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Term:cyclosporin A metabolite M1cAL
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Accession:CHEBI:140176 term browser browse the term
Definition:A cyclosporin A derivative that is cyclosporin A metabolite M18 in which the 2-hydroxyethyl substituent of the dioxolane ring has been oxidised to give the corresponding aldehyde.
Synonyms:exact_synonym: {(4R,5R)-5-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,10,16,20,23,25,28,31-nonamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-4-methyltetrahydrofuran-2-yl}acetaldehyde
 related_synonym: AM1cAL;   Formula=C62H109N11O13;   InChI=1S/C62H109N11O13/c1-24-43-58(81)67(17)32-48(75)68(18)44(27-33(2)3)55(78)66-49(37(10)11)61(84)69(19)45(28-34(4)5)54(77)63-40(15)53(76)64-41(16)57(80)70(20)46(29-35(6)7)59(82)71(21)47(30-36(8)9)60(83)72(22)50(38(12)13)62(85)73(23)51(56(79)65-43)52-39(14)31-42(86-52)25-26-74/h26,33-47,49-52H,24-25,27-32H2,1-23H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/t39-,40+,41-,42?,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1;   InChIKey=UFWMVNJLCHMUKS-JFGKHBSWSA-N;   M1cAL;   SMILES=[C@H]1(N(C([C@@H](N(C([C@@H](N(C)C([C@@H](N(C([C@H](NC([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C)C(CN(C([C@@H](NC1=O)CC)=O)C)=O)CC(C)C)=O)C(C)C)=O)C)CC(C)C)=O)C)=O)C)=O)C)CC(C)C)=O)CC(C)C)=O)C)C(C)C)=O)C)[C@]2([C@H](C)CC(O2)(CC=O)[H])[H];   cyclosporin A metabolite AM1cAL;   cyclosporin metabolite AM1cAL;   cyclosporin metabolite M1cAL;   cyclosporine A metabolite AM1cAL;   cyclosporine A metabolite M1cAL;   cyclosporine metabolite AM1cAL;   cyclosporine metabolite M1cAL
 xref: PMID:8745344 "Europe PMC";   PMID:8782089 "Europe PMC"

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  CHEBI ontology 0
    role 0
      biological role 0
        biochemical role 0
          metabolite 0
            cyclosporin A 0
              cyclosporin A derivative 0
                cyclosporin A metabolite M1cAL 0
Path 2
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  CHEBI ontology 0
    subatomic particle 0
      composite particle 0
        hadron 0
          baryon 0
            nucleon 0
              atomic nucleus 0
                atom 0
                  main group element atom 0
                    p-block element atom 0
                      carbon group element atom 0
                        carbon atom 0
                          organic molecular entity 0
                            organic group 0
                              organic divalent group 0
                                organodiyl group 0
                                  carbonyl group 0
                                    carbonyl compound 0
                                      carboxylic acid 0
                                        carboacyl group 0
                                          univalent carboacyl group 0
                                            carbamoyl group 0
                                              carboxamide 0
                                                peptide 0
                                                  cyclic peptide 0
                                                    homodetic cyclic peptide 0
                                                      cyclosporin A 0
                                                        cyclosporin A derivative 0
                                                          cyclosporin A metabolite M17 0
                                                            cyclosporin A metabolite M18 0
                                                              cyclosporin A metabolite M1cAL 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.