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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-(p-amylcinnamoyl)anthranilic acid
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Accession:CHEBI:139349 term browser browse the term
Definition:An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 4-pentylcinnamoyl group. It is a transient receptor potential (TRP) channel blocker and phospholipase A2 (PLA2) inhibitor.
Synonyms:exact_synonym: 2-{[(2E)-3-(4-pentylphenyl)prop-2-enoyl]amino}benzoic acid
 related_synonym: 4-amylcinnamoylanthranilic acid;   ACA;   Formula=C21H23NO3;   InChI=1S/C21H23NO3/c1-2-3-4-7-16-10-12-17(13-11-16)14-15-20(23)22-19-9-6-5-8-18(19)21(24)25/h5-6,8-15H,2-4,7H2,1H3,(H,22,23)(H,24,25)/b15-14+;   InChIKey=GAMRBCZMOOMBSQ-CCEZHUSRSA-N;   SMILES=O=C(O)C1=C(NC(=O)/C=C/C2=CC=C(C=C2)CCCCC)C=CC=C1;   p-amylcinnamoylanthranilic acid
 xref: CAS:110683-10-8
 xref_mesh: MESH:C085901
 xref: PMID:16604090;   PMID:17445088;   PMID:19382906;   PMID:20971070;   PMID:23566164;   PMID:26935063;   PMID:7932202;   Pubchem:329770958;   Reaxys:6521595;   Wikipedia:N-(p-amylcinnamoyl)anthranilic_acid

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N-(p-amylcinnamoyl)anthranilic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO 4-amylcinnamoylanthranilic acid inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP3 protein] CTD PMID:33309544 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO 4-amylcinnamoylanthranilic acid inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP9 protein] CTD PMID:33309544 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Slc13a2 solute carrier family 13 member 2 multiple interactions ISO [4-amylcinnamoylanthranilic acid results in decreased activity of SLC13A2 protein] which results in decreased susceptibility to diethylene glycol metabolite CTD PMID:21856646 NCBI chr10:65,664,665...65,692,046
Ensembl chr10:65,664,667...65,692,023 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions
decreases activity		 ISO 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]
4-amylcinnamoylanthranilic acid results in decreased activity of TRPM2 protein
4-amylcinnamoylanthranilic acid inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]		 CTD PMID:18204483 PMID:30229906 PMID:33309544 NCBI chr20:11,434,062...11,482,880
Ensembl chr20:11,436,267...11,482,051 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        biophysical role 12665
          membrane transport modulator 12464
            TRP channel blocker 120
              N-(p-amylcinnamoyl)anthranilic acid 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic acid 18151
                                        carboacyl group 17410
                                          univalent carboacyl group 17410
                                            carbamoyl group 17208
                                              carboxamide 17208
                                                alpha,beta-unsaturated carboxylic acid amide 6674
                                                  enamide 6674
                                                    cinnamamides 1309
                                                      N-(p-amylcinnamoyl)anthranilic acid 4
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