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ONTOLOGY REPORT - ANNOTATIONS


Term:GSK2656157
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Accession:CHEBI:139047 term browser browse the term
Definition:A pyrrolopyrimidine that is 7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine which has been substituted at position 5 by a 4-fluoro-2,3-dihydro-1H-indol-5-yl group, the nitrogen of which has been acylated by a (6-methylpyridin-2-yl)acetyl group. An orally bioavailable PERK inhibitor.
Synonyms:exact_synonym: 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methylpyridin-2-yl)ethanone
 related_synonym: 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)-ethanone;   Formula=C23H21FN6O;   InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27);   InChIKey=PRWSIEBRGXYXAJ-UHFFFAOYSA-N;   PERK inhibitor;   SMILES=C=1(C2=C(N=CN1)N(C)C=C2C=3C(=C4C(=CC3)N(CC4)C(CC5=CC=CC(=N5)C)=O)F)N
 xref: CAS:1337532-29-2 "SUBMITTER"
 xref_mesh: MESH:C000597302
 xref: PMID:23333938 "Europe PMC";   PMID:24401334 "Europe PMC";   PMID:24900593 "Europe PMC";   PMID:27251848 "Europe PMC";   PMID:27682474 "Europe PMC";   PMID:28212323 "Europe PMC";   PMID:28452996 "Europe PMC";   PMID:28522733 "Europe PMC";   PMID:28641278 "Europe PMC";   PMID:28672279 "Europe PMC";   PMID:28686850 "Europe PMC";   PMID:28763567 "Europe PMC";   PMID:28867195 "Europe PMC";   Reaxys:21981813 "Reaxys"


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GSK2656157 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:6480464
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha JBrowse link 6 102,048,372 102,073,041 RGD:6480464
G Ostn osteocrin JBrowse link 11 76,851,923 76,888,140 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            antineoplastic agent 16555
              GSK2656157 3
Path 2
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  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                tertiary carboxamide 120
                                                  GSK2656157 3
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