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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:6beta-hydroxycortisol
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Accession:CHEBI:139271 term browser browse the term
Definition:A C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.
Synonyms:exact_synonym: 6beta,11beta,17,21-tetrahydroxypregn-4-ene-3,20-dione
 related_synonym: (6beta,11beta)-6,11,17,21-tetrahydroxypregn-4-ene-3,20-dione;   6beta,11beta,17alpha,21-tetrahydroxypregn-4-ene-3,20-dione;   6beta-HO-cortisol;   6beta-OH-cortisol;   Formula=C21H30O6;   InChI=1S/C21H30O6/c1-19-5-3-11(23)7-14(19)15(24)8-12-13-4-6-21(27,17(26)10-22)20(13,2)9-16(25)18(12)19/h7,12-13,15-16,18,22,24-25,27H,3-6,8-10H2,1-2H3/t12-,13-,15+,16-,18+,19-,20-,21-/m0/s1;   InChIKey=GNFTWPCIRXSCQF-UJXAPRPESA-N;   NSC 76163;   SMILES=C1[C@@]2([C@@]([C@@]3(C([C@@H]1O)=CC(CC3)=O)C)([C@H](C[C@@]4([C@@](CC[C@@]24[H])(O)C(CO)=O)C)O)[H])[H]
 xref: CAS:53-35-0
 xref_mesh: MESH:C001380
 xref: PMID:14605790;   PMID:16149517;   PMID:16792464;   PMID:17386716;   PMID:19959402;   PMID:20963880;   PMID:21490593;   Reaxys:2512454


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6beta-hydroxycortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects chemical synthesis ISO CYP3A4 protein affects the chemical synthesis of 6 beta-hydroxycortisol CTD PMID:15941677 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      application 19630
        probe 508
          6beta-hydroxycortisol 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbonyl compound 18858
                                    ketone 17163
                                      oxyketone 8906
                                        alpha-oxyketone 8900
                                          alpha-hydroxy ketone 8900
                                            primary alpha-hydroxy ketone 7785
                                              cortisol 275
                                                6beta-hydroxycortisol 1
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