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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antalarmin
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Accession:CHEBI:139557 term browser browse the term
Definition:A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidin-4-amine which is substituted by methyl groups at positions 2, 5, and 6, by a mesityl group at position 7, and in which the amino substituent at position 4 has been substituted by ethyl and butyl groups. It is an antagonist of corticotropin-releasing factor 1 (CRF-1) receptors (Ki = 1 nM).
Synonyms:exact_synonym: N-butyl-N-ethyl-7-mesityl-2,5,6-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
 related_synonym: Formula=C24H34N4;   InChI=1S/C24H34N4/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5/h13-14H,9-12H2,1-8H3;   InChIKey=IXPROWGEHNVJOY-UHFFFAOYSA-N;   SMILES=C12=C(N=C(N=C1N(C(=C2C)C)C=3C(=CC(=CC3C)C)C)C)N(CCCC)CC
 xref: CAS:157284-96-3
 xref_mesh: MESH:C103016
 xref: PMID:12097816;   PMID:15696320;   PMID:16820021;   PMID:17182090;   PMID:17397037;   PMID:17705061;   PMID:18423834;   PMID:18428980;   PMID:18830607;   PMID:19573565;   PMID:21203337;   PMID:23211705;   PMID:23796983;   PMID:24444675;   PMID:8940412;   PMID:9886810;   Wikipedia:Antalarmin


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antalarmin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions ISO antalarmin binds to and results in decreased activity of CRHR1 protein CTD PMID:16014403 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO antalarmin results in decreased expression of CYP11A1 mRNA CTD PMID:16014403 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO antalarmin results in decreased expression of CYP17A1 mRNA CTD PMID:16014403 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Faah fatty acid amide hydrolase multiple interactions EXP antalarmin inhibits the reaction [Corticosterone results in increased activity of FAAH protein] CTD PMID:26821211 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO antalarmin results in decreased expression of STAR mRNA CTD PMID:16014403 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression ISO antalarmin results in decreased expression of SULT2A1 mRNA CTD PMID:16014403 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link

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  CHEBI ontology 19785
    role 19732
      application 19391
        refrigerant 17418
          ammonia 16939
            organic amino compound 16938
              tertiary amino compound 8629
                antalarmin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        tertiary amino compound 8629
                                          antalarmin 6
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