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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:etazolate
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Accession:CHEBI:138502 term browser browse the term
Definition:A pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties.
Synonyms:exact_synonym: ethyl 1-ethyl-4-(2-isopropylidenehydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
 related_synonym: 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)-5-pyrazolo[3,4-b]pyridinecarboxylic acid ethyl ester;   1H-pyrazolo(3,4-b)pyridine-5-carboxylic acid, 1-ethyl-4-((1-methylethylidene)hydrazino)-, ethyl ester;   EHT-0202;   Formula=C14H19N5O2;   InChI=1S/C14H19N5O2/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2/h7-8H,5-6H2,1-4H3,(H,15,18);   InChIKey=OPQRBXUBWHDHPQ-UHFFFAOYSA-N;   SMILES=CCN1C2=NC=C(C(=C2C=N1)NN=C(C)C)C(=O)OCC;   SQ-20,009;   etazolato;   etazolatum;   ethyl 1-ethyl-4-(2-isopropylidenehydrazino)pyrazolo[3,4-b]pyridine-5-carboxylate;   ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[3,4-b]pyridine-5-carboxylate;   ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[4,5-e]pyridine-5-carboxylate;   ethyl 1-ethyl-4-[2-(1-methylethylidene)hydrazino]-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
 alt_id: CHEBI:93135
 xref: CAS:51022-77-6;   Chemspider:3162;   LINCS:LSM-3446
 xref_mesh: MESH:D004974
 xref: PMID:18397369;   PMID:20223232;   PMID:22698578;   PMID:23178198;   PMID:23384434;   PMID:23926692;   PMID:23974048;   PMID:24434771;   PMID:24705918;   PMID:25120105;   PMID:25136630;   PMID:27988361;   PMID:449623;   PMID:6131949;   PMID:6132997;   PMID:6991258;   Pubchem:3277;   Reaxys:548872;   Wikipedia:Etazolate


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etazolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 decreases expression
decreases secretion
ISO Etazolate results in decreased expression of IL13 mRNA
Etazolate results in decreased secretion of IL13 protein
CTD PMID:16083514 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Ltc4s leukotriene C4 synthase decreases secretion ISO Etazolate results in decreased secretion of LTC4S protein CTD PMID:16083514 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      biological role 19717
        pharmacological role 18795
          neurotransmitter agent 16422
            GABA agent 15418
              etazolate 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      chalcogen 19359
                        oxygen atom 19320
                          oxygen molecular entity 19320
                            hydroxides 19064
                              organic hydroxy compound 18631
                                alcohol 14979
                                  primary alcohol 13881
                                    ethanols 8106
                                      ethanol 8106
                                        ethyl ester 3173
                                          etazolate 2
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