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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:apoprotein
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Accession:CHEBI:13850 term browser browse the term
Definition:An apoprotein is a protein devoid of its characteristic prosthetic group or metal.
Synonyms:related_synonym: apoproteins
 xref: KEGG:C16240


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high-density lipoprotein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgam integrin subunit alpha M multiple interactions ISO High-density lipoprotein inhibits the reaction [cholesterol increases expression of ITGAM protein on monocytes and granulocytes]
High-density lipoprotein inhibits the reaction [PMA increases expression of ITGAM protein on monocytes]		 RGD PMID:26026058 PMID:18617650 RGD:329853768, RGD:329901662 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
low-density lipoprotein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgam integrin subunit alpha M increases expression ISO Low-density lipoprotein increases expression of ITGAM protein on monocytes RGD PMID:22901456 RGD:329853769 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
oxidised LDL term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions
increases phosphorylation		 ISO Albiflorin inhibits the reaction [oxidized LDL increases phosphorylation of MAP3K7 protein in umbilical vein endothelial cells]
Oxidized LDL increases phosphorylation of MAP3K7 protein in umbilical vein endothelial cells		 RGD PMID:35601145 PMID:35601145 RGD:155804296, RGD:155804296 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 decreases expression
increases expression 		ISO Oxidized LDL decreases expression of Nr1h3 mRNA and protein in vascular smooth muscle cells
Oxidized LDL increases expression of NR1H3 protein in macrophages		 RGD PMID:27807703 PMID:32780606 RGD:401850553, RGD:401850600 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Phactr1 phosphatase and actin regulator 1 increases expression
decreases expression 		ISO Oxidized low-density lipoprotein increases expression of PHACTR1 mRNA in umbilical vein endothelial cells
Oxidized low density lipoprotein decreases expression of intermediate length PHACTR1 mRNA in macrophages
Oxidized low density lipoprotein increases expression of short length PHACTR1 mRNA in macrophages		 RGD PMID:36091033 PMID:27187934 PMID:27187934 RGD:401900131, RGD:401900169, RGD:401900169 NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831 		JBrowse link
G Ptgis prostaglandin I2 synthase decreases expression ISO Oxidized LDL decreases expression of PTGIS mRNA in aortic endothelial cells and aortic smooth muscle cells RGD PMID:22112851 RGD:401959395 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 increases expression ISO Oxidized-LDL increases expression of PTPN1 mRNA and protein in endothelial cell of umbilical vein RGD PMID:35747159 RGD:401976383 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      molecular entity 19829
        polyatomic entity 19787
          macromolecule 8787
            polypeptide 251
              protein polypeptide chain 26
                protein 26
                  simple protein 6
                    apoprotein 6
                      Apoferritin 0
                      Apotransferrin 0
                      apocytochrome c 0
                      apolipoprotein + 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbon oxoacid 18613
                                    carboxylic acid 18610
                                      carboacyl group 17699
                                        univalent carboacyl group 17699
                                          carbamoyl group 17549
                                            carboxamide 17549
                                              peptide 11125
                                                polypeptide 251
                                                  protein polypeptide chain 26
                                                    protein 26
                                                      simple protein 6
                                                        apoprotein 6
                                                          Apoferritin 0
                                                          Apotransferrin 0
                                                          apocytochrome c 0
                                                          apolipoprotein + 6
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