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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:S-nitroso-L-cysteine
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Accession:CHEBI:138935 term browser browse the term
Definition:An L-cysteine derivative in which the sulfur atom carries a nitroso substituent. A cell-permeable low-molecular-weight nitrosothiol and nitric oxide donor.
Synonyms:related_synonym: CysNO;   Formula=C3H6N2O3S;   InChI=1S/C3H6N2O3S/c4-2(3(6)7)1-9-5-8/h2H,1,4H2,(H,6,7)/t2-/m0/s1;   InChIKey=XOWVFANEOZMPKG-REOHCLBHSA-N;   L-CysSNO;   NO-L-cysteine;   NO-cysteine;   Nitrosocysteine;   S-Nitrosocysteine;   SMILES=C([C@@H](N)CSN=O)(=O)O
 alt_id: CHEBI:45691
 xref: CAS:51209-75-7
 xref_mesh: MESH:C021315
 xref: PDBeChem:SNC;   PMID:22304688;   PMID:26444682;   PMID:26686469;   PMID:27064847;   PMID:27126574;   PMID:28081246;   PMID:28381519;   PMID:28440386;   PMID:28600633;   PMID:28764371;   Reaxys:3538115


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S-nitroso-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 multiple interactions ISO S-nitrosocysteine inhibits the reaction [Isoproterenol affects the localization of ARRB2 protein] CTD PMID:17482545 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Casp3 caspase 3 multiple interactions ISO S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased cleavage of CASP3 protein] CTD PMID:24451382 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 increases nitrosation ISO S-nitrosocysteine results in increased nitrosation of GRK2 protein CTD PMID:17482545 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP [S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein] CTD PMID:16386761 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased acetylation of TP53 protein]; S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased cleavage of CASP3 protein] CTD PMID:24451382 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased acetylation of TP53 protein] CTD PMID:24451382 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            hematologic agent 4367
              S-nitroso-L-cysteine 6
                S-nitroso-L-cysteine residue 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        amino acid 14085
                                          alpha-amino acid 11550
                                            L-alpha-amino acid 11385
                                              serine family amino acid 1878
                                                L-cysteine 1137
                                                  L-cysteine derivative 1126
                                                    S-nitroso-L-cysteine 6
                                                      S-nitroso-L-cysteine residue 0
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