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Term:piericidin A
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Accession:CHEBI:138511 term browser browse the term
Definition:A member of the class of monohydroxypyridines that acts as an irreversible mitochondrial Complex I inhibitor that strongly associates with ubiquinone binding sites in both mitochondrial and bacterial forms of NADH:ubiquinone oxidoreductase
Synonyms:exact_synonym: 2-[(2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraen-1-yl]-5,6-dimethoxy-3-methylpyridin-4-ol
 related_synonym: 2-[(2E,5E,7E,11E)-10R-hydroxy-3,7,9R,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl]-5,6-dimethoxy-3-methyl-4-pyridinol;   2-[(2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraenyl]-5,6-dimethoxy-3-methyl-1H-pyridin-4-one;   AR 054;   Formula=C25H37NO4;   InChI=1S/C25H37NO4/c1-9-18(4)22(27)19(5)15-17(3)12-10-11-16(2)13-14-21-20(6)23(28)24(29-7)25(26-21)30-8/h9-10,12-13,15,19,22,27H,11,14H2,1-8H3,(H,26,28)/b12-10+,16-13+,17-15+,18-9+/t19-,22+/m1/s1;   InChIKey=BBLGCDSLCDDALX-LKGBESRRSA-N;   Piericidin A1;   SMILES=C/C=C(/[C@@H]([C@@H](/C=C(/C=C/C/C(=C/CC=1C(=C(C(=C(N1)OC)OC)O)C)/C)\\C)C)O)\\C;   SN 198E;   Shaoguanmycin B
 xref: CAS:2738-64-9 "ChemIDplus"
 xref_mesh: MESH:C100213
 xref: MetaCyc:CPD0-1233;   PMID:12400692 "Europe PMC";   PMID:16277503 "Europe PMC";   PMID:16953619 "Europe PMC";   PMID:17721005 "Europe PMC";   PMID:17941090 "Europe PMC";   PMID:19138148 "Europe PMC";   PMID:22365607 "Europe PMC";   PMID:24295981 "Europe PMC";   PMID:24409990 "Europe PMC";   PMID:25437199 "Europe PMC";   PMID:25812110 "Europe PMC";   PMID:26856451 "Europe PMC";   PMID:27301663 "Europe PMC";   PMID:28217742 "Europe PMC";   PMID:9684860 "Europe PMC";   Pubchem:6437838 "SUBMITTER";   Reaxys:4720916 "Reaxys"

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piericidin A term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        antimicrobial agent 17151
          piericidin A 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  organic heteromonocyclic compound 16249
                                    pyridines 8322
                                      hydroxypyridine 51
                                        monohydroxypyridine 50
                                          piericidin A 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.