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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxysafflor yellow A
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Accession:CHEBI:139030 term browser browse the term
Definition:A C-glycosyl compound that is 3,4,5-trihydroxycyclohexa-2,5-dien-1-one which is substituted by beta-D-glucosyl groups at positions 2 and 4, and by a p-hydroxycinnamoyl group at position 6. It is the main bioactive compound of a traditional Chinese medicine obtained from safflower (Carthamus tinctorius).
Synonyms:related_synonym: 2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl-1-oxo-2-propen-1-yl)]-2,5-cyclohexadien-1-one;   2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl-1-oxo-prop-2-en-1-yl)]cyclohexa-2,5-dien-1-one;   Formula=C27H32O16;   HSYA;   InChI=1S/C27H32O16/c28-7-12-16(32)19(35)21(37)23(42-12)15-18(34)14(11(31)6-3-9-1-4-10(30)5-2-9)24(39)27(41,25(15)40)26-22(38)20(36)17(33)13(8-29)43-26/h1-6,12-13,16-17,19-23,26,28-30,32-33,35-41H,7-8H2/b6-3+/t12-,13-,16-,17-,19+,20+,21-,22-,23+,26-,27?/m1/s1;   InChIKey=LIPJRCGLQNIXGO-ONZBGLOFSA-N;   SMILES=O1[C@H]([C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)C2=C(O)C(C(O)=C(C2=O)C(=O)/C=C/C3=CC=C(O)C=C3)(O)[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO;   safflomin A
 xref: CAS:78281-02-4;   FooDB:FDB020474;   HMDB:HMDB0040677
 xref_mesh: MESH:C085278
 xref: PMID:25626885;   PMID:26607471;   PMID:26754542;   PMID:26777519;   PMID:27063983;   PMID:27086971;   PMID:27176815;   PMID:27457091;   PMID:27599591;   PMID:27713966;   PMID:27731393;   PMID:27894114;   PMID:27909717;   PMID:28068632;   PMID:28074914;   PMID:28097465;   PMID:28122306;   PMID:28154251;   PMID:28191279;   PMID:28264629;   PMID:28468657;   PMID:28553231;   PMID:28840700;   PMID:28932195;   PMID:28966242;   PMID:29076598;   PMID:29107614;   PMID:29107696;   Reaxys:8669627


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hydroxysafflor yellow A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule multiple interactions EXP hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40 protein]]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of CD40 protein] CTD PMID:24192212 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd40lg CD40 ligand multiple interactions EXP hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40LG protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40LG protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of CD40LG protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of CD40LG protein] CTD PMID:24192212 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
EXP
ISO
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of ICAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of ICAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 protein]
hydroxysafflor yellow A results in decreased expression of ICAM1 protein
hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]
CTD PMID:22007554, PMID:24192212, PMID:32705535 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of IL6 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of IL6 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of IL6 protein]
hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD PMID:22007554, PMID:24192212 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions EXP hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of ITGB3 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of ITGB3 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of ITGB3 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of ITGB3 protein] CTD PMID:24192212 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP
ISO
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of MMP9 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of MMP9 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of MMP9 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of MMP9 protein]
hydroxysafflor yellow A results in decreased expression of MMP9 protein
CTD PMID:24192212, PMID:32705535 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO hydroxysafflor yellow A results in decreased phosphorylation of and results in decreased expression of NFKBIA protein modified form CTD PMID:32705535 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in decreased expression of PPARG protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in decreased expression of PPARG protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in decreased expression of PPARG protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in decreased expression of PPARG protein] CTD PMID:24192212 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in decreased activity of PRKACA protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in decreased activity of PRKACA protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in decreased activity of PRKACA protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in decreased activity of PRKACA protein] CTD PMID:24192212 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO hydroxysafflor yellow A results in decreased phosphorylation of and results in decreased expression of RELA protein modified form CTD PMID:32705535 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
hydroxysafflor yellow A results in decreased expression of TNF protein
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of TNF protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of TNF protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of TNF protein]
CTD PMID:22007554, PMID:24192212, PMID:32705535 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
ISO
EXP
hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]
hydroxysafflor yellow A results in decreased expression of VCAM1 protein
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of VCAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of VCAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of VCAM1 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of VCAM1 protein]
CTD PMID:22007554, PMID:24192212, PMID:32705535 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

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  CHEBI ontology 19792
    role 19738
      chemical role 19275
        antioxidant 14222
          hydroxysafflor yellow A 12
Path 2
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  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            heteroorganic entity 19165
                              organochalcogen compound 18873
                                organooxygen compound 18795
                                  carbohydrates and carbohydrate derivatives 12193
                                    carbohydrate 12193
                                      carbohydrate derivative 11814
                                        glycosyl compound 10854
                                          C-glycosyl compound 235
                                            hydroxysafflor yellow A 12
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.