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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:isotopically modified compound
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Accession:CHEBI:139358 term browser browse the term
Definition:Any molecular entity in which the isotopic ratio of nuclides for at least one element deviates measurably from that occurring in nature. The term includes both isotopically substituted compounds (in which essentially all the molecules of the compound have only the indicated nuclide(s) at each designated position) and isotopically labeled compounds (a formal mixture of an isotopically unmodified compound with one or more analogous isotopically substituted compound(s).
Synonyms:related_synonym: isotopically modified compounds


show annotations for term's descendants           Sort by:
2-deoxy-2-((18)F)fluoro-D-glucose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a1 solute carrier family 2 member 1 multiple interactions
affects uptake		 ISO [MRK 003 results in decreased expression of SLC2A1 protein] which results in decreased uptake of Fluorodeoxyglucose F18
SLC2A1 mRNA affects the uptake of Fluorodeoxyglucose F18		 CTD PMID:16595493 PMID:20197467 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
dideuterium oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO Deuterium Oxide results in decreased phosphorylation of AKT1 protein
Acetylcysteine inhibits the reaction [Deuterium Oxide results in decreased phosphorylation of AKT1 protein]		 CTD PMID:37751786 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases phosphorylation
multiple interactions		 ISO Deuterium Oxide results in decreased phosphorylation of AKT2 protein
Acetylcysteine inhibits the reaction [Deuterium Oxide results in decreased phosphorylation of AKT2 protein]		 CTD PMID:37751786 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 decreases phosphorylation
multiple interactions		 ISO Deuterium Oxide results in decreased phosphorylation of AKT3 protein
Acetylcysteine inhibits the reaction [Deuterium Oxide results in decreased phosphorylation of AKT3 protein]		 CTD PMID:37751786 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Deuterium Oxide results in increased expression of BAX protein CTD PMID:37751786 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions		 ISO Deuterium Oxide results in increased expression of BECN1 protein
Acetylcysteine inhibits the reaction [Deuterium Oxide results in increased expression of BECN1 protein]		 CTD PMID:37751786 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO Deuterium Oxide results in increased cleavage of CASP3 protein CTD PMID:37751786 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Acetylcysteine inhibits the reaction [Deuterium Oxide results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Deuterium Oxide results in increased expression of and results in increased lipidation of MAP1LC3B protein CTD PMID:37751786 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions		 ISO Deuterium Oxide results in decreased phosphorylation of MTOR protein
Acetylcysteine inhibits the reaction [Deuterium Oxide results in decreased phosphorylation of MTOR protein]		 CTD PMID:37751786 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [Deuterium Oxide results in decreased phosphorylation of PIK3R1 protein] CTD PMID:37751786 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
Palmitic acid(d3) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO Palmitic acid increases expression of BAX mRNA in cardiomyocytes
ghrelin inhibits the reaction [Palmitic acid increases expression of BAX mRNA in cardiomyocytes]		 RGD PMID:32084395 PMID:32084395 RGD:242905211, RGD:242905211 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Palmitic acid decreases expression of BCL2 mRNA in cardiomyocytes
ghrelin inhibits the reaction [Palmitic acid decreases expression of BCL2 mRNA in cardiomyocytes]		 RGD PMID:32084395 PMID:32084395 RGD:242905211, RGD:242905211 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO Palmitic acid increases expression of IL1b mRNA in cardiomyocytes
ghrelin inhibits the reaction [Palmitic acid increases expression of IL1b mRNA in cardiomyocytes]		 RGD PMID:32084395 PMID:32084395 RGD:242905211, RGD:242905211 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Palmitic acid increases expression of IL6 mRNA in cardiomyocytes
ghrelin inhibits the reaction [Palmitic acid increases expression of IL6 mRNA in cardiomyocytes]		 RGD PMID:32084395 PMID:32084395 RGD:242905211, RGD:242905211 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions		 ISO Palmitic acid increases expression of IL1b mRNA in cardiomyocytes
ghrelin inhibits the reaction [Palmitic acid increases expression of TGFB1 mRNA in cardiomyocytes] 		RGD PMID:32084395 PMID:32084395 RGD:242905211, RGD:242905211 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		ISO ghrelin inhibits the reaction [Palmitic acid increases expression of TNF mRNA in cardiomyocytes] RGD PMID:32084395 PMID:32084395 RGD:242905211, RGD:242905211 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      molecular entity 19880
        isotopically modified compound 15
          ((18)O)water 0
          ((201)Tl)thallium monochloride 0
          (11)C-modified compound + 0
          (13)C-modified compound + 0
          (13)N-modified compound + 0
          (14)C-modified compound + 0
          (15)N-modified compound + 0
          (18)F radiopharmaceutical + 1
          (223)RaCl2 0
          chlormerodrin ((197)Hg) 0
          chlormerodrin ((203)Hg) 0
          deuterated compound + 14
          sodium 2-((125)I)iodohippurate 0
          sodium 2-((131)I)iodohippurate 0
          tritiated compound + 0
paths to the root