Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:6beta-hydroxycortisol
go back to main search page
Accession:CHEBI:139271 term browser browse the term
Definition:A C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.
Synonyms:exact_synonym: 6beta,11beta,17,21-tetrahydroxypregn-4-ene-3,20-dione
 related_synonym: (6beta,11beta)-6,11,17,21-tetrahydroxypregn-4-ene-3,20-dione;   6beta,11beta,17alpha,21-tetrahydroxypregn-4-ene-3,20-dione;   6beta-HO-cortisol;   6beta-OH-cortisol;   Formula=C21H30O6;   InChI=1S/C21H30O6/c1-19-5-3-11(23)7-14(19)15(24)8-12-13-4-6-21(27,17(26)10-22)20(13,2)9-16(25)18(12)19/h7,12-13,15-16,18,22,24-25,27H,3-6,8-10H2,1-2H3/t12-,13-,15+,16-,18+,19-,20-,21-/m0/s1;   InChIKey=GNFTWPCIRXSCQF-UJXAPRPESA-N;   NSC 76163;   SMILES=C1[C@@]2([C@@]([C@@]3(C([C@@H]1O)=CC(CC3)=O)C)([C@H](C[C@@]4([C@@](CC[C@@]24[H])(O)C(CO)=O)C)O)[H])[H]
 xref: CAS:53-35-0
 xref_mesh: MESH:C001380
 xref: PMID:14605790;   PMID:16149517;   PMID:16792464;   PMID:17386716;   PMID:19959402;   PMID:20963880;   PMID:21490593;   Reaxys:2512454



show annotations for term's descendants           Sort by:
 
6beta-hydroxycortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects chemical synthesis ISO CYP3A4 protein affects the chemical synthesis of 6 beta-hydroxycortisol CTD PMID:15941677 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      application 19492
        probe 501
          6beta-hydroxycortisol 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      ketone 16955
                                        oxyketone 8674
                                          alpha-oxyketone 8674
                                            alpha-hydroxy ketone 8674
                                              primary alpha-hydroxy ketone 7544
                                                cortisol 168
                                                  6beta-hydroxycortisol 1
paths to the root