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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxysafflor yellow A
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Accession:CHEBI:139030 term browser browse the term
Definition:A C-glycosyl compound that is 3,4,5-trihydroxycyclohexa-2,5-dien-1-one which is substituted by beta-D-glucosyl groups at positions 2 and 4, and by a p-hydroxycinnamoyl group at position 6. It is the main bioactive compound of a traditional Chinese medicine obtained from safflower (Carthamus tinctorius).
Synonyms:related_synonym: 2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl-1-oxo-2-propen-1-yl)]-2,5-cyclohexadien-1-one;   2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl-1-oxo-prop-2-en-1-yl)]cyclohexa-2,5-dien-1-one;   Formula=C27H32O16;   HSYA;   InChI=1S/C27H32O16/c28-7-12-16(32)19(35)21(37)23(42-12)15-18(34)14(11(31)6-3-9-1-4-10(30)5-2-9)24(39)27(41,25(15)40)26-22(38)20(36)17(33)13(8-29)43-26/h1-6,12-13,16-17,19-23,26,28-30,32-33,35-41H,7-8H2/b6-3+/t12-,13-,16-,17-,19+,20+,21-,22-,23+,26-,27?/m1/s1;   InChIKey=LIPJRCGLQNIXGO-ONZBGLOFSA-N;   SMILES=O1[C@H]([C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)C2=C(O)C(C(O)=C(C2=O)C(=O)/C=C/C3=CC=C(O)C=C3)(O)[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO;   safflomin A
 xref: CAS:78281-02-4;   FooDB:FDB020474;   HMDB:HMDB0040677
 xref_mesh: MESH:C085278
 xref: PMID:25626885;   PMID:26607471;   PMID:26754542;   PMID:26777519;   PMID:27063983;   PMID:27086971;   PMID:27176815;   PMID:27457091;   PMID:27599591;   PMID:27713966;   PMID:27731393;   PMID:27894114;   PMID:27909717;   PMID:28068632;   PMID:28074914;   PMID:28097465;   PMID:28122306;   PMID:28154251;   PMID:28191279;   PMID:28264629;   PMID:28468657;   PMID:28553231;   PMID:28840700;   PMID:28932195;   PMID:28966242;   PMID:29076598;   PMID:29107614;   PMID:29107696;   Reaxys:8669627


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hydroxysafflor yellow A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule multiple interactions EXP hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40 protein]]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of CD40 protein] CTD PMID:24192212 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd40lg CD40 ligand multiple interactions EXP hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40LG protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40LG protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of CD40LG protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of CD40LG protein] CTD PMID:24192212 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
EXP
ISO
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of ICAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of ICAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 protein]
hydroxysafflor yellow A results in decreased expression of ICAM1 protein
hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]
CTD PMID:22007554 PMID:24192212 PMID:32705535 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of IL6 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of IL6 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of IL6 protein]
hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD PMID:22007554 PMID:24192212 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions EXP hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of ITGB3 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of ITGB3 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of ITGB3 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of ITGB3 protein] CTD PMID:24192212 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP
ISO
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of MMP9 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of MMP9 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of MMP9 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of MMP9 protein]
hydroxysafflor yellow A results in decreased expression of MMP9 protein
CTD PMID:24192212 PMID:32705535 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO hydroxysafflor yellow A results in decreased phosphorylation of and results in decreased expression of NFKBIA protein modified form CTD PMID:32705535 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in decreased expression of PPARG protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in decreased expression of PPARG protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in decreased expression of PPARG protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in decreased expression of PPARG protein] CTD PMID:24192212 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in decreased activity of PRKACA protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in decreased activity of PRKACA protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in decreased activity of PRKACA protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in decreased activity of PRKACA protein] CTD PMID:24192212 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO hydroxysafflor yellow A results in decreased phosphorylation of and results in decreased expression of RELA protein modified form CTD PMID:32705535 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
hydroxysafflor yellow A results in decreased expression of TNF protein
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of TNF protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of TNF protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of TNF protein]
CTD PMID:22007554 PMID:24192212 PMID:32705535 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
ISO
EXP
hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]
hydroxysafflor yellow A results in decreased expression of VCAM1 protein
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of VCAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of VCAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of VCAM1 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of VCAM1 protein]
CTD PMID:22007554 PMID:24192212 PMID:32705535 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

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  CHEBI ontology 19821
    role 19769
      chemical role 19345
        antioxidant 14443
          hydroxysafflor yellow A 12
Path 2
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            heteroorganic entity 19294
                              organochalcogen compound 19064
                                organooxygen compound 19014
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      carbohydrate derivative 11947
                                        glycosyl compound 10977
                                          C-glycosyl compound 258
                                            hydroxysafflor yellow A 12
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