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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methacetin-(methoxy-(13)C)
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Accession:CHEBI:139355 term browser browse the term
Definition:A (13)C-modified compound that is methacetin which has (13)C as the predominant isotope of the methoxy carbon. In normal subjects, methacetin is rapidly metabolised in the liver, being dealkylated by hepatic CYP1A2 to give paracetamol (acetaminophen); the methyl of the methoxy group is eliminated as CO2. Administering methacetin-(methoxy-(13)C) to a patient enables the liver (cytochrome P-450 1A2) function to be determined quickly and precisely by measuring the (13)CO2 in the breath (e.g. by isotope-selective non-dispersive infrared spectrometry (NDIRS)).
Synonyms:exact_synonym: N-{4-[((13)C)methyloxy]phenyl}acetamide
 related_synonym: (13)C-MBT;   Formula=C8[13C]H11NO2;   InChI=1S/C9H11NO2/c1-7(11)10-8-3-5-9(12-2)6-4-8/h3-6H,1-2H3,(H,10,11)/i2+1;   InChIKey=XVAIDCNLVLTVFM-VQEHIDDOSA-N;   SMILES=C=1C=C(O[13CH3])C=CC1NC(C)=O;   methacetin C-13;   p-acetanisidine C-13
 xref: CAS:72156-70-8;   PMID:17593076;   PMID:18339592;   PMID:18763185;   PMID:19248196;   PMID:19297040;   PMID:20149989;   PMID:21287423;   PMID:21386198;   PMID:21687605;   PMID:22174547;   PMID:22540278;   PMID:22612381;   PMID:22827182;   PMID:23322130;   PMID:23549507;   PMID:23642250;   PMID:23967104;   PMID:25170215;   PMID:26220750;   PMID:26935501;   Reaxys:31580327


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Term Annotations click to browse term
  CHEBI ontology 499
    chemical entity 499
      molecular entity 499
        isotopically modified compound 0
          (13)C-modified compound 0
            methacetin-(methoxy-(13)C) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 499
    subatomic particle 499
      composite particle 499
        hadron 499
          baryon 499
            nucleon 499
              atomic nucleus 499
                atom 499
                  main group element atom 492
                    p-block element atom 492
                      carbon group element atom 481
                        carbon atom 480
                          organic molecular entity 480
                            heteroorganic entity 476
                              organochalcogen compound 430
                                organooxygen compound 428
                                  carbon oxoacid 368
                                    carboxylic acid 368
                                      carboacyl group 307
                                        univalent carboacyl group 307
                                          carbamoyl group 305
                                            carboxamide 305
                                              acetamides 8
                                                methacetin-(methoxy-(13)C) 0
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