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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxysafflor yellow A
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Accession:CHEBI:139030 term browser browse the term
Definition:A C-glycosyl compound that is 3,4,5-trihydroxycyclohexa-2,5-dien-1-one which is substituted by beta-D-glucosyl groups at positions 2 and 4, and by a p-hydroxycinnamoyl group at position 6. It is the main bioactive compound of a traditional Chinese medicine obtained from safflower (Carthamus tinctorius).
Synonyms:related_synonym: 2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl-1-oxo-2-propen-1-yl)]-2,5-cyclohexadien-1-one;   2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl-1-oxo-prop-2-en-1-yl)]cyclohexa-2,5-dien-1-one;   Formula=C27H32O16;   HSYA;   InChI=1S/C27H32O16/c28-7-12-16(32)19(35)21(37)23(42-12)15-18(34)14(11(31)6-3-9-1-4-10(30)5-2-9)24(39)27(41,25(15)40)26-22(38)20(36)17(33)13(8-29)43-26/h1-6,12-13,16-17,19-23,26,28-30,32-33,35-41H,7-8H2/b6-3+/t12-,13-,16-,17-,19+,20+,21-,22-,23+,26-,27?/m1/s1;   InChIKey=LIPJRCGLQNIXGO-ONZBGLOFSA-N;   SMILES=O1[C@H]([C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)C2=C(O)C(C(O)=C(C2=O)C(=O)/C=C/C3=CC=C(O)C=C3)(O)[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO;   safflomin A
 xref: CAS:78281-02-4;   FooDB:FDB020474;   HMDB:HMDB0040677
 xref_mesh: MESH:C085278
 xref: PMID:25626885;   PMID:26607471;   PMID:26754542;   PMID:26777519;   PMID:27063983;   PMID:27086971;   PMID:27176815;   PMID:27457091;   PMID:27599591;   PMID:27713966;   PMID:27731393;   PMID:27894114;   PMID:27909717;   PMID:28068632;   PMID:28074914;   PMID:28097465;   PMID:28122306;   PMID:28154251;   PMID:28191279;   PMID:28264629;   PMID:28468657;   PMID:28553231;   PMID:28840700;   PMID:28932195;   PMID:28966242;   PMID:29076598;   PMID:29107614;   PMID:29107696;   Reaxys:8669627



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hydroxysafflor yellow A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 multiple interactions ISO HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of CASP1 protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of and results in increased cleavage of CASP1 protein]
hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased activity of and results in increased cleavage of CASP1 protein]
CTD PMID:37001609 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Cat catalase multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in increased expression of CAT protein] CTD PMID:37195255 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cd40 CD40 molecule multiple interactions EXP hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40 protein]]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of CD40 protein] CTD PMID:24192212 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd40lg CD40 ligand multiple interactions EXP hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40LG protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40LG protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of CD40LG protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of CD40LG protein] CTD PMID:24192212 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cldn1 claudin 1 multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in decreased expression of CLDN1 protein] CTD PMID:37001609 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in decreased expression of FOXP3 protein] CTD PMID:37195255 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Gsdmd gasdermin D multiple interactions ISO HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein]
hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased cleavage of GSDMD protein]
CTD PMID:37001609 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
JBrowse link
G Hk1 hexokinase 1 multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased expression of HK1 protein]
HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of CASP1 protein]]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein]]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of HK1 protein]
CTD PMID:37001609 NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in decreased expression of HMOX1 protein] CTD PMID:37195255 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
EXP
ISO
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of ICAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of ICAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 protein]
hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]
hydroxysafflor yellow A results in decreased expression of ICAM1 protein
CTD PMID:22007554 PMID:24192212 PMID:32705535 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il10 interleukin 10 multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in decreased expression of IL10 protein] CTD PMID:37195255 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in increased expression of IL13 protein] CTD PMID:37195255 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il17a interleukin 17A multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in increased expression of IL17A protein] CTD PMID:37195255 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased secretion of IL18 protein] CTD PMID:37001609 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of IL1B protein]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein]
hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased cleavage of IL1B protein]; hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein]; hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in increased expression of IL1B protein]
CTD PMID:37001609 PMID:37195255 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in increased expression of IL4 protein] CTD PMID:37195255 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in increased expression of IL5 protein] CTD PMID:37195255 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of IL6 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of IL6 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of IL6 protein]
hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL6 protein]; hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased secretion of IL6 protein]; hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in increased expression of IL6 protein]
CTD PMID:22007554 PMID:24192212 PMID:37001609 PMID:37195255 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions EXP hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of ITGB3 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of ITGB3 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of ITGB3 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of ITGB3 protein] CTD PMID:24192212 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP
ISO
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of MMP9 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of MMP9 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of MMP9 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of MMP9 protein]
hydroxysafflor yellow A results in decreased expression of MMP9 protein
CTD PMID:24192212 PMID:32705535 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in increased expression of MPO protein] CTD PMID:37001609 PMID:37195255 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in decreased expression of NFE2L2 protein] CTD PMID:37195255 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO hydroxysafflor yellow A results in decreased phosphorylation of and results in decreased expression of NFKBIA protein modified form CTD PMID:32705535 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 protein] CTD PMID:37001609 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Ocln occludin multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in decreased expression of OCLN protein] CTD PMID:37001609 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in decreased expression of PPARG protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in decreased expression of PPARG protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in decreased expression of PPARG protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in decreased expression of PPARG protein] CTD PMID:24192212 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in decreased activity of PRKACA protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in decreased activity of PRKACA protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in decreased activity of PRKACA protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in decreased activity of PRKACA protein] CTD PMID:24192212 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO hydroxysafflor yellow A results in decreased phosphorylation of and results in decreased expression of RELA protein modified form CTD PMID:32705535 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in increased expression of RORC protein] CTD PMID:37195255 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in increased expression of and results in increased phosphorylation of STAT3 protein] CTD PMID:37195255 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of TNF protein]; hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of TNF protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of TNF protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of TNF protein]
hydroxysafflor yellow A results in decreased expression of TNF protein
hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased secretion of TNF protein]; hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in increased expression of TNF protein]
CTD PMID:22007554 PMID:24192212 PMID:32705535 PMID:37001609 PMID:37195255 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
ISO
EXP
hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of VCAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of VCAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of VCAM1 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of VCAM1 protein]
hydroxysafflor yellow A results in decreased expression of VCAM1 protein
CTD PMID:22007554 PMID:24192212 PMID:32705535 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

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  CHEBI ontology 19918
    role 19894
      chemical role 19512
        antioxidant 16062
          hydroxysafflor yellow A 32
Path 2
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  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            heteroorganic entity 19548
                              organochalcogen compound 19303
                                organooxygen compound 19217
                                  carbohydrates and carbohydrate derivatives 15307
                                    carbohydrate 15307
                                      carbohydrate derivative 14311
                                        glycosyl compound 13060
                                          C-glycosyl compound 319
                                            hydroxysafflor yellow A 32
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