CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: poly(ethylene glycol) derivative
Accession: CHEBI:139322
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Definition: A polyether that is any poly(ethylene glycol) in which one or both of the terminal hydroxy groups has been substituted or undergone modification.
Synonyms: related_synonym: PEG derivative; PEG derivatives; PEO derivative; PEO derivatives; POE derivative; POE derivatives; poly(ethylene glycol) derivatives; poly(ethyleneoxide) derivative; poly(ethyleneoxide) derivatives; poly(oxyethylene) derivative; poly(oxyethylene) derivatives
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Arnt
aryl hydrocarbon receptor nuclear translocator
decreases expression
ISO
Nonidet P-40 results in decreased expression of ARNT mRNA
CTD
PMID:26552463
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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Atf4
activating transcription factor 4
increases expression
ISO
Nonidet P-40 results in increased expression of ATF4 mRNA
CTD
PMID:26552463
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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Atf6
activating transcription factor 6
increases expression
ISO
Nonidet P-40 results in increased expression of ATF6 mRNA
CTD
PMID:26552463
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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Atf6b
activating transcription factor 6 beta
increases expression
ISO
Nonidet P-40 results in increased expression of ATF6B mRNA
CTD
PMID:26552463
NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894
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Atg12
autophagy related 12
increases expression
ISO
Nonidet P-40 results in increased expression of ATG12 mRNA
CTD
PMID:26552463
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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Atg5
autophagy related 5
decreases expression
ISO
Nonidet P-40 results in decreased expression of ATG5 mRNA
CTD
PMID:26552463
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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Atg7
autophagy related 7
decreases expression
ISO
Nonidet P-40 results in decreased expression of ATG7 mRNA
CTD
PMID:26552463
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
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Atr
ATR serine/threonine kinase
decreases expression
ISO
Nonidet P-40 results in decreased expression of ATR mRNA
CTD
PMID:26552463
NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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Bbc3
Bcl-2 binding component 3
increases expression
ISO
Nonidet P-40 results in increased expression of BBC3 mRNA
CTD
PMID:26552463
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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Becn1
beclin 1
increases expression
ISO
Nonidet P-40 results in increased expression of BECN1 mRNA
CTD
PMID:26552463
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Bid
BH3 interacting domain death agonist
increases expression
ISO
Nonidet P-40 results in increased expression of BID mRNA
CTD
PMID:26552463
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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Bnip3l
BCL2 interacting protein 3 like
increases expression
ISO
Nonidet P-40 results in increased expression of BNIP3L mRNA
CTD
PMID:26552463
NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
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Calr
calreticulin
decreases expression
ISO
Nonidet P-40 results in decreased expression of CALR mRNA
CTD
PMID:26552463
NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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Car9
carbonic anhydrase 9
decreases expression
ISO
Nonidet P-40 results in decreased expression of CA9 mRNA
CTD
PMID:26552463
NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
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Casp1
caspase 1
decreases expression
ISO
Nonidet P-40 results in decreased expression of CASP1 mRNA
CTD
PMID:26552463
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Ccl2
C-C motif chemokine ligand 2
increases expression
ISO
Nonidet P-40 results in increased expression of CCL2 mRNA
CTD
PMID:26552463
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Nonidet P-40 results in increased expression of CDKN1A mRNA
CTD
PMID:26552463
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Chek2
checkpoint kinase 2
increases expression
ISO
Nonidet P-40 results in increased expression of CHEK2 mRNA
CTD
PMID:26552463
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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Crp
C-reactive protein
increases expression
ISO
Nonidet P-40 results in increased expression of CRP mRNA
CTD
PMID:26552463
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Ddb2
damage specific DNA binding protein 2
decreases expression
ISO
Nonidet P-40 results in decreased expression of DDB2 mRNA
CTD
PMID:26552463
NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Nonidet P-40 results in increased expression of DDIT3 mRNA
CTD
PMID:26552463
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Dnajc3
DnaJ heat shock protein family (Hsp40) member C3
increases expression
ISO
Nonidet P-40 results in increased expression of DNAJC3 mRNA
CTD
PMID:26552463
NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181
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Epo
erythropoietin
decreases expression
ISO
Nonidet P-40 results in decreased expression of EPO mRNA
CTD
PMID:26552463
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
Nonidet P-40 results in increased expression of GADD45A mRNA
CTD
PMID:26552463
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gclc
glutamate-cysteine ligase, catalytic subunit
decreases expression
ISO
Nonidet P-40 results in decreased expression of GCLC mRNA
CTD
PMID:26552463
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
Nonidet P-40 results in increased expression of GCLM mRNA
CTD
PMID:26552463
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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Grb2
growth factor receptor bound protein 2
decreases expression
ISO
Nonidet P-40 results in decreased expression of GRB2 mRNA
CTD
PMID:26552463
NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
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Hmox1
heme oxygenase 1
increases expression
ISO
Nonidet P-40 results in increased expression of HMOX1 mRNA
CTD
PMID:26552463
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hsp90aa1
heat shock protein 90 alpha family class A member 1
increases expression
ISO
Nonidet P-40 results in increased expression of HSP90AA1 mRNA
CTD
PMID:26552463
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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Hspa4
heat shock protein family A (Hsp70) member 4
increases expression
ISO
Nonidet P-40 results in increased expression of HSPA4 mRNA
CTD
PMID:26552463
NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
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Hspa4l
heat shock protein family A (Hsp70) member 4 like
increases expression
ISO
Nonidet P-40 results in increased expression of HSPA4L mRNA
CTD
PMID:26552463
NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084
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Hspa5
heat shock protein family A (Hsp70) member 5
decreases expression
ISO
Nonidet P-40 results in decreased expression of HSPA5 mRNA
CTD
PMID:26552463
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Hus1
HUS1 checkpoint clamp component
increases expression
ISO
Nonidet P-40 results in increased expression of HUS1 mRNA
CTD
PMID:26552463
NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442
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Ifng
interferon gamma
decreases expression
ISO
Nonidet P-40 results in decreased expression of IFNG mRNA
CTD
PMID:26552463
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il1a
interleukin 1 alpha
decreases expression
ISO
Nonidet P-40 results in decreased expression of IL1A mRNA
CTD
PMID:26552463
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il6
interleukin 6
increases expression
ISO
Nonidet P-40 results in increased expression of IL6 mRNA
CTD
PMID:26552463
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Ldha
lactate dehydrogenase A
decreases expression
ISO
Nonidet P-40 results in decreased expression of LDHA mRNA
CTD
PMID:26552463
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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Mcl1
MCL1 apoptosis regulator, BCL2 family member
increases expression
ISO
Nonidet P-40 results in increased expression of MCL1 mRNA
CTD
PMID:26552463
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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Mmp9
matrix metallopeptidase 9
decreases expression
ISO
Nonidet P-40 results in decreased expression of MMP9 mRNA
CTD
PMID:26552463
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mre11
MRE11 homolog, double strand break repair nuclease
increases expression
ISO
Nonidet P-40 results in increased expression of MRE11A mRNA
CTD
PMID:26552463
NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
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Nbn
nibrin
increases expression
ISO
Nonidet P-40 results in increased expression of NBN mRNA
CTD
PMID:26552463
NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
Nonidet P-40 results in increased expression of NQO1 mRNA
CTD
PMID:26552463
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Parp1
poly (ADP-ribose) polymerase 1
decreases expression
ISO
Nonidet P-40 results in decreased expression of PARP1 mRNA
CTD
PMID:26552463
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Rad17
RAD17 checkpoint clamp loader component
increases expression
ISO
Nonidet P-40 results in increased expression of RAD17 mRNA
CTD
PMID:26552463
NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072
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Rad51
RAD51 recombinase
decreases expression
ISO
Nonidet P-40 results in decreased expression of RAD51 mRNA
CTD
PMID:26552463
NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
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Rad9a
RAD9 checkpoint clamp component A
increases expression
ISO
Nonidet P-40 results in increased expression of RAD9A mRNA
CTD
PMID:26552463
NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608
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Serpine1
serpin family E member 1
decreases expression
ISO
Nonidet P-40 results in decreased expression of SERPINE1 mRNA
CTD
PMID:26552463
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Slc2a1
solute carrier family 2 member 1
increases expression
ISO
Nonidet P-40 results in increased expression of SLC2A1 mRNA
CTD
PMID:26552463
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Sqstm1
sequestosome 1
decreases expression
ISO
Nonidet P-40 results in decreased expression of SQSTM1 mRNA
CTD
PMID:26552463
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Tlr4
toll-like receptor 4
decreases expression
ISO
Nonidet P-40 results in decreased expression of TLR4 mRNA
CTD
PMID:26552463
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tnfrsf10b
TNF receptor superfamily member 10b
decreases expression
ISO
Nonidet P-40 results in decreased expression of TNFRSF10A mRNA
CTD
PMID:26552463
NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
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Tnfrsf1a
TNF receptor superfamily member 1A
decreases expression
ISO
Nonidet P-40 results in decreased expression of TNFRSF1A mRNA
CTD
PMID:26552463
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Tp53
tumor protein p53
decreases expression
ISO
Nonidet P-40 results in decreased expression of TP53 mRNA
CTD
PMID:26552463
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Txn1
thioredoxin 1
decreases expression
ISO
Nonidet P-40 results in decreased expression of TXN mRNA
CTD
PMID:26552463
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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Txnrd1
thioredoxin reductase 1
increases expression
ISO
Nonidet P-40 results in increased expression of TXNRD1 mRNA
CTD
PMID:26552463
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Ulk1
unc-51 like autophagy activating kinase 1
decreases expression
ISO
Nonidet P-40 results in decreased expression of ULK1 mRNA
CTD
PMID:26552463
NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
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Vegfa
vascular endothelial growth factor A
decreases expression
ISO
Nonidet P-40 results in decreased expression of VEGFA mRNA
CTD
PMID:26552463
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Xpc
XPC complex subunit, DNA damage recognition and repair factor
decreases expression
ISO
Nonidet P-40 results in decreased expression of XPC mRNA
CTD
PMID:26552463
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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Hmox1
heme oxygenase 1
increases expression
ISO
polysorbate 40 results in increased expression of HMOX1 mRNA
CTD
PMID:17225922
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Cnfn
cornifelin
increases expression
ISO
Octoxynol results in increased expression of CNFN mRNA; Octoxynol results in increased expression of CNFN protein
CTD
PMID:25377654
NCBI chr 1:80,949,699...80,953,747
Ensembl chr 1:80,951,600...80,953,747
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Egr1
early growth response 1
increases expression
ISO
Octoxynol results in increased expression of EGR1 mRNA
CTD
PMID:25377654
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Ezr
ezrin
increases expression
ISO
Octoxynol results in increased expression of EZR mRNA
CTD
PMID:29893927
NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
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Fn1
fibronectin 1
decreases expression
ISO
Octoxynol results in decreased expression of FN1 mRNA
CTD
PMID:25377654
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Il1a
interleukin 1 alpha
increases secretion
ISO
Octoxynol results in increased secretion of IL1A protein
CTD
PMID:23999410
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Octoxynol results in decreased activity of KCNH2 protein
CTD
PMID:24052561
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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LOC120100208
small nucleolar RNA SNORA71
decreases expression
ISO
Octoxynol results in decreased expression of SNORA71D mRNA
CTD
PMID:25377654
NCBI chr 1:232,131,169...232,131,300
Ensembl chr 1:232,131,169...232,131,300
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Scd
stearoyl-CoA desaturase
increases expression
ISO
Octoxynol results in increased expression of SCD mRNA
CTD
PMID:29155129
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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Trpv1
transient receptor potential cation channel, subfamily V, member 1
multiple interactions
EXP
Octoxynol inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]
CTD
PMID:17038422
NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
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