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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:etazolate
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Accession:CHEBI:138502 term browser browse the term
Definition:A pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties.
Synonyms:exact_synonym: ethyl 1-ethyl-4-(2-isopropylidenehydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
 related_synonym: 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)-5-pyrazolo[3,4-b]pyridinecarboxylic acid ethyl ester;   1H-pyrazolo(3,4-b)pyridine-5-carboxylic acid, 1-ethyl-4-((1-methylethylidene)hydrazino)-, ethyl ester;   EHT-0202;   Formula=C14H19N5O2;   InChI=1S/C14H19N5O2/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2/h7-8H,5-6H2,1-4H3,(H,15,18);   InChIKey=OPQRBXUBWHDHPQ-UHFFFAOYSA-N;   SMILES=CCN1C2=NC=C(C(=C2C=N1)NN=C(C)C)C(=O)OCC;   SQ-20,009;   etazolato;   etazolatum;   ethyl 1-ethyl-4-(2-isopropylidenehydrazino)pyrazolo[3,4-b]pyridine-5-carboxylate;   ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[3,4-b]pyridine-5-carboxylate;   ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[4,5-e]pyridine-5-carboxylate;   ethyl 1-ethyl-4-[2-(1-methylethylidene)hydrazino]-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
 alt_id: CHEBI:93135
 xref: CAS:51022-77-6;   Chemspider:3162;   LINCS:LSM-3446
 xref_mesh: MESH:D004974
 xref: PMID:18397369;   PMID:20223232;   PMID:22698578;   PMID:23178198;   PMID:23384434;   PMID:23926692;   PMID:23974048;   PMID:24434771;   PMID:24705918;   PMID:25120105;   PMID:25136630;   PMID:27988361;   PMID:449623;   PMID:6131949;   PMID:6132997;   PMID:6991258;   Pubchem:3277;   Reaxys:548872;   Wikipedia:Etazolate


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etazolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 decreases expression
decreases secretion
ISO Etazolate results in decreased expression of IL13 mRNA
Etazolate results in decreased secretion of IL13 protein
CTD PMID:16083514 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Ltc4s leukotriene C4 synthase decreases secretion ISO Etazolate results in decreased secretion of LTC4S protein CTD PMID:16083514 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19781
    role 19726
      biological role 19726
        pharmacological role 18834
          neurotransmitter agent 16445
            GABA agent 15441
              etazolate 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      chalcogen 19401
                        oxygen atom 19364
                          oxygen molecular entity 19364
                            hydroxides 19087
                              organic hydroxy compound 18659
                                alcohol 15031
                                  primary alcohol 13922
                                    ethanols 8184
                                      ethanol 8184
                                        ethyl ester 3289
                                          etazolate 2
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