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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:S-nitroso-L-cysteine
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Accession:CHEBI:138935 term browser browse the term
Definition:An L-cysteine derivative in which the sulfur atom carries a nitroso substituent. A cell-permeable low-molecular-weight nitrosothiol and nitric oxide donor.
Synonyms:related_synonym: CysNO;   Formula=C3H6N2O3S;   InChI=1S/C3H6N2O3S/c4-2(3(6)7)1-9-5-8/h2H,1,4H2,(H,6,7)/t2-/m0/s1;   InChIKey=XOWVFANEOZMPKG-REOHCLBHSA-N;   L-CysSNO;   NO-L-cysteine;   NO-cysteine;   Nitrosocysteine;   S-Nitrosocysteine;   SMILES=C([C@@H](N)CSN=O)(=O)O
 alt_id: CHEBI:45691
 xref: CAS:51209-75-7
 xref_mesh: MESH:C021315
 xref: PDBeChem:SNC;   PMID:22304688;   PMID:26444682;   PMID:26686469;   PMID:27064847;   PMID:27126574;   PMID:28081246;   PMID:28381519;   PMID:28440386;   PMID:28600633;   PMID:28764371;   Reaxys:3538115


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S-nitroso-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 multiple interactions ISO S-nitrosocysteine inhibits the reaction [Isoproterenol affects the localization of ARRB2 protein] CTD PMID:17482545 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased cleavage of CASP3 protein] CTD PMID:24451382 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 increases nitrosation ISO S-nitrosocysteine results in increased nitrosation of GRK2 protein CTD PMID:17482545 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP [S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein] CTD PMID:16386761 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased acetylation of TP53 protein]; S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased cleavage of CASP3 protein] CTD PMID:24451382 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased acetylation of TP53 protein] CTD PMID:24451382 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        pharmaceutical 19499
          drug 19499
            hematologic agent 4772
              S-nitroso-L-cysteine 6
                S-nitroso-L-cysteine residue 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        amino acid 15541
                                          alpha-amino acid 13675
                                            L-alpha-amino acid 12607
                                              serine family amino acid 4910
                                                L-cysteine 3394
                                                  L-cysteine derivative 3385
                                                    S-nitroso-L-cysteine 6
                                                      S-nitroso-L-cysteine residue 0
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