 affects localization ISO leptomycin B affects the localization of STAT4 protein CTD PMID:15004198 NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stk4 serine/threonine kinase 4 multiple interactions ISO leptomycin B promotes the reaction [Bortezomib results in increased activity of STK4 protein] CTD PMID:16778179 NCBI chr 3:160,467,552...160,546,540
Ensembl chr 3:160,467,552...160,546,540
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]] CTD PMID:26354774 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 increases expression
multiple interactions
ISO leptomycin B results in increased expression of TNFRSF10D mRNA
[leptomycin B co-treated with TP53 gene mutant form] results in increased expression of TNFRSF10D mRNA
CTD PMID:20803015 NCBI chr 1:216,808,642...216,829,361
Ensembl chr 1:216,808,632...216,828,651
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases response to substance
increases expression
affects expression
decreases degradation
ISO
EXP
3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [leptomycin B results in increased expression of TP53 protein]; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of BRCA1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of CHEK2 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of DNMT1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of HK2 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of MDM4 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of PRKCA mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of TP63 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of APAF1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of BIRC5 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of IL6 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of NFKB1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of TNFRSF10D mRNA; [sodium arsenite co-treated with leptomycin B] results in increased phosphorylation of TP53 protein; leptomycin B affects the localization of and results in decreased degradation of TP53 protein; leptomycin B inhibits the reaction [Cycloheximide results in increased degradation of TP53 protein]; leptomycin B inhibits the reaction [sodium arsenite affects the localization of TP53 protein]; leptomycin B inhibits the reaction [sodium arsenite results in increased degradation of TP53 protein mutant form]; leptomycin B inhibits the reaction [TP53 protein results in increased susceptibility to trichostatin A]; PCB 180 promotes the reaction [leptomycin B results in increased expression of TP53 protein]; Pravastatin inhibits the reaction [leptomycin B results in decreased degradation of TP53 protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in decreased expression of BIRC5 protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in increased expression of CDKN1A protein]
TP53 gene mutant form results in increased susceptibility to leptomycin B
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [leptomycin B results in increased expression of TP53 protein]]; Tetrachlorodibenzodioxin inhibits the reaction [leptomycin B results in increased expression of TP53 protein]
leptomycin B affects the expression of TP53 protein
CTD PMID:11751435, PMID:15459018, PMID:15625077, PMID:16467109, PMID:19010883, PMID:19751709, PMID:20803015, PMID:21454520, PMID:24792400, PMID:31645432 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp63 tumor protein p63 multiple interactions
decreases expression
ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of TP63 mRNA
leptomycin B results in decreased expression of TP63 mRNA
CTD PMID:20803015 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Txndc5 thioredoxin domain containing 5 increases expression
multiple interactions
ISO leptomycin B results in increased expression of TXNDC5 mRNA
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [leptomycin B results in increased expression of TXNDC5 mRNA]
CTD PMID:24515801 NCBI chr17:26,925,828...26,953,981
Ensembl chr17:26,925,828...26,953,970
JBrowse link
G Wtip WT1 interacting protein decreases localization ISO leptomycin B results in decreased localization of WTIP protein CTD PMID:14736876 NCBI chr 1:89,966,496...89,999,892 JBrowse link
G Xpo1 exportin 1 decreases activity
multiple interactions
ISO leptomycin B results in decreased activity of XPO1 protein
[leptomycin B results in decreased activity of XPO1 protein] which results in decreased export of SMAD4 protein
CTD PMID:26354774 NCBI chr14:108,007,421...108,049,088
Ensembl chr14:108,007,724...108,049,660
JBrowse link
G Xpo4 exportin 4 multiple interactions ISO leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]] CTD PMID:26354774 NCBI chr15:37,835,580...37,926,715
Ensembl chr15:37,835,580...37,926,715
JBrowse link
leukotriene B4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle increases expression ISO Leukotriene B4 results in increased expression of ACTA2 protein
Leukotriene B4 results in increased expression of ACTA2 mRNA
CTD PMID:27697457, PMID:30818366 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions EXP AHR mRNA promotes the reaction [Tetrachlorodibenzodioxin results in increased chemical synthesis of Leukotriene B4] CTD PMID:28487374 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Leukotriene B4 inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein] CTD PMID:23747687 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases secretion
increases chemical synthesis
multiple interactions
ISO
EXP
ALOX5 protein results in increased secretion of Leukotriene B4
ALOX5 protein results in increased chemical synthesis of Leukotriene B4
[benoxaprofen results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [Hydrogen Peroxide results in increased activity of ALOX5 protein] which results in increased chemical synthesis of Leukotriene B4; [Masoprocol results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [RS 43179 results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [Tamoxifen results in increased expression of ALOX5 protein] which results in increased abundance of Leukotriene B4; [tenidap results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of Leukotriene B4]; ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]; kaempferol inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]; Luteolin inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]; quercetin 3'-sulfate inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]; quercetin 3-O-glucuronide inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]; Quercetin inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]; Resveratrol inhibits the reaction [[Hydrogen Peroxide results in increased activity of ALOX5 protein] which results in increased chemical synthesis of Leukotriene B4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of Leukotriene B4]]; zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]
[[A 78773 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [[CMI 392 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [[zileuton co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] which results in increased abundance of Leukotriene B4; [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [tepoxalin results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]; [troglitazone results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Leukotriene B4]; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; ALOX5 protein promotes the reaction [CXCL8 protein results in increased abundance of Leukotriene B4]; tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4]
[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]]
CTD PMID:1781415, PMID:2849922, PMID:8058773, PMID:9223651, PMID:9445378, PMID:9593866, PMID:9609743, PMID:9742967, PMID:10491155, PMID:10694244, PMID:11286996, PMID:11325678, PMID:11529688, PMID:12388339, PMID:12794006, PMID:15501964, PMID:18096136, PMID:18475545 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein multiple interactions ISO ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]; L 655238 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]; MK-886 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] CTD PMID:9609743 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
ISO Leukotriene B4 results in decreased expression of BAX mRNA; Leukotriene B4 results in decreased expression of BAX protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Leukotriene B4 results in increased expression of BAX protein]; wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of BAX protein]
CTD PMID:15970427 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G C5 complement C5 multiple interactions
increases abundance
ISO MK 0591 inhibits the reaction [C5 protein results in increased abundance of Leukotriene B4] CTD PMID:10477617 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Ccl12 chemokine (C-C motif) ligand 12 increases abundance
multiple interactions
ISO CCL12 protein results in increased abundance of Leukotriene B4
zileuton inhibits the reaction [CCL12 protein results in increased abundance of Leukotriene B4]
CTD PMID:12388339 NCBI chr10:69,476,866...69,478,416
Ensembl chr10:69,476,775...69,478,462
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
increases abundance
ISO Leukotriene B4 results in increased expression of CCL2 protein
zileuton inhibits the reaction [CCL2 protein results in increased abundance of Leukotriene B4]
CTD PMID:12388339, PMID:19880577 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP [Calcimycin co-treated with CCL5 protein] results in increased secretion of Leukotriene B4; Dexamethasone inhibits the reaction [[Calcimycin co-treated with CCL5 protein] results in increased secretion of Leukotriene B4]; Masoprocol inhibits the reaction [[Calcimycin co-treated with CCL5 protein] results in increased secretion of Leukotriene B4] CTD PMID:18083043 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Leukotriene B4 results in increased expression of COL1A1 mRNA CTD PMID:30818366 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Csf2 colony stimulating factor 2 increases secretion ISO Leukotriene B4 results in increased secretion of CSF2 protein CTD PMID:15136573 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases abundance
multiple interactions
ISO CXCL1 protein results in increased abundance of Leukotriene B4
zileuton inhibits the reaction [CXCL1 protein results in increased abundance of Leukotriene B4]
CTD PMID:12388339 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions ISO [LY 171883 binds to and results in decreased activity of CYSLTR1 protein] which results in decreased abundance of Leukotriene B4 CTD PMID:8014878 NCBI chr  X:77,671,028...77,700,491
Ensembl chr  X:77,674,150...77,700,269
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Leukotriene B4 results in increased expression of FGF2 mRNA CTD PMID:30818366 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Leukotriene B4 inhibits the reaction [Zymosan results in increased expression of HMOX1 protein] CTD PMID:11454666 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
decreases expression
decreases activity
ISO [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; [Masoprocol co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; Leukotriene B4 inhibits the reaction [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein]; Leukotriene B4 inhibits the reaction [Masoprocol results in increased activity of HSD11B2 protein]
Leukotriene B4 results in decreased expression of HSD11B2 mRNA
Leukotriene B4 results in decreased activity of HSD11B2 protein
CTD PMID:10377029, PMID:18032417 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Leukotriene B4; Mangifera indica extract inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Leukotriene B4]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Leukotriene B4] CTD PMID:15177302 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Leukotriene B4 promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:16313356 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Leukotriene B4 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:16313356 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il13 interleukin 13 increases abundance
multiple interactions
EXP IL13 protein results in increased abundance of Leukotriene B4
zileuton inhibits the reaction [IL13 protein results in increased abundance of Leukotriene B4]
CTD PMID:12654629 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance
ISO resveratrol inhibits the reaction [IL1B protein results in increased abundance of Leukotriene B4] CTD PMID:18759268 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions ISO IL4 protein inhibits the reaction [Calcimycin results in increased metabolism of Leukotriene B4]; IL4 protein inhibits the reaction [Zymosan affects the metabolism of Leukotriene B4] CTD PMID:11861792 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]; LY 255283 analog inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]; LY 255283 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]; LY 293111 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]] CTD PMID:7473568 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb2 integrin subunit beta 2 increases expression
multiple interactions
EXP
ISO
Leukotriene B4 results in increased expression of ITGB2 protein
Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]; LY 255283 analog inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]; LY 255283 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]; LY 293111 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]
CTD PMID:7473568, PMID:14716214 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Lta4h leukotriene A4 hydrolase multiple interactions
increases chemical synthesis
ISO 1-(4-(benzothiazol-2-yloxy)benzyl)piperidine-4-carboxylic acid inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; cyclohexene inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; Oxygen inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; Piperonyl Butoxide inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; propanethiol inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4] CTD PMID:2827578, PMID:17371808 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235
JBrowse link
G Ltb4r leukotriene B4 receptor multiple interactions
affects response to substance
affects binding
ISO [SC 41930 binds to and results in decreased activity of LTB4R protein] which results in decreased abundance of Leukotriene B4; Leukotriene B4 binds to and affects the activity of LTB4R1 protein
Leukotriene B4 binds to and results in increased activity of LTB4R protein; LY 255283 analog inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]; LY 255283 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]; LY 293111 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]
LTB4R1 protein affects the susceptibility to Leukotriene B4
Leukotriene B4 analog binds to LTB4R1 protein
CTD PMID:7473568, PMID:8014878, PMID:10934232, PMID:11006272 NCBI chr15:34,449,299...34,453,352
Ensembl chr15:34,452,116...34,453,171
JBrowse link
G Ltb4r2 leukotriene B4 receptor 2 affects binding ISO Leukotriene B4 binds to LTB4R2 protein CTD PMID:11006272 NCBI chr15:34,446,478...34,448,220
Ensembl chr15:34,446,878...34,447,954
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Leukotriene B4 results in increased phosphorylation of MAPK1 protein CTD PMID:19837106 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Leukotriene B4 results in increased phosphorylation of MAPK3 protein CTD PMID:19837106 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression
multiple interactions
ISO Leukotriene B4 results in increased expression of MCL1 mRNA; Leukotriene B4 results in increased expression of MCL1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Leukotriene B4 results in increased expression of MCL1 protein]; wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of MCL1 protein]
CTD PMID:15970427 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases activity EXP Leukotriene B4 results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Leukotriene B4 results in increased expression of MMP9 protein]; SB 203580 inhibits the reaction [Leukotriene B4 results in increased expression of MMP9 protein] CTD PMID:19837106 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression EXP Leukotriene B4 results in increased expression of MUC5AC protein CTD PMID:12654629 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Leukotriene B4 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites] CTD PMID:11454666 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO PLA2G4A protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased metabolism of Leukotriene B4]; PLA2G4A protein promotes the reaction [Zymosan analog results in increased metabolism of Leukotriene B4] CTD PMID:11741884 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
affects binding
ISO Leukotriene B4 binds to and results in increased activity of PPARA protein
Leukotriene B4 binds to PPARA protein
CTD PMID:10403814, PMID:12009843, PMID:15491415 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Sell selectin L increases expression EXP Leukotriene B4 results in increased expression of SELL protein CTD PMID:14716214 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Leukotriene B4 results in increased expression of TGFB1 mRNA CTD PMID:30818366 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
leukotriene B5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ltb4r2 leukotriene B4 receptor 2 affects binding ISO leukotriene B5 binds to LTB4R2 protein CTD PMID:11006272 NCBI chr15:34,446,478...34,448,220
Ensembl chr15:34,446,878...34,447,954
JBrowse link
lipoxin A4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR affects the reaction [lipoxin A4 results in increased expression of SOCS2 mRNA] CTD PMID:16415877 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
affects abundance
EXP zileuton inhibits the reaction [ALOX5 protein affects the abundance of lipoxin A4] CTD PMID:15326064 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein] CTD PMID:23063943 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO lipoxin A4 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein] CTD PMID:23063943 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of CXCL2 protein] CTD PMID:10377187 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Fpr2 formyl peptide receptor 2 multiple interactions
increases activity
ISO
EXP
[Aspirin results in increased abundance of lipoxin A4] which results in increased expression of FPR2; lipoxin A4 analog binds to and results in decreased activity of FPR2 protein
lipoxin A4 inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FPR2 mRNA]
lipoxin A4 results in increased activity of FPR2
CTD PMID:12594298, PMID:19597002, PMID:21765620 NCBI chr 1:59,800,558...59,809,507
Ensembl chr 1:59,800,984...59,802,401
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP lipoxin A4 results in increased expression of HMOX1 mRNA; lipoxin A4 results in increased expression of HMOX1 protein
lipoxin A4 promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]
CTD PMID:23826208 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 affects response to substance ISO ICAM1 protein affects the susceptibility to lipoxin A4 CTD PMID:7602232 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
decreases secretion
ISO lipoxin A4 analog results in decreased expression of IL1B protein
butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
lipoxin A4 analog results in decreased secretion of IL1B protein
lipoxin A4 analog inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; lipoxin A4 inhibits the reaction [TNF protein results in increased secretion of IL1B protein]
CTD PMID:10377187, PMID:21659618, PMID:21831303 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 increases secretion ISO lipoxin A4 analog results in increased secretion of IL4 protein CTD PMID:10377187 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO lipoxin A4 inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of IL6 protein] CTD PMID:27663891 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:21831303 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:21831303 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
EXP lipoxin A4 affects the localization of NFE2L2 protein
lipoxin A4 promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]
CTD PMID:23826208 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:21831303 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:21831303 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO lipoxin A4 affects the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]; PDGFB protein promotes the reaction [lipoxin A4 results in decreased phosphorylation of PDGFRB protein] CTD PMID:12223454, PMID:20709806 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions
decreases phosphorylation
ISO lipoxin A4 affects the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]; lipoxin A4 inhibits the reaction [Leukotriene D4 results in increased activity of PDGFRB protein]; PDGFB protein promotes the reaction [lipoxin A4 results in decreased phosphorylation of PDGFRB protein] CTD PMID:12223454, PMID:20709806 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP lipoxin A4 binds to and results in increased activity of PPARG protein CTD PMID:19321784 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptafr platelet-activating factor receptor multiple interactions ISO [WEB 2086 binds to and results in decreased activity of PTAFR protein] which results in decreased susceptibility to lipoxin A4 CTD PMID:7602232 NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
affects abundance
EXP [lipoxin A4 co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PTGS2 protein; Celecoxib inhibits the reaction [PTGS2 protein affects the abundance of lipoxin A4]; lipoxin A4 inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] CTD PMID:15326064, PMID:21765620 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO lipoxin A4 inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
CTD PMID:21831303, PMID:23063943 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Selp selectin P affects response to substance ISO SELP protein affects the susceptibility to lipoxin A4 CTD PMID:7602232 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Socs2 suppressor of cytokine signaling 2 multiple interactions
increases expression
ISO AHR affects the reaction [lipoxin A4 results in increased expression of SOCS2 mRNA]; butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 results in increased expression of SOCS2 mRNA]
lipoxin A4 results in increased expression of SOCS2 mRNA; lipoxin A4 results in increased expression of SOCS2 protein
CTD PMID:16415877 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO lipoxin A4 analog inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; lipoxin A4 inhibits the reaction [TNF protein results in increased secretion of IL1B protein]
butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of CXCL2 protein]; lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:10377187, PMID:21575454, PMID:21831303, PMID:23063943 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
resolvin D1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO resolvin D1 inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; t-butyloxycarbonyl-methionyl-leucyl-phenylalanine inhibits the reaction [resolvin D1 inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]] CTD PMID:21724996 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO resolvin D1 inhibits the reaction [Dextran Sulfate results in increased expression of CXCL2 protein] CTD PMID:21724996 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO resolvin D1 inhibits the reaction [Dextran Sulfate results in increased expression of CXCL1 protein] CTD PMID:21724996 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO resolvin D1 analog inhibits the reaction [Paraquat results in decreased expression of GPX1 mRNA] CTD PMID:30562684 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO resolvin D1 analog inhibits the reaction [Paraquat results in decreased expression of HMOX1 mRNA]; resolvin D1 inhibits the reaction [Paraquat results in decreased expression of HMOX1 mRNA] CTD PMID:30562684, PMID:30571954 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO resolvin D1 inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA] CTD PMID:21724996 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO resolvin D1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]; t-butyloxycarbonyl-methionyl-leucyl-phenylalanine inhibits the reaction [resolvin D1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]] CTD PMID:21724996 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO resolvin D1 analog inhibits the reaction [Paraquat results in increased expression of IL1B protein]; resolvin D1 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] CTD PMID:21724996, PMID:30562684, PMID:30571954 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO resolvin D1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; t-butyloxycarbonyl-methionyl-leucyl-phenylalanine inhibits the reaction [resolvin D1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]] CTD PMID:21724996 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO resolvin D1 inhibits the reaction [Dextran Sulfate results in increased expression of ITGAL mRNA] CTD PMID:21724996 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO resolvin D1 analog inhibits the reaction [Paraquat results in increased activity of MPO protein]; resolvin D1 inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; resolvin D1 inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:21724996, PMID:30562684, PMID:30571954 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO resolvin D1 analog inhibits the reaction [Paraquat affects the localization of NFE2L2 protein]; resolvin D1 inhibits the reaction [Paraquat affects the localization of NFE2L2 protein]; resolvin D1 inhibits the reaction [Paraquat results in decreased expression of NFE2L2 mRNA] CTD PMID:30562684, PMID:30571954 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO resolvin D1 inhibits the reaction [Dextran Sulfate results in increased expression of NFKBIA mRNA] CTD PMID:21724996 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO resolvin D1 analog inhibits the reaction [Paraquat results in decreased expression of NQO1 mRNA] CTD PMID:30562684 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO resolvin D1 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21724996 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO resolvin D1 analog inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein]; resolvin D1 inhibits the reaction [Dextran Sulfate results in increased activity of RELA protein] CTD PMID:21724996, PMID:30562684, PMID:30571954 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Selp selectin P multiple interactions ISO resolvin D1 analog inhibits the reaction [Paraquat results in increased expression of SELP protein] CTD PMID:30562684, PMID:30571954 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO resolvin D1 analog inhibits the reaction [Paraquat results in decreased expression of SOD1 mRNA] CTD PMID:30562684 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO resolvin D1 analog inhibits the reaction [Paraquat results in increased expression of TNF protein]; resolvin D1 inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; resolvin D1 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; t-butyloxycarbonyl-methionyl-leucyl-phenylalanine inhibits the reaction [resolvin D1 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] CTD PMID:21724996, PMID:30562684, PMID:30571954 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO resolvin D1 inhibits the reaction [Dextran Sulfate results in increased expression of VCAM1 mRNA] CTD PMID:21724996 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
resolvin D2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:21724996 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of CXCL2 protein] CTD PMID:21724996 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of CXCL1 protein] CTD PMID:21724996 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA] CTD PMID:21724996 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein] CTD PMID:21724996 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] CTD PMID:21724996 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:21724996 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of ITGAL mRNA] CTD PMID:21724996 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; resolvin D2 inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:21724996 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of NFKBIA mRNA] CTD PMID:21724996 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21724996 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased activity of RELA protein] CTD PMID:21724996 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:21724996 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of VCAM1 mRNA] CTD PMID:21724996 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          carbon atom 19597
            organic molecular entity 19597
              lipid 17059
                fatty acid 15990
                  hydroxy fatty acid 186
                    hydroxy polyunsaturated fatty acid 149
                      (10E,15Z)-9,12,13-trihydroxy-10,15-octadecadienoic acid 0
                      (12Z,15Z,18Z,21Z,24Z)-2-hydroxytriacontapentaenoic acid 0
                      (13Z,16Z,19Z,22Z)-2-hydroxyoctacosatetraenoic acid 0
                      (14Z,17Z,20Z,23Z,26Z)-2-hydroxydotriacontapentaenoic acid 0
                      (18R)-resolvin E3 0
                      (18S)-resolvin E1 0
                      (18S)-resolvin E2 0
                      (2E,4E,6R,8Z)-6-hydroxytetradeca-2,4,8-trienoic acid 0
                      (2E,4Z)-8-hydroxydeca-2,4-dienoic acid + 0
                      (2E,6E,10E,14E)-omega-hydroxygeranylgeranic acid 0
                      (4Z,9E,11E,13Z,15E,17S,19Z)-7,8-epoxy-17-hydroxydocosahexaenoic acid 0
                      (5Z,9E,12S,14Z)-8,11,12,20-tetrahydroxyicosa-5,9,14-trienoic acid 0
                      (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoic acid 0
                      (6E,8Z,10E,12S,14Z)-12-hydroxy-5-oxoicosatetraenoic acid 0
                      (6E,8Z,11Z,13E,15S)-15-hydroxy-5-oxoicosatetraenoic acid 0
                      (6Z,8E,10E,14Z,16E,18R)-5,12,18-trihydroxyicosapentaenoic acid 0
                      (7R,14S)-dihydroxy-(8E,10E,12Z,16Z,19Z)-docosapentaenoic acid 0
                      (7S,8,17S)-trihydroxy-(15E,19Z)-docosa-9,11,13,15,19-pentaenoic acid 0
                      (9Z,12Z)-17-hydroxyoctadeca-9,12-dienoic acid 0
                      10,11-dihydro-12-oxoleukotriene B4 0
                      10,11-dihydro-20,20,20-trihydroxyleukotriene B4 0
                      10,11-dihydro-20,20-dihydroxyleukotriene B4 0
                      10,11-dihydroleukotriene B4 0
                      10-hydroxy-(2E,8E)-decadien-4-ynoic acid 0
                      11,12,15-THETA 0
                      12,20-dioxoleukotriene B4 0
                      12-HHTrE + 2
                      12-dehydro-leukotriene B4 0
                      12-oxo-20-hydroxyleukotriene B4 0
                      12-oxo-6-trans-leukotriene B4 0
                      13,14(S)-dihydroxy-(7Z,9E,11E,16Z,19Z)-docosapentaenoic acid 0
                      13,14-dihydro-15-oxolipoxin A4 0
                      13,14-dihydrolipoxin A4 0
                      14(S),21-dihydroxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoic acid 0
                      15-HEPE + 0
                      15-epi-lipoxin A4 0
                      15-epi-lipoxin B4 0
                      15-oxolipoxin A4 0
                      16-oxoresolvin D2 0
                      17-oxoresolvin D1 0
                      18-hydroxyleukotriene B4 0
                      18-oxoresolvin E1 0
                      19-hydroxyleukotriene B4 0
                      2-hydroxypenta-2,4-dienoic acid + 0
                      20,20,20-trihydroxyleukotriene B4 0
                      20,20-dihydroxyleukotriene B4 0
                      20-hydroxy-6-trans-leukotriene B4 0
                      20-hydroxylipoxin A4 0
                      20-hydroxylipoxin B4 0
                      22-hydroxyprotectin D1 0
                      5(S),6(S)-epoxy-18(R)-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid 0
                      5(S),6(S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid + 0
                      5(S)6-epoxy-18(S)-HEPE 0
                      5-hydroperoxy-15-HETE + 0
                      6-epi-lipoxin A4 0
                      6-trans-leukotriene B4 + 0
                      7,16,17-trihydroxy-(14E,19Z)-docosa-8,10,12,14,19-pentaenoic acid 0
                      7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoic acid 0
                      7-oxoresolvin D2 0
                      8-oxoresolvin D1 0
                      DHET + 0
                      Delta(6)-trans,Delta(8)-cis-leukotriene B4 0
                      Delta(6)-trans-12-epi-leukotriene B4 0
                      DiHDPE + 0
                      HEPE + 0
                      HETE + 33
                      HOTrE + 0
                      all-trans-7-hydroxyhexadeca-2,4,8,10-tetraenoic acid + 0
                      aspirin-triggered resolvin D1 0
                      aspirin-triggered resolvin D2 0
                      aspirin-triggered resolvin D3 0
                      aspirin-triggered resolvin D4 0
                      aspirin-triggered resolvin D5 0
                      aspirin-triggered resolvin D6 0
                      dihydroxydocosahexaenoic acid + 0
                      dihydroxyicosatetraenoic acid + 0
                      epoxy(hydroxy)icosatrienoic acid + 0
                      hepoxilin A3 + 0
                      hepoxilin B3 0
                      hydroperoxy(hydroxy)icosapentaenoic acid + 0
                      hydroperoxy(hydroxy)icosatetraenoic acid + 0
                      hydroxydocosahexaenoic acid + 16
                      hydroxydocosapentaenoic acid + 0
                      laetisaric acid 0
                      leptomycin A 0
                      leptomycin B 74
                      leukotriene B4 + 39
                      leukotriene B5 1
                      lipoxin A4 + 25
                      lipoxin B4 + 0
                      minquartynoic acid 0
                      resolvin D1 20
                      resolvin D2 14
                      resolvin D3 0
                      resolvin D4 0
                      resolvin D5 0
                      resolvin D6 0
                      resolvin E1 0
                      resolvin E2 0
                      resolvin E3 0
                      resolvin T1 0
                      resolvin T2 0
                      resolvin T3 0
                      resolvin T4 0
                      tetranor-12R-HETE 0
                      trihydroxyicosatrienoic acid + 0
                      trioxilin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        monocarboxylic acid 17476
                                          fatty acid 15990
                                            unsaturated fatty acid 923
                                              polyunsaturated fatty acid 664
                                                hydroxy polyunsaturated fatty acid 149
                                                  (10E,15Z)-9,12,13-trihydroxy-10,15-octadecadienoic acid 0
                                                  (12Z,15Z,18Z,21Z,24Z)-2-hydroxytriacontapentaenoic acid 0
                                                  (13Z,16Z,19Z,22Z)-2-hydroxyoctacosatetraenoic acid 0
                                                  (14Z,17Z,20Z,23Z,26Z)-2-hydroxydotriacontapentaenoic acid 0
                                                  (18R)-resolvin E3 0
                                                  (18S)-resolvin E1 0
                                                  (18S)-resolvin E2 0
                                                  (2E,4E,6R,8Z)-6-hydroxytetradeca-2,4,8-trienoic acid 0
                                                  (2E,4Z)-8-hydroxydeca-2,4-dienoic acid + 0
                                                  (2E,6E,10E,14E)-omega-hydroxygeranylgeranic acid 0
                                                  (4Z,9E,11E,13Z,15E,17S,19Z)-7,8-epoxy-17-hydroxydocosahexaenoic acid 0
                                                  (5Z,9E,12S,14Z)-8,11,12,20-tetrahydroxyicosa-5,9,14-trienoic acid 0
                                                  (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoic acid 0
                                                  (6E,8Z,10E,12S,14Z)-12-hydroxy-5-oxoicosatetraenoic acid 0
                                                  (6E,8Z,11Z,13E,15S)-15-hydroxy-5-oxoicosatetraenoic acid 0
                                                  (6Z,8E,10E,14Z,16E,18R)-5,12,18-trihydroxyicosapentaenoic acid 0
                                                  (7R,14S)-dihydroxy-(8E,10E,12Z,16Z,19Z)-docosapentaenoic acid 0
                                                  (7S,8,17S)-trihydroxy-(15E,19Z)-docosa-9,11,13,15,19-pentaenoic acid 0
                                                  (9Z,12Z)-17-hydroxyoctadeca-9,12-dienoic acid 0
                                                  10,11-dihydro-12-oxoleukotriene B4 0
                                                  10,11-dihydro-20,20,20-trihydroxyleukotriene B4 0
                                                  10,11-dihydro-20,20-dihydroxyleukotriene B4 0
                                                  10,11-dihydroleukotriene B4 0
                                                  10-hydroxy-(2E,8E)-decadien-4-ynoic acid 0
                                                  11,12,15-THETA 0
                                                  12,20-dioxoleukotriene B4 0
                                                  12-HHTrE + 2
                                                  12-dehydro-leukotriene B4 0
                                                  12-oxo-20-hydroxyleukotriene B4 0
                                                  12-oxo-6-trans-leukotriene B4 0
                                                  13,14(S)-dihydroxy-(7Z,9E,11E,16Z,19Z)-docosapentaenoic acid 0
                                                  13,14-dihydro-15-oxolipoxin A4 0
                                                  13,14-dihydrolipoxin A4 0
                                                  14(S),21-dihydroxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoic acid 0
                                                  15-HEPE + 0
                                                  15-epi-lipoxin A4 0
                                                  15-epi-lipoxin B4 0
                                                  15-oxolipoxin A4 0
                                                  16-oxoresolvin D2 0
                                                  17-oxoresolvin D1 0
                                                  18-hydroxyleukotriene B4 0
                                                  18-oxoresolvin E1 0
                                                  19-hydroxyleukotriene B4 0
                                                  2-hydroxypenta-2,4-dienoic acid + 0
                                                  20,20,20-trihydroxyleukotriene B4 0
                                                  20,20-dihydroxyleukotriene B4 0
                                                  20-hydroxy-6-trans-leukotriene B4 0
                                                  20-hydroxylipoxin A4 0
                                                  20-hydroxylipoxin B4 0
                                                  22-hydroxyprotectin D1 0
                                                  5(S),6(S)-epoxy-18(R)-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid 0
                                                  5(S),6(S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid + 0
                                                  5(S)6-epoxy-18(S)-HEPE 0
                                                  5-hydroperoxy-15-HETE + 0
                                                  6-epi-lipoxin A4 0
                                                  6-trans-leukotriene B4 + 0
                                                  7,16,17-trihydroxy-(14E,19Z)-docosa-8,10,12,14,19-pentaenoic acid 0
                                                  7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoic acid 0
                                                  7-oxoresolvin D2 0
                                                  8-oxoresolvin D1 0
                                                  DHET + 0
                                                  Delta(6)-trans,Delta(8)-cis-leukotriene B4 0
                                                  Delta(6)-trans-12-epi-leukotriene B4 0
                                                  DiHDPE + 0
                                                  HEPE + 0
                                                  HETE + 33
                                                  HOTrE + 0
                                                  all-trans-7-hydroxyhexadeca-2,4,8,10-tetraenoic acid + 0
                                                  aspirin-triggered resolvin D1 0
                                                  aspirin-triggered resolvin D2 0
                                                  aspirin-triggered resolvin D3 0
                                                  aspirin-triggered resolvin D4 0
                                                  aspirin-triggered resolvin D5 0
                                                  aspirin-triggered resolvin D6 0
                                                  dihydroxydocosahexaenoic acid + 0
                                                  dihydroxyicosatetraenoic acid + 0
                                                  epoxy(hydroxy)icosatrienoic acid + 0
                                                  hepoxilin A3 + 0
                                                  hepoxilin B3 0
                                                  hydroperoxy(hydroxy)icosapentaenoic acid + 0
                                                  hydroperoxy(hydroxy)icosatetraenoic acid + 0
                                                  hydroxydocosahexaenoic acid + 16
                                                  hydroxydocosapentaenoic acid + 0
                                                  laetisaric acid 0
                                                  leptomycin A 0
                                                  leptomycin B 74
                                                  leukotriene B4 + 39
                                                  leukotriene B5 1
                                                  lipoxin A4 + 25
                                                  lipoxin B4 + 0
                                                  minquartynoic acid 0
                                                  resolvin D1 20
                                                  resolvin D2 14
                                                  resolvin D3 0
                                                  resolvin D4 0
                                                  resolvin D5 0
                                                  resolvin D6 0
                                                  resolvin E1 0
                                                  resolvin E2 0
                                                  resolvin E3 0
                                                  resolvin T1 0
                                                  resolvin T2 0
                                                  resolvin T3 0
                                                  resolvin T4 0
                                                  tetranor-12R-HETE 0
                                                  trihydroxyicosatrienoic acid + 0
                                                  trioxilin + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.