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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:6beta-hydroxycortisol
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Accession:CHEBI:139271 term browser browse the term
Definition:A C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.
Synonyms:exact_synonym: 6beta,11beta,17,21-tetrahydroxypregn-4-ene-3,20-dione
 related_synonym: (6beta,11beta)-6,11,17,21-tetrahydroxypregn-4-ene-3,20-dione;   6beta,11beta,17alpha,21-tetrahydroxypregn-4-ene-3,20-dione;   6beta-HO-cortisol;   6beta-OH-cortisol;   Formula=C21H30O6;   InChI=1S/C21H30O6/c1-19-5-3-11(23)7-14(19)15(24)8-12-13-4-6-21(27,17(26)10-22)20(13,2)9-16(25)18(12)19/h7,12-13,15-16,18,22,24-25,27H,3-6,8-10H2,1-2H3/t12-,13-,15+,16-,18+,19-,20-,21-/m0/s1;   InChIKey=GNFTWPCIRXSCQF-UJXAPRPESA-N;   NSC 76163;   SMILES=C1[C@@]2([C@@]([C@@]3(C([C@@H]1O)=CC(CC3)=O)C)([C@H](C[C@@]4([C@@](CC[C@@]24[H])(O)C(CO)=O)C)O)[H])[H]
 xref: CAS:53-35-0
 xref_mesh: MESH:C001380
 xref: PMID:14605790;   PMID:16149517;   PMID:16792464;   PMID:17386716;   PMID:19959402;   PMID:20963880;   PMID:21490593;   Reaxys:2512454



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6beta-hydroxycortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects chemical synthesis ISO CYP3A4 protein affects the chemical synthesis of 6 beta-hydroxycortisol CTD PMID:15941677 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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  CHEBI ontology 19741
    role 19714
      application 19547
        probe 502
          6beta-hydroxycortisol 1
Path 2
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  CHEBI ontology 19741
    subatomic particle 19739
      composite particle 19739
        hadron 19739
          baryon 19739
            nucleon 19739
              atomic nucleus 19739
                atom 19739
                  main group element atom 19687
                    p-block element atom 19687
                      carbon group element atom 19633
                        carbon atom 19629
                          organic molecular entity 19629
                            organic group 18837
                              organic divalent group 18822
                                organodiyl group 18822
                                  carbonyl group 18786
                                    carbonyl compound 18786
                                      ketone 17094
                                        oxyketone 8793
                                          alpha-oxyketone 8793
                                            alpha-hydroxy ketone 8793
                                              primary alpha-hydroxy ketone 7672
                                                cortisol 273
                                                  6beta-hydroxycortisol 1
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